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Last Name

Patrick Michael McNutt, Ph.D.

TitleAssociate Professor
InstitutionWake Forest School of Medicine
DepartmentWF Institute for Regen Medicine
Address
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    Collapse ORNG Applications 
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    Collapse Biography 
    Collapse education and training
    Princeton University, Princeton, NJPhD12/2000Cellular and Molecular Biology
    Wake Forest University, Winston-Salem, NCBS12/1994Biology
    Wake Forest University, Winston-Salem, NCBA12/1994Chemistry
    Princeton University, Princeton, NJMA05/1996Cellular and Molecular Biology

    Collapse Overview 
    Collapse overview
    I am excited to return to Wake Forest University, where I earned degrees in biology and chemistry before completing a PhD in Cellular and Molecular Biology at Princeton University. I served as an Army officer for eight years after graduate school, including a tour in Iraq. I accepted a DoD Principal Investigator position in 2010, and for ten years ran a large research program to develop countermeasures for highly dangerous biological and chemical poisons affecting the central and peripheral nervous systems as well as the cornea of the eye. I am excited to translate my DoD research experience to WFIRM, where I will (1) use fundamental studies to understand toxic mechanisms of diverse poisons at scales ranging from individual receptors to multi-organ physiological responses; (2) develop comprehensive therapies that mitigate toxicity and promote regeneration; and (3) exploit WFIRM's unique capabilities to develop organoid models of complex diseases and toxic injuries.

    My research priorities are:
    1. Investigate molecular, cellular and functional mechanisms underlying toxicity and regeneration, with the goal of applying new knowledge to treat and cure human disease
    2. Expand scientific knowledge through creativity, excellence and rigor
    3. Advance the next generation of scientists.

    A current list of publications is available at
    https://orcid.org/0000-0002-5703-4565
    and
    https://scholar.google.com/citations?user=ceRIHocAAAAJ&hl


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. McNutt PM, Kelly KEM, Altvater AC, Nelson MR, Lyman ME, O'Brien S, Conroy MT, Ondeck CA, Bodt SML, Wolfe SE, Schulz SM, Kniffin DM, Hall NB, Hamilton TA. Dose-dependent emergence of acute and recurrent corneal lesions in sulfur mustard-exposed rabbit eyes. Toxicol Lett. 2021 May 01; 341:33-42. PMID: 33497768.
      View in: PubMed
    2. McNutt PM, Vazquez-Cintron EJ, Tenezaca L, Ondeck CA, Kelly KE, Mangkhalakhili M, Machamer JB, Angeles CA, Glotfelty EJ, Cika J, Benjumea CH, Whitfield JT, Band PA, Shoemaker CB, Ichtchenko K. Neuronal delivery of antibodies has therapeutic effects in animal models of botulism. Sci Transl Med. 2021 Jan 06; 13(575). PMID: 33408188.
      View in: PubMed
    3. Winner BM, Bodt SML, McNutt PM. Special Delivery: Potential Mechanisms of Botulinum Neurotoxin Uptake and Trafficking within Motor Nerve Terminals. Int J Mol Sci. 2020 Nov 18; 21(22). PMID: 33218099.
      View in: PubMed
    4. McNutt PM, Mohan RR. The Need for Improved Therapeutic Approaches to Protect the Cornea Against Chemotoxic Injuries. Transl Vis Sci Technol. 2020 11; 9(12):2. PMID: 33200044.
      View in: PubMed
    5. Tremblay JM, Vazquez-Cintron E, Lam KH, Mukherjee J, Bedenice D, Ondeck CA, Conroy MT, Bodt SML, Winner BM, Webb RP, Ichtchenko K, Jin R, McNutt PM, Shoemaker CB. Camelid VHH Antibodies that Neutralize Botulinum Neurotoxin Serotype E Intoxication or Protease Function. Toxins (Basel). 2020 09 24; 12(10). PMID: 32987745.
      View in: PubMed
    6. Machamer JB, Apland JP, Winner BM, Wolfe SE, Pagarigan KT, Bounader KM, Kasten SA, Adler M, McNutt PM. Functional basis for dose-dependent antagonism of rat and rabbit neuromuscular transmission by the bis-pyridinium oxime MMB4. Arch Toxicol. 2020 11; 94(11):3877-3891. PMID: 32691075.
      View in: PubMed
    7. Yeung DT, Araj H, McNutt PM. Abstracts of Presentations from the 2020 Trans-Agency Scientific Meeting on Developing Medical Countermeasures to Treat the Acute and Chronic Effects of Ocular Chemical Toxicity, 25-26 February, Bethesda, Maryland. Toxicol Lett. 2020 May 25; 1-3. PMID: 32464237.
      View in: PubMed
    8. McNutt PM, Nguyen DL, Nelson MR, Lyman ME, Eisen MM, Ondeck CA, Wolfe SE, Pagarigan KT, Mangkhalakhili MC, Kniffin DM, Hamilton TA. Corneal Endothelial Cell Toxicity Determines Long-Term Outcome After Ocular Exposure to Sulfur Mustard Vapor. Cornea. 2020 May; 39(5):640-648. PMID: 32044824.
      View in: PubMed
    9. McCarren HS, Eisen MR, Nguyen DL, Dubée PB, Ardinger CE, Dunn EN, Haines KM, Santoro AN, Bodner PM, Ondeck CA, Honnold CL, McDonough JH, Beske PH, McNutt PM. Characterization and treatment of spontaneous recurrent seizures following nerve agent-induced status epilepticus in mice. Epilepsy Res. 2020 05; 162:106320. PMID: 32182542.
      View in: PubMed
    10. Lam KH, Tremblay JM, Vazquez-Cintron E, Perry K, Ondeck C, Webb RP, McNutt PM, Shoemaker CB, Jin R. Structural Insights into Rational Design of Single-Domain Antibody-Based Antitoxins against Botulinum Neurotoxins. Cell Rep. 2020 02 25; 30(8):2526-2539.e6. PMID: 32101733.
      View in: PubMed
    11. Vazquez-Cintron E, Machamer J, Ondeck C, Pagarigan K, Winner B, Bodner P, Kelly K, Pennington MR, McNutt P. Symptomatic treatment of botulism with a clinically approved small molecule. JCI Insight. 2020 01 30; 5(2). PMID: 31996484.
      View in: PubMed
    12. Hoffman KM, Eisen MR, Chandler JK, Nelson MR, Johnson EA, McNutt PM. Retrograde activation of CB1R by muscarinic receptors protects against central organophosphorus toxicity. Neuropharmacology. 2019 09 01; 155:113-120. PMID: 31132436.
      View in: PubMed
    13. Thirunavukkarasu N, Johnson E, Pillai S, Hodge D, Stanker L, Wentz T, Singh B, Venkateswaran K, McNutt P, Adler M, Brown E, Hammack T, Burr D, Sharma S. Botulinum Neurotoxin Detection Methods for Public Health Response and Surveillance. Front Bioeng Biotechnol. 2018; 6:80. PMID: 29988463.
      View in: PubMed
    14. Wang H, Wagner GW, Lu AX, Nguyen DL, Buchanan JH, McNutt PM, Karwacki CJ. Photocatalytic Oxidation of Sulfur Mustard and Its Simulant on BODIPY-Incorporated Polymer Coatings and Fabrics. ACS Appl Mater Interfaces. 2018 Jun 06; 10(22):18771-18777. PMID: 29766717.
      View in: PubMed
    15. Bradford AB, Machamer JB, Russo TM, McNutt PM. 3,4-diaminopyridine reverses paralysis in botulinum neurotoxin-intoxicated diaphragms through two functionally distinct mechanisms. Toxicol Appl Pharmacol. 2018 02 15; 341:77-86. PMID: 29366638.
      View in: PubMed
    16. Beske PH, Hoffman KM, Machamer JB, Eisen MR, McNutt PM. Use-dependent potentiation of voltage-gated calcium channels rescues neurotransmission in nerve terminals intoxicated by botulinum neurotoxin serotype A. Sci Rep. 2017 Nov 20; 7(1):15862. PMID: 29158500.
      View in: PubMed
    17. Beske PH, Bradford AB, Hoffman KM, Mason SJ, McNutt PM. In vitro and ex vivo screening of candidate therapeutics to restore neurotransmission in nerve terminals intoxicated by botulinum neurotoxin serotype A1. Toxicon. 2018 Jun 01; 147:47-53. PMID: 29054436.
      View in: PubMed
    18. Vazquez-Cintron EJ, Beske PH, Tenezaca L, Tran BQ, Oyler JM, Glotfelty EJ, Angeles CA, Syngkon A, Mukherjee J, Kalb SR, Band PA, McNutt PM, Shoemaker CB, Ichtchenko K. Engineering Botulinum Neurotoxin C1 as a Molecular Vehicle for Intra-Neuronal Drug Delivery. Sci Rep. 2017 02 21; 7:42923. PMID: 28220863.
      View in: PubMed
    19. McNutt PM, Tuznik KM, Glotfelty EJ, Nelson MR, Lyman ME, Hamilton TA. Contributions of tissue-specific pathologies to corneal injuries following exposure to SM vapor. Ann N Y Acad Sci. 2016 06; 1374(1):132-43. PMID: 27310673.
      View in: PubMed
    20. Beske PH, Bradford AB, Grynovicki JO, Glotfelty EJ, Hoffman KM, Hubbard KS, Tuznik KM, McNutt PM. Botulinum and Tetanus Neurotoxin-Induced Blockade of Synaptic Transmission in Networked Cultures of Human and Rodent Neurons. Toxicol Sci. 2016 Feb; 149(2):503-15. PMID: 26615023.
      View in: PubMed
    21. Bradford AB, McNutt PM. Importance of being Nernst: Synaptic activity and functional relevance in stem cell-derived neurons. World J Stem Cells. 2015 Jul 26; 7(6):899-921. PMID: 26240679.
      View in: PubMed
    22. McNutt P, Gut I, Hubbard K, Beske P. A novel method to prioritize RNAseq data for post-hoc analysis based on absolute changes in transcript abundance. Stat Appl Genet Mol Biol. 2015 Jun; 14(3):227-41. PMID: 25781714.
      View in: PubMed
    23. Beske PH, Scheeler SM, Adler M, McNutt PM. Accelerated intoxication of GABAergic synapses by botulinum neurotoxin A disinhibits stem cell-derived neuron networks prior to network silencing. Front Cell Neurosci. 2015; 9:159. PMID: 25954159.
      View in: PubMed
    24. Hubbard K, Beske P, Lyman M, McNutt P. Functional evaluation of biological neurotoxins in networked cultures of stem cell-derived central nervous system neurons. J Vis Exp. 2015 Feb 05; (96). PMID: 25742030.
      View in: PubMed
    25. Gore A, Horwitz V, Gutman H, Tveria L, Cohen L, Cohen-Jacob O, Turetz J, McNutt PM, Dachir S, Kadar T. Cultivation and characterization of limbal epithelial stem cells on contact lenses with a feeder layer: toward the treatment of limbal stem cell deficiency. Cornea. 2014 Jan; 33(1):65-71. PMID: 24162749.
      View in: PubMed
    26. McNutt P, Tuznik K, Nelson M, Adkins A, Lyman M, Glotfelty E, Hughes J, Hamilton T. Structural, morphological, and functional correlates of corneal endothelial toxicity following corneal exposure to sulfur mustard vapor. Invest Ophthalmol Vis Sci. 2013 Oct 15; 54(10):6735-44. PMID: 24045986.
      View in: PubMed
    27. Gut IM, Beske PH, Hubbard KS, Lyman ME, Hamilton TA, McNutt PM. Novel application of stem cell-derived neurons to evaluate the time- and dose-dependent progression of excitotoxic injury. PLoS One. 2013; 8(5):e64423. PMID: 23691214.
      View in: PubMed
    28. Andres D, Keyser BM, Petrali J, Benton B, Hubbard KS, McNutt PM, Ray R. Morphological and functional differentiation in BE(2)-M17 human neuroblastoma cells by treatment with Trans-retinoic acid. BMC Neurosci. 2013 Apr 18; 14:49. PMID: 23597229.
      View in: PubMed
    29. Hubbard KS, Gut IM, Lyman ME, McNutt PM. Longitudinal RNA sequencing of the deep transcriptome during neurogenesis of cortical glutamatergic neurons from murine ESCs. F1000Res. 2013; 2:35. PMID: 24358889.
      View in: PubMed
    30. Hubbard KS, Gut IM, Lyman ME, Tuznik KM, Mesngon MT, McNutt PM. High yield derivation of enriched glutamatergic neurons from suspension-cultured mouse ESCs for neurotoxicology research. BMC Neurosci. 2012 Oct 24; 13:127. PMID: 23095170.
      View in: PubMed
    31. Hubbard KS, Gut IM, Scheeler SM, Lyman ME, McNutt PM. Compatibility of SYTO 13 and Hoechst 33342 for longitudinal imaging of neuron viability and cell death. BMC Res Notes. 2012 Aug 14; 5:437. PMID: 22892216.
      View in: PubMed
    32. McNutt P, Lyman M, Swartz A, Tuznik K, Kniffin D, Whitten K, Milhorn D, Hamilton T. Architectural and biochemical expressions of mustard gas keratopathy: preclinical indicators and pathogenic mechanisms. PLoS One. 2012; 7(8):e42837. PMID: 22900056.
      View in: PubMed
    33. McNutt P, Hamilton T, Nelson M, Adkins A, Swartz A, Lawrence R, Milhorn D. Pathogenesis of acute and delayed corneal lesions after ocular exposure to sulfur mustard vapor. Cornea. 2012 Mar; 31(3):280-90. PMID: 22316652.
      View in: PubMed
    34. Mesngon M, McNutt P. Alpha-latrotoxin rescues SNAP-25 from BoNT/A-mediated proteolysis in embryonic stem cell-derived neurons. Toxins (Basel). 2011 05; 3(5):489-503. PMID: 22069721.
      View in: PubMed
    35. McNutt P, Celver J, Hamilton T, Mesngon M. Embryonic stem cell-derived neurons are a novel, highly sensitive tissue culture platform for botulinum research. Biochem Biophys Res Commun. 2011 Feb 04; 405(1):85-90. PMID: 21215258.
      View in: PubMed
    36. Milhorn D, Hamilton T, Nelson M, McNutt P. Progression of ocular sulfur mustard injury: development of a model system. Ann N Y Acad Sci. 2010 Apr; 1194:72-80. PMID: 20536452.
      View in: PubMed
    37. Gotkin JL, Celver J, McNutt P, Shields AD, Howard BC, Paonessa DJ, Napolitano PG. Progesterone reduces lipopolysaccharide induced interleukin-6 secretion in fetoplacental chorionic arteries, fractionated cord blood, and maternal mononuclear cells. Am J Obstet Gynecol. 2006 Oct; 195(4):1015-9. PMID: 17000234.
      View in: PubMed
    38. Cronk DR, Houseworth TP, Cuadrado DG, Herbert GS, McNutt PM, Azarow KS. Intestinal fatty acid binding protein (I-FABP) for the detection of strangulated mechanical small bowel obstruction. Curr Surg. 2006 Sep-Oct; 63(5):322-5. PMID: 16971202.
      View in: PubMed
    39. McNutt PM, Dehart MJ, Matej LA. Characterization of the 16S-23S internal transcribed spacer among 34 higher plants: suitability for interspecific plastid transformation. . 2007 Jan; 26(1):47-60. PMID: 16912867.
      View in: PubMed
    40. Harsha WT, Kalandarova E, McNutt P, Irwin R, Noel J. Nutritional supplementation with transforming growth factor-beta, glutamine, and short chain fatty acids minimizes methotrexate-induced injury. J Pediatr Gastroenterol Nutr. 2006 Jan; 42(1):53-8. PMID: 16385254.
      View in: PubMed
    41. Steinberg MS, McNutt PM. Cadherins and their connections: adhesion junctions have broader functions. Curr Opin Cell Biol. 1999 Oct; 11(5):554-60. PMID: 10508659.
      View in: PubMed
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