William Gmeiner to Enzyme Inhibitors
This is a "connection" page, showing publications William Gmeiner has written about Enzyme Inhibitors.
Connection Strength
0.804
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Pardee TS, Gomes E, Jennings-Gee J, Caudell D, Gmeiner WH. Unique dual targeting of thymidylate synthase and topoisomerase1 by FdUMP[10] results in high efficacy against AML and low toxicity. Blood. 2012 Apr 12; 119(15):3561-70.
Score: 0.395
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Liu C, Willingham M, Liu J, Gmeiner WH. Efficacy and safety of FdUMP[10] in treatment of HT-29 human colon cancer xenografts. Int J Oncol. 2002 Aug; 21(2):303-8.
Score: 0.204
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Gmeiner WH, Yu S, Pon RT, Pourquier P, Pommier Y. Structural basis for topoisomerase I inhibition by nucleoside analogs. Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug; 22(5-8):653-8.
Score: 0.054
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Pourquier P, Gioffre C, Kohlhagen G, Urasaki Y, Goldwasser F, Hertel LW, Yu S, Pon RT, Gmeiner WH, Pommier Y. Gemcitabine (2',2'-difluoro-2'-deoxycytidine), an antimetabolite that poisons topoisomerase I. Clin Cancer Res. 2002 Aug; 8(8):2499-504.
Score: 0.051
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Liu J, Skradis A, Kolar C, Kolath J, Anderson J, Lawson T, Talmadge J, Gmeiner WH. Increased cytotoxicity and decreased in vivo toxicity of FdUMP[10] relative to 5-FU. Nucleosides Nucleotides. 1999 Aug; 18(8):1789-802.
Score: 0.041
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Gmeiner WH, Skradis A, Pon RT, Liu J. Cytotoxicity and in-vivo tolerance of FdUMP[10]: a novel pro-drug of the TS inhibitory nucleotide FdUMP. Nucleosides Nucleotides. 1999 Jun-Jul; 18(6-7):1729-30.
Score: 0.041
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Bijnsdorp IV, Comijn EM, Padron JM, Gmeiner WH, Peters GJ. Mechanisms of action of FdUMP[10]: metabolite activation and thymidylate synthase inhibition. Oncol Rep. 2007 Jul; 18(1):287-91.
Score: 0.018