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Mary F. Lyles MD

TitleProfessor Emeritus
InstitutionWake Forest School of Medicine
DepartmentInternal Medicine, Gerontology & Geriatric Medicine
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Messier SP, Mihalko SL, Beavers DP, Nicklas BJ, DeVita P, Carr JJ, Hunter DJ, Lyles M, Guermazi A, Bennell KL, Loeser RF. Effect of High-Intensity Strength Training on Knee Pain and Knee Joint Compressive Forces Among Adults With Knee Osteoarthritis: The START Randomized Clinical Trial. JAMA. 2021 02 16; 325(7):646-657. PMID: 33591346.
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    2. Egbuche O, Biggs ML, Ix JH, Kizer JR, Lyles MF, Siscovick DS, Djoussé L, Mukamal KJ. Fatty Acid Binding Protein-4 and Risk of Cardiovascular Disease: The Cardiovascular Health Study. J Am Heart Assoc. 2020 04 07; 9(7):e014070. PMID: 32248728.
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    3. Opina MTD, Brinkley TE, Gordon M, Lyles MF, Nicklas BJ. Association of Breathing Reserve at Peak Exercise With Body Composition and Physical Function in Older Adults With Obesity. J Gerontol A Biol Sci Med Sci. 2019 11 13; 74(12):1973-1979. PMID: 30535050.
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    4. Messier SP, Beavers DP, Mihalko SL, Miller GD, Lyles MF, Hunter DJ, Carr JJ, Eckstein F, Guermazi A, Loeser RF, DeVita P. The effects of intensive dietary weight loss and exercise on gait in overweight and obese adults with knee osteoarthritis. The Intensive Diet and Exercise for Arthritis (IDEA) trial. J Biomech. 2020 01 02; 98:109477. PMID: 31732174.
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    5. Nicklas BJ, Brinkley TE, Houston DK, Lyles MF, Hugenschmidt CE, Beavers KM, Leng X. Effects of Caloric Restriction on Cardiorespiratory Fitness, Fatigue, and Disability Responses to Aerobic Exercise in Older Adults With Obesity: A Randomized Controlled Trial. J Gerontol A Biol Sci Med Sci. 2019 06 18; 74(7):1084-1090. PMID: 29982294.
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    6. Hugenschmidt CE, Leng X, Lyles M, Michael L, Dougherty A, Babcock P, Baker LD, Brinkley TE, Nicklas BJ. Cognitive Effects of Adding Caloric Restriction to Aerobic Exercise Training in Older Adults with Obesity. Obesity (Silver Spring). 2019 08; 27(8):1266-1274. PMID: 31199592.
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    7. Houston DK, Miller ME, Kitzman DW, Rejeski WJ, Messier SP, Lyles MF, Kritchevsky SB, Nicklas BJ. Long-Term Effects of Randomization to a Weight Loss Intervention in Older Adults: A Pilot Study. J Nutr Gerontol Geriatr. 2019 Jan-Mar; 38(1):83-99. PMID: 30849296.
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    8. Mihalko SL, Cox P, Beavers DP, Miller GD, Nicklas BJ, Lyles M, Hunter DJ, Eckstein F, Guermazi A, Loeser RF, DeVita P, Messier SP. Effect of intensive diet and exercise on self-efficacy in overweight and obese adults with knee osteoarthritis: The IDEA randomized clinical trial. Transl Behav Med. 2019 03 01; 9(2):227-235. PMID: 29635402.
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    9. Weaver AA, Houston DK, Shapses SA, Lyles MF, Henderson RM, Beavers DP, Baker AC, Beavers KM. Effect of a hypocaloric, nutritionally complete, higher-protein meal plan on bone density and quality in older adults with obesity: a randomized trial. Am J Clin Nutr. 2019 02 01; 109(2):478-486. PMID: 30624598.
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    10. Messier SP, Resnik AE, Beavers DP, Mihalko SL, Miller GD, Nicklas BJ, deVita P, Hunter DJ, Lyles MF, Eckstein F, Guermazi A, Loeser RF. Intentional Weight Loss in Overweight and Obese Patients With Knee Osteoarthritis: Is More Better? Arthritis Care Res (Hoboken). 2018 11; 70(11):1569-1575. PMID: 29911741.
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    11. Stacey RB, Zgibor J, Leaverton PE, Schocken DD, Peregoy JA, Lyles MF, Bertoni AG, Burke GL. Abnormal Fasting Glucose Increases Risk of Unrecognized Myocardial Infarctions in an Elderly Cohort. J Am Geriatr Soc. 2019 01; 67(1):43-49. PMID: 30298627.
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    12. Sink KM, Evans GW, Shorr RI, Bates JT, Berlowitz D, Conroy MB, Felton DM, Gure T, Johnson KC, Kitzman D, Lyles MF, Servilla K, Supiano MA, Whittle J, Wiggers A, Fine LJ. Syncope, Hypotension, and Falls in the Treatment of Hypertension: Results from the Randomized Clinical Systolic Blood Pressure Intervention Trial. J Am Geriatr Soc. 2018 04; 66(4):679-686. PMID: 29601076.
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    13. Beavers KM, Beavers DP, Martin SB, Marsh AP, Lyles MF, Lenchik L, Shapses SA, Nicklas BJ. Change in Bone Mineral Density During Weight Loss with Resistance Versus Aerobic Exercise Training in Older Adults. J Gerontol A Biol Sci Med Sci. 2017 Oct 12; 72(11):1582-1585. PMID: 28379325.
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    14. Brenes GA, Danhauer SC, Lyles MF, Anderson A, Miller ME. Long-Term Effects of Telephone-Delivered Psychotherapy for Late-Life GAD. Am J Geriatr Psychiatry. 2017 Nov; 25(11):1249-1257. PMID: 28673741.
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    15. Normandin E, Chmelo E, Lyles MF, Marsh AP, Nicklas BJ. Effect of Resistance Training and Caloric Restriction on the Metabolic Syndrome. Med Sci Sports Exerc. 2017 03; 49(3):413-419. PMID: 27741216.
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    16. Messier SP, Callahan LF, Beavers DP, Queen K, Mihalko SL, Miller GD, Losina E, Katz JN, Loeser RF, Quandt SA, DeVita P, Hunter DJ, Lyles MF, Newman J, Hackney B, Jordan JM. Weight-loss and exercise for communities with arthritis in North Carolina (we-can): design and rationale of a pragmatic, assessor-blinded, randomized controlled trial. BMC Musculoskelet Disord. 2017 02 22; 18(1):91. PMID: 28228115.
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    17. Henderson RM, Leng XI, Chmelo EA, Brinkley TE, Lyles MF, Marsh AP, Nicklas BJ. Gait speed response to aerobic versus resistance exercise training in older adults. Aging Clin Exp Res. 2017 Oct; 29(5):969-976. PMID: 27682435.
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    18. Molina AJ, Bharadwaj MS, Van Horn C, Nicklas BJ, Lyles MF, Eggebeen J, Haykowsky MJ, Brubaker PH, Kitzman DW. Skeletal Muscle Mitochondrial Content, Oxidative Capacity, and Mfn2 Expression Are Reduced in Older Patients With Heart Failure and Preserved Ejection Fraction and Are Related to Exercise Intolerance. JACC Heart Fail. 2016 08; 4(8):636-45. PMID: 27179829.
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    19. Brenes GA, Danhauer SC, Lyles MF, Anderson A, Miller ME. Effects of Telephone-Delivered Cognitive-Behavioral Therapy and Nondirective Supportive Therapy on Sleep, Health-Related Quality of Life, and Disability. Am J Geriatr Psychiatry. 2016 10; 24(10):846-54. PMID: 27421617.
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    20. Wang X, You T, Murphy K, Lyles MF, Nicklas BJ. Addition of Exercise Increases Plasma Adiponectin and Release from Adipose Tissue. Med Sci Sports Exerc. 2015 Nov; 47(11):2450-5. PMID: 25811948.
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    21. Bharadwaj MS, Tyrrell DJ, Leng I, Demons JL, Lyles MF, Carr JJ, Nicklas BJ, Molina AJ. Relationships between mitochondrial content and bioenergetics with obesity, body composition and fat distribution in healthy older adults. BMC Obes. 2015; 2:40. PMID: 26448868.
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    22. Brenes GA, Danhauer SC, Lyles MF, Hogan PE, Miller ME. Telephone-Delivered Cognitive Behavioral Therapy and Telephone-Delivered Nondirective Supportive Therapy for Rural Older Adults With Generalized Anxiety Disorder: A Randomized Clinical Trial. JAMA Psychiatry. 2015 Oct; 72(10):1012-20. PMID: 26244854.
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    23. Choi SJ, Files DC, Zhang T, Wang ZM, Messi ML, Gregory H, Stone J, Lyles MF, Dhar S, Marsh AP, Nicklas BJ, Delbono O. Intramyocellular Lipid and Impaired Myofiber Contraction in Normal Weight and Obese Older Adults. J Gerontol A Biol Sci Med Sci. 2016 Apr; 71(4):557-64. PMID: 26405061.
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    24. Brenes GA, Danhauer SC, Lyles MF, Hogan PE, Miller ME. Barriers to Mental Health Treatment in Rural Older Adults. Am J Geriatr Psychiatry. 2015 Nov; 23(11):1172-8. PMID: 26245880.
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    25. Corrales-Medina VF, Taljaard M, Yende S, Kronmal R, Dwivedi G, Newman AB, Elkind MS, Lyles MF, Chirinos JA. Intermediate and long-term risk of new-onset heart failure after hospitalization for pneumonia in elderly adults. Am Heart J. 2015 Aug; 170(2):306-12. PMID: 26299228.
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    26. Nicklas BJ, Chmelo E, Delbono O, Carr JJ, Lyles MF, Marsh AP. Effects of resistance training with and without caloric restriction on physical function and mobility in overweight and obese older adults: a randomized controlled trial. Am J Clin Nutr. 2015 May; 101(5):991-9. PMID: 25762810.
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    27. Chmelo EA, Crotts CI, Newman JC, Brinkley TE, Lyles MF, Leng X, Marsh AP, Nicklas BJ. Heterogeneity of physical function responses to exercise training in older adults. J Am Geriatr Soc. 2015 Mar; 63(3):462-9. PMID: 25752778.
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    28. Bharadwaj MS, Tyrrell DJ, Lyles MF, Demons JL, Rogers GW, Molina AJ. Preparation and respirometric assessment of mitochondria isolated from skeletal muscle tissue obtained by percutaneous needle biopsy. J Vis Exp. 2015 Feb 07; (96). PMID: 25741892.
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    29. Corrales-Medina VF, Alvarez KN, Weissfeld LA, Angus DC, Chirinos JA, Chang CC, Newman A, Loehr L, Folsom AR, Elkind MS, Lyles MF, Kronmal RA, Yende S. Association between hospitalization for pneumonia and subsequent risk of cardiovascular disease. JAMA. 2015 Jan 20; 313(3):264-74. PMID: 25602997.
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    30. You T, Wang X, Murphy KM, Lyles MF, Demons JL, Yang R, Gong DW, Nicklas BJ. Regional adipose tissue hormone/cytokine production before and after weight loss in abdominally obese women. Obesity (Silver Spring). 2014 Jul; 22(7):1679-84. PMID: 24634403.
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    31. Kitzman DW, Nicklas B, Kraus WE, Lyles MF, Eggebeen J, Morgan TM, Haykowsky M. Skeletal muscle abnormalities and exercise intolerance in older patients with heart failure and preserved ejection fraction. . 2014 May; 306(9):H1364-70. PMID: 24658015.
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    32. Brenes GA, Danhauer SC, Lyles MF, Miller ME. Telephone-delivered psychotherapy for rural-dwelling older adults with generalized anxiety disorder: study protocol of a randomized controlled trial. BMC Psychiatry. 2014 Feb 08; 14:34. PMID: 24506950.
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    33. Messier SP, Mihalko SL, Legault C, Miller GD, Nicklas BJ, DeVita P, Beavers DP, Hunter DJ, Lyles MF, Eckstein F, Williamson JD, Carr JJ, Guermazi A, Loeser RF. Effects of intensive diet and exercise on knee joint loads, inflammation, and clinical outcomes among overweight and obese adults with knee osteoarthritis: the IDEA randomized clinical trial. JAMA. 2013 Sep 25; 310(12):1263-73. PMID: 24065013.
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    34. Messier SP, Mihalko SL, Beavers DP, Nicklas BJ, DeVita P, Carr JJ, Hunter DJ, Williamson JD, Bennell KL, Guermazi A, Lyles M, Loeser RF. Strength Training for Arthritis Trial (START): design and rationale. BMC Musculoskelet Disord. 2013 Jul 15; 14:208. PMID: 23855596.
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    35. Atkinson HH, Lambros A, Davis BR, Lawlor JS, Lovato J, Sink KM, Demons JL, Lyles MF, Watkins FS, Callahan KE, Williamson JD. Teaching medical student geriatrics competencies in 1 week: an efficient model to teach and document selected competencies using clinical and community resources. J Am Geriatr Soc. 2013 Jul; 61(7):1182-7. PMID: 23710572.
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    36. Marsh AP, Shea MK, Vance Locke RM, Miller ME, Isom S, Miller GD, Nicklas BJ, Lyles MF, Carr JJ, Kritchevsky SB. Resistance training and pioglitazone lead to improvements in muscle power during voluntary weight loss in older adults. J Gerontol A Biol Sci Med Sci. 2013 Jul; 68(7):828-36. PMID: 23292287.
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    37. Beavers DP, Beavers KM, Lyles MF, Nicklas BJ. Cardiometabolic risk after weight loss and subsequent weight regain in overweight and obese postmenopausal women. J Gerontol A Biol Sci Med Sci. 2013 Jun; 68(6):691-8. PMID: 23183902.
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    38. Walker FO, Lyles MF, Li Z. Sheet fitting palsy. J Clin Neuromuscul Dis. 2012 Sep; 14(1):48-50. PMID: 22922583.
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    39. Beavers KM, Lyles MF, Davis CC, Wang X, Beavers DP, Nicklas BJ. Is lost lean mass from intentional weight loss recovered during weight regain in postmenopausal women? Am J Clin Nutr. 2011 Sep; 94(3):767-74. PMID: 21795437.
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    40. Shea MK, Nicklas BJ, Marsh AP, Houston DK, Miller GD, Isom S, Miller ME, Carr JJ, Lyles MF, Harris TB, Kritchevsky SB. The effect of pioglitazone and resistance training on body composition in older men and women undergoing hypocaloric weight loss. Obesity (Silver Spring). 2011 Aug; 19(8):1636-46. PMID: 21233810.
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    41. Welmerink DB, Longstreth WT, Lyles MF, Fitzpatrick AL. Cognition and the risk of hospitalization for serious falls in the elderly: results from the Cardiovascular Health Study. J Gerontol A Biol Sci Med Sci. 2010 Nov; 65(11):1242-9. PMID: 20584769.
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    42. Wang X, You T, Yang R, Lyles MF, Demons J, Gong DW, Nicklas BJ. Muscle strength is associated with adipose tissue gene expression of inflammatory adipokines in postmenopausal women. Age Ageing. 2010 Sep; 39(5):656-9. PMID: 20233733.
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    43. Messier SP, Legault C, Mihalko S, Miller GD, Loeser RF, DeVita P, Lyles M, Eckstein F, Hunter DJ, Williamson JD, Nicklas BJ. The Intensive Diet and Exercise for Arthritis (IDEA) trial: design and rationale. BMC Musculoskelet Disord. 2009 Jul 28; 10:93. PMID: 19638215.
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    44. Nicklas BJ, Wang X, You T, Lyles MF, Demons J, Easter L, Berry MJ, Lenchik L, Carr JJ. Effect of exercise intensity on abdominal fat loss during calorie restriction in overweight and obese postmenopausal women: a randomized, controlled trial. Am J Clin Nutr. 2009 Apr; 89(4):1043-52. PMID: 19211823.
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    45. Wang X, Lyles MF, You T, Berry MJ, Rejeski WJ, Nicklas BJ. Weight regain is related to decreases in physical activity during weight loss. Med Sci Sports Exerc. 2008 Oct; 40(10):1781-8. PMID: 18799988.
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    46. Nicklas BJ, Leng I, Delbono O, Kitzman DW, Marsh AP, Hundley WG, Lyles MF, O'Rourke KS, Annex BH, Kraus WE. Relationship of physical function to vastus lateralis capillary density and metabolic enzyme activity in elderly men and women. Aging Clin Exp Res. 2008 Aug; 20(4):302-9. PMID: 18852542.
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    47. Schellenbaum GD, Smith NL, Heckbert SR, Lumley T, Rea TD, Furberg CD, Lyles MF, Psaty BM. Weight loss, muscle strength, and angiotensin-converting enzyme inhibitors in older adults with congestive heart failure or hypertension. J Am Geriatr Soc. 2005 Nov; 53(11):1996-2000. PMID: 16274385.
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    48. O'Meara ES, White M, Siscovick DS, Lyles MF, Kuller LH. Hospitalization for pneumonia in the Cardiovascular Health Study: incidence, mortality, and influence on longer-term survival. J Am Geriatr Soc. 2005 Jul; 53(7):1108-16. PMID: 16108926.
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    49. You T, Yang R, Lyles MF, Gong D, Nicklas BJ. Abdominal adipose tissue cytokine gene expression: relationship to obesity and metabolic risk factors. Am J Physiol Endocrinol Metab. 2005 Apr; 288(4):E741-7. PMID: 15562250.
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    50. Mozaffarian D, Psaty BM, Rimm EB, Lemaitre RN, Burke GL, Lyles MF, Lefkowitz D, Siscovick DS. Fish intake and risk of incident atrial fibrillation. Circulation. 2004 Jul 27; 110(4):368-73. PMID: 15262826.
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    51. Mackey RH, Sutton-Tyrrell K, Vaitkevicius PV, Sakkinen PA, Lyles MF, Spurgeon HA, Lakatta EG, Kuller LH. Correlates of aortic stiffness in elderly individuals: a subgroup of the Cardiovascular Health Study. Am J Hypertens. 2002 Jan; 15(1 Pt 1):16-23. PMID: 11824854.
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