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Last Name

Linda J. Metheny-Barlow, Ph.D.

TitleAssociate Professor
InstitutionWake Forest School of Medicine
DepartmentRadiation Oncology
Address
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    Other Positions
    TitleAssociate Professor
    InstitutionWake Forest School of Medicine
    DepartmentCancer Biology


    Collapse Research 
    Collapse research activities and funding
    R21CA115829     (METHENY-BARLOW, LINDA J)Jul 12, 2005 - Jun 30, 2008
    NIH/NCI
    Tumorigenic subversion of mural cells in breast cancer
    Role: Principal Investigator

    R01CA138727     (METHENY-BARLOW, LINDA J)Mar 1, 2009 - Jan 31, 2014
    NIH/NCI
    Regulation of Vascular Stabilization by Connexin 43
    Role: Principal Investigator

    R01CA112593     (METHENY-BARLOW, LINDA J)Aug 1, 2009 - Jun 30, 2009
    NIH/NCI
    PPARs and Radiation-induced Brain Injury
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Sharma S, Wu SY, Jimenez H, Xing F, Zhu D, Liu Y, Wu K, Tyagi A, Zhao D, Lo HW, Metheny-Barlow L, Sun P, Bourland JD, Chan MD, Thomas A, Barbault A, D'Agostino RB, Whitlow CT, Kirchner V, Blackman C, Pasche B, Watabe K. Ca2+ and CACNA1H mediate targeted suppression of breast cancer brain metastasis by AM RF EMF. EBioMedicine. 2019 Jun; 44:194-208. PMID: 31129098.
      View in: PubMed
    2. Dohm A, Su J, McTyre ER, Taylor JM, Miller LD, Petty WJ, Xing F, Lo HW, Metheny-Barlow LJ, O'Neill S, Bellinger C, Dotson T, Pasche B, Watabe K, Chan MD, Ruiz J. Identification of CD37, cystatin A, and IL-23A gene expression in association with brain metastasis: analysis of a prospective trial. Int J Biol Markers. 2019 Mar; 34(1):90-97. PMID: 30854931.
      View in: PubMed
    3. Cramer CK, Alphonse-Sullivan N, Isom S, Metheny-Barlow LJ, Cummings TL, Page BR, Brown DR, Blackstock AW, Peiffer AM, Strowd RE, Rapp S, Lesser GJ, Shaw EG, Chan MD. Safety of pioglitazone during and after radiation therapy in patients with brain tumors: a phase I clinical trial. J Cancer Res Clin Oncol. 2019 Feb; 145(2):337-344. PMID: 30417218.
      View in: PubMed
    4. Xing F, Liu Y, Wu SY, Wu K, Sharma S, Mo YY, Feng J, Sanders S, Jin G, Singh R, Vidi PA, Tyagi A, Chan MD, Ruiz J, Debinski W, Pasche BC, Lo HW, Metheny-Barlow LJ, D'Agostino RB, Watabe K. Loss of XIST in Breast Cancer Activates MSN-c-Met and Reprograms Microglia via Exosomal miRNA to Promote Brain Metastasis. Cancer Res. 2018 08 01; 78(15):4316-4330. PMID: 30026327.
      View in: PubMed
    5. Andrews RN, Caudell DL, Metheny-Barlow LJ, Peiffer AM, Tooze JA, Bourland JD, Hampson RE, Deadwyler SA, Cline JM. Fibronectin Produced by Cerebral Endothelial and Vascular Smooth Muscle Cells Contributes to Perivascular Extracellular Matrix in Late-Delayed Radiation-Induced Brain Injury. Radiat Res. 2018 10; 190(4):361-373. PMID: 30016219.
      View in: PubMed
    6. Shenker RF, Hughes RT, McTyre ER, Lanier C, Lo HW, Metheny-Barlow L, Su J, Thomas A, Brown DR, Avery T, Pasche B, Cramer CK, Laxton AW, Tatter SB, Watabe K, Chan MD. Potential prognostic markers for survival and neurologic death in patients with breast cancer brain metastases who receive upfront SRS alone. J Radiosurg SBRT. 2018; 5(4):277-283. PMID: 30538888.
      View in: PubMed
    7. Okoukoni C, McTyre ER, Ayala Peacock DN, Peiffer AM, Strowd R, Cramer C, Hinson WH, Rapp S, Metheny-Barlow L, Shaw EG, Chan MD. Hippocampal dose volume histogram predicts Hopkins Verbal Learning Test scores after brain irradiation. Adv Radiat Oncol. 2017 Oct-Dec; 2(4):624-629. PMID: 29204530.
      View in: PubMed
    8. Carpenter RL, Sirkisoon S, Zhu D, Rimkus T, Harrison A, Anderson A, Paw I, Qasem S, Xing F, Liu Y, Chan M, Metheny-Barlow L, Pasche BC, Debinski W, Watabe K, Lo HW. Combined inhibition of AKT and HSF1 suppresses breast cancer stem cells and tumor growth. Oncotarget. 2017 Sep 26; 8(43):73947-73963. PMID: 29088759.
      View in: PubMed
    9. Wang EC, Huang AJ, Huang KE, McTyre ER, Lo HW, Watabe K, Metheny-Barlow L, Laxton AW, Tatter SB, Strowd RE, Chan MD, Page BR. Leptomeningeal failure in patients with breast cancer receiving stereotactic radiosurgery for brain metastases. J Clin Neurosci. 2017 Sep; 43:6-10. PMID: 28511975.
      View in: PubMed
    10. Andrews RN, Metheny-Barlow LJ, Peiffer AM, Hanbury DB, Tooze JA, Bourland JD, Hampson RE, Deadwyler SA, Cline JM. Cerebrovascular Remodeling and Neuroinflammation is a Late Effect of Radiation-Induced Brain Injury in Non-Human Primates. Radiat Res. 2017 05; 187(5):599-611. PMID: 28398880.
      View in: PubMed
    11. Xing F, Liu Y, Sharma S, Wu K, Chan MD, Lo HW, Carpenter RL, Metheny-Barlow LJ, Zhou X, Qasem SA, Pasche B, Watabe K. Activation of the c-Met Pathway Mobilizes an Inflammatory Network in the Brain Microenvironment to Promote Brain Metastasis of Breast Cancer. Cancer Res. 2016 09 01; 76(17):4970-80. PMID: 27364556.
      View in: PubMed
    12. Sirkisoon SR, Carpenter RL, Rimkus T, Miller L, Metheny-Barlow L, Lo HW. EGFR and HER2 signaling in breast cancer brain metastasis. Front Biosci (Elite Ed). 2016 Jan 01; 8:245-63. PMID: 26709660.
      View in: PubMed
    13. Devoid HM, McTyre ER, Page BR, Metheny-Barlow L, Ruiz J, Chan MD. Recent advances in radiosurgical management of brain metastases. Front Biosci (Schol Ed). 2016 Jan 01; 8:203-14. PMID: 26709908.
      View in: PubMed
    14. Choudhary M, Naczki C, Chen W, Barlow KD, Case LD, Metheny-Barlow LJ. Tumor-induced loss of mural Connexin 43 gap junction activity promotes endothelial proliferation. BMC Cancer. 2015 May 23; 15:427. PMID: 26002762.
      View in: PubMed
    15. Wheeler KT, Payne V, D'Agostino RB, Walb MC, Munley MT, Metheny-Barlow LJ, Robbins ME. Impact of breathing 100% oxygen on radiation-induced cognitive impairment. Radiat Res. 2014 Nov; 182(5):580-5. PMID: 25338095.
      View in: PubMed
    16. Greene-Schloesser DM, Kooshki M, Payne V, D'Agostino RB, Wheeler KT, Metheny-Barlow LJ, Robbins ME. Cellular response of the rat brain to single doses of (137)Cs ? rays does not predict its response to prolonged 'biologically equivalent' fractionated doses. Int J Radiat Biol. 2014 Sep; 90(9):790-8. PMID: 24937374.
      View in: PubMed
    17. Greene-Schloesser D, Payne V, Peiffer AM, Hsu FC, Riddle DR, Zhao W, Chan MD, Metheny-Barlow L, Robbins ME. The peroxisomal proliferator-activated receptor (PPAR) a agonist, fenofibrate, prevents fractionated whole-brain irradiation-induced cognitive impairment. Radiat Res. 2014 Jan; 181(1):33-44. PMID: 24397438.
      View in: PubMed
    18. Moore ED, Kooshki M, Wheeler KT, Metheny-Barlow LJ, Robbins ME. Differential expression of Homer1a in the hippocampus and cortex likely plays a role in radiation-induced brain injury. Radiat Res. 2014 Jan; 181(1):21-32. PMID: 24377717.
      View in: PubMed
    19. Moore ED, Kooshki M, Metheny-Barlow LJ, Gallagher PE, Robbins ME. Angiotensin-(1-7) prevents radiation-induced inflammation in rat primary astrocytes through regulation of MAP kinase signaling. Free Radic Biol Med. 2013 Dec; 65:1060-1068. PMID: 24012919.
      View in: PubMed
    20. Vincent A, Lesser G, Brown D, Vern-Gross T, Metheny-Barlow L, Lawrence J, Chan M. Prolonged regression of metastatic leptomeningeal breast cancer that has failed conventional therapy: a case report and review of the literature. J Breast Cancer. 2013 Mar; 16(1):122-6. PMID: 23593093.
      View in: PubMed
    21. Vern-Gross TZ, Lawrence JA, Case LD, McMullen KP, Bourland JD, Metheny-Barlow LJ, Ellis TL, Tatter SB, Shaw EG, Urbanic JJ, Chan MD. Breast cancer subtype affects patterns of failure of brain metastases after treatment with stereotactic radiosurgery. J Neurooncol. 2012 Dec; 110(3):381-8. PMID: 23001361.
      View in: PubMed
    22. Buchanan CF, Szot CS, Wilson TD, Akman S, Metheny-Barlow LJ, Robertson JL, Freeman JW, Rylander MN. Cross-talk between endothelial and breast cancer cells regulates reciprocal expression of angiogenic factors in vitro. J Cell Biochem. 2012 Apr; 113(4):1142-51. PMID: 22095586.
      View in: PubMed
    23. Barlow KD, Sanders AM, Soker S, Ergun S, Metheny-Barlow LJ. Pericytes on the tumor vasculature: jekyll or hyde? Cancer Microenviron. 2013 Apr; 6(1):1-17. PMID: 22467426.
      View in: PubMed
    24. Cook KL, Metheny-Barlow LJ, Tallant EA, Gallagher PE. Angiotensin-(1-7) reduces fibrosis in orthotopic breast tumors. Cancer Res. 2010 Nov 01; 70(21):8319-28. PMID: 20837666.
      View in: PubMed
    25. Metheny-Barlow LJ, Li LY. Vascular endothelial growth inhibitor (VEGI), an endogenous negative regulator of angiogenesis. Semin Ophthalmol. 2006 Jan-Mar; 21(1):49-58. PMID: 16517446.
      View in: PubMed
    26. Ramljak D, Romanczyk LJ, Metheny-Barlow LJ, Thompson N, Knezevic V, Galperin M, Ramesh A, Dickson RB. Pentameric procyanidin from Theobroma cacao selectively inhibits growth of human breast cancer cells. Mol Cancer Ther. 2005 Apr; 4(4):537-46. PMID: 15827326.
      View in: PubMed
    27. Li LY, Barlow KD, Metheny-Barlow LJ. Angiopoietins and Tie2 in health and disease. Pediatr Endocrinol Rev. 2005 Mar; 2(3):399-408. PMID: 16429117.
      View in: PubMed
    28. Metheny-Barlow LJ, Tian S, Hayes AJ, Li LY. Direct chemotactic action of angiopoietin-1 on mesenchymal cells in the presence of VEGF. Microvasc Res. 2004 Nov; 68(3):221-30. PMID: 15501241.
      View in: PubMed
    29. Metheny-Barlow LJ, Li LY. The enigmatic role of angiopoietin-1 in tumor angiogenesis. Cell Res. 2003 Oct; 13(5):309-17. PMID: 14672554.
      View in: PubMed
    30. Tian S, Hayes AJ, Metheny-Barlow LJ, Li LY. Stabilization of breast cancer xenograft tumour neovasculature by angiopoietin-1. Br J Cancer. 2002 Feb 12; 86(4):645-51. PMID: 11870550.
      View in: PubMed
    31. Yu J, Tian S, Metheny-Barlow L, Chew LJ, Hayes AJ, Pan H, Yu GL, Li LY. Modulation of endothelial cell growth arrest and apoptosis by vascular endothelial growth inhibitor. Circ Res. 2001 Dec 07; 89(12):1161-7. PMID: 11739281.
      View in: PubMed
    32. Marrogi A, Pass HI, Khan M, Metheny-Barlow LJ, Harris CC, Gerwin BI. Human mesothelioma samples overexpress both cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (NOS2): in vitro antiproliferative effects of a COX-2 inhibitor. Cancer Res. 2000 Jul 15; 60(14):3696-700. PMID: 10919635.
      View in: PubMed
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