Alan Townsend to Humans
This is a "connection" page, showing publications Alan Townsend has written about Humans.
Connection Strength
0.152
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Rudd LP, Kabler SL, Morrow CS, Townsend AJ. Enhanced glutathione depletion, protein adduct formation, and cytotoxicity following exposure to 4-hydroxy-2-nonenal (HNE) in cells expressing human multidrug resistance protein-1 (MRP1) together with human glutathione S-transferase-M1 (GSTM1). Chem Biol Interact. 2011 Nov 15; 194(2-3):113-9.
Score: 0.019
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Kabler SL, Seidel A, Jacob J, Doehmer J, Morrow CS, Townsend AJ. Differential protection by human glutathione S-transferase P1 against cytotoxicity of benzo[a]pyrene, dibenzo[a,l]pyrene, or their dihydrodiol metabolites, in bi-transgenic cell lines that co-express rat versus human cytochrome P4501A1. Chem Biol Interact. 2009 May 15; 179(2-3):240-6.
Score: 0.016
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Ahmad S, Kabler SL, Rudd L, Amin S, Doehmer J, Morrow CS, Townsend AJ. Cytotoxicity and mutagenicity of 5-methylchrysene and its 1,2-dihydrodiol in V79MZ cells modified to express human CYP1A1 or CYP1B1, in the presence or absence of human GSTP1 coexpression. Toxicol Lett. 2008 Dec 15; 183(1-3):99-104.
Score: 0.016
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Kushman ME, Kabler SL, Ahmad S, Doehmer J, Morrow CS, Townsend AJ. Protective efficacy of hGSTM1-1 against B[a]P and (+)- or (-)-B[a]P-7,8-dihydrodiol cytotoxicity, mutagenicity, and macromolecular adducts in V79 cells coexpressing hCYP1A1. Toxicol Sci. 2007 Sep; 99(1):51-7.
Score: 0.014
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Kushman ME, Kabler SL, Ahmad S, Doehmer J, Morrow CS, Townsend AJ. Cytotoxicity and mutagenicity of dibenzo[a,l]pyrene and (+/-)-dibenzo[a,l]pyrene-11,12-dihydrodiol in V79MZ cells co-expressing either hCYP1A1 or hCYP1B1 together with human glutathione-S-transferase A1. Mutat Res. 2007 Nov 01; 624(1-2):80-7.
Score: 0.014
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Kushman ME, Kabler SL, Fleming MH, Ravoori S, Gupta RC, Doehmer J, Morrow CS, Townsend AJ. Expression of human glutathione S-transferase P1 confers resistance to benzo[a]pyrene or benzo[a]pyrene-7,8-dihydrodiol mutagenesis, macromolecular alkylation and formation of stable N2-Gua-BPDE adducts in stably transfected V79MZ cells co-expressing hCYP1A1. Carcinogenesis. 2007 Jan; 28(1):207-14.
Score: 0.013
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Morrow CS, Peklak-Scott C, Bishwokarma B, Kute TE, Smitherman PK, Townsend AJ. Multidrug resistance protein 1 (MRP1, ABCC1) mediates resistance to mitoxantrone via glutathione-dependent drug efflux. Mol Pharmacol. 2006 Apr; 69(4):1499-505.
Score: 0.013
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Townsend AJ, Kabler SL, Doehmer J, Morrow CS. Modeling the metabolic competency of glutathione S-transferases using genetically modified cell lines. Toxicology. 2002 Dec 27; 181-182:265-9.
Score: 0.010
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Bates DJ, Smitherman PK, Townsend AJ, King SB, Morrow CS. Nitroalkene fatty acids mediate activation of Nrf2/ARE-dependent and PPAR?-dependent transcription by distinct signaling pathways and with significantly different potencies. Biochemistry. 2011 Sep 13; 50(36):7765-73.
Score: 0.005
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Bates DJ, Lively MO, Gorczynski MJ, King SB, Townsend AJ, Morrow CS. Noncatalytic interactions between glutathione S-transferases and nitroalkene fatty acids modulate nitroalkene-mediated activation of peroxisomal proliferator-activated receptor gamma. Biochemistry. 2009 May 19; 48(19):4159-69.
Score: 0.004
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Peklak-Scott C, Smitherman PK, Townsend AJ, Morrow CS. Role of glutathione S-transferase P1-1 in the cellular detoxification of cisplatin. . 2008 Oct; 7(10):3247-55.
Score: 0.004
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Sibhatu MB, Smitherman PK, Townsend AJ, Morrow CS. Expression of MRP1 and GSTP1-1 modulate the acute cellular response to treatment with the chemopreventive isothiocyanate, sulforaphane. Carcinogenesis. 2008 Apr; 29(4):807-15.
Score: 0.004
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Riddick DS, Lee C, Ramji S, Chinje EC, Cowen RL, Williams KJ, Patterson AV, Stratford IJ, Morrow CS, Townsend AJ, Jounaidi Y, Chen CS, Su T, Lu H, Schwartz PS, Waxman DJ. Cancer chemotherapy and drug metabolism. Drug Metab Dispos. 2005 Aug; 33(8):1083-96.
Score: 0.003
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Peklak-Scott C, Townsend AJ, Morrow CS. Dynamics of glutathione conjugation and conjugate efflux in detoxification of the carcinogen, 4-nitroquinoline 1-oxide: contributions of glutathione, glutathione S-transferase, and MRP1. Biochemistry. 2005 Mar 22; 44(11):4426-33.
Score: 0.003
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Paumi CM, Smitherman PK, Townsend AJ, Morrow CS. Glutathione S-transferases (GSTs) inhibit transcriptional activation by the peroxisomal proliferator-activated receptor gamma (PPAR gamma) ligand, 15-deoxy-delta 12,14prostaglandin J2 (15-d-PGJ2). Biochemistry. 2004 Mar 02; 43(8):2345-52.
Score: 0.003
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Smitherman PK, Townsend AJ, Kute TE, Morrow CS. Role of multidrug resistance protein 2 (MRP2, ABCC2) in alkylating agent detoxification: MRP2 potentiates glutathione S-transferase A1-1-mediated resistance to chlorambucil cytotoxicity. J Pharmacol Exp Ther. 2004 Jan; 308(1):260-7.
Score: 0.003
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Paumi CM, Wright M, Townsend AJ, Morrow CS. Multidrug resistance protein (MRP) 1 and MRP3 attenuate cytotoxic and transactivating effects of the cyclopentenone prostaglandin, 15-deoxy-Delta(12,14)prostaglandin J2 in MCF7 breast cancer cells. Biochemistry. 2003 May 13; 42(18):5429-37.
Score: 0.003
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Pappa A, Chen C, Koutalos Y, Townsend AJ, Vasiliou V. Aldh3a1 protects human corneal epithelial cells from ultraviolet- and 4-hydroxy-2-nonenal-induced oxidative damage. Free Radic Biol Med. 2003 May 01; 34(9):1178-89.
Score: 0.003
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Pietsch EC, Hurley AL, Scott EE, Duckworth BP, Welker ME, Leone-Kabler S, Townsend AJ, Torti FM, Torti SV. Oxathiolene oxides: a novel family of compounds that induce ferritin, glutathione S-transferase, and other proteins of the phase II response. Biochem Pharmacol. 2003 Apr 15; 65(8):1261-9.
Score: 0.003