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Swapan K. Das PhD, MSc

TitleAssociate Professor
InstitutionWake Forest School of Medicine
DepartmentInternal Medicine, Endocrinology & Metabolism
Address
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    Calcutta University, West Bengal, IndiaPh.D.10/2000Zoloogy (Molecular Human Genetics)
    Kalyani University, West Bengal, IndiaM.Sc.04/1994Zoology (Specialization: Cytogenetics)
    Calcutta University, West Bengal, IndiaB.Sc04/1991Zoology (Major)

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    R01DK039311     (DAS, SWAPAN KUMAR)May 1, 1988 - Jun 30, 2013
    NIH
    Genetics of Type 2 Diabetes
    Role: Principal Investigator
    R01DK071100     (DAS, SWAPAN KUMAR)Mar 1, 2006 - Feb 28, 2013
    NIH
    Mapping T2DM Genes in GENNID Families
    Role: Principal Investigator
    R01DK090111     (DAS, SWAPAN KUMAR)Apr 1, 2011 - Mar 31, 2019
    NIH
    Mapping Diabetes Susceptibility by Expression Traits in African Americans
    Role: Principal Investigator
    1-18-ICTS-113     (DAS, SWAPAN KUMAR)Jan 1, 2018 - Dec 31, 2020
    American Diabetes Association
    Altered DNA methylation modulates adipose tissue transcript expression and insulin resistance in African Americans
    Role: Principal Investigator
    R01DK118243     (DAS, SWAPAN KUMAR)Jul 1, 2018 - Jun 30, 2021
    NIH
    Identifying Genetic Drivers of Expression Networks Causing Insulin Resistance
    Role: Principal Investigator

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Suzuki K, Hatzikotoulas K, Southam L, Taylor HJ, Yin X, Lorenz KM, Mandla R, Huerta-Chagoya A, Melloni GEM, Kanoni S, Rayner NW, Bocher O, Arruda AL, Sonehara K, Namba S, Lee SSK, Preuss MH, Petty LE, Schroeder P, Vanderwerff B, Kals M, Bragg F, Lin K, Guo X, Zhang W, Yao J, Kim YJ, Graff M, Takeuchi F, Nano J, Lamri A, Nakatochi M, Moon S, Scott RA, Cook JP, Lee JJ, Pan I, Taliun D, Parra EJ, Chai JF, Bielak LF, Tabara Y, Hai Y, Thorleifsson G, Grarup N, Sofer T, Wuttke M, Sarnowski C, Gieger C, Nousome D, Trompet S, Kwak SH, Long J, Sun M, Tong L, Chen WM, Nongmaithem SS, Noordam R, Lim VJY, Tam CHT, Joo YY, Chen CH, Raffield LM, Prins BP, Nicolas A, Yanek LR, Chen G, Brody JA, Kabagambe E, An P, Xiang AH, Choi HS, Cade BE, Tan J, Broadaway KA, Williamson A, Kamali Z, Cui J, Thangam M, Adair LS, Adeyemo A, Aguilar-Salinas CA, Ahluwalia TS, Anand SS, Bertoni A, Bork-Jensen J, Brandslund I, Buchanan TA, Burant CF, Butterworth AS, Canouil M, Chan JCN, Chang LC, Chee ML, Chen J, Chen SH, Chen YT, Chen Z, Chuang LM, Cushman M, Danesh J, Das SK, de Silva HJ, Dedoussis G, Dimitrov L, Doumatey AP, Du S, Duan Q, Eckardt KU, Emery LS, Evans DS, Evans MK, Fischer K, Floyd JS, Ford I, Franco OH, Frayling TM, Freedman BI, Genter P, Gerstein HC, Giedraitis V, González-Villalpando C, González-Villalpando ME, Gordon-Larsen P, Gross M, Guare LA, Hackinger S, Hakaste L, Han S, Hattersley AT, Herder C, Horikoshi M, Howard AG, Hsueh W, Huang M, Huang W, Hung YJ, Hwang MY, Hwu CM, Ichihara S, Ikram MA, Ingelsson M, Islam MT, Isono M, Jang HM, Jasmine F, Jiang G, Jonas JB, Jørgensen T, Kamanu FK, Kandeel FR, Kasturiratne A, Katsuya T, Kaur V, Kawaguchi T, Keaton JM, Kho AN, Khor CC, Kibriya MG, Kim DH, Kronenberg F, Kuusisto J, Läll K, Lange LA, Lee KM, Lee MS, Lee NR, Leong A, Li L, Li Y, Li-Gao R, Ligthart S, Lindgren CM, Linneberg A, Liu CT, Liu J, Locke AE, Louie T, Luan J, Luk AO, Luo X, Lv J, Lynch JA, Lyssenko V, Maeda S, Mamakou V, Mansuri SR, Matsuda K, Meitinger T, Melander O, Metspalu A, Mo H, Morris AD, Moura FA, Nadler JL, Nalls MA, Nayak U, Ntalla I, Okada Y, Orozco L, Patel SR, Patil S, Pei P, Pereira MA, Peters A, Pirie FJ, Polikowsky HG, Porneala B, Prasad G, Rasmussen-Torvik LJ, Reiner AP, Roden M, Rohde R, Roll K, Sabanayagam C, Sandow K, Sankareswaran A, Sattar N, Schönherr S, Shahriar M, Shen B, Shi J, Shin DM, Shojima N, Smith JA, So WY, Stancáková A, Steinthorsdottir V, Stilp AM, Strauch K, Taylor KD, Thorand B, Thorsteinsdottir U, Tomlinson B, Tran TC, Tsai FJ, Tuomilehto J, Tusie-Luna T, Udler MS, Valladares-Salgado A, van Dam RM, van Klinken JB, Varma R, Wacher-Rodarte N, Wheeler E, Wickremasinghe AR, van Dijk KW, Witte DR, Yajnik CS, Yamamoto K, Yamamoto K, Yoon K, Yu C, Yuan JM, Yusuf S, Zawistowski M, Zhang L, Zheng W. Genetic drivers of heterogeneity in type 2 diabetes pathophysiology. Nature. 2024 Feb 19. PMID: 38374256.
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    2. Das SS, Das SK. Common and ethnic-specific derangements in skeletal muscle transcriptome associated with obesity. Int J Obes (Lond). 2023 Nov 22. PMID: 37993634.
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    3. Ruggiero AD, Vemuri R, DeStephanis D, Brock A, Block MR, Chou J, Das SK, Williams AG, Kavanagh K. Visceral adipose microbial and inflammatory signatures in metabolically healthy and unhealthy nonhuman primates. Obesity (Silver Spring). 2023 Oct; 31(10):2543-2556. PMID: 37614163.
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    4. Xu P, Wang M, Sharma NK, Comeau ME, Wabitsch M, Langefeld CD, Civelek M, Zhang B, Das SK. Multi-omic integration reveals cell-type-specific regulatory networks of insulin resistance in distinct ancestry populations. Cell Syst. 2023 Jan 18; 14(1):41-57.e8. PMID: 36630956.
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    5. Ruggiero AD, Vemuri R, Block M, DeStephanis D, Davis M, Chou J, Williams A, Brock A, Das SK, Kavanagh K. Macrophage Phenotypes and Gene Expression Patterns Are Unique in Naturally Occurring Metabolically Healthy Obesity. Int J Mol Sci. 2022 Oct 21; 23(20). PMID: 36293536.
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    6. Le TH, Crouse WL, Keele GR, Holl K, Seshie O, Tschannen M, Craddock A, Das SK, Szalanczy AM, McDonald B, Grzybowski M, Klotz J, Sharma NK, Geurts AM, Chuang Key CC, Hawkins G, Valdar W, Mott R, Solberg Woods LC. Genetic Mapping of Multiple Metabolic Traits Identifies Novel Genes for Adiposity, Lipids and Insulin Secretory Capacity in Outbred Rats. Diabetes. 2022 Oct 11. PMID: 36219827.
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    7. Mahajan A, Spracklen CN, Zhang W, Ng MCY, Petty LE, Kitajima H, Yu GZ, Rüeger S, Speidel L, Kim YJ, Horikoshi M, Mercader JM, Taliun D, Moon S, Kwak SH, Robertson NR, Rayner NW, Loh M, Kim BJ, Chiou J, Miguel-Escalada I, Della Briotta Parolo P, Lin K, Bragg F, Preuss MH, Takeuchi F, Nano J, Guo X, Lamri A, Nakatochi M, Scott RA, Lee JJ, Huerta-Chagoya A, Graff M, Chai JF, Parra EJ, Yao J, Bielak LF, Tabara Y, Hai Y, Steinthorsdottir V, Cook JP, Kals M, Grarup N, Schmidt EM, Pan I, Sofer T, Wuttke M, Sarnowski C, Gieger C, Nousome D, Trompet S, Long J, Sun M, Tong L, Chen WM, Ahmad M, Noordam R, Lim VJY, Tam CHT, Joo YY, Chen CH, Raffield LM, Lecoeur C, Prins BP, Nicolas A, Yanek LR, Chen G, Jensen RA, Tajuddin S, Kabagambe EK, An P, Xiang AH, Choi HS, Cade BE, Tan J, Flanagan J, Abaitua F, Adair LS, Adeyemo A, Aguilar-Salinas CA, Akiyama M, Anand SS, Bertoni A, Bian Z, Bork-Jensen J, Brandslund I, Brody JA, Brummett CM, Buchanan TA, Canouil M, Chan JCN, Chang LC, Chee ML, Chen J, Chen SH, Chen YT, Chen Z, Chuang LM, Cushman M, Das SK, de Silva HJ, Dedoussis G, Dimitrov L, Doumatey AP, Du S, Duan Q, Eckardt KU, Emery LS, Evans DS, Evans MK, Fischer K, Floyd JS, Ford I, Fornage M, Franco OH, Frayling TM, Freedman BI, Fuchsberger C, Genter P, Gerstein HC, Giedraitis V, González-Villalpando C, González-Villalpando ME, Goodarzi MO, Gordon-Larsen P, Gorkin D, Gross M, Guo Y, Hackinger S, Han S, Hattersley AT, Herder C, Howard AG, Hsueh W, Huang M, Huang W, Hung YJ, Hwang MY, Hwu CM, Ichihara S, Ikram MA, Ingelsson M, Islam MT, Isono M, Jang HM, Jasmine F, Jiang G, Jonas JB, Jørgensen ME, Jørgensen T, Kamatani Y, Kandeel FR, Kasturiratne A, Katsuya T, Kaur V, Kawaguchi T, Keaton JM, Kho AN, Khor CC, Kibriya MG, Kim DH, Kohara K, Kriebel J, Kronenberg F, Kuusisto J, Läll K, Lange LA, Lee MS, Lee NR, Leong A, Li L, Li Y, Li-Gao R, Ligthart S, Lindgren CM, Linneberg A, Liu CT, Liu J, Locke AE, Louie T, Luan J, Luk AO, Luo X, Lv J, Lyssenko V, Mamakou V, Mani KR, Meitinger T, Metspalu A, Morris AD, Nadkarni GN, Nadler JL, Nalls MA, Nayak U, Nongmaithem SS, Ntalla I, Okada Y, Orozco L, Patel SR, Pereira MA, Peters A, Pirie FJ, Porneala B, Prasad G, Preissl S, Rasmussen-Torvik LJ, Reiner AP, Roden M, Rohde R, Roll K, Sabanayagam C, Sander M, Sandow K, Sattar N, Schönherr S, Schurmann C, Shahriar M, Shi J, Shin DM, Shriner D, Smith JA, So WY, Stancáková A, Stilp AM, Strauch K, Suzuki K, Takahashi A, Taylor KD, Thorand B, Thorleifsson G, Thorsteinsdottir U, Tomlinson B, Torres JM, Tsai FJ, Tuomilehto J, Tusie-Luna T, Udler MS, Valladares-Salgado A, van Dam RM, van Klinken JB, Varma R, Vujkovic M, Wacher-Rodarte N, Wheeler E, Whitsel EA, Wickremasinghe AR, van Dijk KW, Witte DR, Yajnik CS, Yamamoto K, Yamauchi T, Yengo L, Yoon K, Yu C, Yuan JM, Yusuf S, Zhang L, Zheng W. Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation. Nat Genet. 2022 May; 54(5):560-572. PMID: 35551307.
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    8. Crouse WL, Das SK, Le T, Keele G, Holl K, Seshie O, Craddock A, Sharma NK, Comeau ME, Langefeld C, Hawkins GA, Mott R, Valdar W, Solberg Woods LC. Transcriptome-wide analyses of adipose tissue in outbred rats reveal genetic regulatory mechanisms relevant for human obesity. Physiol Genomics. 2022 Apr 25. PMID: 35467982.
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    9. Das SK, Ainsworth HC, Dimitrov L, Okut H, Comeau ME, Sharma N, Ng MCY, Norris JM, Chen YI, Wagenknecht LE, Bowden DW, Hsu FC, Taylor KD, Langefeld CD, Palmer ND. Metabolomic architecture of obesity implicates metabolonic lactone sulfate in cardiometabolic disease. Mol Metab. 2021 Sep 24; 54:101342. PMID: 34563731.
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    10. Morales LD, Cromack DT, Tripathy D, Fourcaudot M, Kumar S, Curran JE, Carless M, Göring HHH, Hu SL, Lopez-Alvarenga JC, Garske KM, Pajukanta P, Small KS, Glastonbury CA, Das SK, Langefeld C, Hanson RL, Hsueh WC, Norton L, Arya R, Mummidi S, Blangero J, DeFronzo RA, Duggirala R, Jenkinson CP. Further evidence supporting a potential role for ADH1B in obesity. Sci Rep. 2021 Jan 21; 11(1):1932. PMID: 33479282.
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    11. Anderson WD, Soh JY, Innis SE, Dimanche A, Ma L, Langefeld CD, Comeau ME, Das SK, Schadt EE, Björkegren JLM, Civelek M. Sex differences in human adipose tissue gene expression and genetic regulation involve adipogenesis. Genome Res. 2020 10; 30(10):1379-1392. PMID: 32967914.
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    12. Sharma NK, Comeau ME, Montoya D, Pellegrini M, Howard TD, Langefeld CD, Das SK. Integrative Analysis of Glucometabolic Traits, Adipose Tissue DNA Methylation, and Gene Expression Identifies Epigenetic Regulatory Mechanisms of Insulin Resistance and Obesity in African Americans. Diabetes. 2020 12; 69(12):2779-2793. PMID: 32928872.
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    13. Guan M, Keaton JM, Dimitrov L, Hicks PJ, Xu J, Palmer ND, Ma L, Das SK, Chen YI, Coresh J, Fornage M, Franceschini N, Kramer H, Langefeld CD, Mychaleckyj JC, Parekh RS, Post WS, Rasmussen-Torvik LJ, Rich SS, Rotter JI, Sedor JR, Thornley-Brown D, Tin A, Wilson JG, Freedman BI, Bowden DW, Ng MCY. Genome-wide association study identifies novel loci for type 2 diabetes-attributed end-stage kidney disease in African Americans. Hum Genomics. 2019 05 15; 13(1):21. PMID: 31092297.
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    14. Sharma NK, Chuang Key CC, Civelek M, Wabitsch M, Comeau ME, Langefeld CD, Parks JS, Das SK. Genetic Regulation of Enoyl-CoA Hydratase Domain-Containing 3 in Adipose Tissue Determines Insulin Sensitivity in African Americans and Europeans. Diabetes. 2019 07; 68(7):1508-1522. PMID: 31010960.
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    15. McClain DA, Sharma NK, Jain S, Harrison A, Salaye LN, Comeau ME, Langefeld CD, Lorenzo FR, Das SK. Adipose Tissue Transferrin and Insulin Resistance. J Clin Endocrinol Metab. 2018 11 01; 103(11):4197-4208. PMID: 30099506.
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    16. Taylor KD, Guo X, Zangwill LM, Liebmann JM, Girkin CA, Feldman RM, Dubiner H, Hai Y, Samuels BC, Panarelli JF, Mitchell JP, Al-Aswad LA, Park SC, Tello C, Cotliar J, Bansal R, Sidoti PA, Cioffi GA, Blumberg D, Ritch R, Bell NP, Blieden LS, Davis G, Medeiros FA, Das SK, Divers J, Langefeld CD, Palmer ND, Freedman BI, Bowden DW, Ng MCY, Ida Chen YD, Ayyagari R, Rotter JI, Weinreb RN. Genetic Architecture of Primary Open-Angle Glaucoma in Individuals of African Descent: The African Descent and Glaucoma Evaluation Study III. Ophthalmology. 2019 01; 126(1):38-48. PMID: 30352225.
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    17. Zangwill LM, Ayyagari R, Liebmann JM, Girkin CA, Feldman R, Dubiner H, Dirkes KA, Holmann M, Williams-Steppe E, Hammel N, Saunders LJ, Vega S, Sandow K, Roll K, Slight R, Auerbach D, Samuels BC, Panarelli JF, Mitchell JP, Al-Aswad LA, Park SC, Tello C, Cotliar J, Bansal R, Sidoti PA, Cioffi GA, Blumberg D, Ritch R, Bell NP, Blieden LS, Davis G, Medeiros FA, Ng MCY, Das SK, Palmer ND, Divers J, Langefeld CD, Freedman BI, Bowden DW, Christopher MA, Chen YI, Guo X, Taylor KD, Rotter JI, Weinreb RN. The African Descent and Glaucoma Evaluation Study (ADAGES) III: Contribution of Genotype to Glaucoma Phenotype in African Americans: Study Design and Baseline Data. Ophthalmology. 2019 01; 126(1):156-170. PMID: 29361356.
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    18. Langefeld CD, Comeau ME, Sharma NK, Bowden DW, Freedman BI, Das SK. Transcriptional Regulatory Mechanisms in Adipose and Muscle Tissue Associated with Composite Glucometabolic Phenotypes. Obesity (Silver Spring). 2018 03; 26(3):559-569. PMID: 29377571.
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    19. Sajuthi SP, Sharma NK, Comeau ME, Chou JW, Bowden DW, Freedman BI, Langefeld CD, Parks JS, Das SK. Genetic regulation of adipose tissue transcript expression is involved in modulating serum triglyceride and HDL-cholesterol. Gene. 2017 Oct 20; 632:50-58. PMID: 28844666.
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    20. Schugar RC, Shih DM, Warrier M, Helsley RN, Burrows A, Ferguson D, Brown AL, Gromovsky AD, Heine M, Chatterjee A, Li L, Li XS, Wang Z, Willard B, Meng Y, Kim H, Che N, Pan C, Lee RG, Crooke RM, Graham MJ, Morton RE, Langefeld CD, Das SK, Rudel LL, Zein N, McCullough AJ, Dasarathy S, Tang WHW, Erokwu BO, Flask CA, Laakso M, Civelek M, Naga Prasad SV, Heeren J, Lusis AJ, Hazen SL, Brown JM. The TMAO-Producing Enzyme Flavin-Containing Monooxygenase 3 Regulates Obesity and the Beiging of White Adipose Tissue. Cell Rep. 2017 06 20; 19(12):2451-2461. PMID: 28636934.
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    21. Errazuriz I, Dube S, Slama M, Visentin R, Nayar S, O'Connor H, Cobelli C, Das SK, Basu A, Kremers WK, Port J, Basu R. Randomized Controlled Trial of a MUFA or Fiber-Rich Diet on Hepatic Fat in Prediabetes. J Clin Endocrinol Metab. 2017 05 01; 102(5):1765-1774. PMID: 28323952.
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    22. Sajuthi SP, Sharma NK, Chou JW, Palmer ND, McWilliams DR, Beal J, Comeau ME, Ma L, Calles-Escandon J, Demons J, Rogers S, Cherry K, Menon L, Kouba E, Davis D, Burris M, Byerly SJ, Ng MC, Maruthur NM, Patel SR, Bielak LF, Lange LA, Guo X, Sale MM, Chan KH, Monda KL, Chen GK, Taylor K, Palmer C, Edwards TL, North KE, Haiman CA, Bowden DW, Freedman BI, Langefeld CD, Das SK. Mapping adipose and muscle tissue expression quantitative trait loci in African Americans to identify genes for type 2 diabetes and obesity. Hum Genet. 2016 08; 135(8):869-80. PMID: 27193597.
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    23. Sharma NK, Sajuthi SP, Chou JW, Calles-Escandon J, Demons J, Rogers S, Ma L, Palmer ND, McWilliams DR, Beal J, Comeau ME, Cherry K, Hawkins GA, Menon L, Kouba E, Davis D, Burris M, Byerly SJ, Easter L, Bowden DW, Freedman BI, Langefeld CD, Das SK. Tissue-Specific and Genetic Regulation of Insulin Sensitivity-Associated Transcripts in African Americans. J Clin Endocrinol Metab. 2016 Apr; 101(4):1455-68. PMID: 26789776.
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    24. Das SK, Sharma NK, Zhang B. Integrative network analysis reveals different pathophysiological mechanisms of insulin resistance among Caucasians and African Americans. BMC Med Genomics. 2015 Feb 07; 8:4. PMID: 25868721.
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    25. Sharma NK, Varma V, Ma L, Hasstedt SJ, Das SK. Obesity Associated Modulation of miRNA and Co-Regulated Target Transcripts in Human Adipose Tissue of Non-Diabetic Subjects. Microrna. 2015; 4(3):194-204. PMID: 26527284.
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    26. Das SK, Ma L, Sharma NK. Adipose tissue gene expression and metabolic health of obese adults. Int J Obes (Lond). 2015 May; 39(5):869-73. PMID: 25520251.
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    27. Cao Q, Wang X, Jia L, Mondal AK, Diallo A, Hawkins GA, Das SK, Parks JS, Yu L, Shi H, Shi H, Xue B. Inhibiting DNA Methylation by 5-Aza-2'-deoxycytidine ameliorates atherosclerosis through suppressing macrophage inflammation. Endocrinology. 2014 Dec; 155(12):4925-38. PMID: 25251587.
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    28. Das SK. Integrating transcriptome and epigenome: putting together the pieces of the type 2 diabetes pathogenesis puzzle. Diabetes. 2014 Sep; 63(9):2901-3. PMID: 25146470.
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    29. Das SK, Sharma NK. Expression quantitative trait analyses to identify causal genetic variants for type 2 diabetes susceptibility. World J Diabetes. 2014 Apr 15; 5(2):97-114. PMID: 24748924.
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    30. Sharma NK, Langberg KA, Mondal AK, Das SK. Phospholipid biosynthesis genes and susceptibility to obesity: analysis of expression and polymorphisms. PLoS One. 2013; 8(5):e65303. PMID: 23724137.
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    31. Mondal AK, Sharma NK, Elbein SC, Das SK. Allelic expression imbalance screening of genes in chromosome 1q21-24 region to identify functional variants for Type 2 diabetes susceptibility. Physiol Genomics. 2013 Jul 02; 45(13):509-20. PMID: 23673729.
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    32. Hasstedt SJ, Highland HM, Elbein SC, Hanis CL, Das SK. Five linkage regions each harbor multiple type 2 diabetes genes in the African American subset of the GENNID Study. J Hum Genet. 2013 Jun; 58(6):378-83. PMID: 23552671.
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    33. Ma L, Murea M, Snipes JA, Marinelarena A, Krüger J, Hicks PJ, Langberg KA, Bostrom MA, Cooke JN, Suzuki D, Babazono T, Uzu T, Tang SC, Mondal AK, Sharma NK, Kobes S, Antinozzi PA, Davis M, Das SK, Rasouli N, Kern PA, Shores NJ, Rudel LL, Blüher M, Stumvoll M, Bowden DW, Maeda S, Parks JS, Kovacs P, Hanson RL, Baier LJ, Elbein SC, Freedman BI. An ACACB variant implicated in diabetic nephropathy associates with body mass index and gene expression in obese subjects. PLoS One. 2013; 8(2):e56193. PMID: 23460794.
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    34. Elbein SC, Gamazon ER, Das SK, Rasouli N, Kern PA, Cox NJ. Genetic risk factors for type 2 diabetes: a trans-regulatory genetic architecture? Am J Hum Genet. 2012 Sep 07; 91(3):466-77. PMID: 22958899.
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    35. Rasouli N, Kern PA, Elbein SC, Sharma NK, Das SK. Improved insulin sensitivity after treatment with PPAR? and PPARa ligands is mediated by genetically modulated transcripts. Pharmacogenet Genomics. 2012 Jul; 22(7):484-97. PMID: 22437669.
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    36. Mondal AK, Das SK, Varma V, Nolen GT, McGehee RE, Elbein SC, Wei JY, Ranganathan G. Effect of endoplasmic reticulum stress on inflammation and adiponectin regulation in human adipocytes. Metab Syndr Relat Disord. 2012 Aug; 10(4):297-306. PMID: 22545589.
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    37. Baral A, Kumar P, Halder R, Mani P, Yadav VK, Singh A, Das SK, Chowdhury S. Quadruplex-single nucleotide polymorphisms (Quad-SNP) influence gene expression difference among individuals. Nucleic Acids Res. 2012 May; 40(9):3800-11. PMID: 22238381.
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    38. Langberg KA, Ma L, Sharma NK, Hanis CL, Elbein SC, Hasstedt SJ, Das SK. Single nucleotide polymorphisms in JAZF1 and BCL11A gene are nominally associated with type 2 diabetes in African-American families from the GENNID study. J Hum Genet. 2012 Jan; 57(1):57-61. PMID: 22113416.
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    39. Ma L, Mondal AK, Murea M, Sharma NK, Tönjes A, Langberg KA, Das SK, Franks PW, Kovacs P, Antinozzi PA, Stumvoll M, Parks JS, Elbein SC, Freedman BI. The effect of ACACB cis-variants on gene expression and metabolic traits. PLoS One. 2011; 6(8):e23860. PMID: 21887335.
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    40. Das SK, Sharma NK, Hasstedt SJ, Mondal AK, Ma L, Langberg KA, Elbein SC. An integrative genomics approach identifies activation of thioredoxin/thioredoxin reductase-1-mediated oxidative stress defense pathway and inhibition of angiogenesis in obese nondiabetic human subjects. J Clin Endocrinol Metab. 2011 Aug; 96(8):E1308-13. PMID: 21593104.
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    41. Hasstedt SJ, Hanis CL, Das SK, Elbein SC. Pleiotropy of type 2 diabetes with obesity. J Hum Genet. 2011 Jul; 56(7):491-5. PMID: 21525879.
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    42. Elbein SC, Kern PA, Rasouli N, Yao-Borengasser A, Sharma NK, Das SK. Global gene expression profiles of subcutaneous adipose and muscle from glucose-tolerant, insulin-sensitive, and insulin-resistant individuals matched for BMI. Diabetes. 2011 Mar; 60(3):1019-29. PMID: 21266331.
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    43. Sharma NK, Langberg KA, Mondal AK, Elbein SC, Das SK. Type 2 diabetes (T2D) associated polymorphisms regulate expression of adjacent transcripts in transformed lymphocytes, adipose, and muscle from Caucasian and African-American subjects. J Clin Endocrinol Metab. 2011 Feb; 96(2):E394-403. PMID: 21084393.
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    44. Das SK, Mondal AK, Elbein SC. Distinct gene expression profiles characterize cellular responses to palmitate and oleate. J Lipid Res. 2010 Aug; 51(8):2121-31. PMID: 20410017.
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    45. Mondal AK, Das SK, Baldini G, Chu WS, Sharma NK, Hackney OG, Zhao J, Grant SF, Elbein SC. Genotype and tissue-specific effects on alternative splicing of the transcription factor 7-like 2 gene in humans. J Clin Endocrinol Metab. 2010 Mar; 95(3):1450-7. PMID: 20097709.
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    46. Das SK, Sharma NK, Elbein SC. Analysis of osteocalcin as a candidate gene for type 2 diabetes (T2D) and intermediate traits in Caucasians and African Americans. Dis Markers. 2010; 28(5):281-6. PMID: 20592451.
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    47. Prokopenko I, Zeggini E, Hanson RL, Mitchell BD, Rayner NW, Akan P, Baier L, Das SK, Elliott KS, Fu M, Frayling TM, Groves CJ, Gwilliam R, Scott LJ, Voight BF, Hattersley AT, Hu C, Morris AD, Ng M, Palmer CN, Tello-Ruiz M, Vaxillaire M, Wang CR, Stein L, Chan J, Jia W, Froguel P, Elbein SC, Deloukas P, Bogardus C, Shuldiner AR, McCarthy MI. Linkage disequilibrium mapping of the replicated type 2 diabetes linkage signal on chromosome 1q. Diabetes. 2009 Jul; 58(7):1704-9. PMID: 19389826.
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    48. Mani P, Yadav VK, Das SK, Chowdhury S. Genome-wide analyses of recombination prone regions predict role of DNA structural motif in recombination. PLoS One. 2009; 4(2):e4399. PMID: 19198658.
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    49. Wang H, Hays NP, Das SK, Craig RL, Chu WS, Sharma N, Elbein SC. Phenotypic and molecular evaluation of a chromosome 1q region with linkage and association to type 2 diabetes in humans. J Clin Endocrinol Metab. 2009 Apr; 94(4):1401-8. PMID: 19141583.
      Citations:    
    50. Elbein SC, Das SK, Hallman DM, Hanis CL, Hasstedt SJ. Genome-wide linkage and admixture mapping of type 2 diabetes in African American families from the American Diabetes Association GENNID (Genetics of NIDDM) Study Cohort. Diabetes. 2009 Jan; 58(1):268-74. PMID: 18840782.
      Citations:    
    51. Sharma NK, Das SK, Mondal AK, Hackney OG, Chu WS, Kern PA, Rasouli N, Spencer HJ, Yao-Borengasser A, Elbein SC. Endoplasmic reticulum stress markers are associated with obesity in nondiabetic subjects. J Clin Endocrinol Metab. 2008 Nov; 93(11):4532-41. PMID: 18728164.
      Citations:    
    52. Das SK, Chu WS, Mondal AK, Sharma NK, Kern PA, Rasouli N, Elbein SC. Effect of pioglitazone treatment on endoplasmic reticulum stress response in human adipose and in palmitate-induced stress in human liver and adipose cell lines. Am J Physiol Endocrinol Metab. 2008 Aug; 295(2):E393-400. PMID: 18544642.
      Citations:    
    53. Das SK, Sharma NK, Chu WS, Wang H, Elbein SC. Aryl hydrocarbon receptor nuclear translocator (ARNT) gene as a positional and functional candidate for type 2 diabetes and prediabetic intermediate traits: Mutation detection, case-control studies, and gene expression analysis. BMC Med Genet. 2008 Mar 17; 9:16. PMID: 18366646.
      Citations:    
    54. Hasstedt SJ, Chu WS, Das SK, Wang H, Elbein SC. Type 2 diabetes susceptibility genes on chromosome 1q21-24. Ann Hum Genet. 2008 Mar; 72(Pt 2):163-9. PMID: 18269685.
      Citations:    
    55. Elbein SC, Chu WS, Das SK, Yao-Borengasser A, Hasstedt SJ, Wang H, Rasouli N, Kern PA. Transcription factor 7-like 2 polymorphisms and type 2 diabetes, glucose homeostasis traits and gene expression in US participants of European and African descent. Diabetologia. 2007 Aug; 50(8):1621-30. PMID: 17579832.
      Citations:    
    56. Das SK, Elbein SC. The search for type 2 diabetes susceptibility loci: the chromosome 1q story. Curr Diab Rep. 2007 Apr; 7(2):154-64. PMID: 17425920.
      Citations:    
    57. Chu WS, Das SK, Wang H, Chan JC, Deloukas P, Froguel P, Baier LJ, Jia W, McCarthy MI, Ng MC, Damcott C, Shuldiner AR, Zeggini E, Elbein SC. Activating transcription factor 6 (ATF6) sequence polymorphisms in type 2 diabetes and pre-diabetic traits. Diabetes. 2007 Mar; 56(3):856-62. PMID: 17327457.
      Citations:    
    58. Das SK, Chu WS, Hale TC, Wang X, Craig RL, Wang H, Shuldiner AR, Froguel P, Deloukas P, McCarthy MI, Zeggini E, Hasstedt SJ, Elbein SC. Polymorphisms in the glucokinase-associated, dual-specificity phosphatase 12 (DUSP12) gene under chromosome 1q21 linkage peak are associated with type 2 diabetes. Diabetes. 2006 Sep; 55(9):2631-9. PMID: 16936214.
      Citations:    
    59. Rawal P, Kummarasetti VB, Ravindran J, Kumar N, Halder K, Sharma R, Mukerji M, Das SK, Chowdhury S. Genome-wide prediction of G4 DNA as regulatory motifs: role in Escherichia coli global regulation. Genome Res. 2006 May; 16(5):644-55. PMID: 16651665.
      Citations:    
    60. Das SK, Elbein SC. The Genetic Basis of Type 2 Diabetes. Cellscience. 2006 Apr 30; 2(4):100-131. PMID: 16892160.
      Citations:    
    61. Kumar J, Das SK, Sharma P, Karthikeyan G, Ramakrishnan L, Sengupta S. Homocysteine levels are associated with MTHFR A1298C polymorphism in Indian population. J Hum Genet. 2005; 50(12):655-63. PMID: 16244782.
      Citations:    
    62. Gupta B, Agrawal C, Raghav SK, Das SK, Das RH, Chaturvedi VP, Das HR. Association of mannose-binding lectin gene (MBL2) polymorphisms with rheumatoid arthritis in an Indian cohort of case-control samples. J Hum Genet. 2005; 50(11):583-591. PMID: 16220211.
      Citations:    
    63. Verma R, Kubendran S, Das SK, Jain S, Brahmachari SK. SYNGR1 is associated with schizophrenia and bipolar disorder in southern India. J Hum Genet. 2005; 50(12):635-40. PMID: 16215643.
      Citations:    
    64. Kumar J, Kumar A, Das SK, Shukla G, Sengupta S. Detection of differential gene copy number using denaturing high performance liquid chromatography. J Biochem Biophys Methods. 2005 Sep 30; 64(3):226-34. PMID: 16198000.
      Citations:    
    65. The Indian Genome Variation database (IGVdb): a project overview. Hum Genet. 2005 Oct; 118(1):1-11. PMID: 16133172.
      Citations:    
    66. Verma R, Mukerji M, Grover D, B-Rao C, Das SK, Kubendran S, Jain S, Brahmachari SK. MLC1 gene is associated with schizophrenia and bipolar disorder in Southern India. Biol Psychiatry. 2005 Jul 01; 58(1):16-22. PMID: 15992519.
      Citations:    
    67. Das SK, Chu W, Zhang Z, Hasstedt SJ, Elbein SC. Calsquestrin 1 (CASQ1) gene polymorphisms under chromosome 1q21 linkage peak are associated with type 2 diabetes in Northern European Caucasians. Diabetes. 2004 Dec; 53(12):3300-6. PMID: 15561963.
      Citations:    
    68. Das SK, Hasstedt SJ, Zhang Z, Elbein SC. Linkage and association mapping of a chromosome 1q21-q24 type 2 diabetes susceptibility locus in northern European Caucasians. Diabetes. 2004 Feb; 53(2):492-9. PMID: 14747303.
      Citations:    
    69. Wang H, Craig RL, Schay J, Chu W, Das SK, Zhang Z, Elbein SC. Alpha-endosulfine, a positional and functional candidate gene for type 2 diabetes: molecular screening, association studies, and role in reduced insulin secretion. Mol Genet Metab. 2004 Jan; 81(1):9-15. PMID: 14728986.
      Citations:    
    70. Wang H, Chu W, Das SK, Zheng Z, Hasstedt SJ, Elbein SC. Molecular screening and association studies of retinoid-related orphan receptor gamma (RORC): a positional and functional candidate for type 2 diabetes. Mol Genet Metab. 2003 Jul; 79(3):176-82. PMID: 12855222.
      Citations:    
    71. Wang H, Chu W, Das SK, Ren Q, Hasstedt SJ, Elbein SC. Liver pyruvate kinase polymorphisms are associated with type 2 diabetes in northern European Caucasians. Diabetes. 2002 Sep; 51(9):2861-5. PMID: 12196482.
      Citations:    
    72. Santra M, Das SK, Talukder G, Sharma A. Induction of micronuclei by zinc in human leukocytes: a study using cytokinesis-block micronucleus assay. Biol Trace Elem Res. 2002 Aug; 88(2):139-44. PMID: 12296424.
      Citations:    
    73. Kukreti R, Dash D, E VK, Chakravarty S, Das SK, De M, Talukder G. Spectrum of beta-thalassemia mutations and their association with allelic sequence polymorphisms at the beta-globin gene cluster in an Eastern Indian population. Am J Hematol. 2002 Aug; 70(4):269-77. PMID: 12210807.
      Citations:    
    74. Kukreti R, B-Rao C, Das SK, De M, Talukder G, Vaz F, Verma IC, Brahmachari SK. Study of the single nucleotide polymorphism (SNP) at the palindromic sequence of hypersensitive site (HS)4 of the human beta-globin locus control region (LCR) in Indian population. Am J Hematol. 2002 Jan; 69(1):77-9. PMID: 11835338.
      Citations:    
    75. Das SK, De M, Bhattacharya DK, Talukder G. Molecular characterization of hereditary persistence of foetal haemoglobin mutation by restriction fragment length polymorphism mapping. Cytobios. 2001; 106 Suppl 2:229-32. PMID: 11545449.
      Citations:    
    76. Das SK, Talukder G. A review on the origin and spread of deleterious mutants of the beta-globin gene in Indian populations. Homo. 2001; 52(2):93-109. PMID: 11802568.
      Citations:    
    77. Das SK, De M, Bhattacharya DK, Sengupta B, Das N, Talukder G. Interaction of different hemoglobinopathies in Eastern India with a view to establish genotype-phenotype correlation. Am J Hum Biol. 2000 Jul; 12(4):454-459. PMID: 11534036.
      Citations:    
    78. De M, Das SK, Bhattacharya DK, Talukder G. The occurrence of beta-thalassemia mutation and its interaction with hemoglobin E in the eastern India. Int J Hematol. 1997 Jul; 66(1):31-4. PMID: 9220658.
      Citations:    
    79. De M, Chakraborty G, Das SK, Bhattacharya DK, Talukder G. Molecular studies of haemoglobin-E in tribal populations of Tripura. Lancet. 1997 May 03; 349(9061):1297. PMID: 9142071.
      Citations:    
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