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Zhiheng He PhD

TitleAssistant Professor
InstitutionWake Forest School of Medicine
DepartmentMicrobiology and Immunology
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. He Z, Zhang J, Du Q, Xu J, Gwack Y, Sun Z. SRC3 Is a Cofactor for ROR?t in Th17 Differentiation but Not Thymocyte Development. J Immunol. 2019 02 01; 202(3):760-769. PMID: 30567733.
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    2. He Z, Zhang J, Huang Z, Du Q, Li N, Zhang Q, Chen Y, Sun Z. Sumoylation of ROR?t regulates TH17 differentiation and thymocyte development. Nat Commun. 2018 11 19; 9(1):4870. PMID: 30451821.
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    3. Sen S, He Z, Ghosh S, Dery KJ, Yang L, Zhang J, Sun Z. PRMT1 Plays a Critical Role in Th17 Differentiation by Regulating Reciprocal Recruitment of STAT3 and STAT5. J Immunol. 2018 07 15; 201(2):440-450. PMID: 29794014.
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    4. Zhang J, He Z, Sen S, Wang F, Zhang Q, Sun Z. TCF-1 Inhibits IL-17 Gene Expression To Restrain Th17 Immunity in a Stage-Specific Manner. J Immunol. 2018 05 15; 200(10):3397-3406. PMID: 29632143.
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    5. Sen S, Wang F, Zhang J, He Z, Ma J, Gwack Y, Xu J, Sun Z. SRC1 promotes Th17 differentiation by overriding Foxp3 suppression to stimulate ROR?t activity in a PKC-?-dependent manner. Proc Natl Acad Sci U S A. 2018 01 16; 115(3):E458-E467. PMID: 29282318.
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    6. He Z, Ma J, Wang R, Zhang J, Huang Z, Wang F, Sen S, Rothenberg EV, Sun Z. A two-amino-acid substitution in the transcription factor ROR?t disrupts its function in TH17 differentiation but not in thymocyte development. Nat Immunol. 2017 Oct; 18(10):1128-1138. PMID: 28846085.
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    7. He Z, Wang F, Zhang J, Sen S, Pang Q, Luo S, Gwack Y, Sun Z. Regulation of Th17 Differentiation by IKKa-Dependent and -Independent Phosphorylation of ROR?t. J Immunol. 2017 08 01; 199(3):955-964. PMID: 28667162.
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    8. Li S, Hu H, He Z, Liang D, Sun R, Lan K. Fine-Tuning of the Kaposi's Sarcoma-Associated Herpesvirus Life Cycle in Neighboring Cells through the RTA-JAG1-Notch Pathway. PLoS Pathog. 2016 Oct; 12(10):e1005900. PMID: 27760204.
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    9. He Z, Wang F, Ma J, Sen S, Zhang J, Gwack Y, Zhou Y, Sun Z. Ubiquitination of ROR?t at Lysine 446 Limits Th17 Differentiation by Controlling Coactivator Recruitment. J Immunol. 2016 08 15; 197(4):1148-58. PMID: 27430721.
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    10. Liang D, Hu H, Li S, Dong J, Wang X, Wang Y, He L, He Z, Gao Y, Gao SJ, Lan K. Oncogenic herpesvirus KSHV Hijacks BMP-Smad1-Id signaling to promote tumorigenesis. PLoS Pathog. 2014 Jul; 10(7):e1004253. PMID: 25010525.
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    11. Wang X, He Z, Xia T, Li X, Liang D, Lin X, Wen H, Lan K. Latency-associated nuclear antigen of Kaposi sarcoma-associated herpesvirus promotes angiogenesis through targeting notch signaling effector Hey1. Cancer Res. 2014 Apr 01; 74(7):2026-37. PMID: 24523441.
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    12. He Z, Zhao J, Zhang J, Jung JU, Feng P. NF-?B activation coordinated by IKKß and IKKe enables latent infection of Kaposi's sarcoma-associated herpesvirus. J Virol. 2014 Jan; 88(1):444-55. PMID: 24155403.
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    13. Jin Y, He Z, Liang D, Zhang Q, Zhang H, Deng Q, Robertson ES, Lan K. Carboxyl-terminal amino acids 1052 to 1082 of the latency-associated nuclear antigen (LANA) interact with RBP-J? and are responsible for LANA-mediated RTA repression. J Virol. 2012 May; 86(9):4956-69. PMID: 22379075.
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    14. Dong X, He Z, Durakoglugil D, Arneson L, Shen Y, Feng P. Murine gammaherpesvirus 68 evades host cytokine production via replication transactivator-induced RelA degradation. J Virol. 2012 Feb; 86(4):1930-41. PMID: 22130545.
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    15. Lin X, Liang D, He Z, Deng Q, Robertson ES, Lan K. miR-K12-7-5p encoded by Kaposi's sarcoma-associated herpesvirus stabilizes the latent state by targeting viral ORF50/RTA. PLoS One. 2011 Jan 20; 6(1):e16224. PMID: 21283761.
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    16. Liang D, Gao Y, Lin X, He Z, Zhao Q, Deng Q, Lan K. A human herpesvirus miRNA attenuates interferon signaling and contributes to maintenance of viral latency by targeting IKKe. Cell Res. 2011 May; 21(5):793-806. PMID: 21221132.
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    17. He Z, Liu Y, Liang D, Wang Z, Robertson ES, Lan K. Cellular corepressor TLE2 inhibits replication-and-transcription- activator-mediated transactivation and lytic reactivation of Kaposi's sarcoma-associated herpesvirus. J Virol. 2010 Feb; 84(4):2047-62. PMID: 19939918.
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    18. Lan K, Murakami M, Bajaj B, Kaul R, He Z, Gan R, Feldman M, Robertson ES. Inhibition of KSHV-infected primary effusion lymphomas in NOD/SCID mice by gamma-secretase inhibitor. Cancer Biol Ther. 2009 Nov; 8(22):2136-43. PMID: 19783901.
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