| Item Type | Name |
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Academic Article
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Peptide requirement for CTL activation reflects the sensitivity to CD3 engagement: correlation with CD8alphabeta versus CD8alphaalpha expression.
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Academic Article
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Molecular mechanisms and biological significance of CTL avidity.
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Academic Article
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High avidity CD8+ T cells generated from CD28-deficient or wildtype mice exhibit a differential dependence on lipid raft integrity for activation.
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Academic Article
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Modulation of CD8+ T cell avidity by increasing the turnover of viral antigen during infection.
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Academic Article
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Abortive versus productive viral infection of dendritic cells with a paramyxovirus results in differential upregulation of select costimulatory molecules.
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Academic Article
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A simian virus 5 (SV5) P/V mutant is less cytopathic than wild-type SV5 in human dendritic cells and is a more effective activator of dendritic cell maturation and function.
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Academic Article
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Transferable anticancer innate immunity in spontaneous regression/complete resistance mice.
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Academic Article
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Vaccinia virus infection of mature dendritic cells results in activation of virus-specific naïve CD8+ T cells: a potential mechanism for direct presentation.
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Academic Article
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Distinct pathways for signaling maturation in macrophages and dendritic cells after infection with paramyxovirus simian virus 5.
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Academic Article
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TLR-4 and -6 agonists reverse apoptosis and promote maturation of simian virus 5-infected human dendritic cells through NFkB-dependent pathways.
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Academic Article
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Cutting edge: CD8+ T cell clones possess the potential to differentiate into both high- and low-avidity effector cells.
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Academic Article
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Cutting edge: Dendritic cells prime a high avidity CTL response independent of the level of presented antigen.
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Academic Article
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Pivotal Advance: Nonfunctional lung effectors exhibit decreased calcium mobilization associated with reduced expression of ORAI1.
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Academic Article
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IFNgamma-producing, virus-specific CD8+ effector cells acquire the ability to produce IL-10 as a result of entry into the infected lung environment.
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Academic Article
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Differentiation-dependent differences in murine T cell susceptibility to negative regulation by the lung.
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Academic Article
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Changes in functional but not structural avidity during differentiation of CD8+ effector cells in vivo after virus infection.
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Academic Article
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Specific prolongation of allograft survival by a T-cell-receptor-derived peptide.
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Academic Article
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Biased T cell receptor usage by Ld-restricted, tum- peptide-specific cytotoxic T lymphocyte clones.
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Academic Article
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Target cell lysis by CTL granule exocytosis is independent of ICE/Ced-3 family proteases.
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Academic Article
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An abrupt and concordant initiation of apoptosis: antigen-dependent death of CD8+ CTL.
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Academic Article
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Suppressed cytotoxic T lymphocyte responses in experimental cysticercosis.
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Academic Article
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Optimal colocalization of TCR and CD8 as a novel mechanism for the control of functional avidity.
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Academic Article
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High avidity CD8+ T cells are the initial population elicited following viral infection of the respiratory tract.
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Academic Article
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High-avidity CD8+ T cells: optimal soldiers in the war against viruses and tumors.
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Academic Article
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Altered function in CD8+ T cells following paramyxovirus infection of the respiratory tract.
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Academic Article
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Exchange of P/V genes between two non-cytopathic simian virus 5 variants results in a recombinant virus that kills cells through death pathways that are sensitive to caspase inhibitors.
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Academic Article
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Dose-dependent modulation of CD8 and functional avidity as a result of peptide encounter.
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Academic Article
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Loss of function in virus-specific lung effector T cells is independent of infection.
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Academic Article
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Regulation of maturation and activating potential in CD8+ versus CD8- dendritic cells following in vivo infection with vaccinia virus.
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Academic Article
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Engineered expression of the TLR5 ligand flagellin enhances paramyxovirus activation of human dendritic cell function.
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Academic Article
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Functional divergence among CD103+ dendritic cell subpopulations following pulmonary poxvirus infection.
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Academic Article
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Increased sensitivity to antigen in high avidity CD8(+) T cells results from augmented membrane proximal T-cell receptor signal transduction.
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Academic Article
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Virion-associated complement regulator CD55 is more potent than CD46 in mediating resistance of mumps virus and vesicular stomatitis virus to neutralization.
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Academic Article
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CD8 marks a subpopulation of lung-derived dendritic cells with differential responsiveness to viral infection and toll-like receptor stimulation.
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Academic Article
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Expression of HLA class I molecules and the transporter associated with antigen processing in hepatocellular carcinoma.
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Academic Article
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Selective expansion of high- or low-avidity cytotoxic T lymphocytes and efficacy for adoptive immunotherapy.
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Academic Article
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Molecular analysis of presentation by HLA-A2.1 of a promiscuously binding V3 loop peptide from the HIV-envelope protein to human cytotoxic T lymphocytes.
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Academic Article
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Role of antigen, CD8, and cytotoxic T lymphocyte (CTL) avidity in high dose antigen induction of apoptosis of effector CTL.
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Academic Article
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Cytotoxic T lymphocyte (CTL) adherence assay (CAA): a non-radioactive assay for murine CTL recognition of peptide-MHC class I complexes.
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Academic Article
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Differential expansion and survival of high and low avidity cytotoxic T cell populations during the immune response to a viral infection.
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Concept
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Jurkat Cells
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Concept
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Cell Movement
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Concept
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Hematopoietic Stem Cells
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Concept
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Cell Death
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Concept
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Clone Cells
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Concept
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Th1 Cells
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Concept
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Dendritic Cells
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Concept
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Gene Rearrangement, alpha-Chain T-Cell Antigen Receptor
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Concept
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Genes, T-Cell Receptor
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Concept
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CHO Cells
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Concept
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Tumor Cells, Cultured
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Concept
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Cell Differentiation
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Concept
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Bone Marrow Cells
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Concept
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Cells, Cultured
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Concept
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Cell Proliferation
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Concept
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Epithelial Cells
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Concept
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Receptors, Antigen, T-Cell, alpha-beta
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Concept
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Receptors, Antigen, T-Cell
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Concept
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Hela Cells
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Concept
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Cell Survival
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Concept
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Cell Adhesion
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Concept
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Antigen-Presenting Cells
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Concept
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Th2 Cells
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Concept
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Cell Line
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Concept
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Anemia, Sickle Cell
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Concept
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Myeloid Cells
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Concept
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Killer Cells, Natural
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Concept
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Cell Line, Tumor
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Academic Article
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High viral burden restricts short-lived effector cell number at late times postinfection through increased natural regulatory T cell expansion.
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Academic Article
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In vivo modulation of avidity in highly sensitive CD8(+) effector T cells following viral infection.
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Academic Article
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Paramyxovirus activation and inhibition of innate immune responses.
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Academic Article
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CD4+ T cell subset differentiation and avidity setpoint are dictated by the interplay of cytokine and antigen mediated signals.
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Academic Article
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Coinfection with Streptococcus pneumoniae negatively modulates the size and composition of the ongoing influenza-specific CD8? T cell response.
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Academic Article
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Correlation between CD8 dependency and determinant density using peptide-induced, Ld-restricted cytotoxic T lymphocytes.
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Academic Article
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Deregulated Bcl-2 gene expression selectively prolongs survival of growth factor-deprived hemopoietic cell lines.
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Academic Article
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Activation-dependent modulation of Streptococcus pneumoniae-mediated death in human lymphocytes.
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Grant
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Control of T cell response during respiratory infection
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Grant
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Control of cytotoxic T cell differentiation and activity
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Grant
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Regulation of avidity in T lymphocytes
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Grant
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Vaccination strategies to overcome immune deficiencies in neonates
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Grant
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Cellular Immune Response to Respiratory Infection
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Academic Article
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Potential therapeutic action of nitrite in sickle cell disease.
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Grant
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Immune regulation by pneumococcus
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Academic Article
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An R848 adjuvanted influenza vaccine promotes early activation of B cells in the draining lymph nodes of non-human primate neonates.
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Academic Article
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A Novel Function for the Streptococcus pneumoniae Aminopeptidase N: Inhibition of T Cell Effector Function through Regulation of TCR Signaling.
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Academic Article
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The choice of linker for conjugating R848 to inactivated influenza virus determines the stimulatory capacity for innate immune cells.
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Academic Article
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Dissecting intratumoral myeloid cell plasticity by single cell RNA-seq.
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Grant
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Development of vaccine approaches to elicit broadly protective influenza-specific immune responses in infants
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Academic Article
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Higher Frequency and Increased Expression of Molecules Associated with Suppression on T Regulatory Cells from Newborn Compared with Adult Nonhuman Primates.
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Academic Article
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TCR Dependent Metabolic Programming Regulates Autocrine IL-4 Production Resulting in Self-Tuning of the CD8+ T Cell Activation Setpoint.
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Academic Article
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Circulating Immune Bioenergetic, Metabolic, and Genetic Signatures Predict Melanoma Patients' Response to Anti-PD-1 Immune Checkpoint Blockade.
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Academic Article
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Targeting the CD47/thrombospondin-1 signaling axis regulates immune cell bioenergetics in the tumor microenvironment to potentiate antitumor immune response.
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Academic Article
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TLR agonists induce sustained IgG to hemagglutinin stem and modulate T cells following newborn vaccination.
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