Header Logo

Samuel N.Lockhart PhD

TitleAssistant Professor
InstitutionWake Forest School of Medicine
DepartmentInternal Medicine, Gerontology & Geriatric Medicine
Address
vCardDownload vCard

    Collapse ORNG Applications 
    Collapse Twitter

    Collapse Biography 
    Collapse education and training
    University of Miami, Coral Gables, FLBS2005Neuroscience
    University of California Davis, Davis, CAPhD2014Neuroscience
    University of California Berkeley, Berkeley, CAPostdoctoral Fellowship2017Neuroimaging of Aging and Dementia

    Collapse Overview 
    Collapse overview
    Samuel N. Lockhart, Ph.D., is a neuroscientist who has spent his research career disentangling normal brain aging from preclinical disease. He earned his Ph.D. in Neuroscience from UC Davis with Dr. Charles DeCarli, investigating the impacts of age and cerebrovascular disease on brain function and cognition, and completed a postdoctoral fellowship with Dr. William Jagust at UC Berkeley, examining how tau and amyloid accumulation affect brain structure and cognitive trajectories. He is an author of publications that have appeared in Neuron, NeuroImage, Neurology, Journal of Neuroscience, Brain, Stroke, Journal of Nuclear Medicine, and JAMA Neurology, among others. At Wake Forest, Dr. Lockhart is an Assistant Professor of Internal Medicine and Gerontology and Geriatric Medicine. He plans to build a research program in multimodal neuroimaging and cognitive analyses of aging and diseases of aging, with a focus on interactions between metabolic dysfunction and vascular and degenerative pathology.

    Collapse Research 
    Collapse research activities and funding
    F32AG050389     (LOCKHART, SAMUEL NEAL)Dec 1, 2015 - Nov 30, 2018
    NIH
    Biomarkers of preclinical Alzheimer disease and cognition
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Lockhart SN, Schaich CL, Craft S, Sachs BC, Rapp SR, Jung Y, Whitlow CT, Solingapuram Sai KK, Cleveland M, Williams BJ, Burke GL, Bertoni A, Hayden KM, Hughes TM. Associations among vascular risk factors, neuroimaging biomarkers, and cognition: Preliminary analyses from the Multi-Ethnic Study of Atherosclerosis (MESA). Alzheimers Dement. 2021 Sep 05. PMID: 34482601.
      Citations:    
    2. Hoscheidt S, Sanderlin AH, Baker LD, Jung Y, Lockhart S, Kellar D, Whitlow C, Hanson AJ, Friedman S, Register T, Leverenz JB, Craft S. Mediterranean and Western diet effects on Alzheimer's disease biomarkers, cerebral perfusion, and cognition in mid-life: A randomized trial. Alzheimers Dement. 2021 Jul 26. PMID: 34310044.
      Citations:    
    3. Kim D, Hughes TM, Lipford ME, Craft S, Baker LD, Lockhart SN, Whitlow CT, Okonmah-Obazee SE, Hugenschmidt CE, Bobinski M, Jung Y. Relationship Between Cerebrovascular Reactivity and Cognition Among People With Risk of Cognitive Decline. Front Physiol. 2021; 12:645342. PMID: 34135768.
      Citations:    
    4. Cho SH, Woo S, Kim C, Kim HJ, Jang H, Kim BC, Kim SE, Kim SJ, Kim JP, Jung YH, Lockhart S, Ossenkoppele R, Landau S, Na DL, Weiner M, Kim S, Seo SW. Disease progression modelling from preclinical Alzheimer's disease (AD) to AD dementia. Sci Rep. 2021 Feb 18; 11(1):4168. PMID: 33603015.
      Citations:    
    5. Sullivan KJ, Ranadive R, Su D, Neyland BR, Hughes TM, Hugenschmidt CE, Lockhart SN, Wong DF, Jack CR, Gottesman RF, Mosley TH, Griswold ME, Windham BG. Imaging-based indices of Neuropathology and gait speed decline in older adults: the atherosclerosis risk in communities study. Brain Imaging Behav. 2021 Jan 13. PMID: 33439369.
      Citations:    
    6. Kellar D, Lockhart SN, Aisen P, Raman R, Rissman RA, Brewer J, Craft S. Intranasal Insulin Reduces White Matter Hyperintensity Progression in Association with Improvements in Cognition and CSF Biomarker Profiles in Mild Cognitive Impairment and Alzheimer's Disease. J Prev Alzheimers Dis. 2021; 8(3):240-248. PMID: 34101779.
      Citations:    
    7. Frye BM, Craft S, Register TC, Andrews RN, Appt SE, Vitolins MZ, Uberseder B, Silverstein-Metzler MG, Chen H, Whitlow CT, Kim J, Barcus RA, Lockhart SN, Hoscheidt S, Say BM, Corbitt SE, Shively CA. Diet, psychosocial stress, and Alzheimer's disease-related neuroanatomy in female nonhuman primates. Alzheimers Dement. 2021 May; 17(5):733-744. PMID: 33270373.
      Citations:    
    8. Pappas C, Klinedinst BS, Le S, Wang Q, Larsen B, McLimans K, Lockhart SN, Allenspach-Jorn K, Mochel JP, Willette AA. CSF glucose tracks regional tau progression based on Alzheimer's disease risk factors. Alzheimers Dement (N Y). 2020; 6(1):e12080. PMID: 32864418.
      Citations:    
    9. Cho SH, Choe YS, Kim HJ, Jang H, Kim Y, Kim SE, Kim SJ, Kim JP, Jung YH, Kim BC, Baker SL, Lockhart SN, Na DL, Park S, Seo SW. Correction to: A new Centiloid method for 18F-florbetaben and 18F-flutemetamol PET without conversion to PiB. Eur J Nucl Med Mol Imaging. 2020 Jun; 47(6):1610. PMID: 32055964.
      Citations:    
    10. Espeland MA, Hayden KM, Lockhart SN, Yassine HN, Hoscheidt S, Yasar S, Luchsinger JA, Neiberg RH, Diaz Brinton R, Carmichael O. Sex-Related Differences in Brain Volumes and Cerebral Blood Flow Among Overweight and Obese Adults With Type 2 Diabetes: Exploratory Analyses From the Action for Health in Diabetes Brain Magnetic Resonance Imaging Study. J Gerontol A Biol Sci Med Sci. 2020 03 09; 75(4):771-778. PMID: 30997482.
      Citations:    
    11. Cho SH, Choe YS, Kim YJ, Kim HJ, Jang H, Kim Y, Kim SE, Kim SJ, Kim JP, Jung YH, Kim BC, Lockhart SN, Farrar G, Na DL, Moon SH, Seo SW. Head-to-Head Comparison of 18F-Florbetaben and 18F-Flutemetamol in the Cortical and Striatal Regions. J Alzheimers Dis. 2020; 76(1):281-290. PMID: 32474468.
      Citations:    
    12. Wang X, Zimmermann HR, Lockhart SN, Craft S, Ma T. Decreased Levels of Blood AMPKa1 but not AMPKa2 Isoform in Patients with Mild Cognitive Impairment and Alzheimer's Disease: A Pilot Study. J Alzheimers Dis. 2020; 76(1):217-224. PMID: 32444538.
      Citations:    
    13. Kim Y, Lee H, Son TO, Jang H, Cho SH, Kim SE, Kim SJ, Lee JS, Kim JP, Jung YH, Lockhart SN, Kim HJ, Na DL, Park HY, Seo SW. Reduced forced vital capacity is associated with cerebral small vessel disease burden in cognitively normal individuals. Neuroimage Clin. 2020; 25:102140. PMID: 31896465.
      Citations:    
    14. Cho SH, Choe YS, Kim HJ, Jang H, Kim Y, Kim SE, Kim SJ, Kim JP, Jung YH, Kim BC, Baker SL, Lockhart SN, Na DL, Park S, Seo SW. A new Centiloid method for 18F-florbetaben and 18F-flutemetamol PET without conversion to PiB. Eur J Nucl Med Mol Imaging. 2020 07; 47(8):1938-1948. PMID: 31834446.
      Citations:    
    15. San Lee J, Yoo S, Park S, Kim HJ, Park KC, Seong JK, Suh MK, Lee J, Jang H, Kim KW, Kim Y, Cho SH, Kim SJ, Kim JP, Jung YH, Kim EJ, Suh YL, Lockhart SN, Seeley WW, Na DL, Seo SW. Differences in neuroimaging features of early- versus late-onset nonfluent/agrammatic primary progressive aphasia. Neurobiol Aging. 2020 02; 86:92-101. PMID: 31784276.
      Citations:    
    16. Neth BJ, Mintz A, Whitlow C, Jung Y, Solingapuram Sai K, Register TC, Kellar D, Lockhart SN, Hoscheidt S, Maldjian J, Heslegrave AJ, Blennow K, Cunnane SC, Castellano CA, Zetterberg H, Craft S. Modified ketogenic diet is associated with improved cerebrospinal fluid biomarker profile, cerebral perfusion, and cerebral ketone body uptake in older adults at risk for Alzheimer's disease: a pilot study. Neurobiol Aging. 2020 02; 86:54-63. PMID: 31757576.
      Citations:    
    17. Jang H, Kim HJ, Park S, Park YH, Choe Y, Cho H, Lyoo CH, Yoon U, Lee JS, Kim Y, Kim SJ, Kim JP, Jung YH, Ryu YH, Choi JY, Moon SH, Seong JK, DeCarli C, Weiner MW, Lockhart SN, Cho SH, Na DL, Seo SW. Application of an amyloid and tau classification system in subcortical vascular cognitive impairment patients. Eur J Nucl Med Mol Imaging. 2020 02; 47(2):292-303. PMID: 31471715.
      Citations:    
    18. Kim SE, Lee JS, Woo S, Kim S, Kim HJ, Park S, Lee BI, Park J, Kim Y, Jang H, Kim SJ, Cho SH, Lee B, Lockhart SN, Na DL, Seo SW. Sex-specific relationship of cardiometabolic syndrome with lower cortical thickness. Neurology. 2019 09 10; 93(11):e1045-e1057. PMID: 31444241.
      Citations:    
    19. Jang H, Park J, Woo S, Kim S, Kim HJ, Na DL, Lockhart SN, Kim Y, Kim KW, Cho SH, Kim SJ, Seong JK, Seo SW. Prediction of fast decline in amyloid positive mild cognitive impairment patients using multimodal biomarkers. Neuroimage Clin. 2019; 24:101941. PMID: 31376643.
      Citations:    
    20. Xia Y, Li L, Lockhart SN, Jagust WJ. Simultaneous Covariance Inference for Multimodal Integrative Analysis. J Am Stat Assoc. 2020; 115(531):1279-1291. PMID: 33867602.
      Citations:    
    21. Adams JN, Lockhart SN, Li L, Jagust WJ. Relationships Between Tau and Glucose Metabolism Reflect Alzheimer's Disease Pathology in Cognitively Normal Older Adults. Cereb Cortex. 2019 05 01; 29(5):1997-2009. PMID: 29912295.
      Citations:    
    22. Alber J, Alladi S, Bae HJ, Barton DA, Beckett LA, Bell JM, Berman SE, Biessels GJ, Black SE, Bos I, Bowman GL, Brai E, Brickman AM, Callahan BL, Corriveau RA, Fossati S, Gottesman RF, Gustafson DR, Hachinski V, Hayden KM, Helman AM, Hughes TM, Isaacs JD, Jefferson AL, Johnson SC, Kapasi A, Kern S, Kwon JC, Kukolja J, Lee A, Lockhart SN, Murray A, Osborn KE, Power MC, Price BR, Rhodius-Meester HFM, Rondeau JA, Rosen AC, Rosene DL, Schneider JA, Scholtzova H, Shaaban CE, Silva NCBS, Snyder HM, Swardfager W, Troen AM, van Veluw SJ, Vemuri P, Wallin A, Wellington C, Wilcock DM, Xie SX, Hainsworth AH. White matter hyperintensities in vascular contributions to cognitive impairment and dementia (VCID): Knowledge gaps and opportunities. Alzheimers Dement (N Y). 2019; 5:107-117. PMID: 31011621.
      Citations:    
    23. Kim JP, Kim J, Park YH, Park SB, Lee JS, Yoo S, Kim EJ, Kim HJ, Na DL, Brown JA, Lockhart SN, Seo SW, Seong JK. Machine learning based hierarchical classification of frontotemporal dementia and Alzheimer's disease. Neuroimage Clin. 2019; 23:101811. PMID: 30981204.
      Citations:    
    24. Kim SJ, Jung NY, Kim YJ, Park SB, Kim K, Kim Y, Jang H, Kim SE, Cho SH, Kim JP, Jung YH, Woo SY, Kim SW, Lockhart SN, Kim EJ, Kim HJ, Lee JM, Chin J, Na DL, Seo SW. Clinical Effects of Frontal Behavioral Impairment: Cortical Thickness and Cognitive Decline in Individuals with Subjective Cognitive Decline and Amnestic Mild Cognitive Impairment. J Alzheimers Dis. 2019; 69(1):213-225. PMID: 30958372.
      Citations:    
    25. Sweeney MD, Montagne A, Sagare AP, Nation DA, Schneider LS, Chui HC, Harrington MG, Pa J, Law M, Wang DJJ, Jacobs RE, Doubal FN, Ramirez J, Black SE, Nedergaard M, Benveniste H, Dichgans M, Iadecola C, Love S, Bath PM, Markus HS, Salman RA, Allan SM, Quinn TJ, Kalaria RN, Werring DJ, Carare RO, Touyz RM, Williams SCR, Moskowitz MA, Katusic ZS, Lutz SE, Lazarov O, Minshall RD, Rehman J, Davis TP, Wellington CL, González HM, Yuan C, Lockhart SN, Hughes TM, Chen CLH, Sachdev P, O'Brien JT, Skoog I, Pantoni L, Gustafson DR, Biessels GJ, Wallin A, Smith EE, Mok V, Wong A, Passmore P, Barkof F, Muller M, Breteler MMB, Román GC, Hamel E, Seshadri S, Gottesman RF, van Buchem MA, Arvanitakis Z, Schneider JA, Drewes LR, Hachinski V, Finch CE, Toga AW, Wardlaw JM, Zlokovic BV. Vascular dysfunction-The disregarded partner of Alzheimer's disease. Alzheimers Dement. 2019 01; 15(1):158-167. PMID: 30642436.
      Citations:    
    26. Jang H, Park JY, Jang YK, Kim HJ, Lee JS, Na DL, Noh Y, Lockhart SN, Seong JK, Seo SW. Distinct amyloid distribution patterns in amyloid positive subcortical vascular cognitive impairment. Sci Rep. 2018 11 01; 8(1):16178. PMID: 30385819.
      Citations:    
    27. La Joie R, Ayakta N, Seeley WW, Borys E, Boxer AL, DeCarli C, Doré V, Grinberg LT, Huang E, Hwang JH, Ikonomovic MD, Jack C, Jagust WJ, Jin LW, Klunk WE, Kofler J, Lesman-Segev OH, Lockhart SN, Lowe VJ, Masters CL, Mathis CA, McLean CL, Miller BL, Mungas D, O'Neil JP, Olichney JM, Parisi JE, Petersen RC, Rosen HJ, Rowe CC, Spina S, Vemuri P, Villemagne VL, Murray ME, Rabinovici GD. Multisite study of the relationships between antemortem [11C]PIB-PET Centiloid values and postmortem measures of Alzheimer's disease neuropathology. Alzheimers Dement. 2019 02; 15(2):205-216. PMID: 30347188.
      Citations:    
    28. He M, Baker SL, Shah VD, Lockhart SN, Jagust WJ. Scan-Time Corrections for 80-100-min Standardizetd Uptake Volume Ratios to Measure the 18F-AV-1451 Tracer for Tau Imaging. IEEE Trans Med Imaging. 2019 03; 38(3):697-709. PMID: 30235119.
      Citations:    
    29. Li L, Kang J, Lockhart SN, Adams J, Jagust WJ. Spatially Adaptive Varying Correlation Analysis for Multimodal Neuroimaging Data. IEEE Trans Med Imaging. 2019 01; 38(1):113-123. PMID: 30028695.
      Citations:    
    30. Lee JS, Cho SK, Kim HJ, Kim YJ, Park KC, Lockhart SN, Na DL, Kim C, Seo SW. Prediction Models of Cognitive Trajectories in Patients with Nonamnestic Mild Cognitive Impairment. Sci Rep. 2018 Jul 11; 8(1):10468. PMID: 29993022.
      Citations:    
    31. Cho SH, Shin JH, Jang H, Park S, Kim HJ, Kim SE, Kim SJ, Kim Y, Lee JS, Na DL, Lockhart SN, Rabinovici GD, Seong JK, Seo SW. Amyloid involvement in subcortical regions predicts cognitive decline. Eur J Nucl Med Mol Imaging. 2018 12; 45(13):2368-2376. PMID: 29980831.
      Citations:    
    32. Leal SL, Lockhart SN, Maass A, Bell RK, Jagust WJ. Subthreshold Amyloid Predicts Tau Deposition in Aging. J Neurosci. 2018 05 09; 38(19):4482-4489. PMID: 29686045.
      Citations:    
    33. Lee JS, Kim C, Shin JH, Cho H, Shin DS, Kim N, Kim HJ, Kim Y, Lockhart SN, Na DL, Seo SW, Seong JK. Machine Learning-based Individual Assessment of Cortical Atrophy Pattern in Alzheimer's Disease Spectrum: Development of the Classifier and Longitudinal Evaluation. Sci Rep. 2018 03 07; 8(1):4161. PMID: 29515131.
      Citations:    
    34. Jang H, Ye BS, Woo S, Kim SW, Chin J, Choi SH, Jeong JH, Yoon SJ, Yoon B, Park KW, Hong YJ, Kim HJ, Lockhart SN, Na DL, Seo SW. Prediction Model of Conversion to Dementia Risk in Subjects with Amnestic Mild Cognitive Impairment: A Longitudinal, Multi-Center Clinic-Based Study. J Alzheimers Dis. 2018; 61(2):825. PMID: 29278893.
      Citations:    
    35. Lee J, Cho H, Jeon S, Kim HJ, Kim YJ, Lee J, Kim ST, Lee JM, Chin J, Lockhart SN, Lee AY, Na DL, Seo SW. Sex-Related Reserve Hypothesis in Alzheimer's Disease: Changes in Cortical Thickness with a Five-Year Longitudinal Follow-Up. J Alzheimers Dis. 2018; 65(2):641-649. PMID: 30056418.
      Citations:    
    36. Kim SE, Woo S, Kim SW, Chin J, Kim HJ, Lee BI, Park J, Park KW, Kang DY, Noh Y, Ye BS, Yoo HS, Lee JS, Kim Y, Kim SJ, Cho SH, Na DL, Lockhart SN, Jang H, Seo SW. A Nomogram for Predicting Amyloid PET Positivity in Amnestic Mild Cognitive Impairment. J Alzheimers Dis. 2018; 66(2):681-691. PMID: 30320571.
      Citations:    
    37. Maass A, Lockhart SN, Harrison TM, Bell RK, Mellinger T, Swinnerton K, Baker SL, Rabinovici GD, Jagust WJ. Entorhinal Tau Pathology, Episodic Memory Decline, and Neurodegeneration in Aging. J Neurosci. 2018 01 17; 38(3):530-543. PMID: 29192126.
      Citations:    
    38. Yun HJ, Moon SH, Kim HJ, Lockhart SN, Choe YS, Lee KH, Na DL, Lee JM, Seo SW. Centiloid method evaluation for amyloid PET of subcortical vascular dementia. Sci Rep. 2017 11 24; 7(1):16322. PMID: 29176753.
      Citations:    
    39. Lee JS, Park S, Kim HJ, Kim Y, Jang H, Kim KW, Rhee HY, Yoon SS, Hwang KJ, Park KC, Moon SH, Kim ST, Lockhart SN, Na DL, Seo SW. Diagonal Earlobe Crease is a Visible Sign for Cerebral Small Vessel Disease and Amyloid-ß. Sci Rep. 2017 10 17; 7(1):13397. PMID: 29042572.
      Citations:    
    40. Hughes TM, Lockhart SN, Smagula SF. Blood Pressure's Role in Alzheimer Disease Pathology. Am J Geriatr Psychiatry. 2018 01; 26(1):23-24. PMID: 29050913.
      Citations:    
    41. Iaccarino L, Tammewar G, Ayakta N, Baker SL, Bejanin A, Boxer AL, Gorno-Tempini ML, Janabi M, Kramer JH, Lazaris A, Lockhart SN, Miller BL, Miller ZA, O'Neil JP, Ossenkoppele R, Rosen HJ, Schonhaut DR, Jagust WJ, Rabinovici GD. Local and distant relationships between amyloid, tau and neurodegeneration in Alzheimer's Disease. Neuroimage Clin. 2018; 17:452-464. PMID: 29159058.
      Citations:    
    42. Martinez K, Lockhart S, Davies M, Lindsay JR, Dempster M. Diabetes distress, illness perceptions and glycaemic control in adults with type 2 diabetes. Psychol Health Med. 2018 Feb; 23(2):171-177. PMID: 28610449.
      Citations:    
    43. Maass A, Landau S, Baker SL, Horng A, Lockhart SN, La Joie R, Rabinovici GD, Jagust WJ. Comparison of multiple tau-PET measures as biomarkers in aging and Alzheimer's disease. Neuroimage. 2017 08 15; 157:448-463. PMID: 28587897.
      Citations:    
    44. Schreiber S, Schreiber F, Lockhart SN, Horng A, Bejanin A, Landau SM, Jagust WJ. Alzheimer Disease Signature Neurodegeneration and APOE Genotype in Mild Cognitive Impairment With Suspected Non-Alzheimer Disease Pathophysiology. JAMA Neurol. 2017 06 01; 74(6):650-659. PMID: 28319241.
      Citations:    
    45. Lockhart SN, Schöll M, Baker SL, Ayakta N, Swinnerton KN, Bell RK, Mellinger TJ, Shah VD, O'Neil JP, Janabi M, Jagust WJ. Amyloid and tau PET demonstrate region-specific associations in normal older people. Neuroimage. 2017 04 15; 150:191-199. PMID: 28232190.
      Citations:    
    46. Marks SM, Lockhart SN, Baker SL, Jagust WJ. Tau and ß-Amyloid Are Associated with Medial Temporal Lobe Structure, Function, and Memory Encoding in Normal Aging. J Neurosci. 2017 03 22; 37(12):3192-3201. PMID: 28213439.
      Citations:    
    47. Lockhart SN, Ayakta N, Winer JR, La Joie R, Rabinovici GD, Jagust WJ. Elevated 18F-AV-1451 PET tracer uptake detected in incidental imaging findings. Neurology. 2017 03 14; 88(11):1095-1097. PMID: 28188303.
      Citations:    
    48. Jang H, Ye BS, Woo S, Kim SW, Chin J, Choi SH, Jeong JH, Yoon SJ, Yoon B, Park KW, Hong YJ, Kim HJ, Lockhart SN, Na DL, Seo SW. Prediction Model of Conversion to Dementia Risk in Subjects with Amnestic Mild Cognitive Impairment: A Longitudinal, Multi-Center Clinic-Based Study. J Alzheimers Dis. 2017; 60(4):1579-1587. PMID: 28968237.
      Citations:    
    49. Baker SL, Lockhart SN, Price JC, He M, Huesman RH, Schonhaut D, Faria J, Rabinovici G, Jagust WJ. Reference Tissue-Based Kinetic Evaluation of 18F-AV-1451 for Tau Imaging. J Nucl Med. 2017 02; 58(2):332-338. PMID: 27587706.
      Citations:    
    50. Lockhart SN, Baker SL, Okamura N, Furukawa K, Ishiki A, Furumoto S, Tashiro M, Yanai K, Arai H, Kudo Y, Harada R, Tomita N, Hiraoka K, Watanuki S, Jagust WJ. Dynamic PET Measures of Tau Accumulation in Cognitively Normal Older Adults and Alzheimer's Disease Patients Measured Using [18F] THK-5351. PLoS One. 2016; 11(6):e0158460. PMID: 27355840.
      Citations:    
    51. Ossenkoppele R, Schonhaut DR, Schöll M, Lockhart SN, Ayakta N, Baker SL, O'Neil JP, Janabi M, Lazaris A, Cantwell A, Vogel J, Santos M, Miller ZA, Bettcher BM, Vossel KA, Kramer JH, Gorno-Tempini ML, Miller BL, Jagust WJ, Rabinovici GD. Tau PET patterns mirror clinical and neuroanatomical variability in Alzheimer's disease. Brain. 2016 05; 139(Pt 5):1551-67. PMID: 26962052.
      Citations:    
    52. Schöll M, Lockhart SN, Schonhaut DR, O'Neil JP, Janabi M, Ossenkoppele R, Baker SL, Vogel JW, Faria J, Schwimmer HD, Rabinovici GD, Jagust WJ. PET Imaging of Tau Deposition in the Aging Human Brain. Neuron. 2016 Mar 02; 89(5):971-982. PMID: 26938442.
      Citations:    
    53. Jung NY, Han CE, Kim HJ, Yoo SW, Kim HJ, Kim EJ, Na DL, Lockhart SN, Jagust WJ, Seong JK, Seo SW. Tract-Specific Correlates of Neuropsychological Deficits in Patients with Subcortical Vascular Cognitive Impairment. J Alzheimers Dis. 2016; 50(4):1125-35. PMID: 26836179.
      Citations:    
    54. Lockhart SN, Luck SJ, Geng J, Beckett L, Disbrow EA, Carmichael O, DeCarli C. White matter hyperintensities among older adults are associated with futile increase in frontal activation and functional connectivity during spatial search. PLoS One. 2015; 10(3):e0122445. PMID: 25793922.
      Citations:    
    55. Lockhart SN, DeCarli C. Structural imaging measures of brain aging. Neuropsychol Rev. 2014 Sep; 24(3):271-89. PMID: 25146995.
      Citations:    
    56. Lockhart S, DeCarli C, Fama R. Neuroimaging of the aging brain: introduction to the special issue of neuropsychology review. Neuropsychol Rev. 2014 Sep; 24(3):267-70. PMID: 25146996.
      Citations:    
    57. Maillard P, Fletcher E, Lockhart SN, Roach AE, Reed B, Mungas D, DeCarli C, Carmichael OT. White matter hyperintensities and their penumbra lie along a continuum of injury in the aging brain. Stroke. 2014 Jun; 45(6):1721-6. PMID: 24781079.
      Citations:    
    58. Lockhart SN, Roach AE, Luck SJ, Geng J, Beckett L, Carmichael O, DeCarli C. White matter hyperintensities are associated with visual search behavior independent of generalized slowing in aging. Neuropsychologia. 2014 Jan; 52:93-101. PMID: 24183716.
      Citations:    
    59. He J, Wong VS, Fletcher E, Maillard P, Lee DY, Iosif AM, Singh B, Martinez O, Roach AE, Lockhart SN, Beckett L, Mungas D, Farias ST, Carmichael O, DeCarli C. The contributions of MRI-based measures of gray matter, white matter hyperintensity, and white matter integrity to late-life cognition. AJNR Am J Neuroradiol. 2012 Oct; 33(9):1797-803. PMID: 22538073.
      Citations:    
    60. Lockhart SN, Mayda AB, Roach AE, Fletcher E, Carmichael O, Maillard P, Schwarz CG, Yonelinas AP, Ranganath C, Decarli C. Episodic memory function is associated with multiple measures of white matter integrity in cognitive aging. Front Hum Neurosci. 2012; 6:56. PMID: 22438841.
      Citations:    
    61. Carmichael O, Lockhart S. The role of diffusion tensor imaging in the study of cognitive aging. Curr Top Behav Neurosci. 2012; 11:289-320. PMID: 22081443.
      Citations:    
    62. Wesson JM, Cooper JA, Jehle LS, Lockhart SN, Draney K, Barber J. The functional index for living with multiple sclerosis: development and validation of a new quality of life questionnaire. Mult Scler. 2009 Oct; 15(10):1239-49. PMID: 19737850.
      Citations:    
    Lockhart's Networks
    Click the
    Explore
    buttons for more information and interactive visualizations!
    Concepts (145)
    Explore
    _
    Co-Authors (9)
    Explore
    _
    Similar People (55)
    Explore
    _
    Same Department Expand Description
    Explore
    _
    Physical Neighbors
    _