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William B. Applegate MD, MPH, MACP

TitleProfessor Emeritus
InstitutionWake Forest School of Medicine
DepartmentInternal Medicine, Gerontology & Geriatric Medicine
Address
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    K07AG000126     (APPLEGATE, WILLIAM B)Jan 1, 1981 - Dec 31, 1985
    NIH
    GERIATRIC MEDICINE ACADEMIC AWARD
    Role: Principal Investigator
    U01HL037849     (SATTERFIELD, SUZANNE)Sep 30, 1986 - Jun 30, 1995
    NIH
    TRIALS OF HYPERTENSION PREVENTION (TOHP) PHASE II
    Role: Co-Principal Investigator
    T32AG000182     (APPLEGATE, WILLIAM B)Sep 1, 1989 - Apr 30, 2001
    NIH
    TRAINING GRANT: GERONTOLOGY AND GERIATRIC MEDICINE
    Role: Principal Investigator
    U01HL044298     (APPLEGATE, WILLIAM B)Jul 1, 1990 - Jun 30, 1992
    NIH
    HMG COA REDUCTASE INHIBITORS IN THE ELDERLY
    Role: Principal Investigator
    P60AG010484     (PAHOR, MARCO)Sep 30, 1991 - Sep 30, 2002
    NIH
    CLAUDE D PEPPER OLDER AMERICANS INDEPENDENCE CENTERS
    Role: Co-Principal Investigator
    R01AG009771     (APPLEGATE, WILLIAM B)Sep 15, 1992 - Mar 31, 1996
    NIH
    DIETARY INTERVENTIONS IN THE ELDERLY TRIAL
    Role: Principal Investigator
    M01RR007122     (APPLEGATE, WILLIAM B)Sep 30, 1992 - Aug 28, 2011
    NIH
    General Clinical Research Center
    Role: Principal Investigator
    N01WH032118     (JOHNSON, KAREN C)Apr 13, 1993 - Sep 14, 2005
    NIH/WHI
    VANGUARD CENTER FOR WOMEN'S HEALTH INITIATIVE
    Role: Co-Principal Investigator
    N01HC045137     (APPLEGATE, WILLIAM B)Sep 28, 1994 - Sep 30, 2000
    NIH/NHLBI
    PHYSICAL ACTIVITY FOR HIGH-RISK SEDENTARY ADULTS
    Role: Principal Investigator
    S07RR018164     (APPLEGATE, WILLIAM B)Sep 1, 2002 - Aug 31, 2005
    NIH
    Human Research Subjects Protections Program Outreach
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Applegate WB, Williamson JD, Berlowitz D. Deprescribing Antihypertensive Medication in Elderly Adults. JAMA. 2020 10 27; 324(16):1682. PMID: 33107935.
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    2. Callahan KE, Willard J, Foley KL, Miller ME, Houston DK, Kritchevsky SB, Williamson JD, Applegate WB, Girma F, Whitehead SE, Rejeski WJ. Promoting Active Aging: Lessons Learned in an Implementation Pilot in Primary Care. J Am Geriatr Soc. 2021 Feb; 69(2):373-380. PMID: 33006763.
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    3. Applegate WB, Colenda CC, Blazer DG, Reifler BV. Feeding the Beast. J Am Geriatr Soc. 2020 10; 68(10):2205-2206. PMID: 32783193.
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    4. Colenda CC, Applegate WB, Reifler BV, Blazer DG. COVID-19: Financial Stress Test for Academic Medical Centers. Acad Med. 2020 08; 95(8):1143-1145. PMID: 32287082.
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    5. Applegate WB, Ouslander JG. COVID-19 Presents High Risk to Older Persons. J Am Geriatr Soc. 2020 04; 68(4):681. PMID: 32154911.
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    6. LaCroix AZ, LaMonte MJ, Applegate WB. The Long View of the LIFE Trial and a Life's Work. J Am Geriatr Soc. 2020 04; 68(4):686-688. PMID: 32105349.
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    7. Glynn NW, Gmelin T, Santanasto AJ, Lovato LC, Lange-Maia BS, Nicklas BJ, Fielding RA, Manini TM, Myers VH, de Rekeneire N, Spring BJ, Pahor M, King AC, Rejeski WJ, Newman AB. Impact of Baseline Fatigue on a Physical Activity Intervention to Prevent Mobility Disability. J Am Geriatr Soc. 2020 03; 68(3):619-624. PMID: 31867713.
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    8. Applegate WB, Upadhya B, Patrick Ober K. Paint by Numbers. J Am Geriatr Soc. 2019 01; 67(1):7-8. PMID: 30481380.
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    9. Applegate WB, Ouslander JG, Kuchel GA. Implementing "Patient-Centered Care": A Revolutionary Change in Health Care Delivery. J Am Geriatr Soc. 2018 10; 66(10):1863-1865. PMID: 30281789.
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    10. Stott DJ, Applegate WB. Perspectives on Hypertension Treatment in Older Persons. J Am Geriatr Soc. 2018 07; 66(6):1060-1061. PMID: 30133691.
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    11. Stott DJ, Applegate WB. Perspectives on hypertension treatment in older persons. Age Ageing. 2018 May 21. PMID: 29788159.
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    12. Colenda CC, Blazer DG, Reifler BV, Applegate WB. Battles Worth Fighting. J Am Geriatr Soc. 2018 03; 66(3):431-432. PMID: 29377060.
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    13. Lundebjerg NE, Trucil DE, Applegate WB. Reply to: Language Matters, So Geriatricians Should Talk of Declining Health and Death. J Am Geriatr Soc. 2017 12; 65(12):2743-2744. PMID: 29091268.
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    14. Applegate WB, Ouslander JG. Inaugural JAGS "Mini-Focus" Issue: Cardiovascular Disease. J Am Geriatr Soc. 2017 11; 65(11):2348. PMID: 29124730.
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    15. Cushman WC, Johnson KC, Applegate WB, Cutler JA. Pharmacologic Treatment of Hypertension in Adults Aged 60 Years or Older. Ann Intern Med. 2017 08 15; 167(4):290-291. PMID: 28806805.
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    16. Lundebjerg NE, Trucil DE, Hammond EC, Applegate WB. When It Comes to Older Adults, Language Matters: Journal of the American Geriatrics Society Adopts Modified American Medical Association Style. J Am Geriatr Soc. 2017 07; 65(7):1386-1388. PMID: 28568284.
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    17. Applegate WB, Ouslander JG. Journal of the American Geriatrics Society: Evolving Strategies and Processes. J Am Geriatr Soc. 2017 06; 65(6):1132-1133. PMID: 28631429.
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    18. Applegate WB. Across the Pond. J Am Geriatr Soc. 2017 05; 65(5):901-902. PMID: 28346657.
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    19. Applegate WB, Ip E. The Evolving Taxonomy of Health in Older Persons. JAMA. 2016 12 20; 316(23):2487-2488. PMID: 27997661.
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    20. Papademetriou V, Lovato L, Tsioufis C, Cushman W, Applegate WB, Mottle A, Punthakee Z, Nylen E, Doumas M. Effects of High Density Lipoprotein Raising Therapies on Cardiovascular Outcomes in Patients with Type 2 Diabetes Mellitus, with or without Renal Impairment: The Action to Control Cardiovascular Risk in Diabetes Study. Am J Nephrol. 2017; 45(2):136-145. PMID: 27992863.
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    21. Odden MC, Wu C, Shlipak MG, Psaty BM, Katz R, Applegate WB, Harris T, Newman AB, Peralta CA. Blood Pressure Trajectory, Gait Speed, and Outcomes: The Health, Aging, and Body Composition Study. J Gerontol A Biol Sci Med Sci. 2016 12; 71(12):e1. PMID: 27838648.
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    22. Yoshikawa TT, Ouslander JG, Applegate WB. Influence of Studies Published by the Journal of the American Geriatrics Society: Top 20 Articles from 2000-2015. J Am Geriatr Soc. 2016 09; 64(9):1763-8. PMID: 27553684.
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    23. Applegate WB. JAGS Evolves: Creating a Proactive Forum. J Am Geriatr Soc. 2016 09; 64(9):1769. PMID: 27549398.
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    24. Applegate WB, Ouslander JG. Journal of the American Geriatrics Society in Transition: 15 Years of Innovation and Excellence Paves the Way for a Bright Future. J Am Geriatr Soc. 2016 07; 64(7):1399. PMID: 27401845.
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    25. Williamson JD, Supiano MA, Applegate WB, Berlowitz DR, Campbell RC, Chertow GM, Fine LJ, Haley WE, Hawfield AT, Ix JH, Kitzman DW, Kostis JB, Krousel-Wood MA, Launer LJ, Oparil S, Rodriguez CJ, Roumie CL, Shorr RI, Sink KM, Wadley VG, Whelton PK, Whittle J, Woolard NF, Wright JT, Pajewski NM. Intensive vs Standard Blood Pressure Control and Cardiovascular Disease Outcomes in Adults Aged =75 Years: A Randomized Clinical Trial. JAMA. 2016 Jun 28; 315(24):2673-82. PMID: 27195814.
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    26. Odden MC, Wu C, Shlipak MG, Psaty BM, Katz R, Applegate WB, Harris T, Newman AB, Peralta CA. Blood Pressure Trajectory, Gait Speed, and Outcomes: The Health, Aging, and Body Composition Study. J Gerontol A Biol Sci Med Sci. 2016 12; 71(12):1688-1694. PMID: 27142696.
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    27. Marsh AP, Applegate WB, Guralnik JM, Jack Rejeski W, Church TS, Fielding RA, Gill TM, King AC, Kritchevsky SB, Manini TM, McDermott MM, Newman AB, Stowe CL, Walkup MP, Pahor M, Miller ME. Hospitalizations During a Physical Activity Intervention in Older Adults at Risk of Mobility Disability: Analyses from the Lifestyle Interventions and Independence for Elders Randomized Clinical Trial. J Am Geriatr Soc. 2016 05; 64(5):933-43. PMID: 27225353.
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    28. Papademetriou V, Zaheer M, Doumas M, Lovato L, Applegate WB, Tsioufis C, Mottle A, Punthakee Z, Cushman WC. Cardiovascular Outcomes in Action to Control Cardiovascular Risk in Diabetes: Impact of Blood Pressure Level and Presence of Kidney Disease. Am J Nephrol. 2016; 43(4):271-80. PMID: 27161620.
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    29. Pajewski NM, Williamson JD, Applegate WB, Berlowitz DR, Bolin LP, Chertow GM, Krousel-Wood MA, Lopez-Barrera N, Powell JR, Roumie CL, Still C, Sink KM, Tang R, Wright CB, Supiano MA. Characterizing Frailty Status in the Systolic Blood Pressure Intervention Trial. J Gerontol A Biol Sci Med Sci. 2016 May; 71(5):649-55. PMID: 26755682.
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    30. Neiberg RH, Rejeski JJ, Applegate WB, Clark JM, Knowler WC, Bray GA, Espeland MA, Cheskin LJ. Self-Reported Gastrointestinal Symptoms in Type 2 Diabetes Improve With an Intensive Lifestyle Intervention: Results From the Action for Health in Diabetes (Look AHEAD) Clinical Trial. Clin Diabetes. 2015 Oct; 33(4):181-8. PMID: 26487792.
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    31. Applegate WB, Sink KM, Williamson JD. Managing high blood pressure in older persons with decline in function. Am J Kidney Dis. 2015 Nov; 66(5):745-7. PMID: 26188432.
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    32. Kalogeropoulos AP, Georgiopoulou VV, Murphy RA, Newman AB, Bauer DC, Harris TB, Yang Z, Applegate WB, Kritchevsky SB. Dietary sodium content, mortality, and risk for cardiovascular events in older adults: the Health, Aging, and Body Composition (Health ABC) Study. JAMA Intern Med. 2015 Mar; 175(3):410-9. PMID: 25599120.
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    33. Ober KP, Applegate WB. The electronic health record. Are we the tools of our tools? Pharos Alpha Omega Alpha Honor Med Soc. 2015; 78(1):8-14. PMID: 25796660.
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    34. Papademetriou V, Lovato L, Doumas M, Nylen E, Mottl A, Cohen RM, Applegate WB, Puntakee Z, Yale JF, Cushman WC. Chronic kidney disease and intensive glycemic control increase cardiovascular risk in patients with type 2 diabetes. Kidney Int. 2015 Mar; 87(3):649-59. PMID: 25229335.
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    35. Gencer B, Butler J, Bauer DC, Auer R, Kalogeropoulos A, Marques-Vidal P, Applegate WB, Satterfield S, Harris T, Newman A, Vittinghoff E, Rodondi N. Association of electrocardiogram abnormalities and incident heart failure events. Am Heart J. 2014 Jun; 167(6):869-75.e3. PMID: 24890537.
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    36. McDermott MM, Applegate WB, Bonds DE, Buford TW, Church T, Espeland MA, Gill TM, Guralnik JM, Haskell W, Lovato LC, Pahor M, Pepine CJ, Reid KF, Newman A. Ankle brachial index values, leg symptoms, and functional performance among community-dwelling older men and women in the lifestyle interventions and independence for elders study. J Am Heart Assoc. 2013 Nov 12; 2(6):e000257. PMID: 24222666.
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    37. Miller ME, Williamson JD, Gerstein HC, Byington RP, Cushman WC, Ginsberg HN, Ambrosius WT, Lovato L, Applegate WB. Effects of randomization to intensive glucose control on adverse events, cardiovascular disease, and mortality in older versus younger adults in the ACCORD Trial. Diabetes Care. 2014; 37(3):634-43. PMID: 24170759.
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    38. Mandyam MC, Soliman EZ, Alonso A, Dewland TA, Heckbert SR, Vittinghoff E, Cummings SR, Ellinor PT, Chaitman BR, Stocke K, Applegate WB, Arking DE, Butler J, Loehr LR, Magnani JW, Murphy RA, Satterfield S, Newman AB, Marcus GM. The QT interval and risk of incident atrial fibrillation. Heart Rhythm. 2013 Oct; 10(10):1562-8. PMID: 23872693.
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    39. Byington RP, Furberg CD, Herrington DM, Herd JA, Hunninghake D, Lowery M, Riley W, Craven T, Chaput L, Ireland CC, Applegate WB. Effect of estrogen plus progestin on progression of carotid atherosclerosis in postmenopausal women with heart disease: HERS B-mode substudy. Arterioscler Thromb Vasc Biol. 2002 Oct 01; 22(10):1692-7. PMID: 12377751.
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    40. Somes GW, Kritchevsky SB, Shorr RI, Pahor M, Applegate WB. Body mass index, weight change, and death in older adults: the systolic hypertension in the elderly program. Am J Epidemiol. 2002 Jul 15; 156(2):132-8. PMID: 12117704.
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    41. Applegate WB. Elderly patients' adherence to statin therapy. JAMA. 2002 Jul 24-31; 288(4):495-7. PMID: 12132982.
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    42. Penninx BW, Rejeski WJ, Pandya J, Miller ME, Di Bari M, Applegate WB, Pahor M. Exercise and depressive symptoms: a comparison of aerobic and resistance exercise effects on emotional and physical function in older persons with high and low depressive symptomatology. J Gerontol B Psychol Sci Soc Sci. 2002 Mar; 57(2):P124-32. PMID: 11867660.
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    43. Pahor M, Franse LV, Deitcher SR, Cushman WC, Johnson KC, Shorr RI, Kottke-Marchant K, Tracy RP, Somes GW, Applegate WB. Fosinopril versus amlodipine comparative treatments study: a randomized trial to assess effects on plasminogen activator inhibitor-1. Circulation. 2002 Jan 29; 105(4):457-61. PMID: 11815428.
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    44. Applegate WB. JAGS Approaches Middle Age with a Growth Spurt! J Am Geriatr Soc. 2002 Jan; 50(1):7-8. PMID: 12028239.
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