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One or more keywords matched the following properties of Drenan, Ryan
keywords Nicotinic Acetylcholine Receptor
overview We study the physiological processes regulated by native nicotinic acetylcholine receptors (nAChRs), a large family of ligand gated ion channel proteins. These receptors mediate key aspects of cholinergic signaling in the brain and are involved in several important cognitive processes, including motivated behavior, affective behavior, attention and learning/memory. Aberrant nAChR activity is linked to several neurological diseases/disorders, such as nicotine addiction, schizophrenia, major depressive disorder, Alzheimer's disease and Parkinson's disease. We use a broad range of techniques, including patch clamp electrophysiology, confocal and two-photon imaging, immunohistochemistry and behavioral approaches such as drug self-administration.
One or more keywords matched the following items that are connected to Drenan, Ryan
Item TypeName
Concept Receptors, Nicotinic
Grant Alpha6* nAChRs in Dopamine Transmission and Nicotine Dependence
Grant Nicotinic ACh Receptors and Noradrenergic Neurotransmission in Nicotine Addiction
Grant Nicotinic receptor gene editing vectors
Grant Alpha6* nAChRs in Dopamine Transmission and Nicotine Dependence
Grant Identifying nicotine withdrawal mechanisms hidden within habenular complexity
Grant Nicotinic acetylcholine receptor function in the mesolimbic dopamine system
Academic Article Nicotine and ethanol cooperate to enhance ventral tegmental area AMPA receptor function via a6-containing nicotinic receptors.
Academic Article Probing Nicotinic Acetylcholine Receptor Function in Mouse Brain Slices via Laser Flash Photolysis of Photoactivatable Nicotine.
Academic Article The nicotinic a6 subunit gene determines variability in chronic pain sensitivity via cross-inhibition of P2X2/3 receptors.
Academic Article Photoactivatable drugs for nicotinic optopharmacology.
Academic Article Enhanced synthesis and release of dopamine in transgenic mice with gain-of-function a6* nAChRs.
Academic Article a6-Containing nicotinic acetylcholine receptors in midbrain dopamine neurons are poised to govern dopamine-mediated behaviors and synaptic plasticity.
Academic Article a4a6ß2* nicotinic acetylcholine receptor activation on ventral tegmental area dopamine neurons is sufficient to stimulate a depolarizing conductance and enhance surface AMPA receptor function.
Academic Article Structural differences determine the relative selectivity of nicotinic compounds for native alpha 4 beta 2*-, alpha 6 beta 2*-, alpha 3 beta 4*- and alpha 7-nicotine acetylcholine receptors.
Academic Article Subcellular trafficking, pentameric assembly, and subunit stoichiometry of neuronal nicotinic acetylcholine receptors containing fluorescently labeled alpha6 and beta3 subunits.
Academic Article Nicotinic Cholinergic Receptors in VTA Glutamate Neurons Modulate Excitatory Transmission.
Academic Article Nicotine exploits a COPI-mediated process for chaperone-mediated up-regulation of its receptors.
Academic Article Differential expression and function of nicotinic acetylcholine receptors in subdivisions of medial habenula.
Academic Article Gene editing vectors for studying nicotinic acetylcholine receptors in cholinergic transmission.
Academic Article Cholinergic modulation of locomotion and striatal dopamine release is mediated by alpha6alpha4* nicotinic acetylcholine receptors.
Academic Article Characterizing functional a6ß2 nicotinic acetylcholine receptors in vitro: mutant ß2 subunits improve membrane expression, and fluorescent proteins reveal responsive cells.
Academic Article a6* nicotinic acetylcholine receptor expression and function in a visual salience circuit.
Academic Article Selectivity of coronaridine congeners at nicotinic acetylcholine receptors and inhibitory activity on mouse medial habenula.
Academic Article Chronic Nicotine Exposure Alters the Neurophysiology of Habenulo-Interpeduncular Circuitry.
Academic Article In vivo activation of midbrain dopamine neurons via sensitized, high-affinity alpha 6 nicotinic acetylcholine receptors.
Academic Article Local application of drugs to study nicotinic acetylcholine receptor function in mouse brain slices.
Academic Article Evidence for a role for a6(*) nAChRs in l-dopa-induced dyskinesias using Parkinsonian a6(*) nAChR gain-of-function mice.
Academic Article Nicotine Dependence Reveals Distinct Responses from Neurons and Their Resident Nicotinic Receptors in Medial Habenula.
Academic Article Nicotinic acetylcholine receptors containing a6 subunits contribute to alcohol reward-related behaviours.
Academic Article Insights into the neurobiology of the nicotinic cholinergic system and nicotine addiction from mice expressing nicotinic receptors harboring gain-of-function mutations.
Academic Article Altered nicotine reward-associated behavior following a4 nAChR subunit deletion in ventral midbrain.
Academic Article TRPV1 regulates excitatory innervation of OLM neurons in the hippocampus.
Academic Article Deletion of lynx1 reduces the function of a6* nicotinic receptors.
Academic Article Nicotinic cholinergic mechanisms causing elevated dopamine release and abnormal locomotor behavior.
Academic Article Differential Nicotinic Modulation of Glutamatergic and GABAergic VTA Microcircuits.
Academic Article Selectivity of (±)-citalopram at nicotinic acetylcholine receptors and different inhibitory mechanisms between habenular a3ß4* and a9a10 subtypes.
Academic Article Nicotine Self-Administration Induces Plastic Changes to Nicotinic Receptors in Medial Habenula.
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  • Nicotinic Acetylcholine Receptor