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Tao Ma PhD

TitleAssociate Professor
InstitutionWake Forest School of Medicine
DepartmentInternal Medicine, Gerontology & Geriatric Medicine
Address
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    Other Positions
    TitleAssistant Professor
    InstitutionWake Forest School of Medicine
    DepartmentNeurobiology and Anatomy

    TitleAssociate Professor
    InstitutionWake Forest School of Medicine
    DepartmentPhysiology & Pharmacology


    Collapse Research 
    Collapse research activities and funding
    K99AG044469     (MA, TAO)Sep 1, 2013 - Jul 31, 2015
    NIH
    AMPK in Alzheimer's Disease-Associated Synaptic Failure and Memory Deficits
    Role: Principal Investigator

    R00AG044469     (MA, TAO)Sep 1, 2015 - Mar 31, 2019
    NIH
    AMPK in Alzheimer's Disease-Associated Synaptic Failure and Memory Deficits
    Role: Principal Investigator

    R01AG055581     (MA, TAO)Jul 15, 2017 - Apr 30, 2022
    NIH
    Isoform-specific roles of AMPK in synaptic failure and memory deficit in Alzheimer's Disease
    Role: Principal Investigator

    R01AG056622     (MA, TAO)Aug 1, 2017 - Apr 30, 2022
    NIH
    Role of protein synthesis in Alzheimers disease-associated impairments of synaptic plasticity and memory
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Zimmermann HR, Yang W, Kasica NP, Zhou X, Wang X, Beckelman BC, Lee J, Furdui CM, Keene CD, Ma T. Brain-specific repression of AMPKa1 alleviates pathophysiology in Alzheimer's model mice. J Clin Invest. 2020 07 01; 130(7):3511-3527. PMID: 32213711.
      Citations:    
    2. Yang W, Zhou X, Zimmermann HR, Ma T. Brain-specific suppression of AMPKa2 isoform impairs cognition and hippocampal LTP by PERK-mediated eIF2a phosphorylation. Mol Psychiatry. 2020 May 04. PMID: 32366952.
      Citations:    
    3. Wang X, Zimmermann HR, Lockhart SN, Craft S, Ma T. Decreased Levels of Blood AMPKa1 but not AMPKa2 Isoform in Patients with Mild Cognitive Impairment and Alzheimer's Disease: A Pilot Study. J Alzheimers Dis. 2020; 76(1):217-224. PMID: 32444538.
      Citations:    
    4. Yang W, Zhou X, Ma T. Memory Decline and Behavioral Inflexibility in Aged Mice Are Correlated With Dysregulation of Protein Synthesis Capacity. Front Aging Neurosci. 2019; 11:246. PMID: 31551760.
      Citations:    
    5. Day SM, Yang W, Wang X, Stern JE, Zhou X, Macauley SL, Ma T. Glucagon-Like Peptide-1 Cleavage Product Improves Cognitive Function in a Mouse Model of Down Syndrome. eNeuro. 2019 Mar/Apr; 6(2). PMID: 31040160.
      Citations:    
    6. Day SM, Ma T. Therapeutic Potential of Glucagon-Like Peptide-1 Cleavage Product for Alzheimer's Disease. Neurosci Bull. 2019 Oct; 35(5):934-936. PMID: 30843143.
      Citations:    
    7. Beckelman BC, Yang W, Kasica NP, Zimmermann HR, Zhou X, Keene CD, Ryazanov AG, Ma T. Genetic reduction of eEF2 kinase alleviates pathophysiology in Alzheimer's disease model mice. J Clin Invest. 2019 02 01; 129(2):820-833. PMID: 30667373.
      Citations:    
    8. Wang X, Zimmermann HR, Ma T. Therapeutic Potential of AMP-Activated Protein Kinase in Alzheimer's Disease. J Alzheimers Dis. 2019; 68(1):33-38. PMID: 30776001.
      Citations:    
    9. Zimmermann HR, Yang W, Beckelman BC, Kasica NP, Zhou X, Galli LD, Ryazanov AG, Ma T. Genetic removal of eIF2a kinase PERK in mice enables hippocampal L-LTP independent of mTORC1 activity. J Neurochem. 2018 07; 146(2):133-144. PMID: 29337352.
      Citations:    
    10. Ding H, Kiguchi N, Kishioka S, Ma T, Peters CM, Ko MC. Differential mRNA expression of neuroinflammatory modulators in the spinal cord and thalamus of type 2 diabetic monkeys. J Diabetes. 2018 Nov; 10(11):886-895. PMID: 29749036.
      Citations:    
    11. Zhou KY, Yang WZ, Cui ZY, Wei RJ, Zhao CL, Ma T, An F. [F4.8 visual miniature nephroscope for the diagnosis and treatment of hematospermia]. Zhonghua Nan Ke Xue. 2018 Jun; 24(6):525-528. PMID: 30173458.
      Citations:    
    12. Cao C, Chai Y, Shou S, Wang J, Huang Y, Ma T. Toll-like receptor 4 deficiency increases resistance in sepsis-induced immune dysfunction. Int Immunopharmacol. 2018 Jan; 54:169-176. PMID: 29149705.
      Citations:    
    13. Day SM, Yang W, Ewin S, Zhou X, Ma T. Glucagon-like peptide-1 cleavage product GLP-1 (9-36) amide enhances hippocampal long-term synaptic plasticity in correlation with suppression of Kv4.2 expression and eEF2 phosphorylation. Hippocampus. 2017 12; 27(12):1264-1274. PMID: 28833775.
      Citations:    
    14. Shah M, Edman MC, Reddy Janga S, Yarber F, Meng Z, Klinngam W, Bushman J, Ma T, Liu S, Louie S, Mehta A, Ding C, MacKay JA, Hamm-Alvarez SF. Rapamycin Eye Drops Suppress Lacrimal Gland Inflammation In a Murine Model of Sjögren's Syndrome. Invest Ophthalmol Vis Sci. 2017 01 01; 58(1):372-385. PMID: 28122086.
      Citations:    
    15. Beckelman BC, Day S, Zhou X, Donohue M, Gouras GK, Klann E, Keene CD, Ma T. Dysregulation of Elongation Factor 1A Expression is Correlated with Synaptic Plasticity Impairments in Alzheimer's Disease. J Alzheimers Dis. 2016 09 06; 54(2):669-78. PMID: 27567813.
      Citations:    
    16. Yang W, Zhou X, Zimmermann HR, Cavener DR, Klann E, Ma T. Repression of the eIF2a kinase PERK alleviates mGluR-LTD impairments in a mouse model of Alzheimer's disease. Neurobiol Aging. 2016 May; 41:19-24. PMID: 27103515.
      Citations:    
    17. Beckelman BC, Zhou X, Keene CD, Ma T. Impaired Eukaryotic Elongation Factor 1A Expression in Alzheimer's Disease. Neurodegener Dis. 2016; 16(1-2):39-43. PMID: 26551858.
      Citations:    
    18. Tan XL, Xue YQ, Ma T, Wang X, Li JJ, Lan L, Malik KU, McDonald MP, Dopico AM, Liao FF. Partial eNOS deficiency causes spontaneous thrombotic cerebral infarction, amyloid angiopathy and cognitive impairment. Mol Neurodegener. 2015 Jun 24; 10:24. PMID: 26104027.
      Citations:    
    19. Ma T, Chen Y, Vingtdeux V, Zhao H, Viollet B, Marambaud P, Klann E. Inhibition of AMP-activated protein kinase signaling alleviates impairments in hippocampal synaptic plasticity induced by amyloid ß. J Neurosci. 2014 Sep 03; 34(36):12230-8. PMID: 25186765.
      Citations:    
    20. Ma T, Klann E. PERK: a novel therapeutic target for neurodegenerative diseases? Alzheimers Res Ther. 2014; 6(3):30. PMID: 25031640.
      Citations:    
    21. Trinh MA, Ma T, Kaphzan H, Bhattacharya A, Antion MD, Cavener DR, Hoeffer CA, Klann E. The eIF2a kinase PERK limits the expression of hippocampal metabotropic glutamate receptor-dependent long-term depression. Learn Mem. 2014 Apr 16; 21(5):298-304. PMID: 24741110.
      Citations:    
    22. Kurinami H, Shimamura M, Ma T, Qian L, Koizumi K, Park L, Klann E, Manfredi G, Iadecola C, Zhou P. Prohibitin viral gene transfer protects hippocampal CA1 neurons from ischemia and ameliorates postischemic hippocampal dysfunction. Stroke. 2014 Apr; 45(4):1131-8. PMID: 24619393.
      Citations:    
    23. Ma T. GSK3 in Alzheimer's disease: mind the isoforms. J Alzheimers Dis. 2014; 39(4):707-10. PMID: 24254703.
      Citations:    
    24. Zhou X, Zhang J, Chen Y, Ma T, Wang Y, Wang J, Zhang Z. Aggravated cognitive and brain functional impairment in mild cognitive impairment patients with type 2 diabetes: a resting-state functional MRI study. J Alzheimers Dis. 2014; 41(3):925-35. PMID: 24705547.
      Citations:    
    25. Finan B, Ma T, Ottaway N, Müller TD, Habegger KM, Heppner KM, Kirchner H, Holland J, Hembree J, Raver C, Lockie SH, Smiley DL, Gelfanov V, Yang B, Hofmann S, Bruemmer D, Drucker DJ, Pfluger PT, Perez-Tilve D, Gidda J, Vignati L, Zhang L, Hauptman JB, Lau M, Brecheisen M, Uhles S, Riboulet W, Hainaut E, Sebokova E, Conde-Knape K, Konkar A, DiMarchi RD, Tschöp MH. Unimolecular dual incretins maximize metabolic benefits in rodents, monkeys, and humans. Sci Transl Med. 2013 Oct 30; 5(209):209ra151. PMID: 24174327.
      Citations:    
    26. Ma T, Trinh MA, Wexler AJ, Bourbon C, Gatti E, Pierre P, Cavener DR, Klann E. Suppression of eIF2a kinases alleviates Alzheimer's disease-related plasticity and memory deficits. Nat Neurosci. 2013 Sep; 16(9):1299-305. PMID: 23933749.
      Citations:    
    27. Xia X, Liang C, Liu H, Xue F, Hu Q, Chen W, Ma T, Zhang Y, Bai X, Liang T. Effects of trichostatin A in a rat model of acute graft-versus-host disease after liver transplantation. Transplantation. 2013 Jul 15; 96(1):25-33. PMID: 23694951.
      Citations:    
    28. Wang XY, Dong WP, Bi SH, Pan ZG, Yu H, Wang XW, Ma T, Wang J, Zhang WD. Protective effects of osthole against myocardial ischemia/reperfusion injury in rats. Int J Mol Med. 2013 Aug; 32(2):365-72. PMID: 23695269.
      Citations:    
    29. Liu W, Shan LP, Dong XS, Liu XW, Ma T, Liu Z. Combined early fluid resuscitation and hydrogen inhalation attenuates lung and intestine injury. World J Gastroenterol. 2013 Jan 28; 19(4):492-502. PMID: 23382627.
      Citations:    
    30. Hoeffer CA, Santini E, Ma T, Arnold EC, Whelan AM, Wong H, Pierre P, Pelletier J, Klann E. Multiple components of eIF4F are required for protein synthesis-dependent hippocampal long-term potentiation. J Neurophysiol. 2013 Jan; 109(1):68-76. PMID: 23054596.
      Citations:    
    31. Ma T, Du X, Pick JE, Sui G, Brownlee M, Klann E. Glucagon-like peptide-1 cleavage product GLP-1(9-36) amide rescues synaptic plasticity and memory deficits in Alzheimer's disease model mice. J Neurosci. 2012 Oct 03; 32(40):13701-8. PMID: 23035082.
      Citations:    
    32. Ma T, Tzavaras N, Tsokas P, Landau EM, Blitzer RD. Synaptic stimulation of mTOR is mediated by Wnt signaling and regulation of glycogen synthetase kinase-3. J Neurosci. 2011 Nov 30; 31(48):17537-46. PMID: 22131415.
      Citations:    
    33. Ma T, Klann E. Amyloid ß: linking synaptic plasticity failure to memory disruption in Alzheimer's disease. J Neurochem. 2012 Jan; 120 Suppl 1:140-8. PMID: 22122128.
      Citations:    
    34. Yang WZ, Guo JY, Li Y, An F, Zhang YQ, Ma T. [Transurethral resection of the prostate for urinary retention after seed implantation for prostate cancer: report of 2 cases]. Zhonghua Nan Ke Xue. 2011 Nov; 17(11):1011-3. PMID: 22141273.
      Citations:    
    35. Ma T, Hoeffer CA, Wong H, Massaad CA, Zhou P, Iadecola C, Murphy MP, Pautler RG, Klann E. Amyloid ß-induced impairments in hippocampal synaptic plasticity are rescued by decreasing mitochondrial superoxide. J Neurosci. 2011 Apr 13; 31(15):5589-95. PMID: 21490199.
      Citations:    
    36. Ma T, Hoeffer CA, Capetillo-Zarate E, Yu F, Wong H, Lin MT, Tampellini D, Klann E, Blitzer RD, Gouras GK. Dysregulation of the mTOR pathway mediates impairment of synaptic plasticity in a mouse model of Alzheimer's disease. PLoS One. 2010 Sep 20; 5(9). PMID: 20862226.
      Citations:    
    37. Tampellini D, Rahman N, Gallo EF, Huang Z, Dumont M, Capetillo-Zarate E, Ma T, Zheng R, Lu B, Nanus DM, Lin MT, Gouras GK. Synaptic activity reduces intraneuronal Abeta, promotes APP transport to synapses, and protects against Abeta-related synaptic alterations. J Neurosci. 2009 Aug 05; 29(31):9704-13. PMID: 19657023.
      Citations:    
    38. Tsokas P, Grace EA, Chan P, Ma T, Sealfon SC, Iyengar R, Landau EM, Blitzer RD. Local protein synthesis mediates a rapid increase in dendritic elongation factor 1A after induction of late long-term potentiation. J Neurosci. 2005 Jun 15; 25(24):5833-43. PMID: 15958750.
      Citations:    
    39. Ma T, Qi QH, Xu J, Dong ZL, Yang WX. Signal pathways involved in emodin-induced contraction of smooth muscle cells from rat colon. World J Gastroenterol. 2004 May 15; 10(10):1476-9. PMID: 15133857.
      Citations:    
    40. Ma T, Qi QH, Yang WX, Xu J, Dong ZL. Contractile effects and intracellular Ca2+ signalling induced by emodin in circular smooth muscle cells of rat colon. World J Gastroenterol. 2003 Aug; 9(8):1804-7. PMID: 12918125.
      Citations:    
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