William Gmeiner to Humans
This is a "connection" page, showing publications William Gmeiner has written about Humans.
Connection Strength
0.747
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Mani C, Pai S, Papke CM, Palle K, Gmeiner WH. Thymineless Death by the Fluoropyrimidine Polymer F10 Involves Replication Fork Collapse and Is Enhanced by Chk1 Inhibition. Neoplasia. 2018 12; 20(12):1236-1245.
Score: 0.038
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Ghosh S, Mallick S, Das U, Verma A, Pal U, Chatterjee S, Nandy A, Saha KD, Maiti NC, Baishya B, Suresh Kumar G, Gmeiner WH. Curcumin stably interacts with DNA hairpin through minor groove binding and demonstrates enhanced cytotoxicity in combination with FdU nucleotides. Biochim Biophys Acta Gen Subj. 2018 Mar; 1862(3):485-494.
Score: 0.035
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Gmeiner WH, Gearhart PJ, Pommier Y, Nakamura J. F10 cytotoxicity via topoisomerase I cleavage complex repair consistent with a unique mechanism for thymineless death. Future Oncol. 2016 Oct; 12(19):2183-8.
Score: 0.032
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Gmeiner WH, Debinski W, Milligan C, Caudell D, Pardee TS. The applications of the novel polymeric fluoropyrimidine F10 in cancer treatment: current evidence. Future Oncol. 2016 Sep; 12(17):2009-20.
Score: 0.032
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Stuart CH, Singh R, Smith TL, D'Agostino R, Caudell D, Balaji KC, Gmeiner WH. Prostate-specific membrane antigen-targeted liposomes specifically deliver the Zn(2+) chelator TPEN inducing oxidative stress in prostate cancer cells. Nanomedicine (Lond). 2016 05; 11(10):1207-22.
Score: 0.031
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Gmeiner WH, Jennings-Gee J, Stuart CH, Pardee TS. Thymineless death in F10-treated AML cells occurs via lipid raft depletion and Fas/FasL co-localization in the plasma membrane with activation of the extrinsic apoptotic pathway. Leuk Res. 2015 Feb; 39(2):229-35.
Score: 0.029
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Gmeiner WH, Boyacioglu O, Stuart CH, Jennings-Gee J, Balaji KC. The cytotoxic and pro-apoptotic activities of the novel fluoropyrimidine F10 towards prostate cancer cells are enhanced by Zn(2+) -chelation and inhibiting the serine protease Omi/HtrA2. Prostate. 2015 Mar 01; 75(4):360-9.
Score: 0.028
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Pardee TS, Stadelman K, Jennings-Gee J, Caudell DL, Gmeiner WH. The poison oligonucleotide F10 is highly effective against acute lymphoblastic leukemia while sparing normal hematopoietic cells. Oncotarget. 2014 Jun 30; 5(12):4170-9.
Score: 0.028
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Stuart CH, Horita DA, Thomas MJ, Salsbury FR, Lively MO, Gmeiner WH. Site-specific DNA-doxorubicin conjugates display enhanced cytotoxicity to breast cancer cells. Bioconjug Chem. 2014 Feb 19; 25(2):406-13.
Score: 0.027
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Gmeiner WH, Lema-Tome C, Gibo D, Jennings-Gee J, Milligan C, Debinski W. Selective anti-tumor activity of the novel fluoropyrimidine polymer F10 towards G48a orthotopic GBM tumors. J Neurooncol. 2014 Feb; 116(3):447-54.
Score: 0.027
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Ghosh S, Ucer KB, D'Agostino R, Grant K, Sirintrapun J, Thomas MJ, Hantgan R, Bharadwaj M, Gmeiner WH. Non-covalent assembly of meso-tetra-4-pyridyl porphine with single-stranded DNA to form nano-sized complexes with hydrophobicity-dependent DNA release and anti-tumor activity. Nanomedicine. 2014 Feb; 10(2):451-61.
Score: 0.026
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Ghosh S, Salsbury FR, Horita DA, Gmeiner WH. Cooperative stabilization of Zn(2+):DNA complexes through netropsin binding in the minor groove of FdU-substituted DNA. J Biomol Struct Dyn. 2013; 31(11):1301-10.
Score: 0.025
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Jennings-Gee J, Pardee TS, Gmeiner WH. Replication-dependent irreversible topoisomerase 1 poisoning is responsible for FdUMP[10] anti-leukemic activity. Exp Hematol. 2013 Feb; 41(2):180-188.e4.
Score: 0.025
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Pardee TS, Gomes E, Jennings-Gee J, Caudell D, Gmeiner WH. Unique dual targeting of thymidylate synthase and topoisomerase1 by FdUMP[10] results in high efficacy against AML and low toxicity. Blood. 2012 Apr 12; 119(15):3561-70.
Score: 0.024
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Ghosh S, Salsbury FR, Horita DA, Gmeiner WH. Zn2+ selectively stabilizes FdU-substituted DNA through a unique major groove binding motif. Nucleic Acids Res. 2011 May; 39(10):4490-8.
Score: 0.022
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Gmeiner WH, Reinhold WC, Pommier Y. Genome-wide mRNA and microRNA profiling of the NCI 60 cell-line screen and comparison of FdUMP[10] with fluorouracil, floxuridine, and topoisomerase 1 poisons. Mol Cancer Ther. 2010 Dec; 9(12):3105-14.
Score: 0.022
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Gmeiner WH, Hellmann GM, Shen P. Tissue-dependent and -independent gene expression changes in metastatic colon cancer. Oncol Rep. 2008 Jan; 19(1):245-51.
Score: 0.018
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Gmeiner WH. Novel chemical strategies for thymidylate synthase inhibition. Curr Med Chem. 2005; 12(2):191-202.
Score: 0.014
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Gmeiner WH, Trump E, Wei C. Enhanced DNA-directed effects of FdUMP[10] compared to 5FU. Nucleosides Nucleotides Nucleic Acids. 2004; 23(1-2):401-10.
Score: 0.013
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Gmeiner WH. Antimetabolite incorporation into DNA: structural and thermodynamic basis for anticancer activity. Biopolymers. 2002 Nov 05; 65(3):180-9.
Score: 0.012
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Comolli LR, Ulyanov NB, Soto AM, Marky LA, James TL, Gmeiner WH. NMR structure of the 3' stem-loop from human U4 snRNA. Nucleic Acids Res. 2002 Oct 15; 30(20):4371-9.
Score: 0.012
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Liu C, Willingham M, Liu J, Gmeiner WH. Efficacy and safety of FdUMP[10] in treatment of HT-29 human colon cancer xenografts. Int J Oncol. 2002 Aug; 21(2):303-8.
Score: 0.012
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Cui W, Gmeiner WH. Effect of 5-FU substitution and mutation on Sm protein binding to human U4 snRNA. Nucleosides Nucleotides Nucleic Acids. 2002; 21(2):139-54.
Score: 0.012
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Liu J, Kolar C, Lawson TA, Gmeiner WH. Targeted drug delivery to chemoresistant cells: folic acid derivatization of FdUMP[10] enhances cytotoxicity toward 5-FU-resistant human colorectal tumor cells. J Org Chem. 2001 Aug 24; 66(17):5655-63.
Score: 0.011
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Guo JX, Gmeiner WH. Molecular dynamics simulation of the human U2B" protein complex with U2 snRNA hairpin IV in aqueous solution. Biophys J. 2001 Aug; 81(2):630-42.
Score: 0.011
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Gmeiner WH, Xu I, Horita DA, Smithgall TE, Engen JR, Smith DL, Byrd RA. Intramolecular binding of a proximal PPII helix to an SH3 domain in the fusion protein SH3Hck : PPIIhGAP. Cell Biochem Biophys. 2001; 35(2):115-26.
Score: 0.011
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Gmeiner WH, Horita DA. Implications of SH3 domain structure and dynamics for protein regulation and drug design. Cell Biochem Biophys. 2001; 35(2):127-40.
Score: 0.011
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Guo J, Daizadeh I, Gmeiner WH. Structure of the Sm binding site from human U4 snRNA derived from a 3 ns PME molecular dynamics simulation. J Biomol Struct Dyn. 2000 Dec; 18(3):335-44.
Score: 0.011
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Liu J, Kolath J, Anderson J, Kolar C, Lawson TA, Talmadge J, Gmeiner WH. Positive interaction between 5-FU and FdUMP[10] in the inhibition of human colorectal tumor cell proliferation. Antisense Nucleic Acid Drug Dev. 1999 Oct; 9(5):481-6.
Score: 0.010
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Mani C, Jonnalagadda S, Lingareddy J, Awasthi S, Gmeiner WH, Palle K. Prexasertib treatment induces homologous recombination deficiency and synergizes with olaparib in triple-negative breast cancer cells. Breast Cancer Res. 2019 09 06; 21(1):104.
Score: 0.010
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Liu J, Skradis A, Kolar C, Kolath J, Anderson J, Lawson T, Talmadge J, Gmeiner WH. Increased cytotoxicity and decreased in vivo toxicity of FdUMP[10] relative to 5-FU. Nucleosides Nucleotides. 1999 Aug; 18(8):1789-802.
Score: 0.010
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Gmeiner WH, Skradis A, Pon RT, Liu J. Cytotoxicity and in-vivo tolerance of FdUMP[10]: a novel pro-drug of the TS inhibitory nucleotide FdUMP. Nucleosides Nucleotides. 1999 Jun-Jul; 18(6-7):1729-30.
Score: 0.010
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Forsythe S, Mehta N, Devarasetty M, Sivakumar H, Gmeiner W, Soker S, Votanopoulos K, Skardal A. Development of a Colorectal Cancer 3D Micro-tumor Construct Platform From Cell Lines and Patient Tumor Biospecimens for Standard-of-Care and Experimental Drug Screening. Ann Biomed Eng. 2020 Mar; 48(3):940-952.
Score: 0.010
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Zhang W, Smithgall TE, Gmeiner WH. Self-association and backbone dynamics of the hck SH2 domain in the free and phosphopeptide-complexed forms. Biochemistry. 1998 May 19; 37(20):7119-26.
Score: 0.009
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Bhatt NB, Pandya DN, Dezarn WA, Marini FC, Zhao D, Gmeiner WH, Triozzi PL, Wadas TJ. Practical Guidelines for Cerenkov Luminescence Imaging with Clinically Relevant Isotopes. Methods Mol Biol. 2018; 1790:197-208.
Score: 0.009
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Godwin RC, Gmeiner WH, Salsbury FR. All-atom molecular dynamics comparison of disease-associated zinc fingers. J Biomol Struct Dyn. 2018 Aug; 36(10):2581-2594.
Score: 0.009
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Zhang W, Smithgall TE, Gmeiner WH. Three-dimensional structure of the Hck SH2 domain in solution. J Biomol NMR. 1997 Oct; 10(3):263-72.
Score: 0.009
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Zhang W, Smithgall TE, Gmeiner WH. Sequential assignment and secondary structure determination for the Src homology 2 domain of hematopoietic cellular kinase. FEBS Lett. 1997 Apr 07; 406(1-2):131-5.
Score: 0.008
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Sahasrabudhe PV, Sun J, Gmeiner WH. The 5' stem-loop from human U4 snRNA adopts a novel conformation stabilized by G-C and G-U base pairs. J Biomol Struct Dyn. 1997 Apr; 14(5):567-77.
Score: 0.008
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Godwin RC, Melvin RL, Gmeiner WH, Salsbury FR. Binding Site Configurations Probe the Structure and Dynamics of the Zinc Finger of NEMO (NF-?B Essential Modulator). Biochemistry. 2017 01 31; 56(4):623-633.
Score: 0.008
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Zhang W, Smithgall TE, Gmeiner WH. Separation of NOEs from degenerate amide protons in 13C/15N-labeled proteins using a 3D 13C'-edited NOESY-H(N)CO experiment. J Magn Reson B. 1996 Jun; 111(3):305-9.
Score: 0.008
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Godwin R, Gmeiner W, Salsbury FR. Importance of long-time simulations for rare event sampling in zinc finger proteins. J Biomol Struct Dyn. 2016; 34(1):125-34.
Score: 0.007
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Wu SY, Chen TM, Gmeiner WH, Chu E, Schmitz JC. Development of modified siRNA molecules incorporating 5-fluoro-2'-deoxyuridine residues to enhance cytotoxicity. Nucleic Acids Res. 2013 Apr; 41(8):4650-9.
Score: 0.006
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Pourquier P, Gioffre C, Kohlhagen G, Urasaki Y, Goldwasser F, Hertel LW, Yu S, Pon RT, Gmeiner WH, Pommier Y. Gemcitabine (2',2'-difluoro-2'-deoxycytidine), an antimetabolite that poisons topoisomerase I. Clin Cancer Res. 2002 Aug; 8(8):2499-504.
Score: 0.003
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Kotchetkov R, Gröschel B, Gmeiner WH, Krivtchik AA, Trump E, Bitoova M, Cinatl J, Kornhuber B, Cinatl J. Antineoplastic activity of a novel multimeric gemcitabine-monophosphate prodrug against thyroid cancer cells in vitro. Anticancer Res. 2000 Sep-Oct; 20(5A):2915-22.
Score: 0.003
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Engen JR, Gmeiner WH, Smithgall TE, Smith DL. Hydrogen exchange shows peptide binding stabilizes motions in Hck SH2. Biochemistry. 1999 Jul 13; 38(28):8926-35.
Score: 0.002
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Engen JR, Smithgall TE, Gmeiner WH, Smith DL. Comparison of SH3 and SH2 domain dynamics when expressed alone or in an SH(3+2) construct: the role of protein dynamics in functional regulation. J Mol Biol. 1999 Apr 02; 287(3):645-56.
Score: 0.002
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Horita DA, Baldisseri DM, Zhang W, Altieri AS, Smithgall TE, Gmeiner WH, Byrd RA. Solution structure of the human Hck SH3 domain and identification of its ligand binding site. J Mol Biol. 1998 Apr 24; 278(1):253-65.
Score: 0.002
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Engen JR, Smithgall TE, Gmeiner WH, Smith DL. Identification and localization of slow, natural, cooperative unfolding in the hematopoietic cell kinase SH3 domain by amide hydrogen exchange and mass spectrometry. Biochemistry. 1997 Nov 25; 36(47):14384-91.
Score: 0.002
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Sherman SA, Gmeiner WH, Kirnarskiy L, Perini F, Ruddon RW. A linear 23-residue peptide reveals a propensity to form an unusual native-like conformation. J Biomol Struct Dyn. 1995 Dec; 13(3):441-6.
Score: 0.002
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McConnell JR, Swindells S, Ong CS, Gmeiner WH, Chu WK, Brown DK, Gendelman HE. Prospective utility of cerebral proton magnetic resonance spectroscopy in monitoring HIV infection and its associated neurological impairment. AIDS Res Hum Retroviruses. 1994 Aug; 10(8):977-82.
Score: 0.002