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Gmeiner, William
One or more keywords matched the following items that are connected to Gmeiner, William
Item TypeName
Academic Article Targeted drug delivery to chemoresistant cells: folic acid derivatization of FdUMP[10] enhances cytotoxicity toward 5-FU-resistant human colorectal tumor cells.
Academic Article Intramolecular binding of a proximal PPII helix to an SH3 domain in the fusion protein SH3Hck : PPIIhGAP.
Academic Article The structure and dynamics of the U4/U6 snRNP: implications for pre-mRNA splicing and use as a model system to investigate the RNA-mediated effects of (5F)Ura.
Academic Article Effect of 5-FU substitution and mutation on Sm protein binding to human U4 snRNA.
Academic Article Novel chemical strategies for thymidylate synthase inhibition.
Academic Article Tissue-dependent and -independent gene expression changes in metastatic colon cancer.
Academic Article Genome-wide mRNA and microRNA profiling of the NCI 60 cell-line screen and comparison of FdUMP[10] with fluorouracil, floxuridine, and topoisomerase 1 poisons.
Academic Article Effects of site-specific substitution of 5-fluorouridine on the stabilities of duplex DNA and RNA.
Academic Article Structure and conformation in solution of the parallel-stranded hybrid alpha-d(CGCAATTCGC).beta-d(GCGTTAAGCG) by high-resolution 2D NMR.
Academic Article Separation of NOEs from degenerate amide protons in 13C/15N-labeled proteins using a 3D 13C'-edited NOESY-H(N)CO experiment.
Academic Article A linear 23-residue peptide reveals a propensity to form an unusual native-like conformation.
Academic Article Solution structures of 5-fluorouracil-substituted DNA and RNA decamer duplexes.
Academic Article The 5' stem-loop from human U4 snRNA adopts a novel conformation stabilized by G-C and G-U base pairs.
Academic Article Three-dimensional structure of the Hck SH2 domain in solution.
Academic Article Identification and localization of slow, natural, cooperative unfolding in the hematopoietic cell kinase SH3 domain by amide hydrogen exchange and mass spectrometry.
Academic Article NMR spectroscopy as a tool to investigate the structural basis of anticancer drugs.
Academic Article Solution structure of the human Hck SH3 domain and identification of its ligand binding site.
Academic Article Effect of cytarabine on the NMR structure of a model okazaki fragment from the SV40 genome.
Academic Article Shape-selective recognition of a model Okazaki fragment by geometrically-constrained bis-distamycins.
Academic Article Shape-selective binding of geometrically-constrained bis-distamycins to a DNA duplex and a model Okazaki fragment of identical sequence.
Academic Article Structure of the Sm binding site from human U4 snRNA derived from a 3 ns PME molecular dynamics simulation.
Academic Article Molecular dynamics simulation of the human U2B" protein complex with U2 snRNA hairpin IV in aqueous solution.
Academic Article NMR structure of a gemcitabine-substituted model Okazaki fragment.
Academic Article Energetic and conformational contributions to the stability of Okazaki fragments.
Academic Article Antimetabolite incorporation into DNA: structural and thermodynamic basis for anticancer activity.
Academic Article NMR structure of the 3' stem-loop from human U4 snRNA.
Academic Article NMR study of the folding-unfolding mechanism for the thrombin-binding DNA aptamer d(GGTTGGTGTGGTTGG).
Academic Article Quantum mechanical calculations and experimental measurement of N-terminal charge effects on 1HN and 1HC alpha chemical shifts in peptides.
Academic Article The affinity of an oligodeoxynucleotide-peptide conjugate for an RNA hairpin loop depends on stereochemistry at the DNA-peptide junction.
Academic Article Sequential assignment and secondary structure determination for the Src homology 2 domain of hematopoietic cellular kinase.
Academic Article Solution structures of 5-fluorouracil-substituted RNA duplexes containing G-U wobble base pairs.
Academic Article Comparison of SH3 and SH2 domain dynamics when expressed alone or in an SH(3+2) construct: the role of protein dynamics in functional regulation.
Academic Article Hydrogen exchange shows peptide binding stabilizes motions in Hck SH2.
Academic Article Polarity of annealing and structural analysis of the RNase H resistant alpha-5'-d[TACACA].beta-5'-r[AUGUGU] hybrid determined by high-field 1H, 13C, and 31P NMR analysis.
Academic Article Cytarabine-induced destabilization and bending of a model Okazaki fragment.
Academic Article Binding of ethidium to DNA measured using a 2D diffusion-modulated gradient COSY NMR experiment.
Concept Genome, Human
Concept Amino Acid Sequence
Concept Molecular Structure
Concept Conserved Sequence
Concept Sequence Deletion
Concept RNA, Messenger
Concept Gene Expression Profiling
Concept src Homology Domains
Concept RNA
Concept RNA, Small Nuclear
Concept RNA, Small Interfering
Concept Sequence Homology, Amino Acid
Concept RNA Splicing
Concept Oligonucleotide Array Sequence Analysis
Concept Base Sequence
Concept Genome, Viral
Concept Molecular Sequence Data
Concept RNA-Binding Proteins
Concept RNA, Double-Stranded
Academic Article Development of modified siRNA molecules incorporating 5-fluoro-2'-deoxyuridine residues to enhance cytotoxicity.
Academic Article Selection of a Novel Aptamer Against Vitronectin Using Capillary Electrophoresis and Next Generation Sequencing.
Academic Article Binding Site Configurations Probe the Structure and Dynamics of the Zinc Finger of NEMO (NF-?B Essential Modulator).
Grant IMPACT OF 5-FU ON THE STRUCTURE OF THE U4-U6 COMPLEX
Grant IMPACT OF 5FU ON THE STRUCTURE OF THE U4/U6 COMPLEX
Grant DNA-DIRECTED EFFECTS OF FdUMP(N)
Academic Article All-Atom MD Predicts Magnesium-Induced Hairpin in Chemically Perturbed RNA Analog of F10 Therapeutic.
Academic Article All-atom molecular dynamics comparison of disease-associated zinc fingers.
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