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Karen M.Haas PhD

TitleAssociate Professor
InstitutionWake Forest School of Medicine
DepartmentMicrobiology and Immunology
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    Other Positions
    TitleAssociate Professor
    InstitutionWake Forest School of Medicine
    DepartmentCancer Biology


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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Kong X, Zeng D, Wu X, Wang B, Yang S, Song Q, Zhu Y, Salas M, Qin H, Nasri U, Haas KM, Riggs AD, Nakamura R, Martin PJ, Huang A, Zeng D. Tissue-resident PSGL1loCD4+ T cells promote B cell differentiation and chronic graft-versus-host disease-associated autoimmunity. J Clin Invest. 2021 Jan 04; 131(1). PMID: 32931481.
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    2. Daly CA, Spurrier MA, Jennings-Gee JE, Haas KM. B Cell Subsets Differentially Contribute to the T Cell-Independent Memory Pool. J Immunol. 2020 11 01; 205(9):2362-2374. PMID: 32978280.
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    3. Dyevoich AM, Disher NS, Haro MA, Haas KM. A TLR4-TRIF-dependent signaling pathway is required for protective natural tumor-reactive IgM production by B1 cells. Cancer Immunol Immunother. 2020 Oct; 69(10):2113-2124. PMID: 32448982.
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    4. Dyevoich AM, Haas KM. Type I IFN, Ly6C+ cells, and Phagocytes Support Suppression of Peritoneal Carcinomatosis Elicited by a TLR and CLR Agonist Combination. Mol Cancer Ther. 2020 06; 19(6):1232-1242. PMID: 32188623.
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    5. Salvador Moreno N, Liu J, Haas KM, Parker LL, Chakraborty C, Kron SJ, Hodges K, Miller LD, Langefeld C, Robinson PJ, Lelièvre SA, Vidi PA. The nuclear structural protein NuMA is a negative regulator of 53BP1 in DNA double-strand break repair. Nucleic Acids Res. 2019 04 08; 47(6):2703-2715. PMID: 30812030.
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    6. Phipps JP, Haas KM. An Adjuvant That Increases Protective Antibody Responses to Polysaccharide Antigens and Enables Recall Responses. J Infect Dis. 2019 01 07; 219(2):323-334. PMID: 30289460.
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    7. Haro MA, Dyevoich AM, Phipps JP, Haas KM. Activation of B-1 Cells Promotes Tumor Cell Killing in the Peritoneal Cavity. Cancer Res. 2019 01 01; 79(1):159-170. PMID: 30224373.
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    8. Haas KM, Johnson KL, Phipps JP, Do C. CD22 Promotes B-1b Cell Responses to T Cell-Independent Type 2 Antigens. J Immunol. 2018 03 01; 200(5):1671-1681. PMID: 29374074.
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    9. McKay JT, Haro MA, Daly CA, Yammani RD, Pang B, Swords WE, Haas KM. PD-L2 Regulates B-1 Cell Antibody Production against Phosphorylcholine through an IL-5-Dependent Mechanism. J Immunol. 2017 09 15; 199(6):2020-2029. PMID: 28768724.
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    10. Haro MA, Littrell CA, Yin Z, Huang X, Haas KM. PD-1 Suppresses Development of Humoral Responses That Protect against Tn-Bearing Tumors. Cancer Immunol Res. 2016 12; 4(12):1027-1037. PMID: 27856425.
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    11. Qin Q, Yin Z, Wu X, Haas KM, Huang X. Valency and density matter: Deciphering impacts of immunogen structures on immune responses against a tumor associated carbohydrate antigen using synthetic glycopolymers. Biomaterials. 2016 09; 101:189-98. PMID: 27294537.
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    12. Haas KM. B-1 lymphocytes in mice and nonhuman primates. Ann N Y Acad Sci. 2015 Dec; 1362:98-109. PMID: 25930711.
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    13. McKay JT, Egan RP, Yammani RD, Chen L, Shin T, Yagita H, Haas KM. PD-1 suppresses protective immunity to Streptococcus pneumoniae through a B cell-intrinsic mechanism. J Immunol. 2015 Mar 01; 194(5):2289-99. PMID: 25624454.
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    14. Shaikh SR, Haas KM, Beck MA, Teague H. The effects of diet-induced obesity on B cell function. Clin Exp Immunol. 2015 Jan; 179(1):90-9. PMID: 25169121.
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    15. Yammani RD, Leyva MA, Jennings RN, Haas KM. C4 Deficiency is a predisposing factor for Streptococcus pneumoniae-induced autoantibody production. J Immunol. 2014 Dec 01; 193(11):5434-43. PMID: 25339671.
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    16. Haas KM, Blevins MW, High KP, Pang B, Swords WE, Yammani RD. Aging promotes B-1b cell responses to native, but not protein-conjugated, pneumococcal polysaccharides: implications for vaccine protection in older adults. J Infect Dis. 2014 Jan 01; 209(1):87-97. PMID: 23964109.
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    17. Yammani RD, Haas KM. Primate B-1 cells generate antigen-specific B cell responses to T cell-independent type 2 antigens. J Immunol. 2013 Apr 01; 190(7):3100-8. PMID: 23455507.
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    18. Crump KE, Juneau DG, Poole LB, Haas KM, Grayson JM. The reversible formation of cysteine sulfenic acid promotes B-cell activation and proliferation. Eur J Immunol. 2012 Aug; 42(8):2152-64. PMID: 22674013.
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    19. Poe JC, Minard-Colin V, Kountikov EI, Haas KM, Tedder TF. A c-Myc and surface CD19 signaling amplification loop promotes B cell lymphoma development and progression in mice. J Immunol. 2012 Sep 01; 189(5):2318-25. PMID: 22826319.
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    20. Haas KM. Programmed cell death 1 suppresses B-1b cell expansion and long-lived IgG production in response to T cell-independent type 2 antigens. J Immunol. 2011 Nov 15; 187(10):5183-95. PMID: 22003198.
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    21. Tracy ET, Haas KM, Gentry T, Danko M, Roberts JL, Kurtzberg J, Rice HE. Partial splenectomy but not total splenectomy preserves immunoglobulin M memory B cells in mice. J Pediatr Surg. 2011 Sep; 46(9):1706-10. PMID: 21929978.
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    22. Poe JC, Smith SH, Haas KM, Yanaba K, Tsubata T, Matsushita T, Tedder TF. Amplified B lymphocyte CD40 signaling drives regulatory B10 cell expansion in mice. PLoS One. 2011; 6(7):e22464. PMID: 21799861.
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    23. Smith SH, Haas KM, Poe JC, Yanaba K, Ward CD, Migone TS, Tedder TF. B-cell homeostasis requires complementary CD22 and BLyS/BR3 survival signals. Int Immunol. 2010 Aug; 22(8):681-91. PMID: 20513733.
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    24. Haas KM, Watanabe R, Matsushita T, Nakashima H, Ishiura N, Okochi H, Fujimoto M, Tedder TF. Protective and pathogenic roles for B cells during systemic autoimmunity in NZB/W F1 mice. J Immunol. 2010 May 01; 184(9):4789-800. PMID: 20368280.
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    25. Haas KM, Poe JC, Tedder TF. CD21/35 promotes protective immunity to Streptococcus pneumoniae through a complement-independent but CD19-dependent pathway that regulates PD-1 expression. J Immunol. 2009 Sep 15; 183(6):3661-71. PMID: 19710450.
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    26. Minard-Colin V, Xiu Y, Poe JC, Horikawa M, Magro CM, Hamaguchi Y, Haas KM, Tedder TF. Lymphoma depletion during CD20 immunotherapy in mice is mediated by macrophage FcgammaRI, FcgammaRIII, and FcgammaRIV. Blood. 2008 Aug 15; 112(4):1205-13. PMID: 18495955.
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    27. Yanaba K, Bouaziz JD, Haas KM, Poe JC, Fujimoto M, Tedder TF. A regulatory B cell subset with a unique CD1dhiCD5+ phenotype controls T cell-dependent inflammatory responses. Immunity. 2008 May; 28(5):639-50. PMID: 18482568.
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    28. DiLillo DJ, Hamaguchi Y, Ueda Y, Yang K, Uchida J, Haas KM, Kelsoe G, Tedder TF. Maintenance of long-lived plasma cells and serological memory despite mature and memory B cell depletion during CD20 immunotherapy in mice. J Immunol. 2008 Jan 01; 180(1):361-71. PMID: 18097037.
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    29. Zabel MD, Heikenwalder M, Prinz M, Arrighi I, Schwarz P, Kranich J, von Teichman A, Haas KM, Zeller N, Tedder TF, Weis JH, Aguzzi A. Stromal complement receptor CD21/35 facilitates lymphoid prion colonization and pathogenesis. J Immunol. 2007 Nov 01; 179(9):6144-52. PMID: 17947689.
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    30. Ford JW, Kilmon MA, Haas KM, Shelburne AE, Chan-Li Y, Conrad DH. In vivo murine CD23 destabilization enhances CD23 shedding and IgE synthesis. Cell Immunol. 2006 Oct; 243(2):107-17. PMID: 17324389.
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    31. Pongratz G, McAlees JW, Conrad DH, Erbe RS, Haas KM, Sanders VM. The level of IgE produced by a B cell is regulated by norepinephrine in a p38 MAPK- and CD23-dependent manner. J Immunol. 2006 Sep 01; 177(5):2926-38. PMID: 16920928.
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    32. Haas KM, Sen S, Sanford IG, Miller AS, Poe JC, Tedder TF. CD22 ligand binding regulates normal and malignant B lymphocyte survival in vivo. J Immunol. 2006 Sep 01; 177(5):3063-73. PMID: 16920943.
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    33. Karen M. Haas, Youngkyun Lee, Thomas F. Tedder. CD21. UCSD Nature Molecule Pages. Aug 11 2006; doi:10.1038/mp.a000541.01. 2006. View Publication.
    34. Lee Y, Haas KM, Gor DO, Ding X, Karp DR, Greenspan NS, Poe JC, Tedder TF. Complement component C3d-antigen complexes can either augment or inhibit B lymphocyte activation and humoral immunity in mice depending on the degree of CD21/CD19 complex engagement. J Immunol. 2005 Dec 15; 175(12):8011-23. PMID: 16339538.
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    35. Haas KM, Poe JC, Steeber DA, Tedder TF. B-1a and B-1b cells exhibit distinct developmental requirements and have unique functional roles in innate and adaptive immunity to S. pneumoniae. Immunity. 2005 Jul; 23(1):7-18. PMID: 16039575.
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    36. Hamaguchi Y, Uchida J, Cain DW, Venturi GM, Poe JC, Haas KM, Tedder TF. The peritoneal cavity provides a protective niche for B1 and conventional B lymphocytes during anti-CD20 immunotherapy in mice. J Immunol. 2005 Apr 01; 174(7):4389-99. PMID: 15778404.
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    37. Tedder TF, Poe JC, Haas KM. CD22: a multifunctional receptor that regulates B lymphocyte survival and signal transduction. Adv Immunol. 2005; 88:1-50. PMID: 16227086.
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    38. Haas KM, Tedder TF. Role of the CD19 and CD21/35 receptor complex in innate immunity, host defense and autoimmunity. Adv Exp Med Biol. 2005; 560:125-39. PMID: 15934172.
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    39. Tedder TF, Poe JC, Fujimoto M, Haas KM, Sato S. The CD19-CD21 signal transduction complex of B lymphocytes regulates the balance between health and autoimmune disease: systemic sclerosis as a model system. Curr Dir Autoimmun. 2005; 8:55-90. PMID: 15564717.
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    40. Poe JC, Fujimoto Y, Hasegawa M, Haas KM, Miller AS, Sanford IG, Bock CB, Fujimoto M, Tedder TF. CD22 regulates B lymphocyte function in vivo through both ligand-dependent and ligand-independent mechanisms. Nat Immunol. 2004 Oct; 5(10):1078-87. PMID: 15378059.
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    41. Uchida J, Hamaguchi Y, Oliver JA, Ravetch JV, Poe JC, Haas KM, Tedder TF. The innate mononuclear phagocyte network depletes B lymphocytes through Fc receptor-dependent mechanisms during anti-CD20 antibody immunotherapy. J Exp Med. 2004 Jun 21; 199(12):1659-69. PMID: 15210744.
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    42. Haas KM, Toapanta FR, Oliver JA, Poe JC, Weis JH, Karp DR, Bower JF, Ross TM, Tedder TF. Cutting edge: C3d functions as a molecular adjuvant in the absence of CD21/35 expression. J Immunol. 2004 May 15; 172(10):5833-7. PMID: 15128761.
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    43. Poe JC, Haas KM, Uchida J, Lee Y, Fujimoto M, Tedder TF. Severely impaired B lymphocyte proliferation, survival, and induction of the c-Myc:Cullin 1 ubiquitin ligase pathway resulting from CD22 deficiency on the C57BL/6 genetic background. J Immunol. 2004 Feb 15; 172(4):2100-10. PMID: 14764675.
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    44. Uchida J, Lee Y, Hasegawa M, Liang Y, Bradney A, Oliver JA, Bowen K, Steeber DA, Haas KM, Poe JC, Tedder TF. Mouse CD20 expression and function. Int Immunol. 2004 Jan; 16(1):119-29. PMID: 14688067.
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    45. Austin AS, Haas KM, Naugler SM, Bajer AA, Garcia-Tapia D, Estes DM. Identification and characterization of a novel regulatory factor: IgA-inducing protein. J Immunol. 2003 Aug 01; 171(3):1336-42. PMID: 12874223.
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    46. Bajer AA, Garcia-Tapia D, Jordan KR, Haas KM, Werling D, Howard CJ, Estes DM. Peripheral blood-derived bovine dendritic cells promote IgG1-restricted B cell responses in vitro. J Leukoc Biol. 2003 Jan; 73(1):100-6. PMID: 12525567.
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    47. Haas KM, Hasegawa M, Steeber DA, Poe JC, Zabel MD, Bock CB, Karp DR, Briles DE, Weis JH, Tedder TF. Complement receptors CD21/35 link innate and protective immunity during Streptococcus pneumoniae infection by regulating IgG3 antibody responses. Immunity. 2002 Dec; 17(6):713-23. PMID: 12479818.
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    48. Davis WC, Konzek RL, Haas K, Estes DM, Hamilton MJ, Call DR, Apostolopoulos V, McKenzie IF. Use of the mannan receptor to selectively target vaccine antigens for processing and antigen presentation through the MHC class I and class II pathways. Ann N Y Acad Sci. 2002 Oct; 969:119-25. PMID: 12381575.
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    49. Tedder TF, Haas KM, Poe JC. CD19-CD21 complex regulates an intrinsic Src family kinase amplification loop that links innate immunity with B-lymphocyte intracellular calcium responses. Biochem Soc Trans. 2002 Aug; 30(4):807-11. PMID: 12196203.
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    50. Haas KM, Taylor KA, MacHugh ND, Kreeger JM, Estes DM. Enhancing effects of anti-CD40 treatment on the immune response of SCID-bovine mice to Trypanosoma congolense infection. J Leukoc Biol. 2001 Dec; 70(6):931-40. PMID: 11739556.
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    51. Haas KM, Estes DM. The identification and characterization of a ligand for bovine CD5. J Immunol. 2001 Mar 01; 166(5):3158-66. PMID: 11207268.
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    52. Haas KM, Estes DM. Activation of bovine B cells via surface immunoglobulin M cross-linking or CD40 ligation results in different B-cell phenotypes. Immunology. 2000 Feb; 99(2):272-8. PMID: 10692047.
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    53. Kowles RV, Yerk GL, Haas KM, Phillips RL. Maternal effects influencing DNA endoreduplication in developing endosperm of Zea mays. Genome. 1997 Dec; 40(6):798-805. PMID: 18464865.
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