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One or more keywords matched the following properties of Singh, Ravi
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overview My interdisciplinary background in biomedical nanotechnology, a field lying at the interface of biomedicine, chemistry, physics and materials science, brings together ideas and techniques from these disciplines. By studying and manipulating the bio-nano interface, I work to facilitate the translation of proof of principle experiments into clinical applications of well-defined materials for cancer therapy and diagnostic use. Most recently, my group showed that carbon nanotubes can be used to target breast and brain tumors, deliver genes and cancer therapeutics, and that appropriately functionalized carbon nanotubes are safe for blood born delivery. Additionally, we demonstrated that unmodified silver nanoparticles act as a self-therapeutic agent with a combination of selective cytotoxicity and radiation dose-enhancement effects toward triple negative breast cancer at doses that are nontoxic to noncancerous breast and other cells. I am dedicated to developing new tools to improve outcomes for cancer treatment and diagnosis.
One or more keywords matched the following items that are connected to Singh, Ravi
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Concept Silver
Academic Article Differential cytotoxic and radiosensitizing effects of silver nanoparticles on triple-negative breast cancer and non-triple-negative breast cells.
Grant Development of a novel therapeutic agent that exploits specific vulnerabilities in claudin low breast cancer
Academic Article Heterogeneous Responses of Ovarian Cancer Cells to Silver Nanoparticles as a Single Agent and in Combination with Cisplatin.
Academic Article Synthesis, Purification, Characterization, and Imaging of Cy3-Functionalized Fluorescent Silver Nanoparticles in 2D and 3D Tumor Models.
Academic Article Silver Nanoparticles Induce Mitochondrial Protein Oxidation in Lung Cells Impacting Cell Cycle and Proliferation.
Academic Article Silver nanoparticles selectively treat triple-negative breast cancer cells without affecting non-malignant breast epithelial cells in vitro and in vivo.
Academic Article The mechanism of cell death induced by silver nanoparticles is distinct from silver cations.
Academic Article Low Doses of Silver Nanoparticles Selectively Induce Lipid Peroxidation and Proteotoxic Stress in Mesenchymal Subtypes of Triple-Negative Breast Cancer.
Academic Article Combined Photothermal and Ionizing Radiation Sensitization of Triple-Negative Breast Cancer Using Triangular Silver Nanoparticles.
Academic Article Integrated Redox Proteomic Analysis Highlights New Mechanisms of Sensitivity to Silver Nanoparticles.
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