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One or more keywords matched the following properties of Hanlon, Colleen
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keywords Transcranial Magnetic Stimulation
overview I lead a clinical research program designed to develop and optimize non-invasive electromagnetic therapeutics. We have primarily focused on transcranial magnetic stimulation (TMS) as a tool to treat substance dependence (e.g. tobacco cessation, alcohol dependence), chronic pain, and other mood disorders – all of which are directly relevant to cancer prevention and survivorship outcomes. Our therapeutic discovery pipeline is divided into 5 themes: 1) Target Identification studies – often achieved through functional and structural MRI measurements in the population interest, 2) Target Engagement studies – typically multimodal imaging studies evaluating the effect of the intervention on cue-reactivity or pain, 3) NIH-supported Clinical Trials – larger, double-blind sham-controlled investigations of safety and efficacy, 4) Methods Refinement – utilizing computational modeling and variance observed in our clinical data, we are able to revisit dosing parameters and develop novel pulse sequences for subsequent testing, 5) Preclinical Translational Research – leveraging the strength of animal models we work closely with basic scientists to investigate novel electromagnetic therapeutics. Through this thematic approach we have made contributions to several areas of science: 1. Evaluating individual differences in neural connectivity and cue-reactivity in substance dependent individuals. 2. Leading National and International efforts to develop a Brain Stimulation based approach for drug and alcohol use disorders (including smoking cessation). Transcranial magnetic stimulation (TMS) is an FDA-approved treatment for depression which has been used for over a decade. In 2020, after demonstrating positive outcomes in a multisite double-blind sham-controlled investigation, a unique form of TMS (‘Deep TMS’) received FDA-clearance for use as a smoking cessation aid. It is now emerging as a promising new tool for the attenuation of craving among multiple substance dependent populations. I am happy to be playing an active part in shaping this emerging field- including recently serving as the senior author on a consensus paper: Ekhtiari,H et al. Transcranial Electrical and Magnetic Stimulation (tES and TMS) for Addiction Medicine: A consensus paper on the present state of the science and the road ahead. Neurosci Biobehav Rev. 2019 Jul 1. PMID: 31271802 3. Methods Refinement. With a staff of engineers and biostatisticians we are continually investigating various aspects of these dosing parameters and attempting to develop open-source tools which can be used by the field of therapeutic brain stimulation at large. 4. Translational/Collaborative research. I have actively collaborated with teams of clinician scientists in Psychiatry, Neurology, Radiology, and Pain Management on various research projects. I am also committed to translational research efforts – working closely with preclinical researchers in 2 NIH supported P50 centers at MUSC and looking forward to greater involvement in the NIAAA P50 and NIDA P50 at Wake Forest Health Sciences. In 2020, for example, our lab joined forces with Dr. Paul Czoty’s laboratory in Physiology & Pharmacology and performed some first-in-class research devoted to developing a non-human primate model for TMS studies. The fruits of these efforts were submitted for publication in August 2020. 5. Mentorship, Teaching, and National Service. I participate in the research training and education community at both a local level (serving as a mentor to over 50 medical, graduate, post-graduate, and fellowship trainees since 2005 on a national and international scale) as well as leading an annual outreach event at the College of Problems on Drug Dependence (CPDD) meeting (2015-2018), serving on the Liaison Committee (2016-2019) and the Education and Training Committee (2019-present) for the American College of Neuropsychopharmacology, Grassroots Advocacy Team for the Society for Neuroscience (2017-2019), Chair of the Education Outreach and Public Policy Committee for CPDD (2017-2019), ad hoc participation in over 20 NIH study sections, and serving as a standing member of NIH NPAS study section (effective 10/2018)I also serve as a consultant and mentor on NIH grants led by several Assistant and Associate Professors whom I have mentored in TMS practices including Rebecca Price (Associate Professor, University of Pittsburg, “Evaluating TMS for OCD patients”, R21 consultant), Christine Sheffer (Assistant Professor, Roswell Park Cancer Institute, “Evaluating TMS for smoking cessation”, R01 consultant), Michael Wesley (Assistant Professor, University of Kentucky, K01 co-mentor), Andrada Neacsiu (Assistant Professor, Duke University), Eleanor Cole (Research fellow, Stanford), Claudia Padula (Assistant Professor, PaloAlto VA, Stanford, VA merit consultant). I am actively involved in mentoring all members of our laboratory as well as graduate students, medical students, and residents.
One or more keywords matched the following items that are connected to Hanlon, Colleen
Item TypeName
Grant Translational approaches to TMS treatment development for smoking
Grant Cortical Inhibition and Corpus Callosum Integrity in Cocaine Users
Grant Developing brain stimulation as a treatment for pain in opiate dependent individuals
Grant Longitudinal investigation of TMS as a tool to improve alcohol treatment outcomes
Academic Article Single pulse TMS to the DLPFC, compared to a matched sham control, induces a direct, causal increase in caudate, cingulate, and thalamic BOLD signal.
Academic Article Mobilization of Medial and Lateral Frontal-Striatal Circuits in Cocaine Users and Controls: An Interleaved TMS/BOLD Functional Connectivity Study.
Academic Article Modulating Neural Circuits with Transcranial Magnetic Stimulation: Implications for Addiction Treatment Development.
Academic Article Cortical substrates of cue-reactivity in multiple substance dependent populations: transdiagnostic relevance of the medial prefrontal cortex.
Academic Article A comprehensive study of sensorimotor cortex excitability in chronic cocaine users: Integrating TMS and functional MRI data.
Academic Article Use of imperceptible wrist vibration to modulate sensorimotor cortical activity.
Academic Article Developing Repetitive Transcranial Magnetic Stimulation (rTMS) as a Treatment Tool for Cocaine Use Disorder: a Series of Six Translational Studies.
Academic Article Non-invasive Brain Stimulation for Alcohol Use Disorders: State of the Art and Future Directions.
Academic Article Guidelines for TMS/tES clinical services and research through the COVID-19 pandemic.
Academic Article A Case for the Frontal Pole as an Empirically Derived Neuromodulation Treatment Target.
Academic Article Gray and white matter integrity influence TMS signal propagation: a multimodal evaluation in cocaine-dependent individuals.
Academic Article Low frequency repetitive transcranial magnetic stimulation of the left dorsolateral prefrontal cortex transiently increases cue-induced craving for methamphetamine: a preliminary study.
Academic Article Transcranial electrical and magnetic stimulation (tES and TMS) for addiction medicine: A consensus paper on the present state of the science and the road ahead.
Academic Article Individual variability in the locus of prefrontal craving for nicotine: implications for brain stimulation studies and treatments.
Academic Article Transcranial magnetic stimulation of the dorsal lateral prefrontal cortex inhibits medial orbitofrontal activity in smokers.
Academic Article What goes up, can come down: Novel brain stimulation paradigms may attenuate craving and craving-related neural circuitry in substance dependent individuals.
Academic Article Noninvasive brain stimulation treatments for addiction and major depression.
Academic Article Probing the frontostriatal loops involved in executive and limbic processing via interleaved TMS and functional MRI at two prefrontal locations: a pilot study.
Academic Article Visual Attention Affects the Amplitude of the Transcranial Magnetic Stimulation-associated Motor-evoked Potential: A Preliminary Study With Clinical Utility.
Academic Article Characterizing the corticomotor connectivity of the bilateral ankle muscles during rest and isometric contraction in healthy adults.
Academic Article Transcranial magnetic stimulation, deep brain stimulation, and other forms of neuromodulation for substance use disorders: Review of modalities and implications for treatment.
Academic Article Brain stimulation in zero gravity: transcranial magnetic stimulation (TMS) motor threshold decreases during zero gravity induced by parabolic flight.
Academic Article Left frontal pole theta burst stimulation decreases orbitofrontal and insula activity in cocaine users and alcohol users.
Academic Article Neural Architecture Influences Repetitive Transcranial Magnetic Stimulation-Induced Functional Change: A Diffusion Tensor Imaging and Functional Magnetic Resonance Imaging Study of Cue-Reactivity Modulation in Alcohol Users.
Academic Article Repetitive transcranial magnetic stimulation of the dorsolateral prefrontal cortex reduces nicotine cue craving.
Academic Article Transdiagnostic Effects of Ventromedial Prefrontal Cortex Transcranial Magnetic Stimulation on Cue Reactivity.
Academic Article Naloxone-reversible modulation of pain circuitry by left prefrontal rTMS.
Academic Article The frontal pole as a target for transcranial magnetic stimulation: A retrospective analysis of feasibility and tolerability.
Academic Article Non-invasive brain stimulation as a tool to decrease chronic pain in current opiate users: A parametric evaluation of two promising cortical targets.
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