William Gmeiner to Antimetabolites, Antineoplastic
This is a "connection" page, showing publications William Gmeiner has written about Antimetabolites, Antineoplastic.
Connection Strength
1.873
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Jennings-Gee J, Pardee TS, Gmeiner WH. Replication-dependent irreversible topoisomerase 1 poisoning is responsible for FdUMP[10] anti-leukemic activity. Exp Hematol. 2013 Feb; 41(2):180-188.e4.
Score: 0.434
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Gmeiner WH. Antimetabolite incorporation into DNA: structural and thermodynamic basis for anticancer activity. Biopolymers. 2002 Nov 05; 65(3):180-9.
Score: 0.218
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Liu J, Kolath J, Anderson J, Kolar C, Lawson TA, Talmadge J, Gmeiner WH. Positive interaction between 5-FU and FdUMP[10] in the inhibition of human colorectal tumor cell proliferation. Antisense Nucleic Acid Drug Dev. 1999 Oct; 9(5):481-6.
Score: 0.176
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Liu J, Skradis A, Kolar C, Kolath J, Anderson J, Lawson T, Talmadge J, Gmeiner WH. Increased cytotoxicity and decreased in vivo toxicity of FdUMP[10] relative to 5-FU. Nucleosides Nucleotides. 1999 Aug; 18(8):1789-802.
Score: 0.174
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Gmeiner WH, Skradis A, Pon RT, Liu J. Cytarabine-induced destabilization and bending of a model Okazaki fragment. Nucleosides Nucleotides. 1999 Jun-Jul; 18(6-7):1577-8.
Score: 0.172
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Gmeiner WH, Skradis A, Pon RT, Liu J. Cytarabine-induced destabilization of a model Okazaki fragment. Nucleic Acids Res. 1998 May 15; 26(10):2359-65.
Score: 0.160
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Sahasrabudhe PV, Gmeiner WH. Solution structures of 5-fluorouracil-substituted RNA duplexes containing G-U wobble base pairs. Biochemistry. 1997 May 20; 36(20):5981-91.
Score: 0.149
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Gmeiner WH, Lema-Tome C, Gibo D, Jennings-Gee J, Milligan C, Debinski W. Selective anti-tumor activity of the novel fluoropyrimidine polymer F10 towards G48a orthotopic GBM tumors. J Neurooncol. 2014 Feb; 116(3):447-54.
Score: 0.118
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Huang SY, Murai J, Dalla Rosa I, Dexheimer TS, Naumova A, Gmeiner WH, Pommier Y. TDP1 repairs nuclear and mitochondrial DNA damage induced by chain-terminating anticancer and antiviral nucleoside analogs. Nucleic Acids Res. 2013 Sep; 41(16):7793-803.
Score: 0.114
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Gmeiner WH, Yu S, Pon RT, Pourquier P, Pommier Y. Structural basis for topoisomerase I inhibition by nucleoside analogs. Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug; 22(5-8):653-8.
Score: 0.056
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Pourquier P, Gioffre C, Kohlhagen G, Urasaki Y, Goldwasser F, Hertel LW, Yu S, Pon RT, Gmeiner WH, Pommier Y. Gemcitabine (2',2'-difluoro-2'-deoxycytidine), an antimetabolite that poisons topoisomerase I. Clin Cancer Res. 2002 Aug; 8(8):2499-504.
Score: 0.053
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Konerding D, James TL, Trump E, Soto AM, Marky LA, Gmeiner WH. NMR structure of a gemcitabine-substituted model Okazaki fragment. Biochemistry. 2002 Jan 22; 41(3):839-46.
Score: 0.052