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Miranda E.Orr PhD

TitleAssistant Professor
InstitutionWake Forest School of Medicine
DepartmentInternal Medicine, Gerontology & Geriatric Medicine
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    Other Positions
    TitleAssistant Professor
    InstitutionWake Forest School of Medicine
    DepartmentPhysiology & Pharmacology


    Collapse Research 
    Collapse research activities and funding
    F31AG031630     (ORR, MIRANDA ETHEL)Sep 19, 2008 - Sep 18, 2011
    NIH
    Novel Stem Cell and Mouse Models to Study Frontotemporal Dementia
    Role: Principal Investigator

    IK2BX003804     (ORR, MIRANDA ETHEL)Jul 1, 2017 - Jun 30, 2022
    NIH
    Alzheimer?s disease-associated tau toxicity induces cellular senescence in the brain.
    Role: Principal Investigator

    K01AG056671     (ORR, MIRANDA ETHEL)Sep 1, 2017 - May 31, 2022
    NIH/NIA
    Alzheimer's Disease Associated Tau Toxicity Induces Cellular Senescence in Brain
    Role: Principal Investigator

    R01AG068293     (ORR, MIRANDA ETHEL)Sep 10, 2020 - May 31, 2025
    NIH
    High Resolution Profiling of Senescent Neurons and Their Microenvironments in Postmortem Human Brain Tissue Spanning Eight Decades of Life
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Liang H, Nie J, Van Skike CE, Valentine JM, Orr ME. Mammalian Target of Rapamycin at the Crossroad Between Alzheimer's Disease and Diabetes. Adv Exp Med Biol. 2019; 1128:185-225. PMID: 31062331.
      Citations:    
    2. Musi N, Valentine JM, Sickora KR, Baeuerle E, Thompson CS, Shen Q, Orr ME. Tau protein aggregation is associated with cellular senescence in the brain. Aging Cell. 2018 12; 17(6):e12840. PMID: 30126037.
      Citations:    
    3. Orr ME, Sullivan AC, Frost B. A Brief Overview of Tauopathy: Causes, Consequences, and Therapeutic Strategies. Trends Pharmacol Sci. 2017 07; 38(7):637-648. PMID: 28455089.
      Citations:    
    4. Orr ME, Garbarino VR, Salinas A, Buffenstein R. Extended Postnatal Brain Development in the Longest-Lived Rodent: Prolonged Maintenance of Neotenous Traits in the Naked Mole-Rat Brain. Front Neurosci. 2016; 10:504. PMID: 27877105.
      Citations:    
    5. Triplett JC, Swomley AM, Kirk J, Grimes KM, Lewis KN, Orr ME, Rodriguez KA, Cai J, Klein JB, Buffenstein R, Butterfield DA. Reaching Out to Send a Message: Proteins Associated with Neurite Outgrowth and Neurotransmission are Altered with Age in the Long-Lived Naked Mole-Rat. Neurochem Res. 2016 Jul; 41(7):1625-34. PMID: 26935741.
      Citations:    
    6. Triplett JC, Tramutola A, Swomley A, Kirk J, Grimes K, Lewis K, Orr M, Rodriguez K, Cai J, Klein JB, Perluigi M, Buffenstein R, Butterfield DA. Age-related changes in the proteostasis network in the brain of the naked mole-rat: Implications promoting healthy longevity. Biochim Biophys Acta. 2015 Oct; 1852(10 Pt A):2213-24. PMID: 26248058.
      Citations:    
    7. Triplett JC, Swomley A, Kirk J, Lewis K, Orr M, Rodriguez K, Cai J, Klein JB, Buffenstein R, Butterfield DA. Metabolic clues to salubrious longevity in the brain of the longest-lived rodent: the naked mole-rat. J Neurochem. 2015 Aug; 134(3):538-50. PMID: 25940666.
      Citations:    
    8. Garbarino VR, Orr ME, Rodriguez KA, Buffenstein R. Mechanisms of oxidative stress resistance in the brain: Lessons learned from hypoxia tolerant extremophilic vertebrates. Arch Biochem Biophys. 2015 Jun 15; 576:8-16. PMID: 25841340.
      Citations:    
    9. Orr ME, Garbarino VR, Salinas A, Buffenstein R. Sustained high levels of neuroprotective, high molecular weight, phosphorylated tau in the longest-lived rodent. Neurobiol Aging. 2015 Mar; 36(3):1496-504. PMID: 25576082.
      Citations:    
    10. Orr ME, Salinas A, Buffenstein R, Oddo S. Mammalian target of rapamycin hyperactivity mediates the detrimental effects of a high sucrose diet on Alzheimer's disease pathology. Neurobiol Aging. 2014 Jun; 35(6):1233-42. PMID: 24411482.
      Citations:    
    11. George L, Chaverra M, Wolfe L, Thorne J, Close-Davis M, Eibs A, Riojas V, Grindeland A, Orr M, Carlson GA, Lefcort F. Familial dysautonomia model reveals Ikbkap deletion causes apoptosis of Pax3+ progenitors and peripheral neurons. Proc Natl Acad Sci U S A. 2013 Nov 12; 110(46):18698-703. PMID: 24173031.
      Citations:    
    12. Orr ME, Oddo S. Autophagic/lysosomal dysfunction in Alzheimer's disease. Alzheimers Res Ther. 2013; 5(5):53. PMID: 24171818.
      Citations:    
    13. Medina DX, Orr ME, Oddo S. Accumulation of C-terminal fragments of transactive response DNA-binding protein 43 leads to synaptic loss and cognitive deficits in human TDP-43 transgenic mice. Neurobiol Aging. 2014 Jan; 35(1):79-87. PMID: 23954172.
      Citations:    
    14. Orr ME, Pitstick R, Canine B, Ashe KH, Carlson GA. Genotype-specific differences between mouse CNS stem cell lines expressing frontotemporal dementia mutant or wild type human tau. PLoS One. 2012; 7(6):e39328. PMID: 22723997.
      Citations:    
    15. Purevdorj-Gage B, Orr ME, Stoodley P, Sheehan KB, Hyman LE. The role of FLO11 in Saccharomyces cerevisiae biofilm development in a laboratory based flow-cell system. FEMS Yeast Res. 2007 May; 7(3):372-9. PMID: 17233763.
      Citations:    
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