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Gemcitabine (2',2'-difluoro-2'-deoxycytidine), an antimetabolite that poisons topoisomerase I.
Genome-wide mRNA and microRNA profiling of the NCI 60 cell-line screen and comparison of FdUMP with fluorouracil, floxuridine, and topoisomerase 1 poisons.
Structural basis for topoisomerase I inhibition by nucleoside analogs.
A novel polypyrimidine antitumor agent FdUMP induces thymineless death with topoisomerase I-DNA complexes.
The stability of a model substrate for topoisomerase 1-mediated DNA religation depends on the presence of mismatched base pairs.
Unique dual targeting of thymidylate synthase and topoisomerase1 by FdUMP results in high efficacy against AML and low toxicity.
Replication-dependent irreversible topoisomerase 1 poisoning is responsible for FdUMP anti-leukemic activity.
DNA Topoisomerases, Type I
F10 cytotoxicity via topoisomerase I cleavage complex repair consistent with a unique mechanism for thymineless death.
DNA-DIRECTED EFFECTS OF FdUMP(N)
Development of a CF10 Predictive Gene Signature in CRC Organoids.
DNA Topoisomerases Type I