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Academic Article
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Activity of one of two engineered heterodimers of AhpF, the NADH:peroxiredoxin oxidoreductase from Salmonella typhimurium, reveals intrasubunit electron transfer between domains.
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Academic Article
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Identification of cysteine sulfenic acid in AhpC of alkyl hydroperoxide reductase.
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Academic Article
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Peroxiredoxin evolution and the regulation of hydrogen peroxide signaling.
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Academic Article
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Analysis of the link between enzymatic activity and oligomeric state in AhpC, a bacterial peroxiredoxin.
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Academic Article
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Discovering mechanisms of signaling-mediated cysteine oxidation.
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Academic Article
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Decreasing peroxiredoxin II expression decreases glutathione, alters cell cycle distribution, and sensitizes glioma cells to ionizing radiation and H(2)O(2).
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Academic Article
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Structural evidence that peroxiredoxin catalytic power is based on transition-state stabilization.
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Academic Article
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Cysteine-based redox switches in enzymes.
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Academic Article
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Structure-based insights into the catalytic power and conformational dexterity of peroxiredoxins.
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Academic Article
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Analysis of the peroxiredoxin family: using active-site structure and sequence information for global classification and residue analysis.
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Academic Article
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Conformational studies of the robust 2-Cys peroxiredoxin Salmonella typhimurium AhpC by solution phase hydrogen/deuterium (H/D) exchange monitored by electrospray ionization mass spectrometry.
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Academic Article
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Crystal structure of alkyl hydroperoxidase D like protein PA0269 from Pseudomonas aeruginosa: homology of the AhpD-like structural family.
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Academic Article
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Overview of peroxiredoxins in oxidant defense and redox regulation.
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Academic Article
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Peroxiredoxins in parasites.
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Academic Article
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Structural and electrostatic asymmetry at the active site in typical and atypical peroxiredoxin dimers.
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Academic Article
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Peroxiredoxin II regulates effector and secondary memory CD8+ T cell responses.
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Academic Article
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AhpF can be dissected into two functional units: tandem repeats of two thioredoxin-like folds in the N-terminus mediate electron transfer from the thioredoxin reductase-like C-terminus to AhpC.
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Academic Article
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An NADH-dependent bacterial thioredoxin reductase-like protein in conjunction with a glutaredoxin homologue form a unique peroxiredoxin (AhpC) reducing system in Clostridium pasteurianum.
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Academic Article
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Dimers to doughnuts: redox-sensitive oligomerization of 2-cysteine peroxiredoxins.
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Academic Article
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Catalytic mechanism of thiol peroxidase from Escherichia coli. Sulfenic acid formation and overoxidation of essential CYS61.
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Academic Article
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Structure, mechanism and regulation of peroxiredoxins.
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Academic Article
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Structural basis for the retroreduction of inactivated peroxiredoxins by human sulfiredoxin.
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Academic Article
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Oxidation state governs structural transitions in peroxiredoxin II that correlate with cell cycle arrest and recovery.
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Academic Article
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Cysteine reactivity and thiol-disulfide interchange pathways in AhpF and AhpC of the bacterial alkyl hydroperoxide reductase system.
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Academic Article
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The catalytic mechanism of peroxiredoxins.
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Academic Article
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Substrate specificity and redox potential of AhpC, a bacterial peroxiredoxin.
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Academic Article
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Mutant AhpC peroxiredoxins suppress thiol-disulfide redox deficiencies and acquire deglutathionylating activity.
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Academic Article
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Cysteine pK(a) values for the bacterial peroxiredoxin AhpC.
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Academic Article
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Redox-dependent dynamics of a dual thioredoxin fold protein: evolution of specialized folds.
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Academic Article
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Typical 2-Cys peroxiredoxins--structures, mechanisms and functions.
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Academic Article
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Structural changes common to catalysis in the Tpx peroxiredoxin subfamily.
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Academic Article
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Water-soluble triarylphosphines as biomarkers for protein S-nitrosation.
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Academic Article
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Broad specificity AhpC-like peroxiredoxin and its thioredoxin reductant in the sparse antioxidant defense system of Treponema pallidum.
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Academic Article
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PREX: PeroxiRedoxin classification indEX, a database of subfamily assignments across the diverse peroxiredoxin family.
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Academic Article
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Kinetic and thermodynamic features reveal that Escherichia coli BCP is an unusually versatile peroxiredoxin.
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Academic Article
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Peroxiredoxins as molecular triage agents, sacrificing themselves to enhance cell survival during a peroxide attack.
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Academic Article
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A new family of membrane electron transporters and its substrates, including a new cell envelope peroxiredoxin, reveal a broadened reductive capacity of the oxidative bacterial cell envelope.
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Academic Article
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Mapping the active site helix-to-strand conversion of CxxxxC peroxiredoxin Q enzymes.
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Academic Article
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Attachment of the N-terminal domain of Salmonella typhimurium AhpF to Escherichia coli thioredoxin reductase confers AhpC reductase activity but does not affect thioredoxin reductase activity.
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Academic Article
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AhpF and other NADH:peroxiredoxin oxidoreductases, homologues of low Mr thioredoxin reductase.
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Academic Article
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Essential thioredoxin-dependent peroxiredoxin system from Helicobacter pylori: genetic and kinetic characterization.
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Concept
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Peroxiredoxins
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Academic Article
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Evaluating peroxiredoxin sensitivity toward inactivation by peroxide substrates.
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Academic Article
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The sensitive balance between the fully folded and locally unfolded conformations of a model peroxiredoxin.
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Academic Article
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Nitration transforms a sensitive peroxiredoxin 2 into a more active and robust peroxidase.
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Academic Article
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Tuning of peroxiredoxin catalysis for various physiological roles.
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Academic Article
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Dissecting peroxiredoxin catalysis: separating binding, peroxidation, and resolution for a bacterial AhpC.
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Academic Article
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Peroxiredoxins: guardians against oxidative stress and modulators of peroxide signaling.
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Academic Article
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Distribution and Features of the Six Classes of Peroxiredoxins.
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Academic Article
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Backbone chemical shift assignments for Xanthomonas campestris peroxiredoxin Q in the reduced and oxidized states: a dramatic change in backbone dynamics.
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Academic Article
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Structural changes upon peroxynitrite-mediated nitration of peroxiredoxin 2; nitrated Prx2 resembles its disulfide-oxidized form.
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Academic Article
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Oxidative Stress Promotes Peroxiredoxin Hyperoxidation and Attenuates Pro-survival Signaling in Aging Chondrocytes.
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Academic Article
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Peroxiredoxin Catalysis at Atomic Resolution.
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Academic Article
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An Atlas of Peroxiredoxins Created Using an Active Site Profile-Based Approach to Functionally Relevant Clustering of Proteins.
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Grant
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Mechanistic Studies of Alkyl Hydroperoxide Reductase and Related Redox Proteins
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Grant
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Mechanisms and Regulation of Peroxiredoxins
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Academic Article
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Experimentally Dissecting the Origins of Peroxiredoxin Catalysis.
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Academic Article
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Novel hyperoxidation resistance motifs in 2-Cys peroxiredoxins.
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Academic Article
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Differential Kinetics of Two-Cysteine Peroxiredoxin Disulfide Formation Reveal a Novel Model for Peroxide Sensing.
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Academic Article
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Chaperone activation and client binding of a 2-cysteine peroxiredoxin.
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Academic Article
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Peroxiredoxins in Cancer and Response to Radiation Therapies.
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Academic Article
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Unraveling the effects of peroxiredoxin 2 nitration; role of C-terminal tyrosine 193.
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Academic Article
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Differential peroxiredoxin hyperoxidation regulates MAP kinase signaling in human articular chondrocytes.
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Grant
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Redox Regulation of Cysteine-Dependent Peroxidases and Signal Transduction Pathways
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Academic Article
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Bioinformatic Analyses of Peroxiredoxins and RF-Prx: A Random Forest-Based Predictor and Classifier for Prxs.
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Academic Article
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Native state fluctuations in a peroxiredoxin active site match motions needed for catalysis.
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