Loading...
Header Logo
Keywords
Last Name

Tao Ma, Ph.D.

TitleAssociate Professor
InstitutionWake Forest School of Medicine
DepartmentInternal Medicine - Gerontology
Address
vCardDownload vCard
    Other Positions
    TitleAssistant Professor
    InstitutionWake Forest School of Medicine
    DepartmentNeurobiology and Anatomy


    Collapse Research 
    Collapse research activities and funding
    K99AG044469     (MA, TAO)Sep 1, 2013 - Jul 31, 2015
    NIH/NIA
    AMPK in Alzheimer's Disease-Associated Synaptic Failure and Memory Deficits
    Role: Principal Investigator

    R00AG044469     (MA, TAO)Sep 1, 2015 - Mar 31, 2018
    NIH/NIA
    AMPK in Alzheimer's Disease-Associated Synaptic Failure and Memory Deficits
    Role: Principal Investigator

    R01AG055581     (MA, TAO)Jul 15, 2017 - Apr 30, 2022
    NIH/NIA
    Isoform-specific roles of AMPK in synaptic failure and memory deficit in Alzheimer's Disease
    Role: Principal Investigator

    R01AG056622     (MA, TAO)Aug 1, 2017 - Apr 30, 2022
    NIH/NIA
    Role of protein synthesis in Alzheimers disease-associated impairments of synaptic plasticity and memory
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Day SM, Yang W, Wang X, Stern JE, Zhou X, Macauley SL, Ma T. Glucagon-Like Peptide-1 Cleavage Product Improves Cognitive Function in a Mouse Model of Down Syndrome. eNeuro. 2019 Mar/Apr; 6(2). PMID: 31040160.
      View in: PubMed
    2. Day SM, Ma T. Therapeutic Potential of Glucagon-Like Peptide-1 Cleavage Product for Alzheimer's Disease. Neurosci Bull. 2019 Mar 07. PMID: 30843143.
      View in: PubMed
    3. Beckelman BC, Yang W, Kasica NP, Zimmermann HR, Zhou X, Keene CD, Ryazanov AG, Ma T. Genetic reduction of eEF2 kinase alleviates pathophysiology in Alzheimer's disease model mice. J Clin Invest. 2019 Feb 01; 129(2):820-833. PMID: 30667373.
      View in: PubMed
    4. Wang X, Zimmermann HR, Ma T. Therapeutic Potential of AMP-Activated Protein Kinase in Alzheimer's Disease. J Alzheimers Dis. 2019; 68(1):33-38. PMID: 30776001.
      View in: PubMed
    5. Zimmermann HR, Yang W, Beckelman BC, Kasica NP, Zhou X, Galli LD, Ryazanov AG, Ma T. Genetic removal of eIF2a kinase PERK in mice enables hippocampal L-LTP independent of mTORC1 activity. J Neurochem. 2018 07; 146(2):133-144. PMID: 29337352.
      View in: PubMed
    6. Ding H, Kiguchi N, Kishioka S, Ma T, Peters CM, Ko MC. Differential mRNA expression of neuroinflammatory modulators in the spinal cord and thalamus of type 2 diabetic monkeys. J Diabetes. 2018 Nov; 10(11):886-895. PMID: 29749036.
      View in: PubMed
    7. Zhou KY, Yang WZ, Cui ZY, Wei RJ, Zhao CL, Ma T, An F. [F4.8 visual miniature nephroscope for the diagnosis and treatment of hematospermia]. Zhonghua Nan Ke Xue. 2018 Jun; 24(6):525-528. PMID: 30173458.
      View in: PubMed
    8. Cao C, Chai Y, Shou S, Wang J, Huang Y, Ma T. Toll-like receptor 4 deficiency increases resistance in sepsis-induced immune dysfunction. Int Immunopharmacol. 2018 Jan; 54:169-176. PMID: 29149705.
      View in: PubMed
    9. Day SM, Yang W, Ewin S, Zhou X, Ma T. Glucagon-like peptide-1 cleavage product GLP-1 (9-36) amide enhances hippocampal long-term synaptic plasticity in correlation with suppression of Kv4.2 expression and eEF2 phosphorylation. Hippocampus. 2017 12; 27(12):1264-1274. PMID: 28833775.
      View in: PubMed
    10. Shah M, Edman MC, Reddy Janga S, Yarber F, Meng Z, Klinngam W, Bushman J, Ma T, Liu S, Louie S, Mehta A, Ding C, MacKay JA, Hamm-Alvarez SF. Rapamycin Eye Drops Suppress Lacrimal Gland Inflammation In a Murine Model of Sjögren's Syndrome. Invest Ophthalmol Vis Sci. 2017 01 01; 58(1):372-385. PMID: 28122086.
      View in: PubMed
    11. Beckelman BC, Day S, Zhou X, Donohue M, Gouras GK, Klann E, Keene CD, Ma T. Dysregulation of Elongation Factor 1A Expression is Correlated with Synaptic Plasticity Impairments in Alzheimer's Disease. J Alzheimers Dis. 2016 09 06; 54(2):669-78. PMID: 27567813.
      View in: PubMed
    12. Yang W, Zhou X, Zimmermann HR, Cavener DR, Klann E, Ma T. Repression of the eIF2a kinase PERK alleviates mGluR-LTD impairments in a mouse model of Alzheimer's disease. Neurobiol Aging. 2016 May; 41:19-24. PMID: 27103515.
      View in: PubMed
    13. Beckelman BC, Zhou X, Keene CD, Ma T. Impaired Eukaryotic Elongation Factor 1A Expression in Alzheimer's Disease. Neurodegener Dis. 2016; 16(1-2):39-43. PMID: 26551858.
      View in: PubMed
    14. Tan XL, Xue YQ, Ma T, Wang X, Li JJ, Lan L, Malik KU, McDonald MP, Dopico AM, Liao FF. Partial eNOS deficiency causes spontaneous thrombotic cerebral infarction, amyloid angiopathy and cognitive impairment. Mol Neurodegener. 2015 Jun 24; 10:24. PMID: 26104027.
      View in: PubMed
    15. Ma T, Chen Y, Vingtdeux V, Zhao H, Viollet B, Marambaud P, Klann E. Inhibition of AMP-activated protein kinase signaling alleviates impairments in hippocampal synaptic plasticity induced by amyloid ß. J Neurosci. 2014 Sep 03; 34(36):12230-8. PMID: 25186765.
      View in: PubMed
    16. Ma T, Klann E. PERK: a novel therapeutic target for neurodegenerative diseases? Alzheimers Res Ther. 2014; 6(3):30. PMID: 25031640.
      View in: PubMed
    17. Trinh MA, Ma T, Kaphzan H, Bhattacharya A, Antion MD, Cavener DR, Hoeffer CA, Klann E. The eIF2a kinase PERK limits the expression of hippocampal metabotropic glutamate receptor-dependent long-term depression. Learn Mem. 2014 Apr 16; 21(5):298-304. PMID: 24741110.
      View in: PubMed
    18. Kurinami H, Shimamura M, Ma T, Qian L, Koizumi K, Park L, Klann E, Manfredi G, Iadecola C, Zhou P. Prohibitin viral gene transfer protects hippocampal CA1 neurons from ischemia and ameliorates postischemic hippocampal dysfunction. Stroke. 2014 Apr; 45(4):1131-8. PMID: 24619393.
      View in: PubMed
    19. Ma T. GSK3 in Alzheimer's disease: mind the isoforms. J Alzheimers Dis. 2014; 39(4):707-10. PMID: 24254703.
      View in: PubMed
    20. Zhou X, Zhang J, Chen Y, Ma T, Wang Y, Wang J, Zhang Z. Aggravated cognitive and brain functional impairment in mild cognitive impairment patients with type 2 diabetes: a resting-state functional MRI study. J Alzheimers Dis. 2014; 41(3):925-35. PMID: 24705547.
      View in: PubMed
    21. Finan B, Ma T, Ottaway N, Müller TD, Habegger KM, Heppner KM, Kirchner H, Holland J, Hembree J, Raver C, Lockie SH, Smiley DL, Gelfanov V, Yang B, Hofmann S, Bruemmer D, Drucker DJ, Pfluger PT, Perez-Tilve D, Gidda J, Vignati L, Zhang L, Hauptman JB, Lau M, Brecheisen M, Uhles S, Riboulet W, Hainaut E, Sebokova E, Conde-Knape K, Konkar A, DiMarchi RD, Tschöp MH. Unimolecular dual incretins maximize metabolic benefits in rodents, monkeys, and humans. Sci Transl Med. 2013 Oct 30; 5(209):209ra151. PMID: 24174327.
      View in: PubMed
    22. Ma T, Trinh MA, Wexler AJ, Bourbon C, Gatti E, Pierre P, Cavener DR, Klann E. Suppression of eIF2a kinases alleviates Alzheimer's disease-related plasticity and memory deficits. Nat Neurosci. 2013 Sep; 16(9):1299-305. PMID: 23933749.
      View in: PubMed
    23. Xia X, Liang C, Liu H, Xue F, Hu Q, Chen W, Ma T, Zhang Y, Bai X, Liang T. Effects of trichostatin A in a rat model of acute graft-versus-host disease after liver transplantation. Transplantation. 2013 Jul 15; 96(1):25-33. PMID: 23694951.
      View in: PubMed
    24. Wang XY, Dong WP, Bi SH, Pan ZG, Yu H, Wang XW, Ma T, Wang J, Zhang WD. Protective effects of osthole against myocardial ischemia/reperfusion injury in rats. Int J Mol Med. 2013 Aug; 32(2):365-72. PMID: 23695269.
      View in: PubMed
    25. Liu W, Shan LP, Dong XS, Liu XW, Ma T, Liu Z. Combined early fluid resuscitation and hydrogen inhalation attenuates lung and intestine injury. World J Gastroenterol. 2013 Jan 28; 19(4):492-502. PMID: 23382627.
      View in: PubMed
    26. Hoeffer CA, Santini E, Ma T, Arnold EC, Whelan AM, Wong H, Pierre P, Pelletier J, Klann E. Multiple components of eIF4F are required for protein synthesis-dependent hippocampal long-term potentiation. J Neurophysiol. 2013 Jan; 109(1):68-76. PMID: 23054596.
      View in: PubMed
    27. Ma T, Du X, Pick JE, Sui G, Brownlee M, Klann E. Glucagon-like peptide-1 cleavage product GLP-1(9-36) amide rescues synaptic plasticity and memory deficits in Alzheimer's disease model mice. J Neurosci. 2012 Oct 03; 32(40):13701-8. PMID: 23035082.
      View in: PubMed
    28. Ma T, Tzavaras N, Tsokas P, Landau EM, Blitzer RD. Synaptic stimulation of mTOR is mediated by Wnt signaling and regulation of glycogen synthetase kinase-3. J Neurosci. 2011 Nov 30; 31(48):17537-46. PMID: 22131415.
      View in: PubMed
    29. Ma T, Klann E. Amyloid ß: linking synaptic plasticity failure to memory disruption in Alzheimer's disease. J Neurochem. 2012 Jan; 120 Suppl 1:140-8. PMID: 22122128.
      View in: PubMed
    30. Yang WZ, Guo JY, Li Y, An F, Zhang YQ, Ma T. [Transurethral resection of the prostate for urinary retention after seed implantation for prostate cancer: report of 2 cases]. Zhonghua Nan Ke Xue. 2011 Nov; 17(11):1011-3. PMID: 22141273.
      View in: PubMed
    31. Ma T, Hoeffer CA, Wong H, Massaad CA, Zhou P, Iadecola C, Murphy MP, Pautler RG, Klann E. Amyloid ß-induced impairments in hippocampal synaptic plasticity are rescued by decreasing mitochondrial superoxide. J Neurosci. 2011 Apr 13; 31(15):5589-95. PMID: 21490199.
      View in: PubMed
    32. Ma T, Hoeffer CA, Capetillo-Zarate E, Yu F, Wong H, Lin MT, Tampellini D, Klann E, Blitzer RD, Gouras GK. Dysregulation of the mTOR pathway mediates impairment of synaptic plasticity in a mouse model of Alzheimer's disease. PLoS One. 2010 Sep 20; 5(9). PMID: 20862226.
      View in: PubMed
    33. Tampellini D, Rahman N, Gallo EF, Huang Z, Dumont M, Capetillo-Zarate E, Ma T, Zheng R, Lu B, Nanus DM, Lin MT, Gouras GK. Synaptic activity reduces intraneuronal Abeta, promotes APP transport to synapses, and protects against Abeta-related synaptic alterations. J Neurosci. 2009 Aug 05; 29(31):9704-13. PMID: 19657023.
      View in: PubMed
    34. Tsokas P, Grace EA, Chan P, Ma T, Sealfon SC, Iyengar R, Landau EM, Blitzer RD. Local protein synthesis mediates a rapid increase in dendritic elongation factor 1A after induction of late long-term potentiation. J Neurosci. 2005 Jun 15; 25(24):5833-43. PMID: 15958750.
      View in: PubMed
    35. Ma T, Qi QH, Xu J, Dong ZL, Yang WX. Signal pathways involved in emodin-induced contraction of smooth muscle cells from rat colon. World J Gastroenterol. 2004 May 15; 10(10):1476-9. PMID: 15133857.
      View in: PubMed
    36. Ma T, Qi QH, Yang WX, Xu J, Dong ZL. Contractile effects and intracellular Ca2+ signalling induced by emodin in circular smooth muscle cells of rat colon. World J Gastroenterol. 2003 Aug; 9(8):1804-7. PMID: 12918125.
      View in: PubMed
    Ma's Networks
    Click the "See All" links for more information and interactive visualizations!
    Concepts Expand Description
    _
    Co-Authors Expand Description
    _
    Similar People Expand Description
    _
    Same Department Expand Description
    Physical Neighbors Expand Description
    _