Martha A. Alexander-Miller PhD
Title | Professor |
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Institution | Wake Forest School of Medicine |
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Department | Microbiology and Immunology |
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Title | Director |
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Institution | Wake Forest School of Medicine |
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Department | Center for Vaccines at the Extremes of Aging (CVEA) |
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Title | Professor |
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Institution | Wake Forest School of Medicine |
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Department | Pediatrics |
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Title | Chair |
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Institution | Wake Forest School of Medicine |
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Department | Microbiology and Immunology |
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Biography
| Dolores G. Evans PhD Chair in Microbiology and Immunology |
Research
T32AI007401 (ALEXANDER-MILLER, MARTHA ANN)Sep 1, 1991 - Jun 30, 2023 NIH Training Program in Immunology and Pathogenesis Role: Principal Investigator |
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R01AI043591 (ALEXANDER-MILLER, MARTHA ANN)Mar 1, 1999 - Feb 28, 2012 NIH Control of cytotoxic T cell differentiation and activity Role: Principal Investigator |
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R03AG017292 (ALEXANDER-MILLER, MARTHA A.)Aug 1, 1999 - Jan 31, 2001 NIH CTL AVIDITY AND THE AGING IMMUNE RESPONSE Role: Principal Investigator |
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R01HL071985 (ALEXANDER-MILLER, MARTHA ANN)Dec 1, 2002 - Jun 30, 2012 NIH Cellular Immune Response to Respiratory Infection Role: Principal Investigator |
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R21AI056096 (ALEXANDER-MILLER, MARTHA A.)Jul 15, 2003 - Jun 30, 2004 NIH Control of T cell response during respiratory infection Role: Principal Investigator |
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R01AI098339 (ALEXANDER-MILLER, MARTHA ANN)Jun 15, 2012 - May 31, 2018 NIH Vaccination strategies to overcome immune deficiencies in neonates Role: Principal Investigator |
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R21AI122330 (ALEXANDER-MILLER, MARTHA ANN)Jan 1, 2016 - Dec 31, 2018 NIH Regulation of avidity in T lymphocytes Role: Principal Investigator |
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R21AI125780 (ALEXANDER-MILLER, MARTHA ANN)Jul 7, 2017 - Jun 30, 2020 NIH Immune regulation by pneumococcus Role: Principal Investigator |
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R21AI137741 (ALEXANDER-MILLER, MARTHA ANN)Jun 10, 2019 - May 31, 2021 NIH Effectiveness of R848 conjugated IPR8 as a vaccine for the elderly Role: Principal Investigator |
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R01AI146059 (ALEXANDER-MILLER, MARTHA ANN)Aug 5, 2020 - Jul 31, 2024 NIH Development of vaccine approaches to elicit broadly protective influenza-specific immune responses in infants Role: Principal Investigator |
Bibliographic
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Crofts KF, Page CL, Swedik SM, Holbrook BC, Meyers AK, Zhu X, Parsonage D, Westcott MM, Alexander-Miller MA. An Analysis of Linker-Dependent Effects on the APC Activation and In Vivo Immunogenicity of an R848-Conjugated Influenza Vaccine. Vaccines (Basel). 2023 Jul 20; 11(7).
PMID: 37515076.
Citations:
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Zuber MJ, Stamilio DM, Holbrook BC, Snively BM, Jensen ET, Alexander-Miller MA. Maternal influenza vaccination preferentially boosts hemagglutinin stem-specific antibody resulting in efficient transplacental transfer of stem-specific IgG. Int J Gynaecol Obstet. 2023 Jul; 162(1):163-168.
PMID: 36690442.
Citations:
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Semelka CT, DeWitt ME, Blevins MW, Holbrook BC, Sanders JW, Alexander-Miller MA. Frailty impacts immune responses to Moderna COVID-19 mRNA vaccine in older adults. Immun Ageing. 2023 Jan 17; 20(1):4.
PMID: 36650551.
Citations:
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Stirling ER, Terabe M, Wilson AS, Kooshki M, Yamaleyeva LM, Alexander-Miller MA, Zhang W, Miller LD, Triozzi PL, Soto-Pantoja DR. Targeting the CD47/thrombospondin-1 signaling axis regulates immune cell bioenergetics in the tumor microenvironment to potentiate antitumor immune response. J Immunother Cancer. 2022 Nov; 10(11).
PMID: 36418073.
Citations:
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Clemens EA, Holbrook BC, McNeilly B, Kanekiyo M, Graham BS, Alexander-Miller MA. TLR agonists induce sustained IgG to hemagglutinin stem and modulate T cells following newborn vaccination. NPJ Vaccines. 2022 Aug 29; 7(1):102.
PMID: 36038596.
Citations:
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Semelka CT, DeWitt ME, Blevins MW, Holbrook BC, Sanders JW, Alexander-Miller MA. Frailty and Age Impact Immune Responses to Moderna COVID-19 mRNA Vaccine. Res Sq. 2022 Aug 01.
PMID: 35982657.
Citations:
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Semelka CT, DeWitt ME, Callahan KE, Herrington DM, Alexander-Miller MA, Yukich JO, Munawar I, McCurdy LH, Gibbs MA, Weintraub WS, Sanders JW. Frailty and COVID-19 mRNA Vaccine Antibody Response in the COVID-19 Community Research Partnership. J Gerontol A Biol Sci Med Sci. 2022 Jul 05; 77(7):1366-1370.
PMID: 35446945.
Citations:
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Crofts KF, Holbrook BC, D'Agostino RB, Alexander-Miller MA. Analysis of R848 as an Adjuvant to Improve Inactivated Influenza Vaccine Immunogenicity in Elderly Nonhuman Primates. Vaccines (Basel). 2022 Mar 23; 10(4).
PMID: 35455242.
Citations:
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Triozzi PL, Stirling ER, Song Q, Westwood B, Kooshki M, Forbes ME, Holbrook BC, Cook KL, Alexander-Miller MA, Miller LD, Zhang W, Soto-Pantoja DR. Circulating Immune Bioenergetic, Metabolic, and Genetic Signatures Predict Melanoma Patients' Response to Anti-PD-1 Immune Checkpoint Blockade. Clin Cancer Res. 2022 03 15; 28(6):1192-1202.
PMID: 35284940.
Citations:
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Clemens EA, Alexander-Miller MA. Understanding Antibody Responses in Early Life: Baby Steps towards Developing an Effective Influenza Vaccine. Viruses. 2021 07 17; 13(7).
PMID: 34372597.
Citations:
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Shultz PK, Crofts KF, Holbrook BC, Alexander-Miller MA. Neuraminidase-specific antibody responses are generated in naive and vaccinated newborn nonhuman primates following virus infection. JCI Insight. 2020 12 17; 5(24).
PMID: 33264104.
Citations:
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Liu L, Ahmed T, Petty WJ, Grant S, Ruiz J, Lycan TW, Topaloglu U, Chou PC, Miller LD, Hawkins GA, Alexander-Miller MA, O'Neill SS, Powell BL, D'Agostino RB, Munden RF, Pasche B, Zhang W. SMARCA4 mutations in KRAS-mutant lung adenocarcinoma: a multi-cohort analysis. Mol Oncol. 2021 02; 15(2):462-472.
PMID: 33107184.
Citations:
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Clemens EA, Holbrook BC, Kanekiyo M, Yewdell JW, Graham BS, Alexander-Miller MA. An R848 conjugated influenza virus vaccine elicits robust IgG to hemagglutinin stem in a newborn nonhuman primate model. J Infect Dis. 2020 Nov 27.
PMID: 33245745.
Citations:
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Crofts KF, Alexander-Miller MA. Challenges for the Newborn Immune Response to Respiratory Virus Infection and Vaccination. Vaccines (Basel). 2020 Sep 24; 8(4).
PMID: 32987691.
Citations:
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Alexander-Miller MA. Challenges for the Newborn Following Influenza Virus Infection and Prospects for an Effective Vaccine. Front Immunol. 2020; 11:568651.
PMID: 33042150.
Citations:
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Holbrook BC, Alexander-Miller MA. Higher Frequency and Increased Expression of Molecules Associated with Suppression on T Regulatory Cells from Newborn Compared with Adult Nonhuman Primates. J Immunol. 2020 10 15; 205(8):2128-2136.
PMID: 32878911.
Citations:
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Crofts KF, Holbrook BC, Soto-Pantoja DR, Ornelles DA, Alexander-Miller MA. TCR Dependent Metabolic Programming Regulates Autocrine IL-4 Production Resulting in Self-Tuning of the CD8+ T Cell Activation Setpoint. Front Immunol. 2020; 11:540.
PMID: 32300344.
Citations:
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Clemens E, Angeletti D, Holbrook BC, Kanekiyo M, Jorgensen MJ, Graham BS, Yewdell J, Alexander-Miller MA. Influenza-infected newborn and adult monkeys exhibit a strong primary antibody response to hemagglutinin stem. JCI Insight. 2020 03 12; 5(5).
PMID: 32078584.
Citations:
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Tschoe C, Bushnell CD, Duncan PW, Alexander-Miller MA, Wolfe SQ. Neuroinflammation after Intracerebral Hemorrhage and Potential Therapeutic Targets. J Stroke. 2020 Jan; 22(1):29-46.
PMID: 32027790.
Citations:
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Song Q, Hawkins GA, Wudel L, Chou PC, Forbes E, Pullikuth AK, Liu L, Jin G, Craddock L, Topaloglu U, Kucera G, O'Neill S, Levine EA, Sun P, Watabe K, Lu Y, Alexander-Miller MA, Pasche B, Miller LD, Zhang W. Dissecting intratumoral myeloid cell plasticity by single cell RNA-seq. Cancer Med. 2019 06; 8(6):3072-3085.
PMID: 31033233.
Citations:
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Martin AN, Alexander-Miller M, Yoza BK, Vachharajani V, McCall CE. Sirtuin1 Targeting Reverses Innate and Adaptive Immune Tolerance in Septic Mice. J Immunol Res. 2018; 2018:2402593.
PMID: 30069485.
Citations:
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Westcott MM, Clemens EA, Holbrook BC, King SB, Alexander-Miller MA. The choice of linker for conjugating R848 to inactivated influenza virus determines the stimulatory capacity for innate immune cells. Vaccine. 2018 02 21; 36(9):1174-1182.
PMID: 29398273.
Citations:
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Strowd RE, Russell G, Hsu FC, Carter AF, Chan M, Tatter SB, Laxton AW, Alexander-Miller MA, High K, Lesser GJ. Immunogenicity of high-dose influenza vaccination in patients with primary central nervous system malignancy. Neurooncol Pract. 2018 Aug; 5(3):176-183.
PMID: 31385974.
Citations:
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Blevins LK, Parsonage D, Oliver MB, Domzalski E, Swords WE, Alexander-Miller MA. A Novel Function for the Streptococcus pneumoniae Aminopeptidase N: Inhibition of T Cell Effector Function through Regulation of TCR Signaling. Front Immunol. 2017; 8:1610.
PMID: 29230212.
Citations:
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Holbrook BC, Aycock ST, Machiele E, Clemens E, Gries D, Jorgensen MJ, Hadimani MB, King SB, Alexander-Miller MA. An R848 adjuvanted influenza vaccine promotes early activation of B cells in the draining lymph nodes of non-human primate neonates. Immunology. 2018 03; 153(3):357-367.
PMID: 28940186.
Citations:
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Holbrook BC, D'Agostino RB, Tyler Aycock S, Jorgensen MJ, Hadimani MB, Bruce King S, Alexander-Miller MA. Adjuvanting an inactivated influenza vaccine with conjugated R848 improves the level of antibody present at 6months in a nonhuman primate neonate model. Vaccine. 2017 10 27; 35(45):6137-6142.
PMID: 28967521.
Citations:
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Wajih N, Basu S, Jailwala A, Kim HW, Ostrowski D, Perlegas A, Bolden CA, Buechler NL, Gladwin MT, Caudell DL, Rahbar E, Alexander-Miller MA, Vachharajani V, Kim-Shapiro DB. Potential therapeutic action of nitrite in sickle cell disease. Redox Biol. 2017 08; 12:1026-1039.
PMID: 28511346.
Citations:
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Wren JT, Blevins LK, Pang B, Basu Roy A, Oliver MB, Reimche JL, Wozniak JE, Alexander-Miller MA, Swords WE. Pneumococcal Neuraminidase A (NanA) Promotes Biofilm Formation and Synergizes with Influenza A Virus in Nasal Colonization and Middle Ear Infection. Infect Immun. 2017 04; 85(4).
PMID: 28096183.
Citations:
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Grayson KM, Blevins LK, Oliver MB, Ornelles DA, Swords WE, Alexander-Miller MA. Activation-dependent modulation of Streptococcus pneumoniae-mediated death in human lymphocytes. Pathog Dis. 2017 03 01; 75(2).
PMID: 28158464.
Citations:
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Shewale SV, Brown AL, Bi X, Boudyguina E, Sawyer JK, Alexander-Miller MA, Parks JS. In vivo activation of leukocyte GPR120/FFAR4 by PUFAs has minimal impact on atherosclerosis in LDL receptor knockout mice. J Lipid Res. 2017 01; 58(1):236-246.
PMID: 27811230.
Citations:
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Holbrook BC, D'Agostino RB, Parks GD, Alexander-Miller MA. Adjuvanting an inactivated influenza vaccine with flagellin improves the function and quantity of the long-term antibody response in a nonhuman primate neonate model. Vaccine. 2016 09 07; 34(39):4712-4717.
PMID: 27516064.
Citations:
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Holbrook BC, Kim JR, Blevins LK, Jorgensen MJ, Kock ND, D'Agostino RB, Aycock ST, Hadimani MB, King SB, Parks GD, Alexander-Miller MA. A Novel R848-Conjugated Inactivated Influenza Virus Vaccine Is Efficacious and Safe in a Neonate Nonhuman Primate Model. J Immunol. 2016 07 15; 197(2):555-64.
PMID: 27279374.
Citations:
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Kim JR, Holbrook BC, Hayward SL, Blevins LK, Jorgensen MJ, Kock ND, De Paris K, D'Agostino RB, Aycock ST, Mizel SB, Parks GD, Alexander-Miller MA. Inclusion of Flagellin during Vaccination against Influenza Enhances Recall Responses in Nonhuman Primate Neonates. J Virol. 2015 Jul; 89(14):7291-303.
PMID: 25948746.
Citations:
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Holbrook BC, Hayward SL, Blevins LK, Kock N, Aycock T, Parks GD, Alexander-Miller MA. Nonhuman primate infants have an impaired respiratory but not systemic IgG antibody response following influenza virus infection. Virology. 2015 Feb; 476:124-133.
PMID: 25543963.
Citations:
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Alexander-Miller MA. Vaccines against respiratory viral pathogens for use in neonates: opportunities and challenges. J Immunol. 2014 Dec 01; 193(11):5363-9.
PMID: 25411431.
Citations:
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Blevins LK, Wren JT, Holbrook BC, Hayward SL, Swords WE, Parks GD, Alexander-Miller MA. Coinfection with Streptococcus pneumoniae negatively modulates the size and composition of the ongoing influenza-specific CD8? T cell response. J Immunol. 2014 Nov 15; 193(10):5076-87.
PMID: 25311807.
Citations:
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Wren JT, Blevins LK, Pang B, King LB, Perez AC, Murrah KA, Reimche JL, Alexander-Miller MA, Swords WE. Influenza A virus alters pneumococcal nasal colonization and middle ear infection independently of phase variation. Infect Immun. 2014 Nov; 82(11):4802-12.
PMID: 25156728.
Citations:
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Shiner EK, Holbrook BC, Alexander-Miller MA. CD4+ T cell subset differentiation and avidity setpoint are dictated by the interplay of cytokine and antigen mediated signals. PLoS One. 2014; 9(6):e100175.
PMID: 24940899.
Citations:
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Parks GD, Alexander-Miller MA. Paramyxovirus activation and inhibition of innate immune responses. J Mol Biol. 2013 Dec 13; 425(24):4872-92.
PMID: 24056173.
Citations:
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Holbrook BC, Yammani RD, Blevins LK, Alexander-Miller MA. In vivo modulation of avidity in highly sensitive CD8(+) effector T cells following viral infection. Viral Immunol. 2013 Oct; 26(5):302-13.
PMID: 23971914.
Citations:
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Amoah S, Holbrook BC, Yammani RD, Alexander-Miller MA. High viral burden restricts short-lived effector cell number at late times postinfection through increased natural regulatory T cell expansion. J Immunol. 2013 May 15; 190(10):5020-9.
PMID: 23589620.
Citations:
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Brown AL, Zhu X, Rong S, Shewale S, Seo J, Boudyguina E, Gebre AK, Alexander-Miller MA, Parks JS. Omega-3 fatty acids ameliorate atherosclerosis by favorably altering monocyte subsets and limiting monocyte recruitment to aortic lesions. Arterioscler Thromb Vasc Biol. 2012 Sep; 32(9):2122-30.
PMID: 22814747.
Citations:
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Beauchamp NM, Yammani RD, Alexander-Miller MA. CD8 marks a subpopulation of lung-derived dendritic cells with differential responsiveness to viral infection and toll-like receptor stimulation. J Virol. 2012 Oct; 86(19):10640-50.
PMID: 22811544.
Citations:
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Johnson JB, Lyles DS, Alexander-Miller MA, Parks GD. Virion-associated complement regulator CD55 is more potent than CD46 in mediating resistance of mumps virus and vesicular stomatitis virus to neutralization. J Virol. 2012 Sep; 86(18):9929-40.
PMID: 22761385.
Citations:
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Amoah S, Yammani RD, Grayson JM, Alexander-Miller MA. Changes in functional but not structural avidity during differentiation of CD8+ effector cells in vivo after virus infection. J Immunol. 2012 Jul 15; 189(2):638-45.
PMID: 22706075.
Citations:
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Sharma SK, Alexander-Miller MA. Increased sensitivity to antigen in high avidity CD8(+) T cells results from augmented membrane proximal T-cell receptor signal transduction. Immunology. 2011 Jul; 133(3):307-17.
PMID: 21501160.
Citations:
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Busick RY, Yammani RD, Alexander-Miller MA. Differentiation-dependent differences in murine T cell susceptibility to negative regulation by the lung. Am J Respir Cell Mol Biol. 2011 May; 44(5):597-605.
PMID: 21216971.
Citations:
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Palmer EM, Holbrook BC, Arimilli S, Parks GD, Alexander-Miller MA. IFNgamma-producing, virus-specific CD8+ effector cells acquire the ability to produce IL-10 as a result of entry into the infected lung environment. Virology. 2010 Sep 01; 404(2):225-30.
PMID: 20627346.
Citations:
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Beauchamp NM, Busick RY, Alexander-Miller MA. Functional divergence among CD103+ dendritic cell subpopulations following pulmonary poxvirus infection. J Virol. 2010 Oct; 84(19):10191-9.
PMID: 20660207.
Citations:
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Arimilli S, Sharma SK, Yammani R, Reid SD, Parks GD, Alexander-Miller MA. Pivotal Advance: Nonfunctional lung effectors exhibit decreased calcium mobilization associated with reduced expression of ORAI1. J Leukoc Biol. 2010 Jun; 87(6):977-88.
PMID: 20103768.
Citations:
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Arimilli S, Johnson JB, Clark KM, Graff AH, Alexander-Miller MA, Mizel SB, Parks GD. Engineered expression of the TLR5 ligand flagellin enhances paramyxovirus activation of human dendritic cell function. J Virol. 2008 Nov; 82(22):10975-85.
PMID: 18787007.
Citations:
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Yates NL, Yammani RD, Alexander-Miller MA. Dose-dependent lymphocyte apoptosis following respiratory infection with Vaccinia virus. Virus Res. 2008 Nov; 137(2):198-205.
PMID: 18692098.
Citations:
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Yammani RD, Pejawar-Gaddy S, Gurley TC, Weimer ET, Hiltbold EM, Alexander-Miller MA. Regulation of maturation and activating potential in CD8+ versus CD8- dendritic cells following in vivo infection with vaccinia virus. Virology. 2008 Aug 15; 378(1):142-50.
PMID: 18586296.
Citations:
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Kroger CJ, Amoah S, Alexander-Miller MA. Cutting edge: Dendritic cells prime a high avidity CTL response independent of the level of presented antigen. J Immunol. 2008 May 01; 180(9):5784-8.
PMID: 18424695.
Citations:
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Arimilli S, Palmer EM, Alexander-Miller MA. Loss of function in virus-specific lung effector T cells is independent of infection. J Leukoc Biol. 2008 Mar; 83(3):564-74.
PMID: 18079210.
Citations:
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Kroger CJ, Alexander-Miller MA. Cutting edge: CD8+ T cell clones possess the potential to differentiate into both high- and low-avidity effector cells. J Immunol. 2007 Jul 15; 179(2):748-51.
PMID: 17617563.
Citations:
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Kroger CJ, Alexander-Miller MA. Dose-dependent modulation of CD8 and functional avidity as a result of peptide encounter. Immunology. 2007 Oct; 122(2):167-78.
PMID: 17484768.
Citations:
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Arimilli S, Johnson JB, Alexander-Miller MA, Parks GD. TLR-4 and -6 agonists reverse apoptosis and promote maturation of simian virus 5-infected human dendritic cells through NFkB-dependent pathways. Virology. 2007 Aug 15; 365(1):144-56.
PMID: 17459446.
Citations:
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Pejawar-Gaddy S, Gitiban-Vaghefi N, Parks GD, Alexander-Miller MA. Distinct pathways for signaling maturation in macrophages and dendritic cells after infection with paramyxovirus simian virus 5. Viral Immunol. 2007; 20(1):76-87.
PMID: 17425423.
Citations:
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Dillon PJ, Wansley EK, Young VA, Alexander-Miller MA, Parks GD. Exchange of P/V genes between two non-cytopathic simian virus 5 variants results in a recombinant virus that kills cells through death pathways that are sensitive to caspase inhibitors. J Gen Virol. 2006 Dec; 87(Pt 12):3643-3648.
PMID: 17098980.
Citations:
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Yates NL, Alexander-Miller MA. Vaccinia virus infection of mature dendritic cells results in activation of virus-specific naĂŻve CD8+ T cells: a potential mechanism for direct presentation. Virology. 2007 Mar 15; 359(2):349-61.
PMID: 17056088.
Citations:
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Pejawar-Gaddy S, Alexander-Miller MA. Ligation of CD80 is critical for high-level CD25 expression on CD8+ T lymphocytes. J Immunol. 2006 Oct 01; 177(7):4495-502.
PMID: 16982886.
Citations:
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Hicks AM, Riedlinger G, Willingham MC, Alexander-Miller MA, Von Kap-Herr C, Pettenati MJ, Sanders AM, Weir HM, Du W, Kim J, Simpson AJ, Old LJ, Cui Z. Transferable anticancer innate immunity in spontaneous regression/complete resistance mice. Proc Natl Acad Sci U S A. 2006 May 16; 103(20):7753-8.
PMID: 16682640.
Citations:
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Arimilli S, Alexander-Miller MA, Parks GD. A simian virus 5 (SV5) P/V mutant is less cytopathic than wild-type SV5 in human dendritic cells and is a more effective activator of dendritic cell maturation and function. J Virol. 2006 Apr; 80(7):3416-27.
PMID: 16537609.
Citations:
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Pejawar SS, Parks GD, Alexander-Miller MA. Abortive versus productive viral infection of dendritic cells with a paramyxovirus results in differential upregulation of select costimulatory molecules. J Virol. 2005 Jun; 79(12):7544-57.
PMID: 15919909.
Citations:
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Gray PM, Arimilli S, Palmer EM, Parks GD, Alexander-Miller MA. Altered function in CD8+ T cells following paramyxovirus infection of the respiratory tract. J Virol. 2005 Mar; 79(6):3339-49.
PMID: 15731228.
Citations:
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Gray PM, Parks GD, Alexander-Miller MA. Modulation of CD8+ T cell avidity by increasing the turnover of viral antigen during infection. Cell Immunol. 2004 Sep-Oct; 231(1-2):14-9.
PMID: 15919365.
Citations:
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Alexander-Miller MA. High-avidity CD8+ T cells: optimal soldiers in the war against viruses and tumors. Immunol Res. 2005; 31(1):13-24.
PMID: 15591619.
Citations:
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Cawthon AG, Kroger CJ, Alexander-Miller MA. High avidity CD8+ T cells generated from CD28-deficient or wildtype mice exhibit a differential dependence on lipid raft integrity for activation. Cell Immunol. 2004 Feb; 227(2):148-55.
PMID: 15135297.
Citations:
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Snyder JT, Alexander-Miller MA, Berzofskyl JA, Belyakov IM. Molecular mechanisms and biological significance of CTL avidity. Curr HIV Res. 2003 Jul; 1(3):287-94.
PMID: 15046253.
Citations:
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Cui Z, Willingham MC, Hicks AM, Alexander-Miller MA, Howard TD, Hawkins GA, Miller MS, Weir HM, Du W, DeLong CJ. Spontaneous regression of advanced cancer: identification of a unique genetically determined, age-dependent trait in mice. Proc Natl Acad Sci U S A. 2003 May 27; 100(11):6682-7.
PMID: 12724523.
Citations:
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Gray PM, Parks GD, Alexander-Miller MA. High avidity CD8+ T cells are the initial population elicited following viral infection of the respiratory tract. J Immunol. 2003 Jan 01; 170(1):174-81.
PMID: 12496398.
Citations:
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Cawthon AG, Alexander-Miller MA. Optimal colocalization of TCR and CD8 as a novel mechanism for the control of functional avidity. J Immunol. 2002 Oct 01; 169(7):3492-8.
PMID: 12244138.
Citations:
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Spolski RJ, Alexander-Miller MA, Kuhn RE. Suppressed cytotoxic T lymphocyte responses in experimental cysticercosis. Vet Parasitol. 2002 Jul 02; 106(4):325-30.
PMID: 12079738.
Citations:
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Parks GD, Alexander-Miller MA. High avidity cytotoxic T lymphocytes to a foreign antigen are efficiently activated following immunization with a recombinant paramyxovirus, simian virus 5. J Gen Virol. 2002 May; 83(Pt 5):1167-1172.
PMID: 11961272.
Citations:
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Gray PM, Parks GD, Alexander-Miller MA. A novel CD8-independent high-avidity cytotoxic T-lymphocyte response directed against an epitope in the phosphoprotein of the paramyxovirus simian virus 5. J Virol. 2001 Nov; 75(21):10065-72.
PMID: 11581375.
Citations:
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Derby MA, Snyder JT, Tse R, Alexander-Miller MA, Berzofsky JA. An abrupt and concordant initiation of apoptosis: antigen-dependent death of CD8+ CTL. Eur J Immunol. 2001 Oct; 31(10):2951-9.
PMID: 11592071.
Citations:
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Cawthon AG, Lu H, Alexander-Miller MA. Peptide requirement for CTL activation reflects the sensitivity to CD3 engagement: correlation with CD8alphabeta versus CD8alphaalpha expression. J Immunol. 2001 Sep 01; 167(5):2577-84.
PMID: 11509598.
Citations:
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Alexander-Miller MA. Differential expansion and survival of high and low avidity cytotoxic T cell populations during the immune response to a viral infection. Cell Immunol. 2000 Apr 10; 201(1):58-62.
PMID: 10805974.
Citations:
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Alexander-Miller MA, Derby MA, Sarin A, Henkart PA, Berzofsky JA. Supraoptimal peptide-major histocompatibility complex causes a decrease in bc1-2 levels and allows tumor necrosis factor alpha receptor II-mediated apoptosis of cytotoxic T lymphocytes. J Exp Med. 1998 Oct 19; 188(8):1391-9.
PMID: 9782116.
Citations:
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Leggatt GR, Alexander-Miller MA, Kumar A, Hoffman SL, Berzofsky JA. Cytotoxic T lymphocyte (CTL) adherence assay (CAA): a non-radioactive assay for murine CTL recognition of peptide-MHC class I complexes. J Immunol Methods. 1997 Feb 14; 201(1):1-10.
PMID: 9053406.
Citations:
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Sarin A, Williams MS, Alexander-Miller MA, Berzofsky JA, Zacharchuk CM, Henkart PA. Target cell lysis by CTL granule exocytosis is independent of ICE/Ced-3 family proteases. Immunity. 1997 Feb; 6(2):209-15.
PMID: 9047242.
Citations:
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Alexander-Miller MA, Leggatt GR, Sarin A, Berzofsky JA. Role of antigen, CD8, and cytotoxic T lymphocyte (CTL) avidity in high dose antigen induction of apoptosis of effector CTL. J Exp Med. 1996 Aug 01; 184(2):485-92.
PMID: 8760802.
Citations:
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Kurokohchi K, Carrington M, Mann DL, Simonis TB, Alexander-Miller MA, Feinstone SM, Akatsuka T, Berzofsky JA. Expression of HLA class I molecules and the transporter associated with antigen processing in hepatocellular carcinoma. Hepatology. 1996 May; 23(5):1181-8.
PMID: 8621152.
Citations:
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Alexander-Miller MA, Parker KC, Tsukui T, Pendleton CD, Coligan JE, Berzofsky JA. Molecular analysis of presentation by HLA-A2.1 of a promiscuously binding V3 loop peptide from the HIV-envelope protein to human cytotoxic T lymphocytes. Int Immunol. 1996 May; 8(5):641-9.
PMID: 8671651.
Citations:
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Alexander-Miller MA, Leggatt GR, Berzofsky JA. Selective expansion of high- or low-avidity cytotoxic T lymphocytes and efficacy for adoptive immunotherapy. Proc Natl Acad Sci U S A. 1996 Apr 30; 93(9):4102-7.
PMID: 8633023.
Citations:
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Goss JA, Alexander-Miller MA, Gorka J, Flye MW, Connolly JM, Hansen TH. Specific prolongation of allograft survival by a T-cell-receptor-derived peptide. Proc Natl Acad Sci U S A. 1993 Nov 01; 90(21):9872-6.
PMID: 8234328.
Citations:
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Alexander-Miller MA, Burke K, Koszinowski UH, Hansen TH, Connolly JM. Alloreactive cytotoxic T lymphocytes generated in the presence of viral-derived peptides show exquisite peptide and MHC specificity. J Immunol. 1993 Jul 01; 151(1):1-10.
PMID: 8392095.
Citations:
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Solheim JC, Alexander-Miller MA, Martinko JM, Connolly JM. Biased T cell receptor usage by Ld-restricted, tum- peptide-specific cytotoxic T lymphocyte clones. J Immunol. 1993 Feb 01; 150(3):800-11.
PMID: 8380825.
Citations:
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Alexander MA, Damico CA, Wieties KM, Hansen TH, Connolly JM. Correlation between CD8 dependency and determinant density using peptide-induced, Ld-restricted cytotoxic T lymphocytes. J Exp Med. 1991 Apr 01; 173(4):849-58.
PMID: 1901079.
Citations:
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Nuñez G, London L, Hockenbery D, Alexander M, McKearn JP, Korsmeyer SJ. Deregulated Bcl-2 gene expression selectively prolongs survival of growth factor-deprived hemopoietic cell lines. J Immunol. 1990 May 01; 144(9):3602-10.
PMID: 2184193.
Citations:
This graph shows the total number of publications by year. To see the data as text,
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This graph shows the total number of publications by year. To return to the graph,
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Year | Publications |
---|
1996 | 4 |
1997 | 2 |
1998 | 1 |
2000 | 1 |
2001 | 3 |
2002 | 3 |
2003 | 3 |
2004 | 1 |
2005 | 4 |
2006 | 5 |
2007 | 5 |
2008 | 4 |
2010 | 3 |
2011 | 2 |
2012 | 4 |
2013 | 3 |
2014 | 5 |
2015 | 1 |
2016 | 3 |
2017 | 6 |
2018 | 3 |
2019 | 1 |
2020 | 9 |
2021 | 1 |
2022 | 6 |
2023 | 3 |
This graph shows the number and percent of publications by field.
Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications.
Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
To see the data as text,
click here.
This graph shows the number and percent of publications by field.
Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications.
Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
To see the data as text,
click here.
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