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Robert W. Gould PhD

TitleAssociate Professor
InstitutionWake Forest School of Medicine
DepartmentTranslational Neuroscience
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    K99DA042129     (GOULD, ROBERT WARREN)May 1, 2017 - Apr 30, 2019
    NIH
    Partial mGlu5 Negative Allosteric Modulators to Prevent Relapse to Cocaine Abuse
    Role: Principal Investigator
    R00DA042129     (GOULD, ROBERT WARREN)Sep 1, 2019 - Aug 31, 2022
    NIH
    Partial mGlu5 Negative Allosteric Modulators to Prevent Relapse to Cocaine Abuse
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Gould RW, Russell JK, Nedelcovych MT, Bubser M, Blobaum AL, Bridges TM, Newhouse PA, Lindsley CW, Conn PJ, Nader MA, Jones CK. Modulation of arousal and sleep/wake architecture by M1 PAM VU0453595 across young and aged rodents and nonhuman primates. Neuropsychopharmacology. 2020 12; 45(13):2219-2228. PMID: 32868847.
      Citations:    
    2. Fisher NM, Gould RW, Gogliotti RG, McDonald AJ, Badivuku H, Chennareddy S, Buch AB, Moore AM, Jenkins MT, Robb WH, Lindsley CW, Jones CK, Conn PJ, Niswender CM. Phenotypic profiling of mGlu7 knockout mice reveals new implications for neurodevelopmental disorders. Genes Brain Behav. 2020 09; 19(7):e12654. PMID: 32248644.
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    3. Gould RW, Gunter BW, Bubser M, Matthews RT, Teal LB, Ragland MG, Bridges TM, Garrison AT, Winder DG, Lindsley CW, Jones CK. Acute Negative Allosteric Modulation of M5 Muscarinic Acetylcholine Receptors Inhibits Oxycodone Self-Administration and Cue-Induced Reactivity with No Effect on Antinociception. ACS Chem Neurosci. 2019 08 21; 10(8):3740-3750. PMID: 31268669.
      Citations:    
    4. Teal LB, Gould RW, Felts AS, Jones CK. Selective allosteric modulation of muscarinic acetylcholine receptors for the treatment of schizophrenia and substance use disorders. Adv Pharmacol. 2019; 86:153-196. PMID: 31378251.
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    5. Gunter BW, Gould RW, Bubser M, McGowan KM, Lindsley CW, Jones CK. Selective inhibition of M5 muscarinic acetylcholine receptors attenuates cocaine self-administration in rats. Addict Biol. 2018 09; 23(5):1106-1116. PMID: 29044937.
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    6. Gould RW, Grannan MD, Gunter BW, Ball J, Bubser M, Bridges TM, Wess J, Wood MW, Brandon NJ, Duggan ME, Niswender CM, Lindsley CW, Conn PJ, Jones CK. Cognitive enhancement and antipsychotic-like activity following repeated dosing with the selective M4 PAM VU0467154. Neuropharmacology. 2018 Jan; 128:492-502. PMID: 28729220.
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    7. Gould RW, Czoty PW, Porrino LJ, Nader MA. Social Status in Monkeys: Effects of Social Confrontation on Brain Function and Cocaine Self-Administration. Neuropsychopharmacology. 2017 Apr; 42(5):1093-1102. PMID: 28025974.
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    8. Grannan MD, Mielnik CA, Moran SP, Gould RW, Ball J, Lu Z, Bubser M, Ramsey AJ, Abe M, Cho HP, Nance KD, Blobaum AL, Niswender CM, Conn PJ, Lindsley CW, Jones CK. Prefrontal Cortex-Mediated Impairments in a Genetic Model of NMDA Receptor Hypofunction Are Reversed by the Novel M1 PAM VU6004256. ACS Chem Neurosci. 2016 12 21; 7(12):1706-1716. PMID: 27617634.
      Citations:    
    9. Gould RW, Nedelcovych MT, Gong X, Tsai E, Bubser M, Bridges TM, Wood MR, Duggan ME, Brandon NJ, Dunlop J, Wood MW, Ivarsson M, Noetzel MJ, Daniels JS, Niswender CM, Lindsley CW, Conn PJ, Jones CK. State-dependent alterations in sleep/wake architecture elicited by the M4 PAM VU0467154 - Relation to antipsychotic-like drug effects. Neuropharmacology. 2016 Mar; 102:244-53. PMID: 26617071.
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    10. Gould RW, Amato RJ, Bubser M, Joffe ME, Nedelcovych MT, Thompson AD, Nickols HH, Yuh JP, Zhan X, Felts AS, Rodriguez AL, Morrison RD, Byers FW, Rook JM, Daniels JS, Niswender CM, Conn PJ, Emmitte KA, Lindsley CW, Jones CK. Partial mGlu5 Negative Allosteric Modulators Attenuate Cocaine-Mediated Behaviors and Lack Psychotomimetic-Like Effects. Neuropsychopharmacology. 2016 Mar; 41(4):1166-78. PMID: 26315507.
      Citations:    
    11. Rook JM, Xiang Z, Lv X, Ghoshal A, Dickerson JW, Bridges TM, Johnson KA, Foster DJ, Gregory KJ, Vinson PN, Thompson AD, Byun N, Collier RL, Bubser M, Nedelcovych MT, Gould RW, Stauffer SR, Daniels JS, Niswender CM, Lavreysen H, Mackie C, Conde-Ceide S, Alcazar J, Bartolomé-Nebreda JM, Macdonald GJ, Talpos JC, Steckler T, Jones CK, Lindsley CW, Conn PJ. Biased mGlu5-Positive Allosteric Modulators Provide In Vivo Efficacy without Potentiating mGlu5 Modulation of NMDAR Currents. Neuron. 2015 May 20; 86(4):1029-1040. PMID: 25937172.
      Citations:    
    12. Kromrey SA, Gould RW, Nader MA, Czoty PW. Effects of prior cocaine self-administration on cognitive performance in female cynomolgus monkeys. Psychopharmacology (Berl). 2015 Jun; 232(11):2007-16. PMID: 25633093.
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    13. Nedelcovych MT, Gould RW, Zhan X, Bubser M, Gong X, Grannan M, Thompson AT, Ivarsson M, Lindsley CW, Conn PJ, Jones CK. A rodent model of traumatic stress induces lasting sleep and quantitative electroencephalographic disturbances. ACS Chem Neurosci. 2015 Mar 18; 6(3):485-93. PMID: 25581551.
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    14. Bubser M, Bridges TM, Dencker D, Gould RW, Grannan M, Noetzel MJ, Lamsal A, Niswender CM, Daniels JS, Poslusney MS, Melancon BJ, Tarr JC, Byers FW, Wess J, Duggan ME, Dunlop J, Wood MW, Brandon NJ, Wood MR, Lindsley CW, Conn PJ, Jones CK. Selective activation of M4 muscarinic acetylcholine receptors reverses MK-801-induced behavioral impairments and enhances associative learning in rodents. ACS Chem Neurosci. 2014 Oct 15; 5(10):920-42. PMID: 25137629.
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    15. Czoty PW, Martelle SE, Gould RW, Nader MA. Effects of chronic methylphenidate on cocaine self-administration under a progressive-ratio schedule of reinforcement in rhesus monkeys. J Pharmacol Exp Ther. 2013 Jun; 345(3):374-82. PMID: 23579044.
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    16. Gould RW, Duke AN, Nader MA. PET studies in nonhuman primate models of cocaine abuse: translational research related to vulnerability and neuroadaptations. Neuropharmacology. 2014 Sep; 84:138-51. PMID: 23458573.
      Citations:    
    17. Gould RW, Garg PK, Garg S, Nader MA. Effects of nicotinic acetylcholine receptor agonists on cognition in rhesus monkeys with a chronic cocaine self-administration history. Neuropharmacology. 2013 Jan; 64:479-88. PMID: 22921923.
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    18. Gould RW, Gage HD, Nader MA. Effects of chronic cocaine self-administration on cognition and cerebral glucose utilization in Rhesus monkeys. Biol Psychiatry. 2012 Nov 15; 72(10):856-63. PMID: 22672928.
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    19. Nader MA, Nader SH, Czoty PW, Riddick NV, Gage HD, Gould RW, Blaylock BL, Kaplan JR, Garg PK, Davies HM, Morton D, Garg S, Reboussin BA. Social dominance in female monkeys: dopamine receptor function and cocaine reinforcement. Biol Psychiatry. 2012 Sep 01; 72(5):414-21. PMID: 22503110.
      Citations:    
    20. Gould RW, Porrino LJ, Nader MA. Nonhuman primate models of addiction and PET imaging: dopamine system dysregulation. Curr Top Behav Neurosci. 2012; 11:25-44. PMID: 22020537.
      Citations:    
    21. Gould RW, Czoty PW, Nader SH, Nader MA. Effects of varenicline on the reinforcing and discriminative stimulus effects of cocaine in rhesus monkeys. J Pharmacol Exp Ther. 2011 Nov; 339(2):678-86. PMID: 21856860.
      Citations:    
    22. Gould RW, Gage HD, Banks ML, Blaylock BL, Czoty PW, Nader MA. Differential effects of cocaine and MDMA self-administration on cortical serotonin transporter availability in monkeys. Neuropharmacology. 2011 Jul-Aug; 61(1-2):245-51. PMID: 21521647.
      Citations:    
    23. Czoty PW, Gould RW, Martelle JL, Nader MA. Prolonged attenuation of the reinforcing strength of cocaine by chronic d-amphetamine in rhesus monkeys. Neuropsychopharmacology. 2011 Jan; 36(2):539-47. PMID: 20962765.
      Citations:    
    24. Nader MA, Czoty PW, Gould RW, Riddick NV. Review. Positron emission tomography imaging studies of dopamine receptors in primate models of addiction. Philos Trans R Soc Lond B Biol Sci. 2008 Oct 12; 363(1507):3223-32. PMID: 18640923.
      Citations:    
    25. Banks ML, Gould RW, Czoty PW, Nader MA. Relationship between response rates and measures of reinforcing strength using a choice procedure in monkeys. Behav Pharmacol. 2008 Jul; 19(4):365-9. PMID: 18622187.
      Citations:    
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