William Gmeiner to Thymidylate Synthase
This is a "connection" page, showing publications William Gmeiner has written about Thymidylate Synthase.
Connection Strength
1.572
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Jennings-Gee J, Pardee TS, Gmeiner WH. Replication-dependent irreversible topoisomerase 1 poisoning is responsible for FdUMP[10] anti-leukemic activity. Exp Hematol. 2013 Feb; 41(2):180-188.e4.
Score: 0.443
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Pardee TS, Gomes E, Jennings-Gee J, Caudell D, Gmeiner WH. Unique dual targeting of thymidylate synthase and topoisomerase1 by FdUMP[10] results in high efficacy against AML and low toxicity. Blood. 2012 Apr 12; 119(15):3561-70.
Score: 0.424
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Gmeiner WH. Novel chemical strategies for thymidylate synthase inhibition. Curr Med Chem. 2005; 12(2):191-202.
Score: 0.258
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Gmeiner WH, Skradis A, Pon RT, Liu J. Cytotoxicity and in-vivo tolerance of FdUMP[10]: a novel pro-drug of the TS inhibitory nucleotide FdUMP. Nucleosides Nucleotides. 1999 Jun-Jul; 18(6-7):1729-30.
Score: 0.175
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Bijnsdorp IV, Comijn EM, Padron JM, Gmeiner WH, Peters GJ. Mechanisms of action of FdUMP[10]: metabolite activation and thymidylate synthase inhibition. Oncol Rep. 2007 Jul; 18(1):287-91.
Score: 0.077
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Liu C, Willingham M, Liu J, Gmeiner WH. Efficacy and safety of FdUMP[10] in treatment of HT-29 human colon cancer xenografts. Int J Oncol. 2002 Aug; 21(2):303-8.
Score: 0.055
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Liu J, Kolar C, Lawson TA, Gmeiner WH. Targeted drug delivery to chemoresistant cells: folic acid derivatization of FdUMP[10] enhances cytotoxicity toward 5-FU-resistant human colorectal tumor cells. J Org Chem. 2001 Aug 24; 66(17):5655-63.
Score: 0.051
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Liu J, Skradis A, Kolar C, Kolath J, Anderson J, Lawson T, Talmadge J, Gmeiner WH. Increased cytotoxicity and decreased in vivo toxicity of FdUMP[10] relative to 5-FU. Nucleosides Nucleotides. 1999 Aug; 18(8):1789-802.
Score: 0.044
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Wu SY, Chen TM, Gmeiner WH, Chu E, Schmitz JC. Development of modified siRNA molecules incorporating 5-fluoro-2'-deoxyuridine residues to enhance cytotoxicity. Nucleic Acids Res. 2013 Apr; 41(8):4650-9.
Score: 0.028
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Liao ZY, Sordet O, Zhang HL, Kohlhagen G, Antony S, Gmeiner WH, Pommier Y. A novel polypyrimidine antitumor agent FdUMP[10] induces thymineless death with topoisomerase I-DNA complexes. Cancer Res. 2005 Jun 01; 65(11):4844-51.
Score: 0.017