| Item Type | Name |
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Academic Article
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The structure and dynamics of the U4/U6 snRNP: implications for pre-mRNA splicing and use as a model system to investigate the RNA-mediated effects of (5F)Ura.
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Academic Article
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Line shape analyses for water 17O NMR quintet observed in a bacteriophage Pf1 solution at different temperatures.
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Academic Article
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Enhanced DNA-directed effects of FdUMP[10] compared to 5FU.
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Academic Article
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NMR structure of the thrombin-binding DNA aptamer stabilized by Sr2+.
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Academic Article
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Unfolding of G-quadruplexes: energetic, and ion and water contributions of G-quartet stacking.
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Academic Article
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Increased heating efficiency and selective thermal ablation of malignant tissue with DNA-encased multiwalled carbon nanotubes.
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Academic Article
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Genome-wide mRNA and microRNA profiling of the NCI 60 cell-line screen and comparison of FdUMP[10] with fluorouracil, floxuridine, and topoisomerase 1 poisons.
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Academic Article
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Zn2+ selectively stabilizes FdU-substituted DNA through a unique major groove binding motif.
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Academic Article
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Cooperative stabilization of Zn(2+):DNA complexes through netropsin binding in the minor groove of FdU-substituted DNA.
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Academic Article
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Effects of site-specific substitution of 5-fluorouridine on the stabilities of duplex DNA and RNA.
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Academic Article
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Solution structures of 5-fluorouracil-substituted DNA and RNA decamer duplexes.
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Academic Article
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NMR spectroscopy as a tool to investigate the structural basis of anticancer drugs.
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Academic Article
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Effect of cytarabine on the NMR structure of a model okazaki fragment from the SV40 genome.
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Academic Article
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Shape-selective recognition of a model Okazaki fragment by geometrically-constrained bis-distamycins.
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Academic Article
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Shape-selective binding of geometrically-constrained bis-distamycins to a DNA duplex and a model Okazaki fragment of identical sequence.
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Academic Article
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NMR structure of a gemcitabine-substituted model Okazaki fragment.
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Academic Article
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Energetic and conformational contributions to the stability of Okazaki fragments.
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Academic Article
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Antimetabolite incorporation into DNA: structural and thermodynamic basis for anticancer activity.
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Academic Article
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NMR study of the folding-unfolding mechanism for the thrombin-binding DNA aptamer d(GGTTGGTGTGGTTGG).
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Academic Article
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A novel polypyrimidine antitumor agent FdUMP[10] induces thymineless death with topoisomerase I-DNA complexes.
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Academic Article
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The stability of a model substrate for topoisomerase 1-mediated DNA religation depends on the presence of mismatched base pairs.
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Academic Article
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Unique dual targeting of thymidylate synthase and topoisomerase1 by FdUMP[10] results in high efficacy against AML and low toxicity.
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Academic Article
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Replication-dependent irreversible topoisomerase 1 poisoning is responsible for FdUMP[10] anti-leukemic activity.
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Academic Article
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The affinity of an oligodeoxynucleotide-peptide conjugate for an RNA hairpin loop depends on stereochemistry at the DNA-peptide junction.
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Academic Article
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Cytarabine-induced destabilization of a model Okazaki fragment.
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Academic Article
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Polarity of annealing and structural analysis of the RNase H resistant alpha-5'-d[TACACA].beta-5'-r[AUGUGU] hybrid determined by high-field 1H, 13C, and 31P NMR analysis.
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Academic Article
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Cytarabine-induced destabilization and bending of a model Okazaki fragment.
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Academic Article
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Binding of ethidium to DNA measured using a 2D diffusion-modulated gradient COSY NMR experiment.
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Concept
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DNA, Viral
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Concept
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DNA, Bacterial
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Concept
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DNA Damage
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Concept
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DNA, Neoplasm
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Concept
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DNA
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Concept
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DNA, Mitochondrial
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Concept
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DNA Breaks, Single-Stranded
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Concept
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DNA Topoisomerases, Type I
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Concept
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DNA Breaks, Double-Stranded
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Concept
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DNA Replication
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Concept
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DNA Repair
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Concept
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DNA, Single-Stranded
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Academic Article
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Dimeric DNA Aptamer Complexes for High-capacity-targeted Drug Delivery Using pH-sensitive Covalent Linkages.
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Academic Article
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TDP1 repairs nuclear and mitochondrial DNA damage induced by chain-terminating anticancer and antiviral nucleoside analogs.
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Academic Article
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Non-covalent assembly of meso-tetra-4-pyridyl porphine with single-stranded DNA to form nano-sized complexes with hydrophobicity-dependent DNA release and anti-tumor activity.
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Academic Article
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Site-specific DNA-doxorubicin conjugates display enhanced cytotoxicity to breast cancer cells.
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Academic Article
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F10 cytotoxicity via topoisomerase I cleavage complex repair consistent with a unique mechanism for thymineless death.
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Academic Article
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The Lown Symposium: The Field of DNA Minor Groove Binders Celebrates the Career of Professor J. William Lown.
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Grant
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DNA-DIRECTED EFFECTS OF FdUMP(N)
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Academic Article
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All-atom MD indicates ion-dependent behavior of therapeutic DNA polymer.
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Academic Article
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Curcumin stably interacts with DNA hairpin through minor groove binding and demonstrates enhanced cytotoxicity in combination with FdU nucleotides.
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Grant
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Development of a CF10 Predictive Gene Signature in CRC Organoids.
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Grant
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Aptamer-Based Radiopharmaceuticals for the Targeted Alpha Particle Therapy of Prostate Cancer
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Academic Article
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Thymineless Death by the Fluoropyrimidine Polymer F10 Involves Replication Fork Collapse and Is Enhanced by Chk1 Inhibition.
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Academic Article
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Prexasertib treatment induces homologous recombination deficiency and synergizes with olaparib in triple-negative breast cancer cells.
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