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Qianqian Song PhD

TitleAssistant Professor
InstitutionWake Forest School of Medicine
DepartmentCancer Biology
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    Collapse Biography 
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    Wake Forest University School of Medicine, United StatesPhD2017Bioinformatics
    Beijing Normal University, ChinaPhD2017Mathematics

    Collapse Overview 
    Collapse overview
    My research focuses on developing innovative computational methods and artificial intelligence algorithms to decipher disease mechanisms and identify therapeutic biomarkers. Current interests lie in developing novel methods to address specific needs facing the emerging challenges in single-cell, spatial transcriptomics, and multi-omics data.

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Tang Z, Zhang T, Yang B, Su J, Song Q. spaCI: deciphering spatial cellular communications through adaptive graph model. Brief Bioinform. 2022 Dec 21. PMID: 36545790.
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    2. Chen M, Jia S, Xue M, Huang H, Xu Z, Yang D, Zhu W, Song Q. Dual-Stream Subspace Clustering Network for revealing gene targets in Alzheimer's disease. Comput Biol Med. 2022 Dec; 151(Pt A):106305. PMID: 36401971.
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    3. Chen M, Xu C, Xu Z, He W, Zhang H, Su J, Song Q. Uncovering the dynamic effects of DEX treatment on lung cancer by integrating bioinformatic inference and multiscale modeling of scRNA-seq and proteomics data. Comput Biol Med. 2022 10; 149:105999. PMID: 35998480.
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    4. Song Q, Zhu X, Jin L, Chen M, Zhang W, Su J. SMGR: a joint statistical method for integrative analysis of single-cell multi-omics data. NAR Genom Bioinform. 2022 Sep; 4(3):lqac056. PMID: 35910046.
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    5. Yoo KW, Yadav MK, Song Q, Atala A, Lu B. Targeting DNA polymerase to DNA double-strand breaks reduces DNA deletion size and increases templated insertions generated by CRISPR/Cas9. Nucleic Acids Res. 2022 04 22; 50(7):3944-3957. PMID: 35323942.
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    6. Zhang J, Wang L, Song Q, Xiao M, Gao J, Cao X, Zheng W. Organoids in recapitulating tumorigenesis driven by risk factors: Current trends and future perspectives. Int J Biol Sci. 2022; 18(7):2729-2743. PMID: 35541903.
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    7. Triozzi PL, Stirling ER, Song Q, Westwood B, Kooshki M, Forbes ME, Holbrook BC, Cook KL, Alexander-Miller MA, Miller LD, Zhang W, Soto-Pantoja DR. Circulating Immune Bioenergetic, Metabolic, and Genetic Signatures Predict Melanoma Patients' Response to Anti-PD-1 Immune Checkpoint Blockade. Clin Cancer Res. 2022 03 15; 28(6):1192-1202. PMID: 35284940.
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    8. Song Q, Bates B, Shao YR, Hsu FC, Liu F, Madhira V, Mitra AK, Bergquist T, Kavuluru R, Li X, Sharafeldin N, Su J, Topaloglu U. Risk and Outcome of Breakthrough COVID-19 Infections in Vaccinated Patients With Cancer: Real-World Evidence From the National COVID Cohort Collaborative. J Clin Oncol. 2022 May 01; 40(13):1414-1427. PMID: 35286152.
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    9. Li T, Mehraein-Ghomi F, Forbes ME, Namjoshi SV, Ballard EA, Song Q, Chou PC, Wang X, Parker Kerrigan BC, Lang FF, Lesser G, Debinski W, Yang X, Zhang W. HSP90-CDC37 functions as a chaperone for the oncogenic FGFR3-TACC3 fusion. Mol Ther. 2022 Apr 06; 30(4):1610-1627. PMID: 35151844.
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    10. Bian S, Ni W, Zhu M, Zhang X, Qiang Y, Zhang J, Ni Z, Shen Y, Qiu S, Song Q, Xiao M, Zheng W. Flap endonuclease 1 Facilitated Hepatocellular Carcinoma Progression by Enhancing USP7/MDM2-mediated P53 Inactivation. Int J Biol Sci. 2022; 18(3):1022-1038. PMID: 35173534.
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    11. Song Q, Liu L. Single-Cell RNA-Seq Technologies and Computational Analysis Tools: Application in Cancer Research. Methods Mol Biol. 2022; 2413:245-255. PMID: 35044670.
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    12. Liu Y, Wang L, Song Q, Ali M, Crowe WN, Kucera GL, Hawkins GA, Soker S, Thomas KW, Miller LD, Lu Y, Bellinger CR, Zhang W, Habib AA, Petty WJ, Zhao D. Intrapleural nano-immunotherapy promotes innate and adaptive immune responses to enhance anti-PD-L1 therapy for malignant pleural effusion. Nat Nanotechnol. 2021 Dec 16. PMID: 34916656.
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    13. Pullikuth AK, Routh ED, Zimmerman KD, Chifman J, Chou JW, Soike MH, Jin G, Su J, Song Q, Black MA, Print C, Bedognetti D, Howard-McNatt M, O'Neill SS, Thomas A, Langefeld CD, Sigalov AB, Lu Y, Miller LD. Bulk and Single-Cell Profiling of Breast Tumors Identifies TREM-1 as a Dominant Immune Suppressive Marker Associated With Poor Outcomes. Front Oncol. 2021; 11:734959. PMID: 34956864.
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    14. Zhu M, Huang Y, Bian S, Song Q, Zhang J, Zheng W, Cheng C. Organoids: Current Implications and Pharmaceutical Applications in Liver Diseases. Curr Mol Pharmacol. 2021 10 25; 14(4):498-508. PMID: 33334301.
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    15. Sharafeldin N, Bates B, Song Q, Madhira V, Shao YR, Liu F, Bergquist T, Su J, Topaloglu U. Reply to K. Takada et al. J Clin Oncol. 2021 12 10; 39(35):3997-3998. PMID: 34623872.
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    16. Song Q, Su J. DSTG: deconvoluting spatial transcriptomics data through graph-based artificial intelligence. Brief Bioinform. 2021 09 02; 22(5). PMID: 33480403.
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    17. Song Q, Su J, Zhang W. scGCN is a graph convolutional networks algorithm for knowledge transfer in single cell omics. Nat Commun. 2021 06 22; 12(1):3826. PMID: 34158507.
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    18. Sharafeldin N, Bates B, Song Q, Madhira V, Yan Y, Dong S, Lee E, Kuhrt N, Shao YR, Liu F, Bergquist T, Guinney J, Su J, Topaloglu U. Outcomes of COVID-19 in Patients With Cancer: Report From the National COVID Cohort Collaborative (N3C). J Clin Oncol. 2021 07 10; 39(20):2232-2246. PMID: 34085538.
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    19. Su J, Song Q, Qasem S, O'Neill S, Lee J, Furdui CM, Pasche B, Metheny-Barlow L, Masters AH, Lo HW, Xing F, Watabe K, Miller LD, Tatter SB, Laxton AW, Whitlow CT, Chan MD, Soike MH, Ruiz J. Multi-Omics Analysis of Brain Metastasis Outcomes Following Craniotomy. Front Oncol. 2020; 10:615472. PMID: 33889540.
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    20. Ni W, Bian S, Zhu M, Song Q, Zhang J, Xiao M, Zheng W. Identification and Validation of Ubiquitin-Specific Proteases as a Novel Prognostic Signature for Hepatocellular Carcinoma. Front Oncol. 2021; 11:629327. PMID: 33718205.
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    21. Zhu M, Wu M, Bian S, Song Q, Xiao M, Huang H, You L, Zhang J, Zhang J, Cheng C, Ni W, Zheng W. DNA primase subunit 1 deteriorated progression of hepatocellular carcinoma by activating AKT/mTOR signaling and UBE2C-mediated P53 ubiquitination. Cell Biosci. 2021 Feb 23; 11(1):42. PMID: 33622397.
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    22. Zheng W, Zhang J, Song Q, Xu Y, Zhu M, Ma J. Rac Family Small GTPase 3 Correlates with Progression and Poor Prognosis in Bladder Cancer. DNA Cell Biol. 2021 Mar; 40(3):469-481. PMID: 33600260.
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    23. Lu Z, Priya Rajan SA, Song Q, Zhao Y, Wan M, Aleman J, Skardal A, Bishop C, Atala A, Lu B. 3D scaffold-free microlivers with drug metabolic function generated by lineage-reprogrammed hepatocytes from human fibroblasts. Biomaterials. 2021 02; 269:120668. PMID: 33461059.
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    24. Kong X, Zeng D, Wu X, Wang B, Yang S, Song Q, Zhu Y, Salas M, Qin H, Nasri U, Haas KM, Riggs AD, Nakamura R, Martin PJ, Huang A, Zeng D. Tissue-resident PSGL1loCD4+ T cells promote B cell differentiation and chronic graft-versus-host disease-associated autoimmunity. J Clin Invest. 2021 Jan 04; 131(1). PMID: 32931481.
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    25. Zhang J, Song Q, Wu M, Zheng W. The Emerging Roles of Exosomes in the Chemoresistance of Hepatocellular Carcinoma. Curr Med Chem. 2021; 28(1):93-109. PMID: 32000636.
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    26. Song Q, Su J, Miller LD, Zhang W. scLM: Automatic Detection of Consensus Gene Clusters Across Multiple Single-cell Datasets. Genomics Proteomics Bioinformatics. 2020 Dec 23. PMID: 33359676.
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    27. Sun L, Zhang X, Song Q, Liu L, Forbes E, Tian W, Zhang Z, Kang Y, Wang H, Fleming JB, Pasche BC, Zhang W. IGFBP2 promotes tumor progression by inducing alternative polarization of macrophages in pancreatic ductal adenocarcinoma through the STAT3 pathway. Cancer Lett. 2021 Mar 01; 500:132-146. PMID: 33309859.
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    28. Bian S, Ni W, Zhu M, Song Q, Zhang J, Ni R, Zheng W. Identification and Validation of the N6-Methyladenosine RNA Methylation Regulator YTHDF1 as a Novel Prognostic Marker and Potential Target for Hepatocellular Carcinoma. Front Mol Biosci. 2020; 7:604766. PMID: 33363211.
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    29. Zhang J, Gu C, Song Q, Zhu M, Xu Y, Xiao M, Zheng W. Identifying cancer-associated fibroblasts as emerging targets for hepatocellular carcinoma. Cell Biosci. 2020 Oct 31; 10(1):127. PMID: 33292459.
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    30. Zhang J, Wu M, Xu Y, Song Q, Zheng W. Secretory Clusterin: A Promising Target for Chemoresistance of Hepatocellular Carcinoma. Mini Rev Med Chem. 2020; 20(12):1153-1165. PMID: 32228422.
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    31. Zhang J, Song Q, Liu J, Lu L, Xu Y, Zheng W. Cyclin-Dependent Kinase Regulatory Subunit 2 Indicated Poor Prognosis and Facilitated Aggressive Phenotype of Hepatocellular Carcinoma. Dis Markers. 2019; 2019:8964015. PMID: 31781310.
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    32. Song Q, Hawkins GA, Wudel L, Chou PC, Forbes E, Pullikuth AK, Liu L, Jin G, Craddock L, Topaloglu U, Kucera G, O'Neill S, Levine EA, Sun P, Watabe K, Lu Y, Alexander-Miller MA, Pasche B, Miller LD, Zhang W. Dissecting intratumoral myeloid cell plasticity by single cell RNA-seq. Cancer Med. 2019 06; 8(6):3072-3085. PMID: 31033233.
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    33. Luo J, Liu L, Venkateswaran S, Song Q, Zhou X. Author Correction: RPI-Bind: a structure-based method for accurate identification of RNA-protein binding sites. Sci Rep. 2018 Apr 05; 8(1):5767. PMID: 29622774.
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    34. Berger AC, Korkut A, Kanchi RS, Hegde AM, Lenoir W, Liu W, Liu Y, Fan H, Shen H, Ravikumar V, Rao A, Schultz A, Li X, Sumazin P, Williams C, Mestdagh P, Gunaratne PH, Yau C, Bowlby R, Robertson AG, Tiezzi DG, Wang C, Cherniack AD, Godwin AK, Kuderer NM, Rader JS, Zuna RE, Sood AK, Lazar AJ, Ojesina AI, Adebamowo C, Adebamowo SN, Baggerly KA, Chen TW, Chiu HS, Lefever S, Liu L, MacKenzie K, Orsulic S, Roszik J, Shelley CS, Song Q, Vellano CP, Wentzensen N, Weinstein JN, Mills GB, Levine DA, Akbani R. A Comprehensive Pan-Cancer Molecular Study of Gynecologic and Breast Cancers. Cancer Cell. 2018 04 09; 33(4):690-705.e9. PMID: 29622464.
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    35. Luo J, Liu L, Venkateswaran S, Song Q, Zhou X. RPI-Bind: a structure-based method for accurate identification of RNA-protein binding sites. Sci Rep. 2017 04 04; 7(1):614. PMID: 28377624.
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    36. Song Q, Wang H, Bao J, Pullikuth AK, Li KC, Miller LD, Zhou X. Systems biology approach to studying proliferation-dependent prognostic subnetworks in breast cancer. Sci Rep. 2015 Aug 10; 5:12981. PMID: 26257336.
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    37. Yu H, Song Q, Freedman BI, Chao J, Chao L, Rich SS, Bowden DW. Association of the tissue kallikrein gene promoter with ESRD and hypertension. Kidney Int. 2002 Mar; 61(3):1030-9. PMID: 11849458.
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