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Oscar G. Gomez

TitleClinical Professor
InstitutionWake Forest School of Medicine
DepartmentPediatrics
Address
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    Collapse Biography 
    Collapse education and training
    Universidad Nacional de Colombia, Bogota, ColombiaMD04/1987Medicine and Surgery
    University of Maryland Baltimore, Baltimore, MDPhD01/1994Microbiology and Immunology
    Collapse awards and honors
    2023Teaching Award, Universidad de Santander
    2019Community Service Award of Excellence for Promoting Inclusion and Cultural Diversity, State University of New York (SUNY), Buffalo
    2020 - 2023Top Doctors award in the field of Pediatrics, Buffalo Spree

    Collapse Research 
    Collapse research activities and funding
    C4931010     (Christine Turley)Jun 11, 2024
    Pfizer
    “A Phase 3, randomized, modified double-blind, active-controlled, parallel-group, 2-arm study to investigate the safety of a 4-dose regimen of a 21-valent pneumococcal conjugate vaccine in healthy infants and toddlers.”
    Role Description: The goal of this study is to characterize the safety profile of PCV21 after each and any dose.
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Burcham ZM, Tweedie JL, Farfán-García AE, Nolan VG, Donohoe D, Gómez-Duarte OG, Johnson JG. Campylobacter infection of young children in Colombia and its impact on the gastrointestinal environment. mSphere. 2024 Oct 29; 9(10):e0034224. PMID: 39320095.
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    2. Kenney PO, Gómez-Duarte OG. Low-volume enrichment method supports high throughput bacteriophage screening and isolation from wastewater. PLoS One. 2024; 19(4):e0298833. PMID: 38626205.
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    3. Imdad A, Pandit NG, Zaman M, Minkoff NZ, Tanner-Smith EE, Gomez-Duarte OG, Acra S, Nicholson MR. Fecal transplantation for treatment of inflammatory bowel disease. Cochrane Database Syst Rev. 2023 Apr 25; 4(4):CD012774. PMID: 37094824.
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    4. Zhou S, Yu KOA, Mabrouk MT, Jahagirdar D, Huang WC, Guerra JA, He X, Ortega J, Poole ST, Hall ER, Gomez-Duarte OG, Maciel M, Lovell JF. Antibody induction in mice by liposome-displayed recombinant enterotoxigenic Escherichia coli (ETEC) colonization antigens. Biomed J. 2023 Dec; 46(6):100588. PMID: 36925108.
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    5. Gómez-Duarte OG, Ogra PL. Editorial: Impact of microbiome on gut mucosal immunity in health and disease. Front Immunol. 2022; 13:1005156. PMID: 36211406.
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    6. Uran-Velasquez J, Alzate JF, Farfan-Garcia AE, Gomez-Duarte OG, Martinez-Rosado LL, Dominguez-Hernandez DD, Rojas W, Galvan-Diaz AL, Garcia-Montoya GM. Multilocus Sequence Typing helps understand the genetic diversity of Cryptosporidium hominis and Cryptosporidium parvum isolated from Colombian patients. PLoS One. 2022; 17(7):e0270995. PMID: 35802653.
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    7. Iqbal J, Malviya N, Gaddy JA, Zhang C, Seier AJ, Haley KP, Doster RS, Farfán-García AE, Gómez-Duarte OG. Enteroinvasive Escherichia coli O96:H19 is an Emergent Biofilm-Forming Pathogen. J Bacteriol. 2022 Apr 19; 204(4):e0056221. PMID: 35343774.
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    8. Varol M, Licka Dieye N, Zang M, Handa D, C Zorich S, Millen AE, Gomez-Duarte OG. Hepatitis C Virus Exposure and Infection in the Perinatal Period. Curr Pediatr Rev. 2022; 19(1):21-33. PMID: 35440312.
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    9. Mannix MK, Blood D, Gomez-Duarte OG, Davidson L. Necrotizing Enterocolitis in a 34-Week Premature Infant with COVID-19. Case Rep Infect Dis. 2021; 2021:1442447. PMID: 34956682.
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    10. Imdad A, Mackoff SP, Urciuoli DM, Syed T, Tanner-Smith EE, Huang D, Gomez-Duarte OG. Interventions for preventing diarrhoea-associated haemolytic uraemic syndrome. Cochrane Database Syst Rev. 2021 Jul 05; 7(7):CD012997. PMID: 34219224.
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    11. Hennon TR, Yu KOA, Penque MD, Abdul-Aziz R, Chang AC, McGreevy MB, Pastore JV, Prout AJ, Schaefer BA, Alibrahim OS, Gomez-Duarte OG, Hicar MD. COVID-19 associated Multisystem Inflammatory Syndrome in Children (MIS-C) guidelines; revisiting the Western New York approach as the pandemic evolves. Prog Pediatr Cardiol. 2021 Sep; 62:101407. PMID: 34121829.
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    12. Guerra JA, Zhang C, Bard JE, Yergeau D, Halasa N, Gómez-Duarte OG. Comparative genomic analysis of a Shiga toxin-producing Escherichia coli (STEC) O145:H25 associated with a severe pediatric case of hemolytic uremic syndrome in Davidson County, Tennessee, US. BMC Genomics. 2020 Aug 17; 21(1):564. PMID: 32807093.
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    13. Farfán-García AE, Imdad A, Zhang C, Arias-Guerrero MY, Sánchez-Álvarez NT, Iqbal J, Hernández-Gamboa AE, Slaughter JC, Gómez-Duarte OG. Etiology of acute gastroenteritis among children less than 5 years of age in Bucaramanga, Colombia: A case-control study. PLoS Negl Trop Dis. 2020 Jun; 14(6):e0008375. PMID: 32603324.
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    14. Hennon TR, Penque MD, Abdul-Aziz R, Alibrahim OS, McGreevy MB, Prout AJ, Schaefer BA, Ambrusko SJ, Pastore JV, Turkovich SJ, Gomez-Duarte OG, Hicar MD. COVID-19 associated Multisystem Inflammatory Syndrome in Children (MIS-C) guidelines; a Western New York approach. Prog Pediatr Cardiol. 2020 May 23; 101232. PMID: 32837142.
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    15. Flórez-Castillo JM, Rondón-Villareal P, Ropero-Vega JL, Mendoza-Espinel SY, Moreno-Amézquita JA, Méndez-Jaimes KD, Farfán-García AE, Gómez-Rangel SY, Gómez-Duarte OG. Ib-M6 Antimicrobial Peptide: Antibacterial Activity against Clinical Isolates of Escherichia coli and Molecular Docking. Antibiotics (Basel). 2020 Feb 12; 9(2). PMID: 32059550.
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    16. Kuhlmann FM, Martin J, Hazen TH, Vickers TJ, Pashos M, Okhuysen PC, Gómez-Duarte OG, Cebelinski E, Boxrud D, Del Canto F, Vidal R, Qadri F, Mitreva M, Rasko DA, Fleckenstein JM. Conservation and global distribution of non-canonical antigens in Enterotoxigenic Escherichia coli. PLoS Negl Trop Dis. 2019 Nov; 13(11):e0007825. PMID: 31756188.
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    17. Aldinger J, Hicar MD, Gomez-Duarte OG, Callanan V, Pierce D, Islam S. A Young Child With Recalcitrant Rhinorrhea. Pediatr Infect Dis J. 2019 Feb; 38(2):214. PMID: 29762361.
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    18. Imdad A, Nicholson MR, Tanner-Smith EE, Zackular JP, Gomez-Duarte OG, Beaulieu DB, Acra S. Fecal transplantation for treatment of inflammatory bowel disease. Cochrane Database Syst Rev. 2018 Nov 13; 11(11):CD012774. PMID: 30480772.
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    19. Nielsen DW, Ricker N, Barbieri NL, Wynn JL, Gómez-Duarte OG, Iqbal J, Nolan LK, Allen HK, Logue CM. Complete Genome Sequence of the Multidrug-Resistant Neonatal Meningitis Escherichia coli Serotype O75:H5:K1 Strain mcjchv-1 (NMEC-O75). Microbiol Resour Announc. 2018 Sep; 7(10). PMID: 30533615.
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    20. Islam S, Selvarangan R, Kanwar N, McHenry R, Chappell JD, Halasa N, Wikswo ME, Payne DC, Azimi PH, McDonald LC, Gomez-Duarte OG. Intestinal Carriage of Third-Generation Cephalosporin-Resistant and Extended-Spectrum ß-Lactamase-Producing Enterobacteriaceae in Healthy US Children. J Pediatric Infect Dis Soc. 2018 Aug 17; 7(3):234-240. PMID: 28992133.
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    21. Imdad A, Foster MA, Iqbal J, Fonnesbeck C, Payne DC, Zhang C, Chappell JD, Halasa N, Gómez-Duarte OG. Diarrheagenic Escherichia coli and Acute Gastroenteritis in Children in Davidson County, Tennessee, United States: A Case-control Study. Pediatr Infect Dis J. 2018 Jun; 37(6):543-548. PMID: 29341983.
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    22. Denby KJ, Byrne RD, Gómez-Duarte OG. Streptococcus intermedius: An Unusual Case of Purulent Pericarditis. Case Rep Infect Dis. 2017; 2017:5864694. PMID: 28932608.
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    23. Farfán-García AE, Zhang C, Imdad A, Arias-Guerrero MY, Sánchez-Alvarez NT, Shah R, Iqbal J, Tamborski ME, Gómez-Duarte OG. Case-Control Pilot Study on Acute Diarrheal Disease in a Geographically Defined Pediatric Population in a Middle Income Country. Int J Pediatr. 2017; 2017:6357597. PMID: 28855919.
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    24. Khalil U, Younus M, Asghar N, Siddiqui F, Gómez-Duarte OG, Wren BW, Bokhari H. Phenotypic and genotypic characterization of enteroaggregative Escherichia coli isolates from pediatric population in Pakistan. APMIS. 2016 Oct; 124(10):872-80. PMID: 27485156.
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    25. Younas M, Siddiqui F, Noreen Z, Bokhari SS, Gomez-Duarte OG, Wren BW, Bokhari H. Characterization of enteropathogenic Escherichia coli of clinical origin from the pediatric population in Pakistan. Trans R Soc Trop Med Hyg. 2016 Jul; 110(7):414-20. PMID: 27496516.
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    26. Carlucci JG, Halasa N, Creech CB, Dulek DE, Gómez-Duarte OG, Nelson GE, Talbot HK, Scalise ML, Scott PL, Mahadevan U, Beaulieu DB. Vertical Transmission of Histoplasmosis Associated With Anti-Tumor Necrosis Factor Therapy. J Pediatric Infect Dis Soc. 2016 Jun; 5(2):e9-e12. PMID: 27012275.
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    27. Iqbal J, Dufendach KR, Wellons JC, Kuba MG, Nickols HH, Gómez-Duarte OG, Wynn JL. Lethal neonatal meningoencephalitis caused by multi-drug resistant, highly virulent Escherichia coli. Infect Dis (Lond). 2016; 48(6):461-6. PMID: 27030919.
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    28. Zhang C, Iqbal J, Gómez-Duarte OG. Murine immunization with CS21 pili or LngA major subunit of enterotoxigenic Escherichia coli (ETEC) elicits systemic and mucosal immune responses and inhibits ETEC gut colonization. Vet Microbiol. 2017 Apr; 202:90-100. PMID: 26878971.
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    29. Guevara C, Zhang C, Gaddy JA, Iqbal J, Guerra J, Greenberg DP, Decker MD, Carbonetti N, Starner TD, McCray PB, Mooi FR, Gómez-Duarte OG. Highly differentiated human airway epithelial cells: a model to study host cell-parasite interactions in pertussis. Infect Dis (Lond). 2016; 48(3):177-88. PMID: 26492208.
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    30. Foster MA, Iqbal J, Zhang C, McHenry R, Cleveland BE, Romero-Herazo Y, Fonnesbeck C, Payne DC, Chappell JD, Halasa N, Gómez-Duarte OG. Enteropathogenic and enteroaggregative E. coli in stools of children with acute gastroenteritis in Davidson County, Tennessee. Diagn Microbiol Infect Dis. 2015 Nov; 83(3):319-24. PMID: 26298817.
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    31. Amézquita-Montes Z, Tamborski M, Kopsombut UG, Zhang C, Arzuza OS, Gómez-Duarte OG. Genetic Relatedness Among Escherichia coli Pathotypes Isolated from Food Products for Human Consumption in Cartagena, Colombia. Foodborne Pathog Dis. 2015 May; 12(5):454-61. PMID: 25786140.
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    32. Cruz-Córdova A, Espinosa-Mazariego K, Ochoa SA, Saldaña Z, Rodea GE, Cázares-Domínguez V, Rodríguez-Ramírez V, Eslava-Campos CA, Navarro-Ocaña A, Arrellano-Galindo J, Hernández-Castro R, Gómez-Duarte OG, Qadri F, Xicohtencatl-Cortes J. CS21 positive multidrug-resistant ETEC clinical isolates from children with diarrhea are associated with self-aggregation, and adherence. Front Microbiol. 2014; 5:709. PMID: 25646093.
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    33. Gómez-Duarte OG. [Acute diarrheal disease caused by enteropathogenic Escherichia coli in Colombia]. Rev Chilena Infectol. 2014 Oct; 31(5):577-86. PMID: 25491457.
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    34. Guerra JA, Romero-Herazo YC, Arzuza O, Gómez-Duarte OG. Phenotypic and genotypic characterization of enterotoxigenic Escherichia coli clinical isolates from northern Colombia, South America. Biomed Res Int. 2014; 2014:236260. PMID: 24877071.
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    35. Guevara CP, Luiz WB, Sierra A, Cruz C, Qadri F, Kaushik RS, Ferreira LCS, Gómez-Duarte OG. Enterotoxigenic Escherichia coli CS21 pilus contributes to adhesion to intestinal cells and to pathogenesis under in vivo conditions. Microbiology (Reading). 2013 Aug; 159(Pt 8):1725-1735. PMID: 23760820.
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    36. Gomez-Duarte OG, Romero-Herazo YC, Paez-Canro CZ, Eslava-Schmalbach JH, Arzuza O. Enterotoxigenic Escherichia coli associated with childhood diarrhoea in Colombia, South America. J Infect Dev Ctries. 2013 May 13; 7(5):372-81. PMID: 23669426.
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    37. Sánchez-Vargas FM, Abu-El-Haija MA, Gómez-Duarte OG. Salmonella infections: an update on epidemiology, management, and prevention. Travel Med Infect Dis. 2011 Nov; 9(6):263-77. PMID: 22118951.
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    38. Pérez C, Gómez-Duarte OG, Arias ML. Diarrheagenic Escherichia coli in children from Costa Rica. Am J Trop Med Hyg. 2010 Aug; 83(2):292-7. PMID: 20682870.
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    39. McDonald DR, Goldman F, Gomez-Duarte OD, Issekutz AC, Kumararatne DS, Doffinger R, Geha RS. Impaired T-cell receptor activation in IL-1 receptor-associated kinase-4-deficient patients. J Allergy Clin Immunol. 2010 Aug; 126(2):332-7, 337.e1-2. PMID: 20621347.
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    40. Clavijo AP, Bai J, Gómez-Duarte OG. The Longus type IV pilus of enterotoxigenic Escherichia coli (ETEC) mediates bacterial self-aggregation and protection from antimicrobial agents. Microb Pathog. 2010 Jun; 48(6):230-8. PMID: 20227481.
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    41. Gómez-Duarte OG, Arzuza O, Urbina D, Bai J, Guerra J, Montes O, Puello M, Mendoza K, Castro GY. Detection of Escherichia coli enteropathogens by multiplex polymerase chain reaction from children's diarrheal stools in two Caribbean-Colombian cities. Foodborne Pathog Dis. 2010 Feb; 7(2):199-206. PMID: 19839760.
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    42. Rúgeles LC, Bai J, Martínez AJ, Vanegas MC, Gómez-Duarte OG. Molecular characterization of diarrheagenic Escherichia coli strains from stools samples and food products in Colombia. Int J Food Microbiol. 2010 Apr 15; 138(3):282-6. PMID: 20153069.
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    43. Gómez-Duarte OG, Bai J, Newell E. Detection of Escherichia coli, Salmonella spp., Shigella spp., Yersinia enterocolitica, Vibrio cholerae, and Campylobacter spp. enteropathogens by 3-reaction multiplex polymerase chain reaction. Diagn Microbiol Infect Dis. 2009 Jan; 63(1):1-9. PMID: 18990527.
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    44. Sánchez-Vargas FM, Gómez-Duarte OG. Mycoplasma pneumoniae-an emerging extra-pulmonary pathogen. Clin Microbiol Infect. 2008 Feb; 14(2):105-17. PMID: 17949442.
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    45. Gomez-Duarte OG, Chattopadhyay S, Weissman SJ, Giron JA, Kaper JB, Sokurenko EV. Genetic diversity of the gene cluster encoding longus, a type IV pilus of enterotoxigenic Escherichia coli. J Bacteriol. 2007 Dec; 189(24):9145-9. PMID: 17951389.
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    46. Chinchilla M, Pasetti MF, Medina-Moreno S, Wang JY, Gomez-Duarte OG, Stout R, Levine MM, Galen JE. Enhanced immunity to Plasmodium falciparum circumsporozoite protein (PfCSP) by using Salmonella enterica serovar Typhi expressing PfCSP and a PfCSP-encoding DNA vaccine in a heterologous prime-boost strategy. Infect Immun. 2007 Aug; 75(8):3769-79. PMID: 17502396.
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    47. Gómez-Duarte OG, Pasetti MF, Santiago A, Sztein MB, Hoffman SL, Levine MM. Expression, extracellular secretion, and immunogenicity of the Plasmodium falciparum sporozoite surface protein 2 in Salmonella vaccine strains. Infect Immun. 2001 Feb; 69(2):1192-8. PMID: 11160021.
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    48. Wu S, Beier M, Sztein MB, Galen J, Pickett T, Holder AA, Gómez-Duarte OG, Levine MM. Construction and immunogenicity in mice of attenuated Salmonella typhi expressing Plasmodium falciparum merozoite surface protein 1 (MSP-1) fused to tetanus toxin fragment C. J Biotechnol. 2000 Sep 29; 83(1-2):125-35. PMID: 11000468.
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    49. Gómez-Duarte OG, Ruiz-Tagle A, Gómez DC, Viboud GI, Jarvis KG, Kaper JB, Girón JA. Identification of lngA, the structural gene of longus type IV pilus of enterotoxigenic Escherichia coli. Microbiology (Reading). 1999 Jul; 145 ( Pt 7):1809-1816. PMID: 10439420.
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    50. Gómez-Duarte OG, Bumann D, Meyer TF. The attenuated Salmonella vaccine approach for the control of Helicobacter pylori-related diseases. Vaccine. 1999 Mar 26; 17(13-14):1667-73. PMID: 10194821.
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    51. Dehio C, Freissler E, Lanz C, Gómez-Duarte OG, David G, Meyer TF. Ligation of cell surface heparan sulfate proteoglycans by antibody-coated beads stimulates phagocytic uptake into epithelial cells: a model for cellular invasion by Neisseria gonorrhoeae. Exp Cell Res. 1998 Aug 01; 242(2):528-39. PMID: 9683539.
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    52. Dehio M, Gómez-Duarte OG, Dehio C, Meyer TF. Vitronectin-dependent invasion of epithelial cells by Neisseria gonorrhoeae involves alpha(v) integrin receptors. FEBS Lett. 1998 Mar 06; 424(1-2):84-8. PMID: 9537520.
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    53. Gómez-Duarte OG, Lucas B, Yan ZX, Panthel K, Haas R, Meyer TF. Protection of mice against gastric colonization by Helicobacter pylori by single oral dose immunization with attenuated Salmonella typhimurium producing urease subunits A and B. Vaccine. 1998 Mar; 16(5):460-71. PMID: 9491500.
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    54. Gómez-Duarte OG, Dehio M, Guzmán CA, Chhatwal GS, Dehio C, Meyer TF. Binding of vitronectin to opa-expressing Neisseria gonorrhoeae mediates invasion of HeLa cells. Infect Immun. 1997 Sep; 65(9):3857-66. PMID: 9284164.
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    55. Girón JA, Gómez-Duarte OG, Jarvis KG, Kaper JB. Longus pilus of enterotoxigenic Escherichia coli and its relatedness to other type-4 pili--a minireview. Gene. 1997 Jun 11; 192(1):39-43. PMID: 9224872.
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    56. Galen JE, Gomez-Duarte OG, Losonsky GA, Halpern JL, Lauderbaugh CS, Kaintuck S, Reymann MK, Levine MM. A murine model of intranasal immunization to assess the immunogenicity of attenuated Salmonella typhi live vector vaccines in stimulating serum antibody responses to expressed foreign antigens. Vaccine. 1997; 15(6-7):700-8. PMID: 9178472.
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    57. Kaper JB, Gómez-Duarte OG. The per regulator of enteropathogenic Escherichia coli. Mol Microbiol. 1997 Jan; 23(1):179-81. PMID: 9004231.
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    58. Kaper JB, McDaniel TK, Jarvis KG, Gomez-Duarte O. Genetics of virulence of enteropathogenic E. coli. Adv Exp Med Biol. 1997; 412:279-87. PMID: 9192031.
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    59. Barry EM, Gomez-Duarte O, Chatfield S, Rappuoli R, Pizza M, Losonsky G, Galen J, Levine MM. Expression and immunogenicity of pertussis toxin S1 subunit-tetanus toxin fragment C fusions in Salmonella typhi vaccine strain CVD 908. Infect Immun. 1996 Oct; 64(10):4172-81. PMID: 8926085.
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    60. Postnova T, Gómez-Duarte OG, Richardson K. Motility mutants of Vibrio cholerae O1 have reduced adherence in vitro to human small intestinal epithelial cells as demonstrated by ELISA. Microbiology (Reading). 1996 Oct; 142 ( Pt 10):2767-76. PMID: 8885392.
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    61. Gómez-Duarte OG, Galen J, Chatfield SN, Rappuoli R, Eidels L, Levine MM. Expression of fragment C of tetanus toxin fused to a carboxyl-terminal fragment of diphtheria toxin in Salmonella typhi CVD 908 vaccine strain. Vaccine. 1995 Nov; 13(16):1596-602. PMID: 8578848.
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    62. Girón JA, Viboud GI, Sperandio V, Gómez-Duarte OG, Maneval DR, Albert MJ, Levine MM, Kaper JB. Prevalence and association of the longus pilus structural gene (lngA) with colonization factor antigens, enterotoxin types, and serotypes of enterotoxigenic Escherichia coli. Infect Immun. 1995 Oct; 63(10):4195-8. PMID: 7558343.
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    63. Gómez-Duarte OG, Kaper JB. A plasmid-encoded regulatory region activates chromosomal eaeA expression in enteropathogenic Escherichia coli. Infect Immun. 1995 May; 63(5):1767-76. PMID: 7729884.
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