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Gmeiner, William
One or more keywords matched the following items that are connected to Gmeiner, William
Item TypeName
Academic Article Targeted drug delivery to chemoresistant cells: folic acid derivatization of FdUMP[10] enhances cytotoxicity toward 5-FU-resistant human colorectal tumor cells.
Academic Article Efficacy and safety of FdUMP[10] in treatment of HT-29 human colon cancer xenografts.
Academic Article Enhanced DNA-directed effects of FdUMP[10] compared to 5FU.
Academic Article Mechanisms of action of FdUMP[10]: metabolite activation and thymidylate synthase inhibition.
Academic Article Genome-wide mRNA and microRNA profiling of the NCI 60 cell-line screen and comparison of FdUMP[10] with fluorouracil, floxuridine, and topoisomerase 1 poisons.
Academic Article A novel polypyrimidine antitumor agent FdUMP[10] induces thymineless death with topoisomerase I-DNA complexes.
Academic Article Unique dual targeting of thymidylate synthase and topoisomerase1 by FdUMP[10] results in high efficacy against AML and low toxicity.
Academic Article Replication-dependent irreversible topoisomerase 1 poisoning is responsible for FdUMP[10] anti-leukemic activity.
Academic Article Cytotoxicity and in-vivo tolerance of FdUMP[10]: a novel pro-drug of the TS inhibitory nucleotide FdUMP.
Academic Article Increased cytotoxicity and decreased in vivo toxicity of FdUMP[10] relative to 5-FU.
Academic Article Positive interaction between 5-FU and FdUMP[10] in the inhibition of human colorectal tumor cell proliferation.
Concept Fluorodeoxyuridylate
Academic Article The cytotoxic and pro-apoptotic activities of the novel fluoropyrimidine F10 towards prostate cancer cells are enhanced by Zn(2+) -chelation and inhibiting the serine protease Omi/HtrA2.
Academic Article The applications of the novel polymeric fluoropyrimidine F10 in cancer treatment: current evidence.
Academic Article All-Atom Molecular Dynamics Reveals Mechanism of Zinc Complexation with Therapeutic F10.
Grant DNA-DIRECTED EFFECTS OF FdUMP(N)
Academic Article All-Atom MD Predicts Magnesium-Induced Hairpin in Chemically Perturbed RNA Analog of F10 Therapeutic.
Academic Article Thymineless Death by the Fluoropyrimidine Polymer F10 Involves Replication Fork Collapse and Is Enhanced by Chk1 Inhibition.
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  • Fluorodeoxyuridylate