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Nathaniel S.O'Connell PhD

TitleAssistant Professor
InstitutionWake Forest School of Medicine
DepartmentPHS-Biostatistics and Data Science (Public Health Sciences)
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    Collapse Biography 
    Collapse education and training
    Medical University of South Carolina, Charleston, SCPhD05/2018Biostatistics
    Kennesaw State University, Kennesaw, GABS`05/3013Biology

    Collapse Overview 
    Collapse overview
    I see myself as a collaborative biostatistician that develops statistical methodology for problems encountered when working with collaborative teams. I am a faculty biostatistician a part of the Biostatistics, Epidemiology, and Research Design (BERD) group in the Wake Forest Clinical and Translational Science Institute. From my involvement in BERD and general collaboration with other researchers across WF and beyond, I work across a wide range of medical and public health disciplines, including: cancer, neurology, intensive care, pediatrics, telehealth, and more. My areas of applied statistical experience and expertise include, but are not limited to: design and analysis of clinical trials (particularly dose-finding trials), longitudinal/clustered data analysis, mixed models, analysis of EHR data, analysis of continuously monitored patient data, Bayesian methods, missing data, and prediction modeling using traditional and machine learning methods (e.g. Random Forests).

    My statistical methodology research interests stem from my collaborative work and include: design of dose-finding cancer trials, the development of composite toxicity burden scores in cancer patients, methods for handling missing data (particularly from daily patient diaries), and prediction modelling.

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Reding KW, O'Connell NS, D'Agostino RB, Hundley W, Lucas AR, Ladd AC, Jordan JH, Heiston EM, Ge Y, Hundley WG. Both intermuscular fat and LVEF decline promote heart failure symptoms in cancer survivors. Cardiooncology. 2021 May 08; 7(1):16. PMID: 33964981.
      Citations:    
    2. Wells RE, O'Connell N, Pierce CR, Estave P, Penzien DB, Loder E, Zeidan F, Houle TT. Effectiveness of Mindfulness Meditation vs Headache Education for Adults With Migraine: A Randomized Clinical Trial. JAMA Intern Med. 2021 Mar 01; 181(3):317-328. PMID: 33315046.
      Citations:    
    3. Ghoshal S, O'Connell N, Tegeler C, Freedman BI. Cerebral hemodynamics in peritoneal dialysis versus intermittent hemodialysis: A transcranial Doppler pilot study. Perit Dial Int. 2020 Sep 10; 896860820953712. PMID: 32909931.
      Citations:    
    4. Neitzke DJ, Bowers JS, Andrijauskaite K, O'Connell NS, Garrett-Mayer E, Wrangle J, Li Z, Paulos CM, Cole DJ, Rubinstein MP. Murine Th17 cells utilize IL-2 receptor gamma chain cytokines but are resistant to cytokine withdrawal-induced apoptosis. Cancer Immunol Immunother. 2017 Jun; 66(6):737-751. PMID: 28280853.
      Citations:    
    5. O'Connell NS, Dai L, Jiang Y, Speiser JL, Ward R, Wei W, Carroll R, Gebregziabher M. Methods for Analysis of Pre-Post Data in Clinical Research: A Comparison of Five Common Methods. J Biom Biostat. 2017 Feb 24; 8(1):1-8. PMID: 30555734.
      Citations:    
    6. Welch BM, O'Connell NS, Qanungo S, Halbert-Hughes C, Schiffman JD. Collecting Family Health History using an Online Social Network: a Nationwide Survey among Potential Users. AMIA Annu Symp Proc. 2015; 2015:1316-25. PMID: 26958272.
      Citations:    
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