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Miranda E. Orr PhD

TitleAssociate Professor
InstitutionWake Forest School of Medicine
DepartmentInternal Medicine, Gerontology & Geriatric Medicine
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    Other Positions
    TitleAssociate Professor
    InstitutionWake Forest School of Medicine
    DepartmentTranslational Neuroscience


    Collapse Research 
    Collapse research activities and funding
    F31AG031630     (ORR, MIRANDA ETHEL)Sep 19, 2008 - Sep 18, 2011
    NIH
    Novel Stem Cell and Mouse Models to Study Frontotemporal Dementia
    Role: Principal Investigator
    IK2BX003804     (ORR, MIRANDA, ETHEL)Jul 1, 2017 - Jun 30, 2022
    US Department of Veterans Affairs
    Alzheimer’s disease-associated tau toxicity induces cellular senescence in the brain.
    Role: Principal Investigator
    K01AG056671     (ORR, MIRANDA ETHEL)Sep 1, 2017 - May 31, 2022
    NIH/NIA
    Alzheimer's Disease Associated Tau Toxicity Induces Cellular Senescence in Brain
    Role: Principal Investigator
    R01AG065839     (SOLINGAPURAM SAI, KIRAN)Jan 15, 2020 - Dec 31, 2024
    NIH
    Evaluating microtubule binding as a potential imaging biomarker for Alzheimer's disease
    Role: Co-Investigator
    R01AG068293     (ORR, MIRANDA ETHEL)Sep 10, 2020 - May 31, 2025
    NIH
    High Resolution Profiling of Senescent Neurons and Their Microenvironments in Postmortem Human Brain Tissue Spanning Eight Decades of Life
    Role: Principal Investigator
         (ORR, MIRANDA, ETHEL)Oct 20, 2020 - Apr 1, 2022
    Cure Alzheimer’s Fund
    Investigating the Role of Tau Protein in Neuronal Senescence Induction and Maintenance
    Role Description: The main goal of this project is to determine whether tau protein is necessary for either the induction or maintenance of neuronal senescence using tau transgenic mice.
    Role: Principal Investigator
         (ORR, MIRANDA, ETHEL)Mar 1, 2021 - Feb 29, 2024
    Alzheimer’s Disease Drug Discovery Foundation
    Phase II Clinical Trial to Evaluate the Safety and Feasibility of Senolytic Therapy in Alzheimer’s Disease
    Role Description: The major goal of this project is to gain data on the safety and efficacy of dasatinib and quercetin treatment on senescence, cognition and tau pathology in older adults with mild cognitive impairment/early Alzheimer’s disease.
    Role: Principal Investigator
    R24AG073199     (SHIVELY, CAROL A.)Sep 15, 2021 - May 31, 2025
    NIH
    Development of an Innovative Vervet (Chlorocebus aethiops sabaeus) Model of Early Alzheimer's-like Neuropathology and Symptomatology
    Role: Co-Investigator
    R21NS125171     (MILLIGAN, CAROL)Sep 29, 2021 - Mar 28, 2023
    NIH
    Cell Senescence and Death in Neurodegenerative Diseases
    Role: MPI
    I01BX005717     (ORR, MIRANDA, ETHEL)Oct 1, 2022 - Sep 30, 2026
    US Department of Veterans Affairs
    High Resolution Profiling of Senescent Cells in ALS Brain and Spinal Cord
    Role Description: The major goal of this project is to determine the abundance, identity and microenvironment of senescent cells in postmortem human brain and spinal cord tissue from Veterans that passed away with ALS.
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Damuka N, Orr ME, Bansode AH, Krizan I, Miller M, Lee J, Macauley SL, Whitlow CT, Mintz A, Craft S, Solingapuram Sai KK. Preliminary mechanistic insights of a brain-penetrant microtubule imaging PET ligand in a tau-knockout mouse model. EJNMMI Res. 2022 Jul 26; 12(1):41. PMID: 35881263.
      Citations:    
    2. Gonzales MM, Garbarino VR, Pollet E, Palavicini JP, Kellogg DL, Kraig E, Orr ME. Biological aging processes underlying cognitive decline and neurodegenerative disease. J Clin Invest. 2022 May 16; 132(10). PMID: 35575089.
      Citations:    
    3. Wang M, Song WM, Ming C, Wang Q, Zhou X, Xu P, Krek A, Yoon Y, Ho L, Orr ME, Yuan GC, Zhang B. Guidelines for bioinformatics of single-cell sequencing data analysis in Alzheimer's disease: review, recommendation, implementation and application. Mol Neurodegener. 2022 Mar 02; 17(1):17. PMID: 35236372.
      Citations:    
    4. Walker JM, Kazempour Dehkordi S, Fracassi A, Vanschoiack A, Pavenko A, Taglialatela G, Woltjer R, Richardson TE, Zare H, Orr ME. Differential protein expression in the hippocampi of resilient individuals identified by digital spatial profiling. Acta Neuropathol Commun. 2022 Feb 14; 10(1):23. PMID: 35164877.
      Citations:    
    5. Xu P, Wang M, Song WM, Wang Q, Yuan GC, Sudmant PH, Zare H, Tu Z, Orr ME, Zhang B. The landscape of human tissue and cell type specific expression and co-regulation of senescence genes. Mol Neurodegener. 2022 Jan 09; 17(1):5. PMID: 35000600.
      Citations:    
    6. Gonzales MM, Garbarino VR, Marques Zilli E, Petersen RC, Kirkland JL, Tchkonia T, Musi N, Seshadri S, Craft S, Orr ME. Senolytic Therapy to Modulate the Progression of Alzheimer's Disease (SToMP-AD): A Pilot Clinical Trial. J Prev Alzheimers Dis. 2022; 9(1):22-29. PMID: 35098970.
      Citations:    
    7. Dehkordi SK, Walker J, Sah E, Bennett E, Atrian F, Frost B, Woost B, Bennett RE, Orr TC, Zhou Y, Andhey PS, Colonna M, Sudmant PH, Xu P, Wang M, Zhang B, Zare H, Orr ME. Profiling senescent cells in human brains reveals neurons with CDKN2D/p19 and tau neuropathology. Nat Aging. 2021 Dec; 1(12):1107-1116. PMID: 35531351.
      Citations:    
    8. Gonzales MM, Krishnamurthy S, Garbarino V, Daeihagh AS, Gillispie GJ, Deep G, Craft S, Orr ME. A geroscience motivated approach to treat Alzheimer's disease: Senolytics move to clinical trials. Mech Ageing Dev. 2021 Dec; 200:111589. PMID: 34687726.
      Citations:    
    9. Frye BM, Craft S, Latimer CS, Keene CD, Montine TJ, Register TC, Orr ME, Kavanagh K, Macauley SL, Shively CA. Aging-related Alzheimer's disease-like neuropathology and functional decline in captive vervet monkeys (Chlorocebus aethiops sabaeus). Am J Primatol. 2021 Apr 05; e23260. PMID: 33818801.
      Citations:    
    10. Sah E, Krishnamurthy S, Ahmidouch MY, Gillispie GJ, Milligan C, Orr ME. The Cellular Senescence Stress Response in Post-Mitotic Brain Cells: Cell Survival at the Expense of Tissue Degeneration. Life (Basel). 2021 Mar 11; 11(3). PMID: 33799628.
      Citations:    
    11. Gillispie GJ, Sah E, Krishnamurthy S, Ahmidouch MY, Zhang B, Orr ME. Evidence of the Cellular Senescence Stress Response in Mitotically Active Brain Cells-Implications for Cancer and Neurodegeneration. Life (Basel). 2021 Feb 17; 11(2). PMID: 33671362.
      Citations:    
    12. Orr ME, Reveles KR, Yeh CK, Young EH, Han X. Can oral health and oral-derived biospecimens predict progression of dementia? Oral Dis. 2020 Mar; 26(2):249-258. PMID: 31541581.
      Citations:    
    13. Liang H, Nie J, Van Skike CE, Valentine JM, Orr ME. Mammalian Target of Rapamycin at the Crossroad Between Alzheimer's Disease and Diabetes. Adv Exp Med Biol. 2019; 1128:185-225. PMID: 31062331.
      Citations:    
    14. Musi N, Valentine JM, Sickora KR, Baeuerle E, Thompson CS, Shen Q, Orr ME. Tau protein aggregation is associated with cellular senescence in the brain. Aging Cell. 2018 12; 17(6):e12840. PMID: 30126037.
      Citations:    
    15. Orr ME, Sullivan AC, Frost B. A Brief Overview of Tauopathy: Causes, Consequences, and Therapeutic Strategies. Trends Pharmacol Sci. 2017 07; 38(7):637-648. PMID: 28455089.
      Citations:    
    16. Orr ME, Garbarino VR, Salinas A, Buffenstein R. Extended Postnatal Brain Development in the Longest-Lived Rodent: Prolonged Maintenance of Neotenous Traits in the Naked Mole-Rat Brain. Front Neurosci. 2016; 10:504. PMID: 27877105.
      Citations:    
    17. Triplett JC, Swomley AM, Kirk J, Grimes KM, Lewis KN, Orr ME, Rodriguez KA, Cai J, Klein JB, Buffenstein R, Butterfield DA. Reaching Out to Send a Message: Proteins Associated with Neurite Outgrowth and Neurotransmission are Altered with Age in the Long-Lived Naked Mole-Rat. Neurochem Res. 2016 Jul; 41(7):1625-34. PMID: 26935741.
      Citations:    
    18. Triplett JC, Tramutola A, Swomley A, Kirk J, Grimes K, Lewis K, Orr M, Rodriguez K, Cai J, Klein JB, Perluigi M, Buffenstein R, Butterfield DA. Age-related changes in the proteostasis network in the brain of the naked mole-rat: Implications promoting healthy longevity. Biochim Biophys Acta. 2015 Oct; 1852(10 Pt A):2213-24. PMID: 26248058.
      Citations:    
    19. Triplett JC, Swomley A, Kirk J, Lewis K, Orr M, Rodriguez K, Cai J, Klein JB, Buffenstein R, Butterfield DA. Metabolic clues to salubrious longevity in the brain of the longest-lived rodent: the naked mole-rat. J Neurochem. 2015 Aug; 134(3):538-50. PMID: 25940666.
      Citations:    
    20. Garbarino VR, Orr ME, Rodriguez KA, Buffenstein R. Mechanisms of oxidative stress resistance in the brain: Lessons learned from hypoxia tolerant extremophilic vertebrates. Arch Biochem Biophys. 2015 Jun 15; 576:8-16. PMID: 25841340.
      Citations:    
    21. Orr ME, Garbarino VR, Salinas A, Buffenstein R. Sustained high levels of neuroprotective, high molecular weight, phosphorylated tau in the longest-lived rodent. Neurobiol Aging. 2015 Mar; 36(3):1496-504. PMID: 25576082.
      Citations:    
    22. Orr ME, Salinas A, Buffenstein R, Oddo S. Mammalian target of rapamycin hyperactivity mediates the detrimental effects of a high sucrose diet on Alzheimer's disease pathology. Neurobiol Aging. 2014 Jun; 35(6):1233-42. PMID: 24411482.
      Citations:    
    23. George L, Chaverra M, Wolfe L, Thorne J, Close-Davis M, Eibs A, Riojas V, Grindeland A, Orr M, Carlson GA, Lefcort F. Familial dysautonomia model reveals Ikbkap deletion causes apoptosis of Pax3+ progenitors and peripheral neurons. Proc Natl Acad Sci U S A. 2013 Nov 12; 110(46):18698-703. PMID: 24173031.
      Citations:    
    24. Orr ME, Oddo S. Autophagic/lysosomal dysfunction in Alzheimer's disease. Alzheimers Res Ther. 2013; 5(5):53. PMID: 24171818.
      Citations:    
    25. Medina DX, Orr ME, Oddo S. Accumulation of C-terminal fragments of transactive response DNA-binding protein 43 leads to synaptic loss and cognitive deficits in human TDP-43 transgenic mice. Neurobiol Aging. 2014 Jan; 35(1):79-87. PMID: 23954172.
      Citations:    
    26. Orr ME, Pitstick R, Canine B, Ashe KH, Carlson GA. Genotype-specific differences between mouse CNS stem cell lines expressing frontotemporal dementia mutant or wild type human tau. PLoS One. 2012; 7(6):e39328. PMID: 22723997.
      Citations:    
    27. Purevdorj-Gage B, Orr ME, Stoodley P, Sheehan KB, Hyman LE. The role of FLO11 in Saccharomyces cerevisiae biofilm development in a laboratory based flow-cell system. FEMS Yeast Res. 2007 May; 7(3):372-9. PMID: 17233763.
      Citations:    
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