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Gmeiner, William
One or more keywords matched the following items that are connected to Gmeiner, William
Item TypeName
Academic Article Targeted drug delivery to chemoresistant cells: folic acid derivatization of FdUMP[10] enhances cytotoxicity toward 5-FU-resistant human colorectal tumor cells.
Academic Article Effect of 5-FU substitution and mutation on Sm protein binding to human U4 snRNA.
Academic Article Enhanced DNA-directed effects of FdUMP[10] compared to 5FU.
Academic Article Novel chemical strategies for thymidylate synthase inhibition.
Academic Article Mechanisms of action of FdUMP[10]: metabolite activation and thymidylate synthase inhibition.
Academic Article Genome-wide mRNA and microRNA profiling of the NCI 60 cell-line screen and comparison of FdUMP[10] with fluorouracil, floxuridine, and topoisomerase 1 poisons.
Academic Article Solution structures of 5-fluorouracil-substituted DNA and RNA decamer duplexes.
Academic Article A novel polypyrimidine antitumor agent FdUMP[10] induces thymineless death with topoisomerase I-DNA complexes.
Academic Article Solution structures of 5-fluorouracil-substituted RNA duplexes containing G-U wobble base pairs.
Academic Article Increased cytotoxicity and decreased in vivo toxicity of FdUMP[10] relative to 5-FU.
Academic Article Positive interaction between 5-FU and FdUMP[10] in the inhibition of human colorectal tumor cell proliferation.
Concept Fluorouracil
Academic Article Selective anti-tumor activity of the novel fluoropyrimidine polymer F10 towards G48a orthotopic GBM tumors.
Grant IMPACT OF 5-FU ON THE STRUCTURE OF THE U4-U6 COMPLEX
Grant IMPACT OF 5FU ON THE STRUCTURE OF THE U4/U6 COMPLEX
Grant Development of a CF10 Predictive Gene Signature in CRC Organoids.
Academic Article Improved potency of F10 relative to 5-fluorouracil in colorectal cancer cells with p53 mutations.
Academic Article Dysregulated Pyrimidine Biosynthesis Contributes to 5-FU Resistance in SCLC Patient-Derived Organoids but Response to a Novel Polymeric Fluoropyrimidine, CF10.
Academic Article Chemistry of Fluorinated Pyrimidines in the Era of Personalized Medicine.
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  • Fluorouracil