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Last Name

Martha A. Alexander-Miller, Ph.D.

TitleChair
InstitutionWake Forest School of Medicine
DepartmentMicrobiology_Immunology
Address
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    Other Positions
    TitleChair
    InstitutionWake Forest School of Medicine
    DepartmentMicrobiology and Immunology


    Collapse Research 
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    T32AI007401     (ALEXANDER-MILLER, MARTHA ANN)Sep 1, 1991 - Jun 30, 2023
    NIH/NIAID
    Training Program in Immunology and Pathogenesis
    Role: Principal Investigator

    R01AI043591     (ALEXANDER-MILLER, MARTHA ANN)Mar 1, 1999 - Feb 29, 2004
    NIH/NIAID
    Control of cytotoxic T cell differentiation and activity
    Role: Principal Investigator

    R03AG017292     (ALEXANDER-MILLER, MARTHA A.)Aug 1, 1999 - Jan 31, 2001
    NIH/NIA
    CTL AVIDITY AND THE AGING IMMUNE RESPONSE
    Role: Principal Investigator

    R21AI056096     (ALEXANDER-MILLER, MARTHA A.)Jul 15, 2003 - Jun 30, 2004
    NIH/NIAID
    Control of T cell response during respiratory infection
    Role: Principal Investigator

    R01HL071985     (ALEXANDER-MILLER, MARTHA ANN)Apr 1, 2004 - Mar 31, 2010
    NIH/NHLBI
    Cellular Immune Response to Respiratory Infection
    Role: Principal Investigator

    R01AI098339     (ALEXANDER-MILLER, MARTHA ANN)Jun 15, 2012 - May 31, 2016
    NIH/NIAID
    Vaccination strategies to overcome immune deficiencies in neonates
    Role: Principal Investigator

    R21AI122330     (ALEXANDER-MILLER, MARTHA ANN)Jan 1, 2016 - Dec 31, 2017
    NIH/NIAID
    Regulation of avidity in T lymphocytes
    Role: Principal Investigator

    R21AI125780     (ALEXANDER-MILLER, MARTHA ANN)Jul 7, 2017 - Jun 30, 2019
    NIH/NIAID
    Immune regulation by pneumococcus
    Role: Principal Investigator

    R21AI137741     (ALEXANDER-MILLER, MARTHA ANN)Jun 10, 2019 - May 31, 2021
    NIH/NIAID
    Effectiveness of R848 conjugated IPR8 as a vaccine for the elderly
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Song Q, Hawkins GA, Wudel L, Chou PC, Forbes E, Pullikuth AK, Liu L, Jin G, Craddock L, Topaloglu U, Kucera G, O'Neill S, Levine EA, Sun P, Watabe K, Lu Y, Alexander-Miller MA, Pasche B, Miller LD, Zhang W. Dissecting intratumoral myeloid cell plasticity by single cell RNA-seq. Cancer Med. 2019 Jun; 8(6):3072-3085. PMID: 31033233.
      View in: PubMed
    2. Martin AN, Alexander-Miller M, Yoza BK, Vachharajani V, McCall CE. Sirtuin1 Targeting Reverses Innate and Adaptive Immune Tolerance in Septic Mice. J Immunol Res. 2018; 2018:2402593. PMID: 30069485.
      View in: PubMed
    3. Westcott MM, Clemens EA, Holbrook BC, King SB, Alexander-Miller MA. The choice of linker for conjugating R848 to inactivated influenza virus determines the stimulatory capacity for innate immune cells. Vaccine. 2018 02 21; 36(9):1174-1182. PMID: 29398273.
      View in: PubMed
    4. Strowd RE, Russell G, Hsu FC, Carter AF, Chan M, Tatter SB, Laxton AW, Alexander-Miller MA, High K, Lesser GJ. Immunogenicity of high-dose influenza vaccination in patients with primary central nervous system malignancy. Neurooncol Pract. 2018 Aug; 5(3):176-183. PMID: 31385974.
      View in: PubMed
    5. Blevins LK, Parsonage D, Oliver MB, Domzalski E, Swords WE, Alexander-Miller MA. A Novel Function for the Streptococcus pneumoniae Aminopeptidase N: Inhibition of T Cell Effector Function through Regulation of TCR Signaling. Front Immunol. 2017; 8:1610. PMID: 29230212.
      View in: PubMed
    6. Holbrook BC, Aycock ST, Machiele E, Clemens E, Gries D, Jorgensen MJ, Hadimani MB, King SB, Alexander-Miller MA. An R848 adjuvanted influenza vaccine promotes early activation of B cells in the draining lymph nodes of non-human primate neonates. Immunology. 2018 03; 153(3):357-367. PMID: 28940186.
      View in: PubMed
    7. Holbrook BC, D'Agostino RB, Tyler Aycock S, Jorgensen MJ, Hadimani MB, Bruce King S, Alexander-Miller MA. Adjuvanting an inactivated influenza vaccine with conjugated R848 improves the level of antibody present at 6months in a nonhuman primate neonate model. Vaccine. 2017 10 27; 35(45):6137-6142. PMID: 28967521.
      View in: PubMed
    8. Wajih N, Basu S, Jailwala A, Kim HW, Ostrowski D, Perlegas A, Bolden CA, Buechler NL, Gladwin MT, Caudell DL, Rahbar E, Alexander-Miller MA, Vachharajani V, Kim-Shapiro DB. Potential therapeutic action of nitrite in sickle cell disease. Redox Biol. 2017 08; 12:1026-1039. PMID: 28511346.
      View in: PubMed
    9. Wren JT, Blevins LK, Pang B, Basu Roy A, Oliver MB, Reimche JL, Wozniak JE, Alexander-Miller MA, Swords WE. Pneumococcal Neuraminidase A (NanA) Promotes Biofilm Formation and Synergizes with Influenza A Virus in Nasal Colonization and Middle Ear Infection. Infect Immun. 2017 04; 85(4). PMID: 28096183.
      View in: PubMed
    10. Grayson KM, Blevins LK, Oliver MB, Ornelles DA, Swords WE, Alexander-Miller MA. Activation-dependent modulation of Streptococcus pneumoniae-mediated death in human lymphocytes. Pathog Dis. 2017 03 01; 75(2). PMID: 28158464.
      View in: PubMed
    11. Shewale SV, Brown AL, Bi X, Boudyguina E, Sawyer JK, Alexander-Miller MA, Parks JS. In vivo activation of leukocyte GPR120/FFAR4 by PUFAs has minimal impact on atherosclerosis in LDL receptor knockout mice. J Lipid Res. 2017 01; 58(1):236-246. PMID: 27811230.
      View in: PubMed
    12. Holbrook BC, D'Agostino RB, Parks GD, Alexander-Miller MA. Adjuvanting an inactivated influenza vaccine with flagellin improves the function and quantity of the long-term antibody response in a nonhuman primate neonate model. Vaccine. 2016 09 07; 34(39):4712-4717. PMID: 27516064.
      View in: PubMed
    13. Holbrook BC, Kim JR, Blevins LK, Jorgensen MJ, Kock ND, D'Agostino RB, Aycock ST, Hadimani MB, King SB, Parks GD, Alexander-Miller MA. A Novel R848-Conjugated Inactivated Influenza Virus Vaccine Is Efficacious and Safe in a Neonate Nonhuman Primate Model. J Immunol. 2016 07 15; 197(2):555-64. PMID: 27279374.
      View in: PubMed
    14. Kim JR, Holbrook BC, Hayward SL, Blevins LK, Jorgensen MJ, Kock ND, De Paris K, D'Agostino RB, Aycock ST, Mizel SB, Parks GD, Alexander-Miller MA. Inclusion of Flagellin during Vaccination against Influenza Enhances Recall Responses in Nonhuman Primate Neonates. J Virol. 2015 Jul; 89(14):7291-303. PMID: 25948746.
      View in: PubMed
    15. Holbrook BC, Hayward SL, Blevins LK, Kock N, Aycock T, Parks GD, Alexander-Miller MA. Nonhuman primate infants have an impaired respiratory but not systemic IgG antibody response following influenza virus infection. Virology. 2015 Feb; 476:124-133. PMID: 25543963.
      View in: PubMed
    16. Alexander-Miller MA. Vaccines against respiratory viral pathogens for use in neonates: opportunities and challenges. J Immunol. 2014 Dec 01; 193(11):5363-9. PMID: 25411431.
      View in: PubMed
    17. Blevins LK, Wren JT, Holbrook BC, Hayward SL, Swords WE, Parks GD, Alexander-Miller MA. Coinfection with Streptococcus pneumoniae negatively modulates the size and composition of the ongoing influenza-specific CD8? T cell response. J Immunol. 2014 Nov 15; 193(10):5076-87. PMID: 25311807.
      View in: PubMed
    18. Wren JT, Blevins LK, Pang B, King LB, Perez AC, Murrah KA, Reimche JL, Alexander-Miller MA, Swords WE. Influenza A virus alters pneumococcal nasal colonization and middle ear infection independently of phase variation. Infect Immun. 2014 Nov; 82(11):4802-12. PMID: 25156728.
      View in: PubMed
    19. Shiner EK, Holbrook BC, Alexander-Miller MA. CD4+ T cell subset differentiation and avidity setpoint are dictated by the interplay of cytokine and antigen mediated signals. PLoS One. 2014; 9(6):e100175. PMID: 24940899.
      View in: PubMed
    20. Parks GD, Alexander-Miller MA. Paramyxovirus activation and inhibition of innate immune responses. J Mol Biol. 2013 Dec 13; 425(24):4872-92. PMID: 24056173.
      View in: PubMed
    21. Holbrook BC, Yammani RD, Blevins LK, Alexander-Miller MA. In vivo modulation of avidity in highly sensitive CD8(+) effector T cells following viral infection. Viral Immunol. 2013 Oct; 26(5):302-13. PMID: 23971914.
      View in: PubMed
    22. Amoah S, Holbrook BC, Yammani RD, Alexander-Miller MA. High viral burden restricts short-lived effector cell number at late times postinfection through increased natural regulatory T cell expansion. J Immunol. 2013 May 15; 190(10):5020-9. PMID: 23589620.
      View in: PubMed
    23. Brown AL, Zhu X, Rong S, Shewale S, Seo J, Boudyguina E, Gebre AK, Alexander-Miller MA, Parks JS. Omega-3 fatty acids ameliorate atherosclerosis by favorably altering monocyte subsets and limiting monocyte recruitment to aortic lesions. Arterioscler Thromb Vasc Biol. 2012 Sep; 32(9):2122-30. PMID: 22814747.
      View in: PubMed
    24. Beauchamp NM, Yammani RD, Alexander-Miller MA. CD8 marks a subpopulation of lung-derived dendritic cells with differential responsiveness to viral infection and toll-like receptor stimulation. J Virol. 2012 Oct; 86(19):10640-50. PMID: 22811544.
      View in: PubMed
    25. Johnson JB, Lyles DS, Alexander-Miller MA, Parks GD. Virion-associated complement regulator CD55 is more potent than CD46 in mediating resistance of mumps virus and vesicular stomatitis virus to neutralization. J Virol. 2012 Sep; 86(18):9929-40. PMID: 22761385.
      View in: PubMed
    26. Amoah S, Yammani RD, Grayson JM, Alexander-Miller MA. Changes in functional but not structural avidity during differentiation of CD8+ effector cells in vivo after virus infection. J Immunol. 2012 Jul 15; 189(2):638-45. PMID: 22706075.
      View in: PubMed
    27. Sharma SK, Alexander-Miller MA. Increased sensitivity to antigen in high avidity CD8(+) T cells results from augmented membrane proximal T-cell receptor signal transduction. Immunology. 2011 Jul; 133(3):307-17. PMID: 21501160.
      View in: PubMed
    28. Busick RY, Yammani RD, Alexander-Miller MA. Differentiation-dependent differences in murine T cell susceptibility to negative regulation by the lung. Am J Respir Cell Mol Biol. 2011 May; 44(5):597-605. PMID: 21216971.
      View in: PubMed
    29. Palmer EM, Holbrook BC, Arimilli S, Parks GD, Alexander-Miller MA. IFNgamma-producing, virus-specific CD8+ effector cells acquire the ability to produce IL-10 as a result of entry into the infected lung environment. Virology. 2010 Sep 01; 404(2):225-30. PMID: 20627346.
      View in: PubMed
    30. Beauchamp NM, Busick RY, Alexander-Miller MA. Functional divergence among CD103+ dendritic cell subpopulations following pulmonary poxvirus infection. J Virol. 2010 Oct; 84(19):10191-9. PMID: 20660207.
      View in: PubMed
    31. Arimilli S, Sharma SK, Yammani R, Reid SD, Parks GD, Alexander-Miller MA. Pivotal Advance: Nonfunctional lung effectors exhibit decreased calcium mobilization associated with reduced expression of ORAI1. J Leukoc Biol. 2010 Jun; 87(6):977-88. PMID: 20103768.
      View in: PubMed
    32. Arimilli S, Johnson JB, Clark KM, Graff AH, Alexander-Miller MA, Mizel SB, Parks GD. Engineered expression of the TLR5 ligand flagellin enhances paramyxovirus activation of human dendritic cell function. J Virol. 2008 Nov; 82(22):10975-85. PMID: 18787007.
      View in: PubMed
    33. Yates NL, Yammani RD, Alexander-Miller MA. Dose-dependent lymphocyte apoptosis following respiratory infection with Vaccinia virus. Virus Res. 2008 Nov; 137(2):198-205. PMID: 18692098.
      View in: PubMed
    34. Yammani RD, Pejawar-Gaddy S, Gurley TC, Weimer ET, Hiltbold EM, Alexander-Miller MA. Regulation of maturation and activating potential in CD8+ versus CD8- dendritic cells following in vivo infection with vaccinia virus. Virology. 2008 Aug 15; 378(1):142-50. PMID: 18586296.
      View in: PubMed
    35. Kroger CJ, Amoah S, Alexander-Miller MA. Cutting edge: Dendritic cells prime a high avidity CTL response independent of the level of presented antigen. J Immunol. 2008 May 01; 180(9):5784-8. PMID: 18424695.
      View in: PubMed
    36. Arimilli S, Palmer EM, Alexander-Miller MA. Loss of function in virus-specific lung effector T cells is independent of infection. J Leukoc Biol. 2008 Mar; 83(3):564-74. PMID: 18079210.
      View in: PubMed
    37. Kroger CJ, Alexander-Miller MA. Cutting edge: CD8+ T cell clones possess the potential to differentiate into both high- and low-avidity effector cells. J Immunol. 2007 Jul 15; 179(2):748-51. PMID: 17617563.
      View in: PubMed
    38. Kroger CJ, Alexander-Miller MA. Dose-dependent modulation of CD8 and functional avidity as a result of peptide encounter. Immunology. 2007 Oct; 122(2):167-78. PMID: 17484768.
      View in: PubMed
    39. Arimilli S, Johnson JB, Alexander-Miller MA, Parks GD. TLR-4 and -6 agonists reverse apoptosis and promote maturation of simian virus 5-infected human dendritic cells through NFkB-dependent pathways. Virology. 2007 Aug 15; 365(1):144-56. PMID: 17459446.
      View in: PubMed
    40. Pejawar-Gaddy S, Gitiban-Vaghefi N, Parks GD, Alexander-Miller MA. Distinct pathways for signaling maturation in macrophages and dendritic cells after infection with paramyxovirus simian virus 5. Viral Immunol. 2007; 20(1):76-87. PMID: 17425423.
      View in: PubMed
    41. Dillon PJ, Wansley EK, Young VA, Alexander-Miller MA, Parks GD. Exchange of P/V genes between two non-cytopathic simian virus 5 variants results in a recombinant virus that kills cells through death pathways that are sensitive to caspase inhibitors. J Gen Virol. 2006 Dec; 87(Pt 12):3643-8. PMID: 17098980.
      View in: PubMed
    42. Yates NL, Alexander-Miller MA. Vaccinia virus infection of mature dendritic cells results in activation of virus-specific naïve CD8+ T cells: a potential mechanism for direct presentation. Virology. 2007 Mar 15; 359(2):349-61. PMID: 17056088.
      View in: PubMed
    43. Pejawar-Gaddy S, Alexander-Miller MA. Ligation of CD80 is critical for high-level CD25 expression on CD8+ T lymphocytes. J Immunol. 2006 Oct 01; 177(7):4495-502. PMID: 16982886.
      View in: PubMed
    44. Hicks AM, Riedlinger G, Willingham MC, Alexander-Miller MA, Von Kap-Herr C, Pettenati MJ, Sanders AM, Weir HM, Du W, Kim J, Simpson AJ, Old LJ, Cui Z. Transferable anticancer innate immunity in spontaneous regression/complete resistance mice. Proc Natl Acad Sci U S A. 2006 May 16; 103(20):7753-8. PMID: 16682640.
      View in: PubMed
    45. Arimilli S, Alexander-Miller MA, Parks GD. A simian virus 5 (SV5) P/V mutant is less cytopathic than wild-type SV5 in human dendritic cells and is a more effective activator of dendritic cell maturation and function. J Virol. 2006 Apr; 80(7):3416-27. PMID: 16537609.
      View in: PubMed
    46. Pejawar SS, Parks GD, Alexander-Miller MA. Abortive versus productive viral infection of dendritic cells with a paramyxovirus results in differential upregulation of select costimulatory molecules. J Virol. 2005 Jun; 79(12):7544-57. PMID: 15919909.
      View in: PubMed
    47. Gray PM, Arimilli S, Palmer EM, Parks GD, Alexander-Miller MA. Altered function in CD8+ T cells following paramyxovirus infection of the respiratory tract. J Virol. 2005 Mar; 79(6):3339-49. PMID: 15731228.
      View in: PubMed
    48. Gray PM, Parks GD, Alexander-Miller MA. Modulation of CD8+ T cell avidity by increasing the turnover of viral antigen during infection. Cell Immunol. 2004 Sep-Oct; 231(1-2):14-9. PMID: 15919365.
      View in: PubMed
    49. Alexander-Miller MA. High-avidity CD8+ T cells: optimal soldiers in the war against viruses and tumors. Immunol Res. 2005; 31(1):13-24. PMID: 15591619.
      View in: PubMed
    50. Cawthon AG, Kroger CJ, Alexander-Miller MA. High avidity CD8+ T cells generated from CD28-deficient or wildtype mice exhibit a differential dependence on lipid raft integrity for activation. Cell Immunol. 2004 Feb; 227(2):148-55. PMID: 15135297.
      View in: PubMed
    51. Snyder JT, Alexander-Miller MA, Berzofskyl JA, Belyakov IM. Molecular mechanisms and biological significance of CTL avidity. Curr HIV Res. 2003 Jul; 1(3):287-94. PMID: 15046253.
      View in: PubMed
    52. Cui Z, Willingham MC, Hicks AM, Alexander-Miller MA, Howard TD, Hawkins GA, Miller MS, Weir HM, Du W, DeLong CJ. Spontaneous regression of advanced cancer: identification of a unique genetically determined, age-dependent trait in mice. Proc Natl Acad Sci U S A. 2003 May 27; 100(11):6682-7. PMID: 12724523.
      View in: PubMed
    53. Gray PM, Parks GD, Alexander-Miller MA. High avidity CD8+ T cells are the initial population elicited following viral infection of the respiratory tract. J Immunol. 2003 Jan 01; 170(1):174-81. PMID: 12496398.
      View in: PubMed
    54. Cawthon AG, Alexander-Miller MA. Optimal colocalization of TCR and CD8 as a novel mechanism for the control of functional avidity. J Immunol. 2002 Oct 01; 169(7):3492-8. PMID: 12244138.
      View in: PubMed
    55. Parks GD, Alexander-Miller MA. High avidity cytotoxic T lymphocytes to a foreign antigen are efficiently activated following immunization with a recombinant paramyxovirus, simian virus 5. J Gen Virol. 2002 May; 83(Pt 5):1167-1172. PMID: 11961272.
      View in: PubMed
    56. Alexander MA, Damico CA, Wieties KM, Hansen TH, Connolly JM. Correlation between CD8 dependency and determinant density using peptide-induced, Ld-restricted cytotoxic T lymphocytes. J Exp Med. 1991 Apr 01; 173(4):849-58. PMID: 1901079.
      View in: PubMed
    57. Nuñez G, London L, Hockenbery D, Alexander M, McKearn JP, Korsmeyer SJ. Deregulated Bcl-2 gene expression selectively prolongs survival of growth factor-deprived hemopoietic cell lines. J Immunol. 1990 May 01; 144(9):3602-10. PMID: 2184193.
      View in: PubMed
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