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Parks, John

One or more keywords matched the following items that are connected to Parks, John

Item Type	Name
Academic Article	Alteration of plasma HDL cholesteryl ester composition with transgenic expression of a point mutation (E149A) of human LCAT.
Academic Article	Lecithin:cholesterol acyltransferase deficiency increases atherosclerosis in the low density lipoprotein receptor and apolipoprotein E knockout mice.
Academic Article	Negative charge at amino acid 149 is the molecular determinant for substrate specificity of lecithin: cholesterol acyltransferase for phosphatidylcholine containing 20-carbon sn-2 fatty acyl chains.
Academic Article	Amino acids 149 and 294 of human lecithin:cholesterol acyltransferase affect fatty acyl specificity.
Academic Article	Plasma cholesteryl esters provided by lecithin:cholesterol acyltransferase and acyl-coenzyme a:cholesterol acyltransferase 2 have opposite atherosclerotic potential.
Academic Article	ACAT2 contributes cholesteryl esters to newly secreted VLDL, whereas LCAT adds cholesteryl ester to LDL in mice.
Academic Article	HDLs in apoA-I transgenic Abca1 knockout mice are remodeled normally in plasma but are hypercatabolized by the kidney.
Academic Article	The refined structure of nascent HDL reveals a key functional domain for particle maturation and dysfunction.
Academic Article	Lecithin:cholesterol acyltransferase-induced modifications of liver perfusate discoidal high density lipoproteins from African green monkeys.
Academic Article	Inhibition of lecithin:cholesterol acyltransferase activity by synthetic phosphatidylcholine species containing eicosapentaenoic acid or docosahexaenoic acid in the sn-2 position.
Academic Article	Dietary fatty acid modification of HDL phospholipid molecular species alters lecithin: cholesterol acyltransferase reactivity in cynomolgus monkeys.
Academic Article	Effect of apolipoprotein A-I deficiency on lecithin:cholesterol acyltransferase activation in mouse plasma.
Academic Article	Cytokines decrease apolipoprotein accumulation in medium from Hep G2 cells.
Academic Article	Amino acid residue 149 of lecithin:cholesterol acyltransferase determines phospholipase A2 and transacylase fatty acyl specificity.
Academic Article	Long-chain polyunsaturated fatty acids in the sn-2 position of phosphatidylcholine decrease the stability of recombinant high density lipoprotein apolipoprotein A-I and the activation energy of the lecithin:cholesterol acyltransferase reaction.
Academic Article	Influence of vesicle surface composition on the interfacial binding of lecithin:cholesterol acyltransferase and apolipoprotein A-I.
Academic Article	Cloning and in vitro expression of rat lecithin:cholesterol acyltransferase.
Academic Article	Role of glutamic acid residues 154, 155, and 165 of lecithin:cholesterol acyltransferase in cholesterol esterification and phospholipase A2 activities.
Academic Article	Phosphatidylcholine fluidity and structure affect lecithin:cholesterol acyltransferase activity.
Academic Article	In vivo contribution of LCAT to apolipoprotein B lipoprotein cholesteryl esters in LDL receptor and apolipoprotein E knockout mice.
Academic Article	Transgenic overexpression of human lecithin: cholesterol acyltransferase (LCAT) in mice does not increase aortic cholesterol deposition.
Academic Article	Enhancement of scavenger receptor class B type I-mediated selective cholesteryl ester uptake from apoA-I(-/-) high density lipoprotein (HDL) by apolipoprotein A-I requires HDL reorganization by lecithin cholesterol acyltransferase.
Academic Article	Identification of the lipoprotein initiating domain of apolipoprotein B.
Academic Article	Compared with Acyl-CoA:cholesterol O-acyltransferase (ACAT) 1 and lecithin:cholesterol acyltransferase, ACAT2 displays the greatest capacity to differentiate cholesterol from sitosterol.
Academic Article	Apolipoprotein E is the major physiological activator of lecithin-cholesterol acyltransferase (LCAT) on apolipoprotein B lipoproteins.
Academic Article	Functional LCAT deficiency in human apolipoprotein A-I transgenic, SR-BI knockout mice.
Academic Article	Lipopolysaccharide and tumor necrosis factor cause a fall in plasma concentration of lecithin: cholesterol acyltransferase in cynomolgus monkeys.
Academic Article	LCAT synthesized by primary astrocytes esterifies cholesterol on glia-derived lipoproteins.
Academic Article	The reactivity of plasma phospholipids with lecithin:cholesterol acyltransferase is decreased in fish oil-fed monkeys.
Academic Article	Decreased binding of apoA-I to phosphatidylcholine monolayers containing 22:6 n-3 in the sn-2 position.
Academic Article	High level secretion of wild-type and mutant forms of human proapoA-I using baculovirus-mediated Sf-9 cell expression.
Academic Article	Alteration in apolipoprotein A-I 22-mer repeat order results in a decrease in lecithin:cholesterol acyltransferase reactivity.
Academic Article	Effect of long chain polyunsaturated fatty acids in the sn-2 position of phosphatidylcholine on the interaction with recombinant high density lipoprotein apolipoprotein A-I.
Academic Article	Lecithin-cholesterol acyltransferase. Assay of cholesterol esterification and phospholipase A2 activities.
Academic Article	Characterization of C-terminal histidine-tagged human recombinant lecithin:cholesterol acyltransferase.
Concept	Phosphatidylcholines
Concept	Phosphatidylcholine-Sterol O-Acyltransferase
Academic Article	Hepatic apolipoprotein M (apoM) overexpression stimulates formation of larger apoM/sphingosine 1-phosphate-enriched plasma high density lipoprotein.
Academic Article	A Systematic Investigation of Structure/Function Requirements for the Apolipoprotein A-I/Lecithin Cholesterol Acyltransferase Interaction Loop of High-density Lipoprotein.
Grant	EFFECT OF N-3 FATTY ACIDS ON HDL LIPID INTERACTION
Grant	LCAT, Lipids, and Atherosclerosis

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Phosphatidylcholines