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Paul Czoty PhD

TitleProfessor
InstitutionWake Forest School of Medicine
DepartmentTranslational Neuroscience
Address
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    F31DA005804     (CZOTY, PAUL W.)Jan 24, 1998
    NIH
    NEUROPHARMACOLOGY OF COCAINE AND SEROTONIN IN MONKEYS
    Role: Principal Investigator
    R01DA021658     (CZOTY, PAUL W.)Jul 1, 2007 - Jun 30, 2014
    NIH
    Cocaine discrimination, self-administration and microdialysis in monkeys
    Role: Principal Investigator
    R03DA029178     (CZOTY, PAUL W.)May 1, 2010 - Aug 31, 2012
    NIH
    Brain imaging and cognitive effects of cocaine self-administration in monkeys
    Role: Principal Investigator
    R01DA039953     (CZOTY, PAUL W.)Sep 15, 2016 - Jun 30, 2021
    NIH
    Interactions of Ethanol & Cocaine Self-Administration in Monkeys
    Role: Principal Investigator
    R01AA027556     (CZOTY, PAUL W.)Jul 10, 2020 - Apr 30, 2025
    NIH
    NOP Receptors in nonhuman primate models of AUD
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Flynn SM, Epperly PM, Davenport AT, Cami-Kobeci G, Husbands SM, Ko MC, Czoty PW. Effects of stimulation of mu opioid and nociceptin/orphanin FQ peptide (NOP) receptors on alcohol drinking in rhesus monkeys. Neuropsychopharmacology. 2019 07; 44(8):1476-1484. PMID: 30970376.
      Citations:    
    2. Kiguchi N, Ding H, Cami-Kobeci G, Sukhtankar DD, Czoty PW, DeLoid HB, Hsu FC, Toll L, Husbands SM, Ko MC. BU10038 as a safe opioid analgesic with fewer side-effects after systemic and intrathecal administration in primates. Br J Anaesth. 2019 Jun; 122(6):e146-e156. PMID: 30916003.
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    3. Thomas SG, Czoty PW. Effect of menstrual cycle on ethanol drinking in rhesus monkeys. Drug Alcohol Depend. 2019 01 01; 194:205-209. PMID: 30453105.
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    4. Ding H, Kiguchi N, Yasuda D, Daga PR, Polgar WE, Lu JJ, Czoty PW, Kishioka S, Zaveri NT, Ko MC. A bifunctional nociceptin and mu opioid receptor agonist is analgesic without opioid side effects in nonhuman primates. Sci Transl Med. 2018 08 29; 10(456). PMID: 30158150.
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    5. Banks ML, Czoty PW, Negus SS. Utility of Nonhuman Primates in Substance Use Disorders Research. ILAR J. 2017 12 01; 58(2):202-215. PMID: 28531265.
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    6. Czoty PW, John WS, Newman AH, Nader MA. Yawning elicited by intravenous ethanol in rhesus monkeys with experience self-administering cocaine and ethanol: Involvement of dopamine D3 receptors. Alcohol. 2018 06; 69:1-5. PMID: 29550583.
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    7. Czoty PW, Gould RW, Gage HD, Nader MA. Effects of social reorganization on dopamine D2/D3 receptor availability and cocaine self-administration in male cynomolgus monkeys. Psychopharmacology (Berl). 2017 Sep; 234(18):2673-2682. PMID: 28608008.
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    8. Gould RW, Czoty PW, Porrino LJ, Nader MA. Social Status in Monkeys: Effects of Social Confrontation on Brain Function and Cocaine Self-Administration. Neuropsychopharmacology. 2017 Apr; 42(5):1093-1102. PMID: 28025974.
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    9. Czoty PW. Lack of effect of ethanol on cocaine prime-induced reinstatement of extinguished cocaine self-administration in rhesus monkeys. Behav Pharmacol. 2016 10; 27(7):633-6. PMID: 27509315.
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    10. Ding H, Czoty PW, Kiguchi N, Cami-Kobeci G, Sukhtankar DD, Nader MA, Husbands SM, Ko MC. A novel orvinol analog, BU08028, as a safe opioid analgesic without abuse liability in primates. Proc Natl Acad Sci U S A. 2016 09 13; 113(37):E5511-8. PMID: 27573832.
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    11. Czoty PW, Stoops WW, Rush CR. Evaluation of the "Pipeline" for Development of Medications for Cocaine Use Disorder: A Review of Translational Preclinical, Human Laboratory, and Clinical Trial Research. Pharmacol Rev. 2016 07; 68(3):533-62. PMID: 27255266.
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    12. Czoty PW, Blough BE, Fennell TR, Snyder RW, Nader MA. Attenuation of cocaine self-administration by chronic oral phendimetrazine in rhesus monkeys. Neuroscience. 2016 Jun 02; 324:367-76. PMID: 26964683.
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    13. Kromrey SA, Czoty PW, Nader SH, Register TC, Nader MA. Preclinical laboratory assessments of predictors of social rank in female cynomolgus monkeys. Am J Primatol. 2016 Apr; 78(4):402-417. PMID: 26684077.
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    14. Czoty PW. Effects of chronic binge-like ethanol consumption on cocaine self-administration in rhesus monkeys. Drug Alcohol Depend. 2015 Aug 01; 153:278-85. PMID: 26048636.
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    15. Kromrey SA, Czoty PW, Nader MA. Relationship between estradiol and progesterone concentrations and cognitive performance in normally cycling female cynomolgus monkeys. Horm Behav. 2015 Jun; 72:12-9. PMID: 25921587.
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    16. Keck TM, John WS, Czoty PW, Nader MA, Newman AH. Identifying Medication Targets for Psychostimulant Addiction: Unraveling the Dopamine D3 Receptor Hypothesis. J Med Chem. 2015 Jul 23; 58(14):5361-80. PMID: 25826710.
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    17. Czoty PW, Nader MA. Effects of oral and intravenous administration of buspirone on food-cocaine choice in socially housed male cynomolgus monkeys. Neuropsychopharmacology. 2015 Mar 13; 40(5):1072-83. PMID: 25393717.
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    18. Czoty PW, Tran P, Thomas LN, Martin TJ, Grigg A, Blough BE, Beveridge TJ. Effects of the dopamine/norepinephrine releaser phenmetrazine on cocaine self-administration and cocaine-primed reinstatement in rats. Psychopharmacology (Berl). 2015 Jul; 232(13):2405-14. PMID: 25673020.
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    19. Kromrey SA, Gould RW, Nader MA, Czoty PW. Effects of prior cocaine self-administration on cognitive performance in female cynomolgus monkeys. Psychopharmacology (Berl). 2015 Jun; 232(11):2007-16. PMID: 25633093.
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    20. Martelle SE, Nader SH, Czoty PW, John WS, Duke AN, Garg PK, Garg S, Newman AH, Nader MA. Further characterization of quinpirole-elicited yawning as a model of dopamine D3 receptor activation in male and female monkeys. J Pharmacol Exp Ther. 2014 Aug; 350(2):205-11. PMID: 24876234.
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    21. Phillips KA, Bales KL, Capitanio JP, Conley A, Czoty PW, 't Hart BA, Hopkins WD, Hu SL, Miller LA, Nader MA, Nathanielsz PW, Rogers J, Shively CA, Voytko ML. Why primate models matter. Am J Primatol. 2014 Sep; 76(9):801-27. PMID: 24723482.
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    22. Czoty PW, Gage HD, Garg PK, Garg S, Nader MA. Effects of repeated treatment with the dopamine D2/D3 receptor partial agonist aripiprazole on striatal D2/D3 receptor availability in monkeys. Psychopharmacology (Berl). 2013 Sep 29. PMID: 24077804.
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    23. Czoty PW, Martelle SE, Gould RW, Nader MA. Effects of chronic methylphenidate on cocaine self-administration under a progressive-ratio schedule of reinforcement in rhesus monkeys. J Pharmacol Exp Ther. 2013 Jun; 345(3):374-82. PMID: 23579044.
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    24. Czoty PW, Nader MA. Effects of dopamine D2/D3 receptor ligands on food-cocaine choice in socially housed male cynomolgus monkeys. J Pharmacol Exp Ther. 2013 Feb; 344(2):329-38. PMID: 23211363.
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    25. Nader MA, Czoty PW, Nader SH, Morgan D. Nonhuman primate models of social behavior and cocaine abuse. Psychopharmacology (Berl). 2012 Nov; 224(1):57-67. PMID: 22895674.
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    26. Nader MA, Nader SH, Czoty PW, Riddick NV, Gage HD, Gould RW, Blaylock BL, Kaplan JR, Garg PK, Davies HM, Morton D, Garg S, Reboussin BA. Social dominance in female monkeys: dopamine receptor function and cocaine reinforcement. Biol Psychiatry. 2012 Sep 01; 72(5):414-21. PMID: 22503110.
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    27. Czoty PW, Nader MA. Individual differences in the effects of environmental stimuli on cocaine choice in socially housed male cynomolgus monkeys. Psychopharmacology (Berl). 2012 Nov; 224(1):69-79. PMID: 22083591.
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    28. Czoty PW, Roberts DC. Thinking outside the synapse: pharmacokinetic-based medications for cocaine addiction. Neuropsychopharmacology. 2012 Apr; 37(5):1079-80. PMID: 22071873.
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    29. Gould RW, Czoty PW, Nader SH, Nader MA. Effects of varenicline on the reinforcing and discriminative stimulus effects of cocaine in rhesus monkeys. J Pharmacol Exp Ther. 2011 Nov; 339(2):678-86. PMID: 21856860.
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    30. Gould RW, Gage HD, Banks ML, Blaylock BL, Czoty PW, Nader MA. Differential effects of cocaine and MDMA self-administration on cortical serotonin transporter availability in monkeys. Neuropharmacology. 2011 Jul-Aug; 61(1-2):245-51. PMID: 21521647.
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    31. Hamilton LR, Czoty PW, Nader MA. Behavioral characterization of adult male and female rhesus monkeys exposed to cocaine throughout gestation. Psychopharmacology (Berl). 2011 Feb; 213(4):799-808. PMID: 20959969.
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    32. Czoty PW, Gould RW, Martelle JL, Nader MA. Prolonged attenuation of the reinforcing strength of cocaine by chronic d-amphetamine in rhesus monkeys. Neuropsychopharmacology. 2011 Jan; 36(2):539-47. PMID: 20962765.
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    33. Czoty PW, Martelle JL, Carroll FI, Nader MA. Lower reinforcing strength of the phenyltropane cocaine analogs RTI-336 and RTI-177 compared to cocaine in nonhuman primates. Pharmacol Biochem Behav. 2010 Sep; 96(3):274-8. PMID: 20580733.
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    34. Hamilton LR, Czoty PW, Gage HD, Nader MA. Characterization of the dopamine receptor system in adult rhesus monkeys exposed to cocaine throughout gestation. Psychopharmacology (Berl). 2010 Jul; 210(4):481-8. PMID: 20401746.
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    35. Czoty PW, Martelle JL, Nader MA. Effects of chronic d-amphetamine administration on the reinforcing strength of cocaine in rhesus monkeys. Psychopharmacology (Berl). 2010 May; 209(4):375-82. PMID: 20217052.
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    36. Czoty PW, Gage HD, Nader MA. Differences in D2 dopamine receptor availability and reaction to novelty in socially housed male monkeys during abstinence from cocaine. Psychopharmacology (Berl). 2010 Mar; 208(4):585-92. PMID: 20066401.
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    37. Wilson TW, Godwin DW, Czoty PW, Nader MA, Kraft RA, Buchheimer NC, Daunais JB. A MEG investigation of somatosensory processing in the rhesus monkey. Neuroimage. 2009 Jul 15; 46(4):998-1003. PMID: 19306931.
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    38. Czoty PW, Gould RW, Nader MA. Relationship between social rank and cortisol and testosterone concentrations in male cynomolgus monkeys (Macaca fascicularis). J Neuroendocrinol. 2009 Jan; 21(1):68-76. PMID: 19094095.
      Citations:    
    39. Riddick NV, Czoty PW, Gage HD, Kaplan JR, Nader SH, Icenhower M, Pierre PJ, Bennett A, Garg PK, Garg S, Nader MA. Behavioral and neurobiological characteristics influencing social hierarchy formation in female cynomolgus monkeys. Neuroscience. 2009 Feb 18; 158(4):1257-65. PMID: 19059311.
      Citations:    
    40. Nader MA, Czoty PW, Gould RW, Riddick NV. Review. Positron emission tomography imaging studies of dopamine receptors in primate models of addiction. Philos Trans R Soc Lond B Biol Sci. 2008 Oct 12; 363(1507):3223-32. PMID: 18640923.
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    41. Martelle JL, Czoty PW, Nader MA. Effect of time-out duration on the reinforcing strength of cocaine assessed under a progressive-ratio schedule in rhesus monkeys. Behav Pharmacol. 2008 Oct; 19(7):743-6. PMID: 18797251.
      Citations:    
    42. Banks ML, Gould RW, Czoty PW, Nader MA. Relationship between response rates and measures of reinforcing strength using a choice procedure in monkeys. Behav Pharmacol. 2008 Jul; 19(4):365-9. PMID: 18622187.
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    43. Banks ML, Czoty PW, Sprague JE, Nader MA. Influence of thyroid hormones on 3,4-methylenedioxymethamphetamine-induced thermogenesis and reinforcing strength in monkeys. Behav Pharmacol. 2008 Mar; 19(2):167-70. PMID: 18332682.
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    44. Czoty PW, Riddick NV, Gage HD, Sandridge M, Nader SH, Garg S, Bounds M, Garg PK, Nader MA. Effect of menstrual cycle phase on dopamine D2 receptor availability in female cynomolgus monkeys. Neuropsychopharmacology. 2009 Feb; 34(3):548-54. PMID: 18256593.
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    45. Nader MA, Czoty PW. Brain imaging in nonhuman primates: insights into drug addiction. ILAR J. 2008; 49(1):89-102. PMID: 18172336.
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    46. Banks ML, Sprague JE, Czoty PW, Nader MA. Effects of ambient temperature on the relative reinforcing strength of MDMA using a choice procedure in monkeys. Psychopharmacology (Berl). 2008 Jan; 196(1):63-70. PMID: 17899019.
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    47. Banks ML, Sprague JE, Kisor DF, Czoty PW, Nichols DE, Nader MA. Ambient temperature effects on 3,4-methylenedioxymethamphetamine-induced thermodysregulation and pharmacokinetics in male monkeys. Drug Metab Dispos. 2007 Oct; 35(10):1840-5. PMID: 17640955.
      Citations:    
    48. Banks ML, Czoty PW, Gage HD, Bounds MC, Garg PK, Garg S, Nader MA. Effects of cocaine and MDMA self-administration on serotonin transporter availability in monkeys. Neuropsychopharmacology. 2008 Jan; 33(2):219-25. PMID: 17443127.
      Citations:    
    49. Czoty PW, Gage HD, Nader SH, Reboussin BA, Bounds M, Nader MA. PET imaging of dopamine D2 receptor and transporter availability during acquisition of cocaine self-administration in rhesus monkeys. J Addict Med. 2007 Mar; 1(1):33-9. PMID: 21768930.
      Citations:    
    50. Banks ML, Czoty PW, Nader MA. The influence of reinforcing effects of cocaine on cocaine-induced increases in extinguished responding in cynomolgus monkeys. Psychopharmacology (Berl). 2007 Jul; 192(4):449-56. PMID: 17318506.
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    51. Czoty PW, Reboussin BA, Calhoun TL, Nader SH, Nader MA. Long-term cocaine self-administration under fixed-ratio and second-order schedules in monkeys. Psychopharmacology (Berl). 2007 Apr; 191(2):287-95. PMID: 17216155.
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    52. Czoty PW, Martelle JL, Nader MA. Influence of abstinence and conditions of cocaine access on the reinforcing strength of cocaine in nonhuman primates. Drug Alcohol Depend. 2006 Dec 01; 85(3):213-20. PMID: 16730922.
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    53. Czoty PW, Gage HD, Nader MA. PET imaging of striatal dopamine D2 receptors in nonhuman primates: increases in availability produced by chronic raclopride treatment. Synapse. 2005 Dec 15; 58(4):215-9. PMID: 16206180.
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    54. Nader MA, Czoty PW. PET imaging of dopamine D2 receptors in monkey models of cocaine abuse: genetic predisposition versus environmental modulation. Am J Psychiatry. 2005 Aug; 162(8):1473-82. PMID: 16055768.
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    55. Czoty PW, McCabe C, Nader MA. Effects of the 5-HT(1A) agonist (+/-)-8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) on cocaine choice in cynomolgus monkeys. Behav Pharmacol. 2005 May; 16(3):187-91. PMID: 15864074.
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    56. Czoty PW, McCabe C, Nader MA. Assessment of the relative reinforcing strength of cocaine in socially housed monkeys using a choice procedure. J Pharmacol Exp Ther. 2005 Jan; 312(1):96-102. PMID: 15340005.
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    57. Czoty PW, Ramanathan CR, Mutschler NH, Makriyannis A, Bergman J. Drug discrimination in methamphetamine-trained monkeys: effects of monoamine transporter inhibitors. J Pharmacol Exp Ther. 2004 Nov; 311(2):720-7. PMID: 15240827.
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    58. Czoty PW, Makriyannis A, Bergman J. Methamphetamine discrimination and in vivo microdialysis in squirrel monkeys. Psychopharmacology (Berl). 2004 Sep; 175(2):170-8. PMID: 15064912.
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    59. Czoty PW, Morgan D, Shannon EE, Gage HD, Nader MA. Characterization of dopamine D1 and D2 receptor function in socially housed cynomolgus monkeys self-administering cocaine. Psychopharmacology (Berl). 2004 Jul; 174(3):381-8. PMID: 14767632.
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    60. Czoty PW, Ginsburg BC, Howell LL. Serotonergic attenuation of the reinforcing and neurochemical effects of cocaine in squirrel monkeys. J Pharmacol Exp Ther. 2002 Mar; 300(3):831-7. PMID: 11861788.
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    61. Czoty PW, Howell LL. Behavioral effects of AMI-193, a 5-HT(2A)- and dopamine D(2)-receptor antagonist, in the squirrel monkey. Pharmacol Biochem Behav. 2000 Oct; 67(2):257-64. PMID: 11124389.
      Citations:    
    62. Czoty PW, Justice JB, Howell LL. Cocaine-induced changes in extracellular dopamine determined by microdialysis in awake squirrel monkeys. Psychopharmacology (Berl). 2000 Feb; 148(3):299-306. PMID: 10755743.
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    63. Howell LL, Czoty PW, Kuhar MJ, Carrol FI. Comparative behavioral pharmacology of cocaine and the selective dopamine uptake inhibitor RTI-113 in the squirrel monkey. J Pharmacol Exp Ther. 2000 Feb; 292(2):521-9. PMID: 10640288.
      Citations:    
    64. Howell LL, Czoty PW, Byrd LD. Pharmacological interactions between serotonin and dopamine on behavior in the squirrel monkey. Psychopharmacology (Berl). 1997 May; 131(1):40-8. PMID: 9181634.
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