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Search Results to Donald A. Mcclain, M.D., Ph.D.

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One or more keywords matched the following items that are connected to Mcclain, Donald

Item TypeName
Concept Insulin-Like Growth Factor I
Concept Insulin Resistance
Concept Insulin-Secreting Cells
Concept Receptor, Insulin
Concept Insulin
Concept Insulin Receptor Substrate Proteins
Academic Article PAS kinase is required for normal cellular energy balance.
Academic Article Early mitochondrial adaptations in skeletal muscle to diet-induced obesity are strain dependent and determine oxidative stress and energy expenditure but not insulin sensitivity.
Academic Article Iron-mediated inhibition of mitochondrial manganese uptake mediates mitochondrial dysfunction in a mouse model of hemochromatosis.
Academic Article Activation of the hexosamine signaling pathway in adipose tissue results in decreased serum adiponectin and skeletal muscle insulin resistance.
Academic Article MitoNEET-driven alterations in adipocyte mitochondrial activity reveal a crucial adaptive process that preserves insulin sensitivity in obesity.
Academic Article Adipocyte iron regulates adiponectin and insulin sensitivity.
Academic Article Hyperglycemia and inhibition of glycogen synthase in streptozotocin-treated mice: role of O-linked N-acetylglucosamine.
Academic Article Decreased serum glucose and glycosylated hemoglobin levels in patients with Chuvash polycythemia: a role for HIF in glucose metabolism.
Academic Article Saturated fatty acids inhibit hepatic insulin action by modulating insulin receptor expression and post-receptor signalling.
Academic Article Oxidative stress, beta-cell apoptosis, and decreased insulin secretory capacity in mouse models of hemochromatosis.
Academic Article Cardiac expression of kinase-deficient 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase inhibits glycolysis, promotes hypertrophy, impairs myocyte function, and reduces insulin sensitivity.
Academic Article Manganese supplementation protects against diet-induced diabetes in wild type mice by enhancing insulin secretion.
Academic Article Adipocytes with increased hexosamine flux exhibit insulin resistance, increased glucose uptake, and increased synthesis and storage of lipid.
Academic Article Iron and diabetes risk.
Academic Article Dietary iron restriction or iron chelation protects from diabetes and loss of beta-cell function in the obese (ob/ob lep-/-) mouse.
Academic Article Increased strength and physical performance with eccentric training in women with impaired glucose tolerance: a pilot study.
Academic Article Contribution of insulin and Akt1 signaling to endothelial nitric oxide synthase in the regulation of endothelial function and blood pressure.
Academic Article Increased hexosamine pathway flux and high fat feeding are not additive in inducing insulin resistance: evidence for a shared pathway.
Academic Article Hexosamines regulate sensitivity of glucose-stimulated insulin secretion in beta-cells.
Academic Article Iron overload and diabetes risk: a shift from glucose to Fatty Acid oxidation and increased hepatic glucose production in a mouse model of hereditary hemochromatosis.
Academic Article Muscle damage and muscle remodeling: no pain, no gain?
Academic Article Pleiotropic and age-dependent effects of decreased protein modification by O-linked N-acetylglucosamine on pancreatic ß-cell function and vascularization.
Academic Article Hexosamines as mediators of nutrient sensing and regulation in diabetes.
Academic Article Insulin signaling coordinately regulates cardiac size, metabolism, and contractile protein isoform expression.
Academic Article Transgenic mice overexpressing the rate-limiting enzyme for hexosamine synthesis in skeletal muscle or adipose tissue exhibit total body insulin resistance.
Academic Article Altered glycan-dependent signaling induces insulin resistance and hyperleptinemia.
Academic Article Recipes for creating animal models of diabetic cardiovascular disease.
Academic Article Insulin resistance of glycogen synthase mediated by o-linked N-acetylglucosamine.
Academic Article Mechanisms Linking Glucose Homeostasis and Iron Metabolism Toward the Onset and Progression of Type 2 Diabetes.
Grant Iron reduction by phlebotomy for the prevention and treatment of type 2 diabetes
Grant Hexosamines, Glucose Toxicity and Insulin Resistance
Grant Diabetes in Hemochromatosis: Prevalence and Mechanisms
Academic Article Adipose Tissue Transferrin and Insulin Resistance.
Grant Iron Reduction for the Treatment of Diabetes and Nonalcoholic Fatty Liver Disease
Academic Article Effect of Chronic Hyperglycemia on Glucose Metabolism in Subjects With Normal Glucose Tolerance.
Academic Article Low dose chloroquine decreases insulin resistance in human metabolic syndrome but does not reduce carotid intima-media thickness.

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  • Insulin