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Xuewei Zhu PhD

TitleAssociate Professor
InstitutionWake Forest School of Medicine
DepartmentInternal Medicine, Molecular Medicine
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    Other Positions
    TitleAssociate Professor
    InstitutionWake Forest School of Medicine
    DepartmentMicrobiology and Immunology


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    Collapse education and training
    Bin Zhou Medical College, ChinaMBBS07/1998Clinical Medicine
    Tongji Medical College of Huazhong University of Science and Technology, ChinaMS07/2001Pathology
    Chinese Academy of Medical Sciences and Peking Union Medical College, ChinaPhD07/2005Biochemistry and Molecular Biology

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    Collapse Research 
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    AHA 15SDG22690012     (ZHU, XUEWEI)Jan 1, 2015 - Dec 31, 2018
    American Heart Association
    Dietary PUFAS, NLRP3 Inflammasome, and Atherosclerosis
    Role: Principal Investigator

    R01HL132035     (ZHU, XUEWEI)Mar 1, 2016 - Feb 28, 2021
    NIH
    The role of SLC37A2, a glucose 6 phosphate transporter, in inflammation and metabolic diseases
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Meyers AK, Zhu X. The NLRP3 Inflammasome: Metabolic Regulation and Contribution to Inflammaging. Cells. 2020 07 30; 9(8). PMID: 32751530.
      Citations:    
    2. Key CC, Bishop AC, Wang X, Zhao Q, Chen GY, Quinn MA, Zhu X, Zhang Q, Parks JS. Human GDPD3 overexpression promotes liver steatosis by increasing lysophosphatidic acid production and fatty acid uptake. J Lipid Res. 2020 07; 61(7):1075-1086. PMID: 32430316.
      Citations:    
    3. Ahmadi S, Wang S, Nagpal R, Wang B, Jain S, Razazan A, Mishra SP, Zhu X, Wang Z, Kavanagh K, Yadav H. A human-origin probiotic cocktail ameliorates aging-related leaky gut and inflammation via modulating the microbiota/taurine/tight junction axis. JCI Insight. 2020 05 07; 5(9). PMID: 32302292.
      Citations:    
    4. Wang Z, Zhao Q, Nie Y, Yu Y, Misra BB, Zabalawi M, Chou JW, Key CC, Molina AJ, Quinn MA, Fessler MB, Parks JS, McCall CE, Zhu X. Solute Carrier Family 37 Member 2 (SLC37A2) Negatively Regulates Murine Macrophage Inflammation by Controlling Glycolysis. iScience. 2020 May 22; 23(5):101125. PMID: 32428862.
      Citations:    
    5. Wang Z, Sequeira RC, Zabalawi M, Madenspacher J, Boudyguina E, Ou T, Nelson JM, Nie Y, Zhao Q, Fessler MB, Zhu X. Myeloid atg5 deletion impairs n-3 PUFA-mediated atheroprotection. Atherosclerosis. 2020 02; 295:8-17. PMID: 31978760.
      Citations:    
    6. Zhu X, Long D, Zabalawi M, Ingram B, Yoza BK, Stacpoole PW, McCall CE. Stimulating pyruvate dehydrogenase complex reduces itaconate levels and enhances TCA cycle anabolic bioenergetics in acutely inflamed monocytes. J Leukoc Biol. 2020 03; 107(3):467-484. PMID: 31894617.
      Citations:    
    7. Wang S, Ahmadi S, Nagpal R, Jain S, Mishra SP, Kavanagh K, Zhu X, Wang Z, McClain DA, Kritchevsky SB, Kitzman DW, Yadav H. Lipoteichoic acid from the cell wall of a heat killed Lactobacillus paracasei D3-5 ameliorates aging-related leaky gut, inflammation and improves physical and cognitive functions: from C. elegans to mice. Geroscience. 2020 02; 42(1):333-352. PMID: 31814084.
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    8. Zhang J, Tao J, Ling Y, Li F, Zhu X, Xu L, Wang M, Zhang S, McCall CE, Liu TF. Switch of NAD Salvage to de novo Biosynthesis Sustains SIRT1-RelB-Dependent Inflammatory Tolerance. Front Immunol. 2019; 10:2358. PMID: 31681271.
      Citations:    
    9. Zhu X, Meyers A, Long D, Ingram B, Liu T, Yoza BK, Vachharajani V, McCall CE. Frontline Science: Monocytes sequentially rewire metabolism and bioenergetics during an acute inflammatory response. J Leukoc Biol. 2019 02; 105(2):215-228. PMID: 30633362.
      Citations:    
    10. Shen L, Yang Y, Ou T, Key CC, Tong SH, Sequeira RC, Nelson JM, Nie Y, Wang Z, Boudyguina E, Shewale SV, Zhu X. Dietary PUFAs attenuate NLRP3 inflammasome activation via enhancing macrophage autophagy. J Lipid Res. 2017 09; 58(9):1808-1821. PMID: 28729463.
      Citations:    
    11. Key CC, Liu M, Kurtz CL, Chung S, Boudyguina E, Dinh TA, Bashore A, Phelan PE, Freedman BI, Osborne TF, Zhu X, Ma L, Sethupathy P, Biddinger SB, Parks JS. Hepatocyte ABCA1 Deletion Impairs Liver Insulin Signaling and Lipogenesis. Cell Rep. 2017 06 06; 19(10):2116-2129. PMID: 28591582.
      Citations:    
    12. Ito A, Hong C, Rong X, Zhu X, Tarling EJ, Hedde PN, Gratton E, Parks J, Tontonoz P. LXRs link metabolism to inflammation through Abca1-dependent regulation of membrane composition and TLR signaling. Elife. 2015 Jul 14; 4:e08009. PMID: 26173179.
      Citations:    
    13. Cheng D, Weckerle A, Yu Y, Ma L, Zhu X, Murea M, Freedman BI, Parks JS, Shelness GS. Biogenesis and cytotoxicity of APOL1 renal risk variant proteins in hepatocytes and hepatoma cells. J Lipid Res. 2015 Aug; 56(8):1583-93. PMID: 26089538.
      Citations:    
    14. Pollard RD, Blesso CN, Zabalawi M, Fulp B, Gerelus M, Zhu X, Lyons EW, Nuradin N, Francone OL, Li XA, Sahoo D, Thomas MJ, Sorci-Thomas MG. Procollagen C-endopeptidase Enhancer Protein 2 (PCPE2) Reduces Atherosclerosis in Mice by Enhancing Scavenger Receptor Class B1 (SR-BI)-mediated High-density Lipoprotein (HDL)-Cholesteryl Ester Uptake. J Biol Chem. 2015 Jun 19; 290(25):15496-15511. PMID: 25947382.
      Citations:    
    15. Shewale SV, Boudyguina E, Zhu X, Shen L, Hutchins PM, Barkley RM, Murphy RC, Parks JS. Botanical oils enriched in n-6 and n-3 FADS2 products are equally effective in preventing atherosclerosis and fatty liver. J Lipid Res. 2015 Jun; 56(6):1191-205. PMID: 25921305.
      Citations:    
    16. Chowdhury SM, Zhu X, Aloor JJ, Azzam KM, Gabor KA, Ge W, Addo KA, Tomer KB, Parks JS, Fessler MB. Proteomic Analysis of ABCA1-Null Macrophages Reveals a Role for Stomatin-Like Protein-2 in Raft Composition and Toll-Like Receptor Signaling. Mol Cell Proteomics. 2015 Jul; 14(7):1859-70. PMID: 25910759.
      Citations:    
    17. Liu M, Allegood J, Zhu X, Seo J, Gebre AK, Boudyguina E, Cheng D, Chuang CC, Shelness GS, Spiegel S, Parks JS. Uncleaved ApoM signal peptide is required for formation of large ApoM/sphingosine 1-phosphate (S1P)-enriched HDL particles. J Biol Chem. 2015 Mar 20; 290(12):7861-70. PMID: 25627684.
      Citations:    
    18. Bi X, Zhu X, Gao C, Shewale S, Cao Q, Liu M, Boudyguina E, Gebre AK, Wilson MD, Brown AL, Parks JS. Myeloid cell-specific ATP-binding cassette transporter A1 deletion has minimal impact on atherogenesis in atherogenic diet-fed low-density lipoprotein receptor knockout mice. Arterioscler Thromb Vasc Biol. 2014 Sep; 34(9):1888-99. PMID: 24833800.
      Citations:    
    19. Liu M, Seo J, Allegood J, Bi X, Zhu X, Boudyguina E, Gebre AK, Avni D, Shah D, Sorci-Thomas MG, Thomas MJ, Shelness GS, Spiegel S, Parks JS. Hepatic apolipoprotein M (apoM) overexpression stimulates formation of larger apoM/sphingosine 1-phosphate-enriched plasma high density lipoprotein. J Biol Chem. 2014 Jan 31; 289(5):2801-14. PMID: 24318881.
      Citations:    
    20. Zhu X, Chung S, Bi X, Chuang CC, Brown AL, Liu M, Seo J, Cuffe H, Gebre AK, Boudyguina E, Parks JS. Myeloid cell-specific ABCA1 deletion does not worsen insulin resistance in HF diet-induced or genetically obese mouse models. J Lipid Res. 2013 Oct; 54(10):2708-17. PMID: 23894207.
      Citations:    
    21. Bi X, Zhu X, Duong M, Boudyguina EY, Wilson MD, Gebre AK, Parks JS. Liver ABCA1 deletion in LDLrKO mice does not impair macrophage reverse cholesterol transport or exacerbate atherogenesis. Arterioscler Thromb Vasc Biol. 2013 Oct; 33(10):2288-96. PMID: 23814116.
      Citations:    
    22. Westerterp M, Murphy AJ, Wang M, Pagler TA, Vengrenyuk Y, Kappus MS, Gorman DJ, Nagareddy PR, Zhu X, Abramowicz S, Parks JS, Welch C, Fisher EA, Wang N, Yvan-Charvet L, Tall AR. Deficiency of ATP-binding cassette transporters A1 and G1 in macrophages increases inflammation and accelerates atherosclerosis in mice. Circ Res. 2013 May 24; 112(11):1456-65. PMID: 23572498.
      Citations:    
    23. Zhu X, Westcott MM, Bi X, Liu M, Gowdy KM, Seo J, Cao Q, Gebre AK, Fessler MB, Hiltbold EM, Hitbold EM, Parks JS. Myeloid cell-specific ABCA1 deletion protects mice from bacterial infection. Circ Res. 2012 Nov 09; 111(11):1398-409. PMID: 22955730.
      Citations:    
    24. Brown AL, Zhu X, Rong S, Shewale S, Seo J, Boudyguina E, Gebre AK, Alexander-Miller MA, Parks JS. Omega-3 fatty acids ameliorate atherosclerosis by favorably altering monocyte subsets and limiting monocyte recruitment to aortic lesions. Arterioscler Thromb Vasc Biol. 2012 Sep; 32(9):2122-30. PMID: 22814747.
      Citations:    
    25. Sorci-Thomas MG, Owen JS, Fulp B, Bhat S, Zhu X, Parks JS, Shah D, Jerome WG, Gerelus M, Zabalawi M, Thomas MJ. Nascent high density lipoproteins formed by ABCA1 resemble lipid rafts and are structurally organized by three apoA-I monomers. J Lipid Res. 2012 Sep; 53(9):1890-909. PMID: 22750655.
      Citations:    
    26. Zhu X, Parks JS. New roles of HDL in inflammation and hematopoiesis. Annu Rev Nutr. 2012 Aug 21; 32:161-82. PMID: 22540255.
      Citations:    
    27. Youm YH, Kanneganti TD, Vandanmagsar B, Zhu X, Ravussin A, Adijiang A, Owen JS, Thomas MJ, Francis J, Parks JS, Dixit VD. The Nlrp3 inflammasome promotes age-related thymic demise and immunosenescence. Cell Rep. 2012 Jan 26; 1(1):56-68. PMID: 22832107.
      Citations:    
    28. Zhang X, Zhu X, Chen B. Inhibition of collar-induced carotid atherosclerosis by recombinant apoA-I cysteine mutants in apoE-deficient mice. J Lipid Res. 2010 Dec; 51(12):3434-42. PMID: 20817832.
      Citations:    
    29. Zhu X, Owen JS, Wilson MD, Li H, Griffiths GL, Thomas MJ, Hiltbold EM, Fessler MB, Parks JS. Macrophage ABCA1 reduces MyD88-dependent Toll-like receptor trafficking to lipid rafts by reduction of lipid raft cholesterol. J Lipid Res. 2010 Nov; 51(11):3196-206. PMID: 20650929.
      Citations:    
    30. Smoak KA, Aloor JJ, Madenspacher J, Merrick BA, Collins JB, Zhu X, Cavigiolio G, Oda MN, Parks JS, Fessler MB. Myeloid differentiation primary response protein 88 couples reverse cholesterol transport to inflammation. Cell Metab. 2010 Jun 09; 11(6):493-502. PMID: 20519121.
      Citations:    
    31. Brown JM, Chung S, Sawyer JK, Degirolamo C, Alger HM, Nguyen TM, Zhu X, Duong MN, Brown AL, Lord C, Shah R, Davis MA, Kelley K, Wilson MD, Madenspacher J, Fessler MB, Parks JS, Rudel LL. Combined therapy of dietary fish oil and stearoyl-CoA desaturase 1 inhibition prevents the metabolic syndrome and atherosclerosis. Arterioscler Thromb Vasc Biol. 2010 Jan; 30(1):24-30. PMID: 19834103.
      Citations:    
    32. Brown JM, Chung S, Sawyer JK, Degirolamo C, Alger HM, Nguyen T, Zhu X, Duong MN, Wibley AL, Shah R, Davis MA, Kelley K, Wilson MD, Kent C, Parks JS, Rudel LL. Inhibition of stearoyl-coenzyme A desaturase 1 dissociates insulin resistance and obesity from atherosclerosis. Circulation. 2008 Sep 30; 118(14):1467-75. PMID: 18794388.
      Citations:    
    33. Zhu X, Lee JY, Timmins JM, Brown JM, Boudyguina E, Mulya A, Gebre AK, Willingham MC, Hiltbold EM, Mishra N, Maeda N, Parks JS. Increased cellular free cholesterol in macrophage-specific Abca1 knock-out mice enhances pro-inflammatory response of macrophages. J Biol Chem. 2008 Aug 22; 283(34):22930-41. PMID: 18552351.
      Citations:    
    34. Wang Y, Zhu X, Wu G, Shen L, Chen B. Effect of lipid-bound apoA-I cysteine mutants on lipopolysaccharide-induced endotoxemia in mice. J Lipid Res. 2008 Aug; 49(8):1640-5. PMID: 18458046.
      Citations:    
    35. Shen L, Zhu X, Wang Y, Zeng W, Wu G, Xue H, Chen B. Secreted human apolipoprotein(a) kringle IV-10 and kringle V inhibit angiogenesis and xenografted tumor growth. Biol Chem. 2008 Feb; 389(2):135-41. PMID: 18163888.
      Citations:    
    36. Sun G, Bi N, Li G, Zhu X, Zeng W, Wu G, Xue H, Chen B. Identification of lipid binding and lipoprotein lipase activation domains of human apoAV. Chem Phys Lipids. 2006 Sep; 143(1-2):22-8. PMID: 16806135.
      Citations:    
    37. Zhu X, Wu G, Zeng W, Xue H, Chen B. Cysteine mutants of human apolipoprotein A-I: a study of secondary structural and functional properties. J Lipid Res. 2005 Jun; 46(6):1303-11. PMID: 15805548.
      Citations:    
    38. Yang L, Zhu X, Zhao X, Deng Z. Expression of macrophage inflammatory protein 1 alpha in the endothelial cells exposed to diamide. J Huazhong Univ Sci Technolog Med Sci. 2003; 23(3):219-22, 233. PMID: 14526416.
      Citations:    
    39. Yang L, Zhu X, Zhao X, Deng Z. [The effect of diamide on the expression of macrophage inflammatory protein-1 alpha in endothelial cells]. Zhonghua Bing Li Xue Za Zhi. 2002 Oct; 31(5):427-31. PMID: 12485486.
      Citations:    
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