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Leanne Groban MD

TitleProfessor
InstitutionWake Forest School of Medicine
DepartmentAnesthesiology
Address
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    Collapse Research 
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    R03AG022598     (GROBAN, LEANNE)Sep 15, 2003 - Aug 31, 2005
    NIH
    Role of IGF-1 In Diastolic Dysfunction of Aging
    Role: Principal Investigator

    K08AG026764     (GROBAN, LEANNE)Jul 15, 2005 - Jun 30, 2011
    NIH
    Growth Hormone, Angiotensin II, and Cardiac Aging
    Role: Principal Investigator

    R01AG033727     (GROBAN, LEANNE)Apr 1, 2009 - Jun 30, 2019
    NIH
    Interplay Between Estrogen, GPR30 and Chymase/RAS in Diastolic Function
    Role: Principal Investigator

    R03AG042758     (GROBAN, LEANNE)Sep 15, 2012 - Aug 31, 2015
    NIH
    The conditional GPR30 knockout mouse: a model of female-specific cardiac aging
    Role: Principal Investigator

    R21AG061588     (GROBAN, LEANNE)Jan 15, 2019 - Nov 30, 2021
    NIH
    Effects of cell-based hormone therapy on LV diastolic dysfunction and hypertrophy progression after mid-life estrogen loss
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Alencar AKN, Wang H, Oliveira GMM, Sun X, Zapata-Sudo G, Groban L. Crossroads between Estrogen Loss, Obesity, and Heart Failure with Preserved Ejection Fraction. Arq Bras Cardiol. 2021 Oct 08. PMID: 34644788.
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    2. Zhang X, Li T, Cheng HJ, Wang H, Ferrario CM, Groban L, Cheng CP. Chronic GPR30 agonist therapy causes restoration of normal cardiac functional performance in a male mouse model of progressive heart failure: Insights into cellular mechanisms. Life Sci. 2021 Sep 11; 119955. PMID: 34520767.
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    3. Ogola BO, Clark GL, Abshire CM, Harris NR, Gentry KL, Gunda SS, Kilanowski-Doroh I, Wong TJ, Visniauskas B, Lawrence DJ, Zimmerman MA, Bayer CL, Groban L, Miller KS, Lindsey SH. Sex and the G Protein-Coupled Estrogen Receptor Impact Vascular Stiffness. Hypertension. 2021 May 24; HYPERTENSIONAHA12016915. PMID: 34024124.
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    4. Sun X, Wang H, Hodge H, Wright KN, Ahmad S, Ferrario CM, Groban L. Amplifying effect of chronic lisinopril therapy on diastolic function and the angiotensin-(1-7) Axis by the G1 agonist in ovariectomized spontaneously hypertensive rats. Transl Res. 2021 Apr 26. PMID: 33915312.
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    5. Kim S, Hsu FC, Groban L, Williamson J, Messier S. A pilot study of aquatic prehabilitation in adults with knee osteoarthritis undergoing total knee arthroplasty - short term outcome. BMC Musculoskelet Disord. 2021 Apr 26; 22(1):388. PMID: 33902505.
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    6. Ferrario CM, Groban L, Wang H, Ahmad S. Letter to the Editor: Brain renin-angiotensin system and liver-directed siRNA targeted to angiotensinogen. Clin Sci (Lond). 2021 Apr 16; 135(7):907-910. PMID: 33835151.
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    7. Wang H, Saha AK, Sun X, Kon ND, Ferrario CM, Groban L. Atrial appendage angiotensin-converting enzyme-2, aging and cardiac surgical patients: a platform for understanding aging-related coronavirus disease-2019 vulnerabilities. Curr Opin Anaesthesiol. 2021 Apr 01; 34(2):187-198. PMID: 33606395.
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    8. Ahmad S, Punzi HA, Wright KN, Groban L, Ferrario CM. Newly developed radioimmunoassay for Human Angiotensin-(1-12) measurements in plasma and urine. Mol Cell Endocrinol. 2021 06 01; 529:111256. PMID: 33798634.
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    9. Wang H, Sun X, L VonCannon J, Kon ND, Ferrario CM, Groban L. Estrogen receptors are linked to angiotensin-converting enzyme 2 (ACE2), ADAM metallopeptidase domain 17 (ADAM-17), and transmembrane protease serine 2 (TMPRSS2) expression in the human atrium: insights into COVID-19. Hypertens Res. 2021 Feb 03. PMID: 33536584.
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    10. Groban L. Editorial: Anesthesia for the older surgical patient: beyond standard care? Curr Opin Anaesthesiol. 2021 Feb 01; 34(1):25-26. PMID: 33284151.
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    11. Ferrario CM, Iyer SR, Burnett JC, Ahmad S, Wright KN, VonCannon JL, Saha A, Groban L. Angiotensin (1-12) in Humans With Normal Blood Pressure and Primary Hypertension. Hypertension. 2021 Mar 03; 77(3):882-890. PMID: 33461312.
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    12. Ferrario CM, Groban L, Wang H, Cheng CP, VonCannon JL, Wright KN, Sun X, Ahmad S. The Angiotensin-(1-12)/Chymase axis as an alternate component of the tissue renin angiotensin system. Mol Cell Endocrinol. 2021 06 01; 529:111119. PMID: 33309638.
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    13. Ferrario CM, Ahmad S, Groban L. Twenty years of progress in angiotensin converting enzyme 2 and its link to SARS-CoV-2 disease. Clin Sci (Lond). 2020 10 16; 134(19):2645-2664. PMID: 33063823.
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    14. Groban L, Wang H, Sun X, Ahmad S, Ferrario CM. Is Sex a Determinant of COVID-19 Infection? Truth or Myth? Curr Hypertens Rep. 2020 08 27; 22(9):62. PMID: 32852624.
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    15. Ferrario CM, Ahmad S, Groban L. Mechanisms by which angiotensin-receptor blockers increase ACE2 levels. Nat Rev Cardiol. 2020 06; 17(6):378. PMID: 32332868.
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    16. Wang H, Varagic J, Nagata S, Kon ND, Ahmad S, VonCannon JL, Wright KN, Sun X, Deal D, Groban L, Ferrario CM. Atrial angiotensin-(1-12)/chymase expression data in patient of heart diseases. Data Brief. 2020 Aug; 31:105744. PMID: 32490094.
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    17. Wang H, Varagic J, Nagata S, Kon ND, Ahmad S, VonCannon JL, Wright KN, Sun X, Deal D, Groban L, Ferrario CM. Differential Expression of the Angiotensin-(1-12)/Chymase Axis in Human Atrial Tissue. J Surg Res. 2020 09; 253:173-184. PMID: 32361612.
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    18. Groban L, Tran QK, Ferrario CM, Sun X, Cheng CP, Kitzman DW, Wang H, Lindsey SH. Female Heart Health: Is GPER the Missing Link? Front Endocrinol (Lausanne). 2019; 10:919. PMID: 31993020.
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    19. Yamashita T, Ahmad S, Wright KN, Roberts DJ, VonCannon JL, Wang H, Groban L, Dell'Italia LJ, Ferrario CM. Noncanonical Mechanisms for Direct Bone Marrow Generating Ang II (Angiotensin II) Predominate in CD68 Positive Myeloid Lineage Cells. Hypertension. 2020 02; 75(2):500-509. PMID: 31813348.
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    20. Ferrario CM, VonCannon J, Ahmad S, Wright KN, Roberts DJ, Wang H, Yamashita T, Groban L, Cheng CP, Collawn JF, Dell'Italia LJ, Varagic J. Activation of the Human Angiotensin-(1-12)-Chymase Pathway in Rats With Human Angiotensinogen Gene Transcripts. Front Cardiovasc Med. 2019; 6:163. PMID: 31803758.
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    21. da Silva JS, Sun X, Ahmad S, Wang H, Sudo RT, Varagic J, Ferrario CM, Zapata-Sudo G, Groban L. G-Protein-Coupled Estrogen Receptor Agonist G1 Improves Diastolic Function and Attenuates Cardiac Renin-Angiotensin System Activation in Estrogen-Deficient Hypertensive Rats. J Cardiovasc Pharmacol. 2019 11; 74(5):443-452. PMID: 31361702.
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    22. Ahmad S, Wright KN, Sun X, Groban L, Ferrario CM. Mast cell peptidases (carboxypeptidase A and chymase)-mediated hydrolysis of human angiotensin-(1-12) substrate. Biochem Biophys Res Commun. 2019 10 22; 518(4):651-656. PMID: 31466718.
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    23. Wang H, Sun X, Hodge HS, Ferrario CM, Groban L. NLRP3 inhibition improves heart function in GPER knockout mice. Biochem Biophys Res Commun. 2019 06 30; 514(3):998-1003. PMID: 31092335.
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    24. Wang H, Sun X, Ahmad S, Su J, Ferrario CM, Groban L. Estrogen modulates the differential expression of cardiac myocyte chymase isoforms and diastolic function. Mol Cell Biochem. 2019 Jun; 456(1-2):85-93. PMID: 30712071.
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    25. Michalson KT, Groban L, Howard TD, Shively CA, Sophonsritsuk A, Appt SE, Cline JM, Clarkson TB, Carr JJ, Kitzman DW, Register TC. Estradiol Treatment Initiated Early After Ovariectomy Regulates Myocardial Gene Expression and Inhibits Diastolic Dysfunction in Female Cynomolgus Monkeys: Potential Roles for Calcium Homeostasis and Extracellular Matrix Remodeling. J Am Heart Assoc. 2018 11 06; 7(21):e009769. PMID: 30571375.
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    26. Alencar AKN, Montes GC, Costa DG, Mendes LVP, Silva AMS, Martinez ST, Trachez MM, Cunha VDMN, Montagnoli TL, Fraga AGM, Wang H, Groban L, Fraga CAM, Sudo RT, Zapata-Sudo G. Cardioprotection Induced by Activation of GPER in Ovariectomized Rats With Pulmonary Hypertension. J Gerontol A Biol Sci Med Sci. 2018 08 10; 73(9):1158-1166. PMID: 29790948.
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    27. Kim S, Neiberg R, Rejeski WJ, Marsh AP, Kritchevsky SB, Leng XI, Groban L. Self-reported mobility as a preoperative risk assessment tool in older surgical patients compared to the American College of Surgeons National Surgical Quality Improvement Program. Perioper Med (Lond). 2018; 7:12. PMID: 29951202.
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    28. Kim S, Miller ME, Lin M, Rejeski WJ, Kritchevsky SB, Marsh AP, Groban L. Self- vs proxy-reported mobility using the mobility assessment tool-short form in elderly preoperative patients. Eur Rev Aging Phys Act. 2018; 15:5. PMID: 29721102.
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    29. Wang H, Sun X, Lin MS, Ferrario CM, Van Remmen H, Groban L. G protein-coupled estrogen receptor (GPER) deficiency induces cardiac remodeling through oxidative stress. Transl Res. 2018 09; 199:39-51. PMID: 29758174.
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    30. Kim S, Duncan PW, Groban L, Segal H, Abbott RM, Williamson JD. Development and Implementation of a Tool to Assess Patient-Reported Outcome Measures (PROM) in Preoperative Setting. Glob J Perioper Med. 2017; 1:017-21. PMID: 29932173.
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    31. Kim S, Duncan PW, Groban L, Segal H, Abbott RM, Williamson JD. Patient-Reported Outcome Measures (PROM) as A Preoperative Assessment Tool. J Anesth Perioper Med. 2017 Nov 28; 4(6):274-281. PMID: 29333531.
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    32. Ahmad S, Sun X, Lin M, Varagic J, Zapata-Sudo G, Ferrario CM, Groban L, Wang H. Blunting of estrogen modulation of cardiac cellular chymase/RAS activity and function in SHR. J Cell Physiol. 2018 04; 233(4):3330-3342. PMID: 28888034.
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    33. Silverstein-Metzler MG, Justice JN, Appt SE, Groban L, Kitzman DW, Carr JJ, Register TC, Shively CA. Long-term sertraline treatment and depression effects on carotid artery atherosclerosis in premenopausal female primates. Menopause. 2017 Oct; 24(10):1175-1184. PMID: 28609387.
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    34. da Silva JS, Gabriel-Costa D, Wang H, Ahmad S, Sun X, Varagic J, Sudo RT, Ferrario CM, Dell Italia LJ, Sudo GZ, Groban L. Blunting of cardioprotective actions of estrogen in female rodent heart linked to altered expression of cardiac tissue chymase and ACE2. J Renin Angiotensin Aldosterone Syst. 2017 Jul-Sep; 18(3):1470320317722270. PMID: 28748720.
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    35. da Silva JS, Gabriel-Costa D, Sudo RT, Wang H, Groban L, Ferraz EB, Nascimento JH, Fraga CA, Barreiro EJ, Zapata-Sudo G. Adenosine A2A receptor agonist prevents cardiac remodeling and dysfunction in spontaneously hypertensive male rats after myocardial infarction. Drug Des Devel Ther. 2017; 11:553-562. PMID: 28293100.
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    36. Reyes S, Varagic J, Ahmad S, VonCannon J, Kon ND, Wang H, Groban L, Cheng CP, Dell'Italia LJ, Ferrario CM. Novel Cardiac Intracrine Mechanisms Based on Ang-(1-12)/Chymase Axis Require a Revision of Therapeutic Approaches in Human Heart Disease. Curr Hypertens Rep. 2017 Feb; 19(2):16. PMID: 28233239.
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    37. Wang H, Sun X, Chou J, Lin M, Ferrario CM, Zapata-Sudo G, Groban L. Inflammatory and mitochondrial gene expression data in GPER-deficient cardiomyocytes from male and female mice. Data Brief. 2017 Feb; 10:465-473. PMID: 28054009.
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    38. Alencar AK, Montes GC, Montagnoli T, Silva AM, Martinez ST, Fraga AG, Wang H, Groban L, Sudo RT, Zapata-Sudo G. Activation of GPER ameliorates experimental pulmonary hypertension in male rats. Eur J Pharm Sci. 2017 Jan 15; 97:208-217. PMID: 27836751.
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    39. Wang H, Sun X, Chou J, Lin M, Ferrario CM, Zapata-Sudo G, Groban L. Cardiomyocyte-specific deletion of the G protein-coupled estrogen receptor (GPER) leads to left ventricular dysfunction and adverse remodeling: A sex-specific gene profiling analysis. Biochim Biophys Acta Mol Basis Dis. 2017 08; 1863(8):1870-1882. PMID: 27725247.
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    40. Ahmad S, Varagic J, VonCannon JL, Groban L, Collawn JF, Dell'Italia LJ, Ferrario CM. Primacy of cardiac chymase over angiotensin converting enzyme as an angiotensin-(1-12) metabolizing enzyme. Biochem Biophys Res Commun. 2016 09 16; 478(2):559-64. PMID: 27465904.
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    41. Wang H, da Silva J, Alencar A, Zapata-Sudo G, Lin MR, Sun X, Ahmad S, Ferrario CM, Groban L. Mast Cell Inhibition Attenuates Cardiac Remodeling and Diastolic Dysfunction in Middle-aged, Ovariectomized Fischer 344 × Brown Norway Rats. J Cardiovasc Pharmacol. 2016 Jul; 68(1):49-57. PMID: 26981683.
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    42. Ferrario CM, Ahmad S, Varagic J, Cheng CP, Groban L, Wang H, Collawn JF, Dell Italia LJ. Intracrine angiotensin II functions originate from noncanonical pathways in the human heart. . 2016 08 01; 311(2):H404-14. PMID: 27233763.
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    43. Wang H, Alencar A, Lin M, Sun X, Sudo RT, Zapata-Sudo G, Lowe DA, Groban L. Activation of GPR30 improves exercise capacity and skeletal muscle strength in senescent female Fischer344 × Brown Norway rats. Biochem Biophys Res Commun. 2016 06 17; 475(1):81-6. PMID: 27173878.
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    44. Kim S, Marsh AP, Rustowicz L, Roach C, Leng XI, Kritchevsky SB, Rejeski WJ, Groban L. Self-reported Mobility in Older Patients Predicts Early Postoperative Outcomes after Elective Noncardiac Surgery. Anesthesiology. 2016 Apr; 124(4):815-25. PMID: 26978144.
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    45. Alencar AK, da Silva JS, Lin M, Silva AM, Sun X, Ferrario CM, Cheng C, Sudo RT, Zapata-Sudo G, Wang H, Groban L. Effect of Age, Estrogen Status, and Late-Life GPER Activation on Cardiac Structure and Function in the Fischer344×Brown Norway Female Rat. J Gerontol A Biol Sci Med Sci. 2017 02; 72(2):152-162. PMID: 27006078.
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    46. Ferrario CM, VonCannon J, Jiao Y, Ahmad S, Bader M, Dell'Italia LJ, Groban L, Varagic J. Cardiac angiotensin-(1-12) expression and systemic hypertension in rats expressing the human angiotensinogen gene. . 2016 Apr 15; 310(8):H995-1002. PMID: 26873967.
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    47. Johnson KN, Botros DB, Groban L, Bryan YF. Anatomic and physiopathologic changes affecting the airway of the elderly patient: implications for geriatric-focused airway management. Clin Interv Aging. 2015; 10:1925-34. PMID: 26673904.
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    48. Nagata S, Varagic J, Kon ND, Wang H, Groban L, Simington SW, Ahmad S, Dell'Italia LJ, VonCannon JL, Deal D, Ferrario CM. Differential expression of the angiotensin-(1-12)/chymase axis in human atrial tissue. Ther Adv Cardiovasc Dis. 2015 Aug; 9(4):168-80. PMID: 26082339.
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    49. Wang H, Zhao Z, Lin M, Groban L. Activation of GPR30 inhibits cardiac fibroblast proliferation. Mol Cell Biochem. 2015 Jul; 405(1-2):135-48. PMID: 25893735.
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    50. Xie P, Kadegowda AK, Ma Y, Guo F, Han X, Wang M, Groban L, Xue B, Shi H, Li H, Yu L. Muscle-specific deletion of comparative gene identification-58 (CGI-58) causes muscle steatosis but improves insulin sensitivity in male mice. Endocrinology. 2015 May; 156(5):1648-58. PMID: 25751639.
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    51. Zhao Z, Wang H, Lin M, Groban L. GPR30 decreases cardiac chymase/angiotensin II by inhibiting local mast cell number. Biochem Biophys Res Commun. 2015 Mar 27; 459(1):131-6. PMID: 25712524.
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    52. Kim S, Brooks AK, Groban L. Preoperative assessment of the older surgical patient: honing in on geriatric syndromes. Clin Interv Aging. 2015; 10:13-27. PMID: 25565783.
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    53. Ahmad S, Varagic J, Groban L, Dell'Italia LJ, Nagata S, Kon ND, Ferrario CM. Angiotensin-(1-12): a chymase-mediated cellular angiotensin II substrate. Curr Hypertens Rep. 2014 May; 16(5):429. PMID: 24633843.
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    54. Groban L, Kitzman DW, Register TC, Shively CA. Effect of depression and sertraline treatment on cardiac function in female nonhuman primates. Psychosom Med. 2014 Feb; 76(2):137-46. PMID: 24470133.
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    55. Zhao Z, Wang H, Jessup JA, Lindsey SH, Chappell MC, Groban L. Role of estrogen in diastolic dysfunction. . 2014 Mar 01; 306(5):H628-40. PMID: 24414072.
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    56. Wang H, Jessup JA, Zhao Z, Da Silva J, Lin M, MacNamara LM, Ahmad S, Chappell MC, Ferrario CM, Groban L. Characterization of the cardiac renin angiotensin system in oophorectomized and estrogen-replete mRen2.Lewis rats. PLoS One. 2013; 8(10):e76992. PMID: 24204720.
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    57. Jessup JA, Wang H, MacNamara LM, Presley TD, Kim-Shapiro DB, Zhang L, Chen AF, Groban L. Estrogen therapy, independent of timing, improves cardiac structure and function in oophorectomized mRen2.Lewis rats. Menopause. 2013 Aug; 20(8):860-8. PMID: 23481117.
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    58. Moniwa N, Varagic J, Ahmad S, VonCannon JL, Simington SW, Wang H, Groban L, Brosnihan KB, Nagata S, Kato J, Kitamura K, Gomez RA, Lopez ML, Ferrario CM. Hemodynamic and hormonal changes to dual renin-angiotensin system inhibition in experimental hypertension. Hypertension. 2013 Feb; 61(2):417-24. PMID: 23232645.
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    59. Groban L, Wang H, Machado FS, Trask AJ, Kritchevsky SB, Ferrario CM, Diz DI. Low glial angiotensinogen improves body habitus, diastolic function, and exercise tolerance in aging male rats. Cardiovasc Endocrinol. 2012 Sep 01; 1(3):49-58. PMID: 23795309.
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    60. Wang H, Jessup JA, Lin MS, Chagas C, Lindsey SH, Groban L. Activation of GPR30 attenuates diastolic dysfunction and left ventricle remodelling in oophorectomized mRen2.Lewis rats. Cardiovasc Res. 2012 Apr 01; 94(1):96-104. PMID: 22328091.
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    61. Bharadwaj MS, Strawn WB, Groban L, Yamaleyeva LM, Chappell MC, Horta C, Atkins K, Firmes L, Gurley SB, Brosnihan KB. Angiotensin-converting enzyme 2 deficiency is associated with impaired gestational weight gain and fetal growth restriction. Hypertension. 2011 Nov; 58(5):852-8. PMID: 21968754.
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    62. Kitzman DW, Groban L. Exercise intolerance. Cardiol Clin. 2011 Aug; 29(3):461-77. PMID: 21803233.
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    63. Groban L, Lindsey S, Wang H, Lin MS, Kassik KA, Machado FS, Carter CS. Differential effects of late-life initiation of low-dose enalapril and losartan on diastolic function in senescent Fischer 344 x Brown Norway male rats. Age (Dordr). 2012 Aug; 34(4):831-43. PMID: 21720770.
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    64. Carter CS, Marzetti E, Leeuwenburgh C, Manini T, Foster TC, Groban L, Scarpace PJ, Morgan D. Usefulness of preclinical models for assessing the efficacy of late-life interventions for sarcopenia. J Gerontol A Biol Sci Med Sci. 2012 Jan; 67(1):17-27. PMID: 21636833.
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    65. Jessup JA, Zhang L, Chen AF, Presley TD, Kim-Shapiro DB, Chappell MC, Wang H, Groban L. Neuronal nitric oxide synthase inhibition improves diastolic function and reduces oxidative stress in ovariectomized mRen2.Lewis rats. Menopause. 2011 Jun; 18(6):698-708. PMID: 21293310.
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    66. Schafer AM, Rains JC, Penzien DB, Groban L, Smitherman TA, Houle TT. Direct costs of preventive headache treatments: comparison of behavioral and pharmacologic approaches. Headache. 2011 Jun; 51(6):985-91. PMID: 21631481.
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    67. Jessup JA, Zhang L, Presley TD, Kim-Shapiro DB, Wang H, Chen AF, Groban L. Tetrahydrobiopterin restores diastolic function and attenuates superoxide production in ovariectomized mRen2.Lewis rats. Endocrinology. 2011 Jun; 152(6):2428-36. PMID: 21427216.
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    68. Sergeant S, McQuail JA, Riddle DR, Chilton FH, Ortmeier SB, Jessup JA, Groban L, Nicolle MM. Dietary fish oil modestly attenuates the effect of age on diastolic function but has no effect on memory or brain inflammation in aged rats. J Gerontol A Biol Sci Med Sci. 2011 May; 66(5):521-33. PMID: 21393424.
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    69. Groban L, Lin M, Kassik KA, Ingram RL, Sonntag WE. Early-onset growth hormone deficiency results in diastolic dysfunction in adult-life and is prevented by growth hormone supplementation. Growth Horm IGF Res. 2011 Apr; 21(2):81-8. PMID: 21371927.
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    70. Jessup JA, Lindsey SH, Wang H, Chappell MC, Groban L. Attenuation of salt-induced cardiac remodeling and diastolic dysfunction by the GPER agonist G-1 in female mRen2.Lewis rats. PLoS One. 2010 Nov 03; 5(11):e15433. PMID: 21082029.
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    71. Brock MF, Grace BE, Morley B, Hillegass G, Houle TT, Groban L. Does lidocaine more effectively prevent pain upon induction with propofol or etomidate when given preemptively than when mixed with the drug? J Clin Anesth. 2010 Nov; 22(7):505-9. PMID: 21056806.
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    72. Groban L, Kitzman DW. Diastolic function: a barometer for cardiovascular risk? Anesthesiology. 2010 Jun; 112(6):1303-6. PMID: 20502111.
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    73. Delo DM, Guan X, Wang Z, Groban L, Callahan M, Smith T, Sane DC, Payne RM, Atala A, Soker S. Calcification after myocardial infarction is independent of amniotic fluid stem cell injection. Cardiovasc Pathol. 2011 Mar-Apr; 20(2):e69-78. PMID: 20382039.
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    74. Trask AJ, Groban L, Westwood BM, Varagic J, Ganten D, Gallagher PE, Chappell MC, Ferrario CM. Inhibition of angiotensin-converting enzyme 2 exacerbates cardiac hypertrophy and fibrosis in Ren-2 hypertensive rats. Am J Hypertens. 2010 Jun; 23(6):687-93. PMID: 20300067.
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    75. Groban L, Sanders DM, Houle TT, Antonio BL, Ntuen EC, Zvara DA, Kon ND, Kincaid EH. Prognostic value of tissue Doppler-Derived E/e' on early morbid events after cardiac surgery. Echocardiography. 2010 Feb; 27(2):131-8. PMID: 20380676.
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    76. Varagic J, Ahmad S, Brosnihan KB, Groban L, Chappell MC, Tallant EA, Gallagher PE, Ferrario CM. Decreased cardiac Ang-(1-7) is associated with salt-induced cardiac remodeling and dysfunction. Ther Adv Cardiovasc Dis. 2010 Feb; 4(1):17-25. PMID: 19946038.
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    77. König M, Lin M, Nelson TE, Groban L. Sevoflurane modulation of Ca2+ regulation in skeletal muscle sarcoplasmic reticulum vesicles from young and mature rabbits. Paediatr Anaesth. 2009 Dec; 19(12):1166-74. PMID: 19863735.
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    78. Sanders D, Dudley M, Groban L. Diastolic dysfunction, cardiovascular aging, and the anesthesiologist. Anesthesiol Clin. 2009 Sep; 27(3):497-517. PMID: 19825489.
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    79. Groban L, Butterworth J. Fentanyl: destiny or devil? Anesth Analg. 2009 Aug; 109(2):301-2. PMID: 19608795.
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    80. Jessup JA, Westwood BM, Chappell MC, Groban L. Dual ACE-inhibition and AT1 receptor antagonism improves ventricular lusitropy without affecting cardiac fibrosis in the congenic mRen2.Lewis rat. Ther Adv Cardiovasc Dis. 2009 Aug; 3(4):245-57. PMID: 19531557.
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    81. Groban L, Jobe H, Lin M, Houle T, Kitzman DA, Sonntag W. Effects of short-term treadmill exercise training or growth hormone supplementation on diastolic function and exercise tolerance in old rats. J Gerontol A Biol Sci Med Sci. 2008 Sep; 63(9):911-20. PMID: 18840795.
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    82. Diz DI, Varagic J, Groban L. Aging and the brain renin-angiotensin system: relevance to age-related decline in cardiac function. Future Cardiol. 2008 May; 4(3):237-45. PMID: 19804328.
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    83. Carter CS, Groban L. Role of the renin-angiotensin system in age-related sarcopenia and diastolic dysfunction. Aging health. 2008 Feb 01; 4(1):37-46. PMID: 20445808.
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    84. Groban L, Yamaleyeva LM, Westwood BM, Houle TT, Lin M, Kitzman DW, Chappell MC. Progressive diastolic dysfunction in the female mRen(2). Lewis rat: influence of salt and ovarian hormones. J Gerontol A Biol Sci Med Sci. 2008 Jan; 63(1):3-11. PMID: 18245755.
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    85. Kitzman DW, Groban L. Exercise intolerance. Heart Fail Clin. 2008 Jan; 4(1):99-115. PMID: 18313628.
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    86. Marzetti E, Groban L, Wohlgemuth SE, Lees HA, Lin M, Jobe H, Giovannini S, Leeuwenburgh C, Carter CS. Effects of short-term GH supplementation and treadmill exercise training on physical performance and skeletal muscle apoptosis in old rats. . 2008 Feb; 294(2):R558-67. PMID: 18003794.
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    87. Yamaleyeva LM, Pendergrass KD, Pirro NT, Gallagher PE, Groban L, Chappell MC. Ovariectomy is protective against renal injury in the high-salt-fed older mRen2. Lewis rat. . 2007 Oct; 293(4):H2064-71. PMID: 17630347.
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    88. Corcoran W, Butterworth J, Weller RS, Beck JC, Gerancher JC, Houle TT, Groban L. Local anesthetic-induced cardiac toxicity: a survey of contemporary practice strategies among academic anesthesiology departments. Anesth Analg. 2006 Nov; 103(5):1322-6. PMID: 17056977.
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    89. Groban L, Butterworth J. Perioperative management of chronic heart failure. Anesth Analg. 2006 Sep; 103(3):557-75. PMID: 16931661.
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    90. Groban L, Pailes NA, Bennett CD, Carter CS, Chappell MC, Kitzman DW, Sonntag WE. Growth hormone replacement attenuates diastolic dysfunction and cardiac angiotensin II expression in senescent rats. J Gerontol A Biol Sci Med Sci. 2006 Jan; 61(1):28-35. PMID: 16456192.
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    91. Groban L, Dolinski SY. Transesophageal echocardiographic evaluation of diastolic function. Chest. 2005 Nov; 128(5):3652-63. PMID: 16304327.
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    92. Groban L. Diastolic dysfunction in the older heart. J Cardiothorac Vasc Anesth. 2005 Apr; 19(2):228-36. PMID: 15868536.
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    93. Groban L, Vernon JC, Butterworth J. Intrathecal morphine reduces infarct size in a rat model of ischemia-reperfusion injury. Anesth Analg. 2004 Apr; 98(4):903-9, table of contents. PMID: 15041570.
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    94. Groban L, Butterworth J. Lipid reversal of bupivacaine toxicity: has the silver bullet been identified? Reg Anesth Pain Med. 2003 May-Jun; 28(3):167-9. PMID: 12772133.
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    95. Murphy BA, Groban L, Kon ND. Diagnosis of a unicuspid aortic valve using transesophageal echocardiography. J Cardiothorac Vasc Anesth. 2003 Feb; 17(1):82-3. PMID: 12635067.
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    96. Groban L. Central nervous system and cardiac effects from long-acting amide local anesthetic toxicity in the intact animal model. Reg Anesth Pain Med. 2003 Jan-Feb; 28(1):3-11. PMID: 12567336.
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    97. Prielipp RC, Wall MH, Tobin JR, Groban L, Cannon MA, Fahey FH, Gage HD, Stump DA, James RL, Bennett J, Butterworth J. Dexmedetomidine-induced sedation in volunteers decreases regional and global cerebral blood flow. Anesth Analg. 2002 Oct; 95(4):1052-9, table of contents. PMID: 12351293.
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    98. Groban L, Deal DD, Vernon JC, James RL, Butterworth J. Does local anesthetic stereoselectivity or structure predict myocardial depression in anesthetized canines? Reg Anesth Pain Med. 2002 Sep-Oct; 27(5):460-8. PMID: 12373692.
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    99. Groban L, Butterworth J, Legault C, Rogers AT, Kon ND, Hammon JW. Intraoperative insulin therapy does not reduce the need for inotropic or antiarrhythmic therapy after cardiopulmonary bypass. J Cardiothorac Vasc Anesth. 2002 Aug; 16(4):405-12. PMID: 12154416.
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    100. Groban L, Zapata-Sudo G, Lin M, Nelson TE. Effects of moderate and deep hypothermia on Ca2+ signaling in rat ventricular myocytes. Cell Physiol Biochem. 2002; 12(2-3):101-10. PMID: 12077555.
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    101. Prielipp RC, Wall MH, Groban L, Tobin JR, Fahey FH, Harkness BA, Stump DA, James RL, Cannon MA, Bennett J, Butterworth J. Reduced regional and global cerebral blood flow during fenoldopam-induced hypotension in volunteers. Anesth Analg. 2001 Jul; 93(1):45-52. PMID: 11429337.
      Citations:    
    102. Groban L, Deal DD, Vernon JC, James RL, Butterworth J. Cardiac resuscitation after incremental overdosage with lidocaine, bupivacaine, levobupivacaine, and ropivacaine in anesthetized dogs. Anesth Analg. 2001 Jan; 92(1):37-43. PMID: 11133597.
      Citations:    
    103. Dolinski SY, Groban L. Look before you leap. Anesth Analg. 2000 Dec; 91(6):1563-4. PMID: 11094025.
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    104. Groban L, Dolinski SY, Zvara DA, Oaks T. Thoracic epidural analgesia: its role in postthoracotomy atrial arrhythmias. J Cardiothorac Vasc Anesth. 2000 Dec; 14(6):662-5. PMID: 11139105.
      Citations:    
    105. Groban L, Deal DD, Vernon JC, James RL, Butterworth J. Ventricular arrhythmias with or without programmed electrical stimulation after incremental overdosage with lidocaine, bupivacaine, levobupivacaine, and ropivacaine. Anesth Analg. 2000 Nov; 91(5):1103-11. PMID: 11049891.
      Citations:    
    106. Zvara DA, Groban L, Rogers AT, Prielipp RC, Murphy B, Hines M, Hammon JW, Kon ND, Royster RL. Prophylactic nitroglycerin did not reduce myocardial ischemia during accelerated recovery management of coronary artery bypass graft surgery patients. J Cardiothorac Vasc Anesth. 2000 Oct; 14(5):571-5. PMID: 11052441.
      Citations:    
    107. Groban L, Zvara DA, Deal DD, Vernon JC, Carpenter RL. Thoracic epidural anesthesia reduces infarct size in a canine model of myocardial ischemia and reperfusion injury. J Cardiothorac Vasc Anesth. 1999 Oct; 13(5):579-85. PMID: 10527228.
      Citations:    
    108. Dolinski SY, Meek E, Groban L. An unusual case of subcutaneous emphysema. Anesth Analg. 1999 Jul; 89(1):150-1. PMID: 10389794.
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    109. Groban L, Zvara DA, Deal DD, Vernon JC, Flye CW, Ma XL, Vinten-Johansen J. Cloricromene reduces infarct size and alters postischaemic blood flow defects in dog myocardium. Clin Exp Pharmacol Physiol. 1998 Jun; 25(6):417-23. PMID: 9673816.
      Citations:    
    110. Groban L, Cheng EY, Mazzeo A, Muzi M. Change in stroke volume by iced temperature injectate for thermodilution cardiac output determination. Anesthesiology. 1993 Dec; 79(6):1444-5. PMID: 8267223.
      Citations:    
    111. Groban L, Ebert TJ, Kreis DU, Skelton MM, Van Wynsberghe DM, Cowley AW. Hemodynamic, renal, and hormonal responses to incremental ANF infusions in humans. Am J Physiol. 1989 May; 256(5 Pt 2):F780-6. PMID: 2524166.
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