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Last Name

Zhiheng He

TitleAssistant Professor
InstitutionWake Forest School of Medicine
DepartmentMicrobiology_Immunology
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. He Z, Zhang J, Du Q, Xu J, Gwack Y, Sun Z. SRC3 Is a Cofactor for ROR?t in Th17 Differentiation but Not Thymocyte Development. J Immunol. 2019 02 01; 202(3):760-769. PMID: 30567733.
      View in: PubMed
    2. He Z, Zhang J, Huang Z, Du Q, Li N, Zhang Q, Chen Y, Sun Z. Sumoylation of ROR?t regulates TH17 differentiation and thymocyte development. Nat Commun. 2018 11 19; 9(1):4870. PMID: 30451821.
      View in: PubMed
    3. Sen S, He Z, Ghosh S, Dery KJ, Yang L, Zhang J, Sun Z. PRMT1 Plays a Critical Role in Th17 Differentiation by Regulating Reciprocal Recruitment of STAT3 and STAT5. J Immunol. 2018 07 15; 201(2):440-450. PMID: 29794014.
      View in: PubMed
    4. Zhang J, He Z, Sen S, Wang F, Zhang Q, Sun Z. TCF-1 Inhibits IL-17 Gene Expression To Restrain Th17 Immunity in a Stage-Specific Manner. J Immunol. 2018 05 15; 200(10):3397-3406. PMID: 29632143.
      View in: PubMed
    5. Sen S, Wang F, Zhang J, He Z, Ma J, Gwack Y, Xu J, Sun Z. SRC1 promotes Th17 differentiation by overriding Foxp3 suppression to stimulate ROR?t activity in a PKC-?-dependent manner. Proc Natl Acad Sci U S A. 2018 01 16; 115(3):E458-E467. PMID: 29282318.
      View in: PubMed
    6. He Z, Ma J, Wang R, Zhang J, Huang Z, Wang F, Sen S, Rothenberg EV, Sun Z. A two-amino-acid substitution in the transcription factor ROR?t disrupts its function in TH17 differentiation but not in thymocyte development. Nat Immunol. 2017 Oct; 18(10):1128-1138. PMID: 28846085.
      View in: PubMed
    7. He Z, Wang F, Zhang J, Sen S, Pang Q, Luo S, Gwack Y, Sun Z. Regulation of Th17 Differentiation by IKKa-Dependent and -Independent Phosphorylation of ROR?t. J Immunol. 2017 08 01; 199(3):955-964. PMID: 28667162.
      View in: PubMed
    8. Li S, Hu H, He Z, Liang D, Sun R, Lan K. Fine-Tuning of the Kaposi's Sarcoma-Associated Herpesvirus Life Cycle in Neighboring Cells through the RTA-JAG1-Notch Pathway. PLoS Pathog. 2016 Oct; 12(10):e1005900. PMID: 27760204.
      View in: PubMed
    9. He Z, Wang F, Ma J, Sen S, Zhang J, Gwack Y, Zhou Y, Sun Z. Ubiquitination of ROR?t at Lysine 446 Limits Th17 Differentiation by Controlling Coactivator Recruitment. J Immunol. 2016 08 15; 197(4):1148-58. PMID: 27430721.
      View in: PubMed
    10. Liang D, Hu H, Li S, Dong J, Wang X, Wang Y, He L, He Z, Gao Y, Gao SJ, Lan K. Oncogenic herpesvirus KSHV Hijacks BMP-Smad1-Id signaling to promote tumorigenesis. PLoS Pathog. 2014 Jul; 10(7):e1004253. PMID: 25010525.
      View in: PubMed
    11. Wang X, He Z, Xia T, Li X, Liang D, Lin X, Wen H, Lan K. Latency-associated nuclear antigen of Kaposi sarcoma-associated herpesvirus promotes angiogenesis through targeting notch signaling effector Hey1. Cancer Res. 2014 Apr 01; 74(7):2026-37. PMID: 24523441.
      View in: PubMed
    12. He Z, Zhao J, Zhang J, Jung JU, Feng P. NF-?B activation coordinated by IKKß and IKKe enables latent infection of Kaposi's sarcoma-associated herpesvirus. J Virol. 2014 Jan; 88(1):444-55. PMID: 24155403.
      View in: PubMed
    13. Jin Y, He Z, Liang D, Zhang Q, Zhang H, Deng Q, Robertson ES, Lan K. Carboxyl-terminal amino acids 1052 to 1082 of the latency-associated nuclear antigen (LANA) interact with RBP-J? and are responsible for LANA-mediated RTA repression. J Virol. 2012 May; 86(9):4956-69. PMID: 22379075.
      View in: PubMed
    14. Dong X, He Z, Durakoglugil D, Arneson L, Shen Y, Feng P. Murine gammaherpesvirus 68 evades host cytokine production via replication transactivator-induced RelA degradation. J Virol. 2012 Feb; 86(4):1930-41. PMID: 22130545.
      View in: PubMed
    15. Lin X, Liang D, He Z, Deng Q, Robertson ES, Lan K. miR-K12-7-5p encoded by Kaposi's sarcoma-associated herpesvirus stabilizes the latent state by targeting viral ORF50/RTA. PLoS One. 2011 Jan 20; 6(1):e16224. PMID: 21283761.
      View in: PubMed
    16. Liang D, Gao Y, Lin X, He Z, Zhao Q, Deng Q, Lan K. A human herpesvirus miRNA attenuates interferon signaling and contributes to maintenance of viral latency by targeting IKKe. Cell Res. 2011 May; 21(5):793-806. PMID: 21221132.
      View in: PubMed
    17. He Z, Liu Y, Liang D, Wang Z, Robertson ES, Lan K. Cellular corepressor TLE2 inhibits replication-and-transcription- activator-mediated transactivation and lytic reactivation of Kaposi's sarcoma-associated herpesvirus. J Virol. 2010 Feb; 84(4):2047-62. PMID: 19939918.
      View in: PubMed
    18. Lan K, Murakami M, Bajaj B, Kaul R, He Z, Gan R, Feldman M, Robertson ES. Inhibition of KSHV-infected primary effusion lymphomas in NOD/SCID mice by gamma-secretase inhibitor. Cancer Biol Ther. 2009 Nov; 8(22):2136-43. PMID: 19783901.
      View in: PubMed
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