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Unique dual targeting of thymidylate synthase and topoisomerase1 by FdUMP results in high efficacy against AML and low toxicity.
Replication-dependent irreversible topoisomerase 1 poisoning is responsible for FdUMP anti-leukemic activity.
DNA Topoisomerases, Type I
A Phase II Clinical Trial of CPI-613 in Patients with Relapsed or Refractory Small Cell Lung Carcinoma.
DNA Topoisomerases Type I