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Pierre-Alexandre Vidi, Ph.D.

TitleAssociate Professor
InstitutionWake Forest School of Medicine
DepartmentCancer Biology
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    Collapse Research 
    Collapse research activities and funding
    K99CA163957     (VIDI, PIERRE-ALEXANDRE)Aug 21, 2012 - Jul 31, 2014
    NIH/NCI
    Interplay Between Tissue Architecture and Nuclear Organization in the DNA Damage
    Role: Principal Investigator
    R00CA163957     (VIDI, PIERRE-ALEXANDRE)Aug 21, 2012 - Dec 31, 2017
    NIH/NCI
    Interplay Between Tissue Architecture and Nuclear Organization in the DNA Damage
    Role: Principal Investigator
    R01CA207222     (Singh)Apr 1, 2017 - Mar 31, 2022
    NCI
    Development of a novel therapeutic agent that exploits specific vulnerabilities in claudin-low breast cancer
    Role Description: The major goals of this project are: (1) To develop silvernanoparticles (AgNP) for selective treatment and radiosensitization of claudin-low breast cancer (CLBC); (2) To identify effects of AgNP exposure on endoplasmic reticulum stress, DNA damage redox-sensitive proteins and metabolic pathways in CLBC and non-CLBC cells; (3) To evaluate a mesenchymal molecular signature as an independent predictor of AgNP sensitivity in multiple types of cancer.
    Role: Co-I
    BC170905     (Vidi)Mar 1, 2018 - Feb 28, 2021
    DoD
    Impact of a community-based diabetes prevention trial on epithelial biomarkers of breast cancer risk
    Role Description: The goal is to test the hypothesis that the metabolic derangement experienced in prediabetes leads to loss of epithelial polarity and DNA damage in mammary epithelial cells, thereby priming cancer initiation, and that reversing metabolic dysfunctions may restore cell polarity and reduce the mutagenic burden.
    Role: PI
    U01CA214282     (Vidi)Sep 9, 2018 - Aug 31, 2023
    NCI
    Chromatin mobility in response to DNA damage
    Role Description: The goals of this project are (1) to develop new imaging technologies to track chromatin motions, (2) to characterize chromatin motions in cells exposed to DNA damaging agents and define functional consequences for DNA repair and genomic translocations, and (3) to evaluate the predictive value of chromatin kinetic measurement for prevention of therapy-induced myeloid neoplasms.
    Role: Multiple-PI
    U01CA214282     (VIDI, PIERRE-ALEXANDRE)Sep 19, 2018 - Aug 31, 2023
    NIH/NCI
    Chromatin mobility in response to DNA damage
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Manning L, Holmes J, Bonin K, Vidi PA. Radial Profile Analysis of Epithelial Polarity in Breast Acini: A Tool for Primary (Breast) Cancer Prevention. Front Med (Lausanne). 2019; 6:314. PMID: 31998733.
      View in: PubMed
    2. Swanner J, Fahrenholtz CD, Tenvooren I, Bernish BW, Sears JJ, Hooker A, Furdui CM, Alli E, Li W, Donati GL, Cook KL, Vidi PA, Singh R. Silver nanoparticles selectively treat triple-negative breast cancer cells without affecting non-malignant breast epithelial cells in vitro and in vivo. FASEB Bioadv. 2019 Oct; 1(10):639-660. PMID: 32123812.
      View in: PubMed
    3. Bazzoun D, Adissu HA, Wang L, Urazaev A, Tenvooren I, Fostok SF, Chittiboyina S, Sturgis J, Hodges K, Chandramouly G, Vidi PA, Talhouk RS, Lelièvre SA. Connexin 43 maintains tissue polarity and regulates mitotic spindle orientation in the breast epithelium. J Cell Sci. 2019 May 16; 132(10). PMID: 30992345.
      View in: PubMed
    4. Salvador Moreno N, Liu J, Haas KM, Parker LL, Chakraborty C, Kron SJ, Hodges K, Miller LD, Langefeld C, Robinson PJ, Lelièvre SA, Vidi PA. The nuclear structural protein NuMA is a negative regulator of 53BP1 in DNA double-strand break repair. Nucleic Acids Res. 2019 Apr 08; 47(6):2703-2715. PMID: 30812030.
      View in: PubMed
    5. Tenvooren I, Jenks MZ, Rashid H, Cook KL, Muhlemann JK, Sistrunk C, Holmes J, Wang K, Bonin K, Hodges K, Lo HW, Shaikh A, Camarillo IG, Lelièvre SA, Seewaldt V, Vidi PA. Elevated leptin disrupts epithelial polarity and promotes premalignant alterations in the mammary gland. Oncogene. 2019 May; 38(20):3855-3870. PMID: 30670780.
      View in: PubMed
    6. Xing F, Liu Y, Wu SY, Wu K, Sharma S, Mo YY, Feng J, Sanders S, Jin G, Singh R, Vidi PA, Tyagi A, Chan MD, Ruiz J, Debinski W, Pasche BC, Lo HW, Metheny-Barlow LJ, D'Agostino RB, Watabe K. Loss of XIST in Breast Cancer Activates MSN-c-Met and Reprograms Microglia via Exosomal miRNA to Promote Brain Metastasis. Cancer Res. 2018 08 01; 78(15):4316-4330. PMID: 30026327.
      View in: PubMed
    7. Bonin K, Smelser A, Moreno NS, Holzwarth G, Wang K, Levy P, Vidi PA. Structured illumination to spatially map chromatin motions. J Biomed Opt. 2018 05; 23(5):1-8. PMID: 29766687.
      View in: PubMed
    8. Jayaraman S, Chittiboyina S, Bai Y, Abad PC, Vidi PA, Stauffacher CV, Lelièvre SA. The nuclear mitotic apparatus protein NuMA controls rDNA transcription and mediates the nucleolar stress response in a p53-independent manner. Nucleic Acids Res. 2017 Nov 16; 45(20):11725-11742. PMID: 28981686.
      View in: PubMed
    9. Vidi PA, Anderson KA, Chen H, Anderson R, Salvador-Moreno N, Mora DC, Poutasse C, Laurienti PJ, Daniel SS, Arcury TA. Personal samplers of bioavailable pesticides integrated with a hair follicle assay of DNA damage to assess environmental exposures and their associated risks in children. Mutat Res. 2017 10; 822:27-33. PMID: 28844239.
      View in: PubMed
    10. Vega SL, Liu E, Arvind V, Bushman J, Sung HJ, Becker ML, Lelièvre S, Kohn J, Vidi PA, Moghe PV. High-content image informatics of the structural nuclear protein NuMA parses trajectories for stem/progenitor cell lineages and oncogenic transformation. Exp Cell Res. 2017 02 01; 351(1):11-23. PMID: 28034673.
      View in: PubMed
    11. Liu J, Vidi PA, Lelièvre SA, Irudayaraj JM. Nanoscale histone localization in live cells reveals reduced chromatin mobility in response to DNA damage. J Cell Sci. 2015 Feb 01; 128(3):599-604. PMID: 25501817.
      View in: PubMed
    12. Vidi PA, Liu J, Salles D, Jayaraman S, Dorfman G, Gray M, Abad P, Moghe PV, Irudayaraj JM, Wiesmüller L, Lelièvre SA. NuMA promotes homologous recombination repair by regulating the accumulation of the ISWI ATPase SNF2h at DNA breaks. Nucleic Acids Res. 2014 Jun; 42(10):6365-79. PMID: 24753406.
      View in: PubMed
    13. Vidi PA, Maleki T, Ochoa M, Wang L, Clark SM, Leary JF, Lelièvre SA. Disease-on-a-chip: mimicry of tumor growth in mammary ducts. Lab Chip. 2014 Jan 07; 14(1):172-7. PMID: 24202525.
      View in: PubMed
    14. Vidi PA, Leary JF, Lelièvre SA. Building risk-on-a-chip models to improve breast cancer risk assessment and prevention. Integr Biol (Camb). 2013 Sep; 5(9):1110-8. PMID: 23681255.
      View in: PubMed
    15. Vidi PA, Bissell MJ, Lelièvre SA. Three-dimensional culture of human breast epithelial cells: the how and the why. Methods Mol Biol. 2013; 945:193-219. PMID: 23097109.
      View in: PubMed
    16. Vidi PA, Chandramouly G, Gray M, Wang L, Liu E, Kim JJ, Roukos V, Bissell MJ, Moghe PV, Lelièvre SA. Interconnected contribution of tissue morphogenesis and the nuclear protein NuMA to the DNA damage response. J Cell Sci. 2012 Jan 15; 125(Pt 2):350-61. PMID: 22331358.
      View in: PubMed
    17. Bischof S, Baerenfaller K, Wildhaber T, Troesch R, Vidi PA, Roschitzki B, Hirsch-Hoffmann M, Hennig L, Kessler F, Gruissem W, Baginsky S. Plastid proteome assembly without Toc159: photosynthetic protein import and accumulation of N-acetylated plastid precursor proteins. Plant Cell. 2011 Nov; 23(11):3911-28. PMID: 22128122.
      View in: PubMed
    18. Cueva JP, Gallardo-Godoy A, Juncosa JI, Vidi PA, Lill MA, Watts VJ, Nichols DE. Probing the steric space at the floor of the D1 dopamine receptor orthosteric binding domain: 7a-, 7ß-, 8a-, and 8ß-methyl substituted dihydrexidine analogues. J Med Chem. 2011 Aug 11; 54(15):5508-21. PMID: 21714510.
      View in: PubMed
    19. Chen J, Nag S, Vidi PA, Irudayaraj J. Single molecule in vivo analysis of toll-like receptor 9 and CpG DNA interaction. PLoS One. 2011 Apr 04; 6(4):e17991. PMID: 21483736.
      View in: PubMed
    20. Grafton MM, Wang L, Vidi PA, Leary J, Lelièvre SA. Breast on-a-chip: mimicry of the channeling system of the breast for development of theranostics. Integr Biol (Camb). 2011 Apr; 3(4):451-9. PMID: 21234506.
      View in: PubMed
    21. Vidi PA, Ejendal KF, Przybyla JA, Watts VJ. Fluorescent protein complementation assays: new tools to study G protein-coupled receptor oligomerization and GPCR-mediated signaling. Mol Cell Endocrinol. 2011 Jan 15; 331(2):185-93. PMID: 20654687.
      View in: PubMed
    22. Vidi PA, Przybyla JA, Hu CD, Watts VJ. Visualization of G protein-coupled receptor (GPCR) interactions in living cells using bimolecular fluorescence complementation (BiFC). Curr Protoc Neurosci. 2010 Apr; Chapter 5:Unit 5.29. PMID: 20373507.
      View in: PubMed
    23. Zbierzak AM, Kanwischer M, Wille C, Vidi PA, Giavalisco P, Lohmann A, Briesen I, Porfirova S, Bréhélin C, Kessler F, Dörmann P. Intersection of the tocopherol and plastoquinol metabolic pathways at the plastoglobule. Biochem J. 2009 Dec 23; 425(2):389-99. PMID: 19843012.
      View in: PubMed
    24. Meskauskiene R, Würsch M, Laloi C, Vidi PA, Coll NS, Kessler F, Baruah A, Kim C, Apel K. A mutation in the Arabidopsis mTERF-related plastid protein SOLDAT10 activates retrograde signaling and suppresses (1)O(2)-induced cell death. Plant J. 2009 Nov; 60(3):399-410. PMID: 19563435.
      View in: PubMed
    25. Vidi PA, Watts VJ. Fluorescent and bioluminescent protein-fragment complementation assays in the study of G protein-coupled receptor oligomerization and signaling. Mol Pharmacol. 2009 Apr; 75(4):733-9. PMID: 19141658.
      View in: PubMed
    26. Vidi PA, Chen J, Irudayaraj JM, Watts VJ. Adenosine A(2A) receptors assemble into higher-order oligomers at the plasma membrane. FEBS Lett. 2008 Dec 10; 582(29):3985-90. PMID: 19013155.
      View in: PubMed
    27. Vidi PA, Chemel BR, Hu CD, Watts VJ. Ligand-dependent oligomerization of dopamine D(2) and adenosine A(2A) receptors in living neuronal cells. Mol Pharmacol. 2008 Sep; 74(3):544-51. PMID: 18524886.
      View in: PubMed
    28. Vidi PA, Kessler F, Bréhélin C. Plastoglobules: a new address for targeting recombinant proteins in the chloroplast. BMC Biotechnol. 2007 Jan 10; 7:4. PMID: 17214877.
      View in: PubMed
    29. Kessler F, Vidi PA. Plastoglobule lipid bodies: their functions in chloroplasts and their potential for applications. Adv Biochem Eng Biotechnol. 2007; 107:153-72. PMID: 17522825.
      View in: PubMed
    30. Austin JR, Frost E, Vidi PA, Kessler F, Staehelin LA. Plastoglobules are lipoprotein subcompartments of the chloroplast that are permanently coupled to thylakoid membranes and contain biosynthetic enzymes. Plant Cell. 2006 Jul; 18(7):1693-703. PMID: 16731586.
      View in: PubMed
    31. Vidi PA, Kanwischer M, Baginsky S, Austin JR, Csucs G, Dörmann P, Kessler F, Bréhélin C. Tocopherol cyclase (VTE1) localization and vitamin E accumulation in chloroplast plastoglobule lipoprotein particles. J Biol Chem. 2006 Apr 21; 281(16):11225-34. PMID: 16414959.
      View in: PubMed
    32. Bauer J, Hiltbrunner A, Weibel P, Vidi PA, Alvarez-Huerta M, Smith MD, Schnell DJ, Kessler F. Essential role of the G-domain in targeting of the protein import receptor atToc159 to the chloroplast outer membrane. J Cell Biol. 2002 Dec 09; 159(5):845-54. PMID: 12460988.
      View in: PubMed
    33. Hiltbrunner A, Bauer J, Vidi PA, Infanger S, Weibel P, Hohwy M, Kessler F. Targeting of an abundant cytosolic form of the protein import receptor at Toc159 to the outer chloroplast membrane. J Cell Biol. 2001 Jul 23; 154(2):309-16. PMID: 11470820.
      View in: PubMed
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