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Academic Article
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Activity of one of two engineered heterodimers of AhpF, the NADH:peroxiredoxin oxidoreductase from Salmonella typhimurium, reveals intrasubunit electron transfer between domains.
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Academic Article
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Identification of cysteine sulfenic acid in AhpC of alkyl hydroperoxide reductase.
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Academic Article
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Identification of a peroxide-sensitive redox switch at the CXXC motif in the human mitochondrial branched chain aminotransferase.
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Academic Article
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Human mitochondrial branched chain aminotransferase: structural basis for substrate specificity and role of redox active cysteines.
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Academic Article
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Peroxiredoxin evolution and the regulation of hydrogen peroxide signaling.
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Academic Article
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Protein sulfenic acids in redox signaling.
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Academic Article
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Analysis of the link between enzymatic activity and oligomeric state in AhpC, a bacterial peroxiredoxin.
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Academic Article
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Isotope-coded, iodoacetamide-based reagent to determine individual cysteine pK(a) values by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.
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Academic Article
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Discovering mechanisms of signaling-mediated cysteine oxidation.
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Academic Article
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Use of dimedone-based chemical probes for sulfenic acid detection evaluation of conditions affecting probe incorporation into redox-sensitive proteins.
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Academic Article
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Structural evidence that peroxiredoxin catalytic power is based on transition-state stabilization.
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Academic Article
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Cysteine-based redox switches in enzymes.
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Academic Article
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Formation and functions of protein sulfenic acids.
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Academic Article
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Structure-based insights into the catalytic power and conformational dexterity of peroxiredoxins.
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Academic Article
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Overview of peroxiredoxins in oxidant defense and redox regulation.
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Academic Article
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Peroxiredoxins in parasites.
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Academic Article
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An NADH-dependent bacterial thioredoxin reductase-like protein in conjunction with a glutaredoxin homologue form a unique peroxiredoxin (AhpC) reducing system in Clostridium pasteurianum.
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Academic Article
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Dimers to doughnuts: redox-sensitive oligomerization of 2-cysteine peroxiredoxins.
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Academic Article
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Catalytic mechanism of thiol peroxidase from Escherichia coli. Sulfenic acid formation and overoxidation of essential CYS61.
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Academic Article
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Structure, mechanism and regulation of peroxiredoxins.
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Academic Article
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Roles for cysteine residues in the regulatory CXXC motif of human mitochondrial branched chain aminotransferase enzyme.
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Academic Article
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Bacterial defenses against oxidants: mechanistic features of cysteine-based peroxidases and their flavoprotein reductases.
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Academic Article
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Structural basis for the retroreduction of inactivated peroxiredoxins by human sulfiredoxin.
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Academic Article
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Oxidized and synchrotron cleaved structures of the disulfide redox center in the N-terminal domain of Salmonella typhimurium AhpF.
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Academic Article
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Novel organic hydroperoxide-sensing and responding mechanisms for OhrR, a major bacterial sensor and regulator of organic hydroperoxide stress.
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Academic Article
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Oxidation state governs structural transitions in peroxiredoxin II that correlate with cell cycle arrest and recovery.
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Academic Article
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The catalytic mechanism of peroxiredoxins.
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Academic Article
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Substrate specificity and redox potential of AhpC, a bacterial peroxiredoxin.
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Academic Article
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Mutant AhpC peroxiredoxins suppress thiol-disulfide redox deficiencies and acquire deglutathionylating activity.
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Academic Article
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Redox regulation and trapping sulfenic acid in the peroxide-sensitive human mitochondrial branched chain aminotransferase.
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Academic Article
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Redox-dependent dynamics of a dual thioredoxin fold protein: evolution of specialized folds.
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Academic Article
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Broad specificity AhpC-like peroxiredoxin and its thioredoxin reductant in the sparse antioxidant defense system of Treponema pallidum.
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Academic Article
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Extracellular SOD-derived H2O2 promotes VEGF signaling in caveolae/lipid rafts and post-ischemic angiogenesis in mice.
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Academic Article
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Engineering of fluorescent reporters into redox domains to monitor electron transfers.
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Academic Article
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Measurement of protein sulfenic acid content.
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Academic Article
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Isoform-specific regulation of Akt by PDGF-induced reactive oxygen species.
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Academic Article
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Kinetic and thermodynamic features reveal that Escherichia coli BCP is an unusually versatile peroxiredoxin.
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Academic Article
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A new family of membrane electron transporters and its substrates, including a new cell envelope peroxiredoxin, reveal a broadened reductive capacity of the oxidative bacterial cell envelope.
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Academic Article
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Attachment of the N-terminal domain of Salmonella typhimurium AhpF to Escherichia coli thioredoxin reductase confers AhpC reductase activity but does not affect thioredoxin reductase activity.
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Concept
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Oxidation-Reduction
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Academic Article
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Evaluating peroxiredoxin sensitivity toward inactivation by peroxide substrates.
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Academic Article
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Thiol-blocking electrophiles interfere with labeling and detection of protein sulfenic acids.
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Academic Article
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Chemical approaches to detect and analyze protein sulfenic acids.
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Academic Article
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Endosomal H2O2 production leads to localized cysteine sulfenic acid formation on proteins during lysophosphatidic acid-mediated cell signaling.
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Academic Article
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Nitration transforms a sensitive peroxiredoxin 2 into a more active and robust peroxidase.
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Academic Article
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Strained cycloalkynes as new protein sulfenic acid traps.
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Academic Article
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Tuning of peroxiredoxin catalysis for various physiological roles.
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Academic Article
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Dissecting peroxiredoxin catalysis: separating binding, peroxidation, and resolution for a bacterial AhpC.
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Academic Article
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Introduction: What we do and do not know regarding redox processes of thiols in signaling pathways.
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Academic Article
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The basics of thiols and cysteines in redox biology and chemistry.
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Academic Article
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Au-ACRAMTU-PEt3 Alters Redox Balance To Inhibit T Cell Proliferation and Function.
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Academic Article
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Cysteine-Mediated Redox Regulation of Cell Signaling in Chondrocytes Stimulated With Fibronectin Fragments.
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Academic Article
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X-ray structures of thioredoxin and thioredoxin reductase from Entamoeba histolytica and prevailing hypothesis of the mechanism of Auranofin action.
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Academic Article
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Backbone chemical shift assignments for Xanthomonas campestris peroxiredoxin Q in the reduced and oxidized states: a dramatic change in backbone dynamics.
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Academic Article
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Structural changes upon peroxynitrite-mediated nitration of peroxiredoxin 2; nitrated Prx2 resembles its disulfide-oxidized form.
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Grant
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Mechanistic Studies of Alkyl Hydroperoxide Reductase and Related Redox Proteins
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Grant
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New Reagents for Tracking Protein Oxidation in Cells by MS and Imaging Methods
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Grant
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2012 Thiol-based Redox Regulation &Signaling GRC and GRS
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Grant
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Proteomic Profiling of Cancer-Related Redox Signaling Pathways
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Grant
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2010 Thiol-based Redox Regulation &Signaling Gordon Research Conference
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Grant
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Profiling of Redox-Sensitive Signaling Proteins
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Grant
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Structural and Computational Biophysics Training Program
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Grant
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Mechanisms and Regulation of Peroxiredoxins
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Academic Article
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The SAMHD1 dNTP Triphosphohydrolase Is Controlled by a Redox Switch.
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Academic Article
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Experimentally Dissecting the Origins of Peroxiredoxin Catalysis.
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Academic Article
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Endogenous, regulatory cysteine sulfenylation of ERK kinases in response to proliferative signals.
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Grant
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Redox Biology and Medicine Training Program
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Academic Article
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SVM-SulfoSite: A support vector machine based predictor for sulfenylation sites.
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Academic Article
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Novel hyperoxidation resistance motifs in 2-Cys peroxiredoxins.
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Academic Article
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Differential Kinetics of Two-Cysteine Peroxiredoxin Disulfide Formation Reveal a Novel Model for Peroxide Sensing.
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Academic Article
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Mitochondria-targeted Probes for Imaging Protein Sulfenylation.
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Academic Article
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NOX4 (NADPH Oxidase 4) and Poldip2 (Polymerase d-Interacting Protein 2) Induce Filamentous Actin Oxidation and Promote Its Interaction With Vinculin During Integrin-Mediated Cell Adhesion.
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Academic Article
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Redox proteins.
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Academic Article
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H2O2 oxidation of cysteine residues in c-Jun N-terminal kinase 2 (JNK2) contributes to redox regulation in human articular chondrocytes.
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Academic Article
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Unraveling the effects of peroxiredoxin 2 nitration; role of C-terminal tyrosine 193.
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Academic Article
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Differential peroxiredoxin hyperoxidation regulates MAP kinase signaling in human articular chondrocytes.
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Grant
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Redox Regulation of Cysteine-Dependent Peroxidases and Signal Transduction Pathways
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Academic Article
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Discovery of Spilanthol Endoperoxide as a Redox Natural Compound Active against Mammalian Prx3 and Chlamydiatrachomatis Infection.
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Academic Article
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Introduction to approaches and tools for the evaluation of protein cysteine oxidation.
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Academic Article
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Sirtuin 6 (SIRT6) regulates redox homeostasis and signaling events in human articular chondrocytes.
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Academic Article
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[18F]Fluoro-DCP, a first generation PET radiotracer for monitoring protein sulfenylation in vivo.
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Academic Article
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Oncogenic KRAS G12C: Kinetic and redox characterization of covalent inhibition.
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Academic Article
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Bioinformatic Analyses of Peroxiredoxins and RF-Prx: A Random Forest-Based Predictor and Classifier for Prxs.
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Academic Article
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Mitigation of doxorubicin-induced cardiotoxicity with an H2O2-Activated, H2S-Donating hybrid prodrug.
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Academic Article
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Cysteine oxidation of copper transporter CTR1 drives VEGFR2 signalling and angiogenesis.
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Academic Article
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Glutathionylation of pyruvate dehydrogenase complex E2 and inflammatory cytokine production during acute inflammation are magnified by mitochondrial oxidative stress.
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