Loading...
Header Logo
Keywords
Last Name

Samuel Neal Lockhart, Ph.D.

TitleAssistant Professor
InstitutionWake Forest School of Medicine
DepartmentInternal Medicine - Gerontology
Address
vCardDownload vCard

    Collapse Biography 
    Collapse education and training
    University of Miami, Coral Gables, FLBS2005Neuroscience
    University of California Davis, Davis, CAPhD2014Neuroscience
    University of California Berkeley, Berkeley, CAPostdoctoral Fellowship2017Neuroimaging of Aging and Dementia

    Collapse Overview 
    Collapse overview
    Samuel N. Lockhart, Ph.D., is a neuroscientist who has spent his research career disentangling normal brain aging from preclinical disease. He earned his Ph.D. in Neuroscience from UC Davis with Dr. Charles DeCarli, investigating the impacts of age and cerebrovascular disease on brain function and cognition, and completed a postdoctoral fellowship with Dr. William Jagust at UC Berkeley, examining how tau and amyloid accumulation affect brain structure and cognitive trajectories. He is an author of publications that have appeared in Neuron, NeuroImage, Neurology, Journal of Neuroscience, Brain, Stroke, Journal of Nuclear Medicine, and JAMA Neurology, among others. At Wake Forest, Dr. Lockhart is an Assistant Professor of Internal Medicine and Gerontology and Geriatric Medicine. He plans to build a research program in multimodal neuroimaging and cognitive analyses of aging and diseases of aging, with a focus on interactions between metabolic dysfunction and vascular and degenerative pathology.


    Collapse Research 
    Collapse research activities and funding
    F32AG050389     (LOCKHART, SAMUEL NEAL)Dec 1, 2015 - Nov 30, 2018
    NIH/NIA
    Biomarkers of preclinical Alzheimer disease and cognition
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Jang H, Park J, Woo S, Kim S, Kim HJ, Na DL, Lockhart SN, Kim Y, Kim KW, Cho SH, Kim SJ, Seong JK, Seo SW. Prediction of fast decline in amyloid positive mild cognitive impairment patients using multimodal biomarkers. Neuroimage Clin. 2019 Jul 19; 24:101941. PMID: 31376643.
      View in: PubMed
    2. Adams JN, Lockhart SN, Li L, Jagust WJ. Relationships Between Tau and Glucose Metabolism Reflect Alzheimer's Disease Pathology in Cognitively Normal Older Adults. Cereb Cortex. 2019 May 01; 29(5):1997-2009. PMID: 29912295.
      View in: PubMed
    3. Alber J, Alladi S, Bae HJ, Barton DA, Beckett LA, Bell JM, Berman SE, Biessels GJ, Black SE, Bos I, Bowman GL, Brai E, Brickman AM, Callahan BL, Corriveau RA, Fossati S, Gottesman RF, Gustafson DR, Hachinski V, Hayden KM, Helman AM, Hughes TM, Isaacs JD, Jefferson AL, Johnson SC, Kapasi A, Kern S, Kwon JC, Kukolja J, Lee A, Lockhart SN, Murray A, Osborn KE, Power MC, Price BR, Rhodius-Meester HFM, Rondeau JA, Rosen AC, Rosene DL, Schneider JA, Scholtzova H, Shaaban CE, Silva NCBS, Snyder HM, Swardfager W, Troen AM, van Veluw SJ, Vemuri P, Wallin A, Wellington C, Wilcock DM, Xie SX, Hainsworth AH. White matter hyperintensities in vascular contributions to cognitive impairment and dementia (VCID): Knowledge gaps and opportunities. Alzheimers Dement (N Y). 2019; 5:107-117. PMID: 31011621.
      View in: PubMed
    4. Espeland MA, Hayden KM, Lockhart SN, Yassine HN, Hoscheidt S, Yasar S, Luchsinger JA, Neiberg RH, Brinton RD, Carmichael O. Sex-Related Differences in Brain Volumes and Cerebral Blood Flow Among Overweight and Obese Adults With Type 2 Diabetes: Exploratory Analyses from the Action for Health in Diabetes Brain Magnetic Resonance Imaging Study. J Gerontol A Biol Sci Med Sci. 2019 Apr 08. PMID: 30997482.
      View in: PubMed
    5. Kim JP, Kim J, Park YH, Park SB, Lee JS, Yoo S, Kim EJ, Kim HJ, Na DL, Brown JA, Lockhart SN, Seo SW, Seong JK. Machine learning based hierarchical classification of frontotemporal dementia and Alzheimer's disease. Neuroimage Clin. 2019 Apr 03; 23:101811. PMID: 30981204.
      View in: PubMed
    6. Kim SJ, Jung NY, Kim YJ, Park SB, Kim K, Kim Y, Jang H, Kim SE, Cho SH, Kim JP, Jung YH, Woo SY, Kim SW, Lockhart SN, Kim EJ, Kim HJ, Lee JM, Chin J, Na DL, Seo SW. Clinical Effects of Frontal Behavioral Impairment: Cortical Thickness and Cognitive Decline in Individuals with Subjective Cognitive Decline and Amnestic Mild Cognitive Impairment. J Alzheimers Dis. 2019; 69(1):213-225. PMID: 30958372.
      View in: PubMed
    7. Sweeney MD, Montagne A, Sagare AP, Nation DA, Schneider LS, Chui HC, Harrington MG, Pa J, Law M, Wang DJJ, Jacobs RE, Doubal FN, Ramirez J, Black SE, Nedergaard M, Benveniste H, Dichgans M, Iadecola C, Love S, Bath PM, Markus HS, Salman RA, Allan SM, Quinn TJ, Kalaria RN, Werring DJ, Carare RO, Touyz RM, Williams SCR, Moskowitz MA, Katusic ZS, Lutz SE, Lazarov O, Minshall RD, Rehman J, Davis TP, Wellington CL, González HM, Yuan C, Lockhart SN, Hughes TM, Chen CLH, Sachdev P, O'Brien JT, Skoog I, Pantoni L, Gustafson DR, Biessels GJ, Wallin A, Smith EE, Mok V, Wong A, Passmore P, Barkof F, Muller M, Breteler MMB, Román GC, Hamel E, Seshadri S, Gottesman RF, van Buchem MA, Arvanitakis Z, Schneider JA, Drewes LR, Hachinski V, Finch CE, Toga AW, Wardlaw JM, Zlokovic BV. Vascular dysfunction-The disregarded partner of Alzheimer's disease. Alzheimers Dement. 2019 01; 15(1):158-167. PMID: 30642436.
      View in: PubMed
    8. Jang H, Park JY, Jang YK, Kim HJ, Lee JS, Na DL, Noh Y, Lockhart SN, Seong JK, Seo SW. Distinct amyloid distribution patterns in amyloid positive subcortical vascular cognitive impairment. Sci Rep. 2018 Nov 01; 8(1):16178. PMID: 30385819.
      View in: PubMed
    9. La Joie R, Ayakta N, Seeley WW, Borys E, Boxer AL, DeCarli C, Doré V, Grinberg LT, Huang E, Hwang JH, Ikonomovic MD, Jack C, Jagust WJ, Jin LW, Klunk WE, Kofler J, Lesman-Segev OH, Lockhart SN, Lowe VJ, Masters CL, Mathis CA, McLean CL, Miller BL, Mungas D, O'Neil JP, Olichney JM, Parisi JE, Petersen RC, Rosen HJ, Rowe CC, Spina S, Vemuri P, Villemagne VL, Murray ME, Rabinovici GD. Multisite study of the relationships between antemortem [11C]PIB-PET Centiloid values and postmortem measures of Alzheimer's disease neuropathology. Alzheimers Dement. 2019 Feb; 15(2):205-216. PMID: 30347188.
      View in: PubMed
    10. He M, Baker SL, Shah VD, Lockhart SN, Jagust WJ. Scan-time Corrections for 80-100 Minute Standardized Uptake Volume Ratios to Measure the 18F-AV-1451 Tracer for Tau Imaging. IEEE Trans Med Imaging. 2018 Sep 17. PMID: 30235119.
      View in: PubMed
    11. Li L, Kang J, Lockhart SN, Adams J, Jagust WJ. Spatially Adaptive Varying Correlation Analysis for Multimodal Neuroimaging Data. IEEE Trans Med Imaging. 2019 01; 38(1):113-123. PMID: 30028695.
      View in: PubMed
    12. Lee JS, Cho SK, Kim HJ, Kim YJ, Park KC, Lockhart SN, Na DL, Kim C, Seo SW. Prediction Models of Cognitive Trajectories in Patients with Nonamnestic Mild Cognitive Impairment. Sci Rep. 2018 Jul 11; 8(1):10468. PMID: 29993022.
      View in: PubMed
    13. Cho SH, Shin JH, Jang H, Park S, Kim HJ, Kim SE, Kim SJ, Kim Y, Lee JS, Na DL, Lockhart SN, Rabinovici GD, Seong JK, Seo SW. Amyloid involvement in subcortical regions predicts cognitive decline. Eur J Nucl Med Mol Imaging. 2018 12; 45(13):2368-2376. PMID: 29980831.
      View in: PubMed
    14. Leal SL, Lockhart SN, Maass A, Bell RK, Jagust WJ. Subthreshold Amyloid Predicts Tau Deposition in Aging. J Neurosci. 2018 05 09; 38(19):4482-4489. PMID: 29686045.
      View in: PubMed
    15. Lee JS, Kim C, Shin JH, Cho H, Shin DS, Kim N, Kim HJ, Kim Y, Lockhart SN, Na DL, Seo SW, Seong JK. Machine Learning-based Individual Assessment of Cortical Atrophy Pattern in Alzheimer's Disease Spectrum: Development of the Classifier and Longitudinal Evaluation. Sci Rep. 2018 03 07; 8(1):4161. PMID: 29515131.
      View in: PubMed
    16. Jang H, Ye BS, Woo S, Kim SW, Chin J, Choi SH, Jeong JH, Yoon SJ, Yoon B, Park KW, Hong YJ, Kim HJ, Lockhart SN, Na DL, Seo SW. Prediction Model of Conversion to Dementia Risk in Subjects with Amnestic Mild Cognitive Impairment: A Longitudinal, Multi-Center Clinic-Based Study. J Alzheimers Dis. 2018; 61(2):825. PMID: 29278893.
      View in: PubMed
    17. Lee J, Cho H, Jeon S, Kim HJ, Kim YJ, Lee J, Kim ST, Lee JM, Chin J, Lockhart SN, Lee AY, Na DL, Seo SW. Sex-Related Reserve Hypothesis in Alzheimer's Disease: Changes in Cortical Thickness with a Five-Year Longitudinal Follow-Up. J Alzheimers Dis. 2018; 65(2):641-649. PMID: 30056418.
      View in: PubMed
    18. Kim SE, Woo S, Kim SW, Chin J, Kim HJ, Lee BI, Park J, Park KW, Kang DY, Noh Y, Ye BS, Yoo HS, Lee JS, Kim Y, Kim SJ, Cho SH, Na DL, Lockhart SN, Jang H, Seo SW. A Nomogram for Predicting Amyloid PET Positivity in Amnestic Mild Cognitive Impairment. J Alzheimers Dis. 2018; 66(2):681-691. PMID: 30320571.
      View in: PubMed
    19. Maass A, Lockhart SN, Harrison TM, Bell RK, Mellinger T, Swinnerton K, Baker SL, Rabinovici GD, Jagust WJ. Entorhinal Tau Pathology, Episodic Memory Decline, and Neurodegeneration in Aging. J Neurosci. 2018 01 17; 38(3):530-543. PMID: 29192126.
      View in: PubMed
    20. Yun HJ, Moon SH, Kim HJ, Lockhart SN, Choe YS, Lee KH, Na DL, Lee JM, Seo SW. Centiloid method evaluation for amyloid PET of subcortical vascular dementia. Sci Rep. 2017 11 24; 7(1):16322. PMID: 29176753.
      View in: PubMed
    21. Lee JS, Park S, Kim HJ, Kim Y, Jang H, Kim KW, Rhee HY, Yoon SS, Hwang KJ, Park KC, Moon SH, Kim ST, Lockhart SN, Na DL, Seo SW. Diagonal Earlobe Crease is a Visible Sign for Cerebral Small Vessel Disease and Amyloid-ß. Sci Rep. 2017 10 17; 7(1):13397. PMID: 29042572.
      View in: PubMed
    22. Hughes TM, Lockhart SN, Smagula SF. Blood Pressure's Role in Alzheimer Disease Pathology. Am J Geriatr Psychiatry. 2018 01; 26(1):23-24. PMID: 29050913.
      View in: PubMed
    23. Iaccarino L, Tammewar G, Ayakta N, Baker SL, Bejanin A, Boxer AL, Gorno-Tempini ML, Janabi M, Kramer JH, Lazaris A, Lockhart SN, Miller BL, Miller ZA, O'Neil JP, Ossenkoppele R, Rosen HJ, Schonhaut DR, Jagust WJ, Rabinovici GD. Local and distant relationships between amyloid, tau and neurodegeneration in Alzheimer's Disease. Neuroimage Clin. 2018; 17:452-464. PMID: 29159058.
      View in: PubMed
    24. Martinez K, Lockhart S, Davies M, Lindsay JR, Dempster M. Diabetes distress, illness perceptions and glycaemic control in adults with type 2 diabetes. Psychol Health Med. 2018 Feb; 23(2):171-177. PMID: 28610449.
      View in: PubMed
    25. Maass A, Landau S, Baker SL, Horng A, Lockhart SN, La Joie R, Rabinovici GD, Jagust WJ. Comparison of multiple tau-PET measures as biomarkers in aging and Alzheimer's disease. Neuroimage. 2017 08 15; 157:448-463. PMID: 28587897.
      View in: PubMed
    26. Schreiber S, Schreiber F, Lockhart SN, Horng A, Bejanin A, Landau SM, Jagust WJ. Alzheimer Disease Signature Neurodegeneration and APOE Genotype in Mild Cognitive Impairment With Suspected Non-Alzheimer Disease Pathophysiology. JAMA Neurol. 2017 06 01; 74(6):650-659. PMID: 28319241.
      View in: PubMed
    27. Lockhart SN, Schöll M, Baker SL, Ayakta N, Swinnerton KN, Bell RK, Mellinger TJ, Shah VD, O'Neil JP, Janabi M, Jagust WJ. Amyloid and tau PET demonstrate region-specific associations in normal older people. Neuroimage. 2017 04 15; 150:191-199. PMID: 28232190.
      View in: PubMed
    28. Marks SM, Lockhart SN, Baker SL, Jagust WJ. Tau and ß-Amyloid Are Associated with Medial Temporal Lobe Structure, Function, and Memory Encoding in Normal Aging. J Neurosci. 2017 03 22; 37(12):3192-3201. PMID: 28213439.
      View in: PubMed
    29. Lockhart SN, Ayakta N, Winer JR, La Joie R, Rabinovici GD, Jagust WJ. Elevated 18F-AV-1451 PET tracer uptake detected in incidental imaging findings. Neurology. 2017 03 14; 88(11):1095-1097. PMID: 28188303.
      View in: PubMed
    30. Jang H, Ye BS, Woo S, Kim SW, Chin J, Choi SH, Jeong JH, Yoon SJ, Yoon B, Park KW, Hong YJ, Kim HJ, Lockhart SN, Na DL, Seo SW. Prediction Model of Conversion to Dementia Risk in Subjects with Amnestic Mild Cognitive Impairment: A Longitudinal, Multi-Center Clinic-Based Study. J Alzheimers Dis. 2017; 60(4):1579-1587. PMID: 28968237.
      View in: PubMed
    31. Baker SL, Lockhart SN, Price JC, He M, Huesman RH, Schonhaut D, Faria J, Rabinovici G, Jagust WJ. Reference Tissue-Based Kinetic Evaluation of 18F-AV-1451 for Tau Imaging. J Nucl Med. 2017 02; 58(2):332-338. PMID: 27587706.
      View in: PubMed
    32. Lockhart SN, Baker SL, Okamura N, Furukawa K, Ishiki A, Furumoto S, Tashiro M, Yanai K, Arai H, Kudo Y, Harada R, Tomita N, Hiraoka K, Watanuki S, Jagust WJ. Dynamic PET Measures of Tau Accumulation in Cognitively Normal Older Adults and Alzheimer's Disease Patients Measured Using [18F] THK-5351. PLoS One. 2016; 11(6):e0158460. PMID: 27355840.
      View in: PubMed
    33. Ossenkoppele R, Schonhaut DR, Schöll M, Lockhart SN, Ayakta N, Baker SL, O'Neil JP, Janabi M, Lazaris A, Cantwell A, Vogel J, Santos M, Miller ZA, Bettcher BM, Vossel KA, Kramer JH, Gorno-Tempini ML, Miller BL, Jagust WJ, Rabinovici GD. Tau PET patterns mirror clinical and neuroanatomical variability in Alzheimer's disease. Brain. 2016 05; 139(Pt 5):1551-67. PMID: 26962052.
      View in: PubMed
    34. Schöll M, Lockhart SN, Schonhaut DR, O'Neil JP, Janabi M, Ossenkoppele R, Baker SL, Vogel JW, Faria J, Schwimmer HD, Rabinovici GD, Jagust WJ. PET Imaging of Tau Deposition in the Aging Human Brain. Neuron. 2016 Mar 02; 89(5):971-982. PMID: 26938442.
      View in: PubMed
    35. Jung NY, Han CE, Kim HJ, Yoo SW, Kim HJ, Kim EJ, Na DL, Lockhart SN, Jagust WJ, Seong JK, Seo SW. Tract-Specific Correlates of Neuropsychological Deficits in Patients with Subcortical Vascular Cognitive Impairment. J Alzheimers Dis. 2016; 50(4):1125-35. PMID: 26836179.
      View in: PubMed
    36. Lockhart SN, Luck SJ, Geng J, Beckett L, Disbrow EA, Carmichael O, DeCarli C. White matter hyperintensities among older adults are associated with futile increase in frontal activation and functional connectivity during spatial search. PLoS One. 2015; 10(3):e0122445. PMID: 25793922.
      View in: PubMed
    37. Lockhart SN, DeCarli C. Structural imaging measures of brain aging. Neuropsychol Rev. 2014 Sep; 24(3):271-89. PMID: 25146995.
      View in: PubMed
    38. Lockhart S, DeCarli C, Fama R. Neuroimaging of the aging brain: introduction to the special issue of neuropsychology review. Neuropsychol Rev. 2014 Sep; 24(3):267-70. PMID: 25146996.
      View in: PubMed
    39. Maillard P, Fletcher E, Lockhart SN, Roach AE, Reed B, Mungas D, DeCarli C, Carmichael OT. White matter hyperintensities and their penumbra lie along a continuum of injury in the aging brain. Stroke. 2014 Jun; 45(6):1721-6. PMID: 24781079.
      View in: PubMed
    40. Lockhart SN, Roach AE, Luck SJ, Geng J, Beckett L, Carmichael O, DeCarli C. White matter hyperintensities are associated with visual search behavior independent of generalized slowing in aging. Neuropsychologia. 2014 Jan; 52:93-101. PMID: 24183716.
      View in: PubMed
    41. He J, Wong VS, Fletcher E, Maillard P, Lee DY, Iosif AM, Singh B, Martinez O, Roach AE, Lockhart SN, Beckett L, Mungas D, Farias ST, Carmichael O, DeCarli C. The contributions of MRI-based measures of gray matter, white matter hyperintensity, and white matter integrity to late-life cognition. AJNR Am J Neuroradiol. 2012 Oct; 33(9):1797-803. PMID: 22538073.
      View in: PubMed
    42. Lockhart SN, Mayda AB, Roach AE, Fletcher E, Carmichael O, Maillard P, Schwarz CG, Yonelinas AP, Ranganath C, Decarli C. Episodic memory function is associated with multiple measures of white matter integrity in cognitive aging. Front Hum Neurosci. 2012; 6:56. PMID: 22438841.
      View in: PubMed
    43. Carmichael O, Lockhart S. The role of diffusion tensor imaging in the study of cognitive aging. Curr Top Behav Neurosci. 2012; 11:289-320. PMID: 22081443.
      View in: PubMed
    44. Wesson JM, Cooper JA, Jehle LS, Lockhart SN, Draney K, Barber J. The functional index for living with multiple sclerosis: development and validation of a new quality of life questionnaire. Mult Scler. 2009 Oct; 15(10):1239-49. PMID: 19737850.
      View in: PubMed
    Lockhart's Networks
    Click the "See All" links for more information and interactive visualizations!
    Concepts Expand Description
    _
    Co-Authors Expand Description
    _
    Similar People Expand Description
    _
    Same Department Expand Description
    Physical Neighbors Expand Description
    _