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Last Name

Katherine Loree Cook, Ph.D.

TitleAssistant Professor
InstitutionWake Forest School of Medicine
DepartmentSurgery Hypertension
Address
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    Collapse Biography 
    Collapse education and training
    State University of New York at Oswego, Oswego, NYBS05/2006Biochemistry
    Wake Forest University, Winston Salem, NCPh.D.05/2010Molecular Medicine
    Georgetown University, Washington, DCPostdoctoral Fellow06/2015Breast Cancer

    Collapse Research 
    Collapse research activities and funding
    388811     (Katherine L. Cook)Jan 15, 2016 - Jan 14, 2018
    Prevent Cancer Foundation
    Prevention of obesity-induced breast cancer and tamoxifen drug resistance.
    Role Description: Determine the effects of n-3 and n-6 PUFA rich obesity inducing diets in normal mammary gland tissue and the effects of diet in breast tumor formation and tamoxifen responsiveness.
    Role: PI

    RSG-16-204-01-NEC     (Katherine L. Cook)Jan 1, 2017 - Dec 31, 2020
    American Cancer Society
    Obesity-Induced Autophagy as an Early Life Factor Mediating Breast Cancer
    Role Description: To determine the effect of varying life time exposure (in utero, pre-pubescent, adulthood or lifetime) to obesity on ER+ breast cancer risk and endocrine therapy responsiveness.
    Role: PI

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. David Soto-Pantoja, Kenysha Clear, and Katherine Loree Cook. Targeting the unfolded protein response components differentially sensitizes breast tumors to doxorubicin while modulating chemotherapy-induced cardiotoxicities. AACR; Cancer Res. 2020; 80(4 Suppl):Abstract nr P5-14-19.
    2. Alaa Bawaneh, Adam S. Wilson, Kenysha YJ Clear, Akiko Chiba, and Katherine L. Cook. Gut microbiota population may be used to predict chemotherapeutic responsiveness in triple negative breast cancer. AACR;Cancer Res. 2019; 79(13 Suppl):Abstract nr 650.
    3. Akiko Chiba, Alaa Bawaneh, Christine Velazquez, Edward Levine, and Katherine L. Cook. Breast tumor microbiota populations are modulated by chemotherapy and may be indicative of outcome. AACR; Cancer Res. 2019; 79(13 Suppl):Abstract nr 2835.
    4. A. Chiba, C. Velazquez, M. Howard-McNatt, E. Levine, K.L. Cook. Neoadjuvant Chemotherapy Modulates Breast Tumor Microbiota. Ann Surg Oncol. 2019; 26(Suppl 1):S102.
    5. Tenvooren I, Jenks MZ, Rashid H, Cook KL, Muhlemann JK, Sistrunk C, Holmes J, Wang K, Bonin K, Hodges K, Lo HW, Shaikh A, Camarillo IG, Lelièvre SA, Seewaldt V, Vidi PA. Elevated leptin disrupts epithelial polarity and promotes premalignant alterations in the mammary gland. Oncogene. 2019 May; 38(20):3855-3870. PMID: 30670780.
      View in: PubMed
    6. Wärri A, Cook KL, Hu R, Jin L, Zwart A, Soto-Pantoja DR, Liu J, Finkel T, Clarke R. Autophagy and unfolded protein response (UPR) regulate mammary gland involution by restraining apoptosis-driven irreversible changes. Cell Death Discov. 2018; 4:40. PMID: 30345078.
      View in: PubMed
    7. Shively CA, Register TC, Appt SE, Clarkson TB, Uberseder B, Clear KYJ, Wilson AS, Chiba A, Tooze JA, Cook KL. Consumption of Mediterranean versus Western Diet Leads to Distinct Mammary Gland Microbiome Populations. Cell Rep. 2018 Oct 02; 25(1):47-56.e3. PMID: 30282037.
      View in: PubMed
    8. Feliz-Mosquea YR, Christensen AA, Wilson AS, Westwood B, Varagic J, Meléndez GC, Schwartz AL, Chen QR, Mathews Griner L, Guha R, Thomas CJ, Ferrer M, Merino MJ, Cook KL, Roberts DD, Soto-Pantoja DR. Combination of anthracyclines and anti-CD47 therapy inhibit invasive breast cancer growth while preventing cardiac toxicity by regulation of autophagy. Breast Cancer Res Treat. 2018 Nov; 172(1):69-82. PMID: 30056566.
      View in: PubMed
    9. David R. Soto-Pantoja, Yismeilin R. Feliz-Mosquea, Kenysha YJ Clear, Adam S. Wilson, and Katherine L. Cook. Targeting PKR-like endoplasmic reticulum kinase modulates metabolism to promote T-cell effector function and PD1 immunotherapy responsiveness. AACR; Cancer Res. 2018; 78(13 Suppl):Abstract nr 449.
    10. Yismelin R. Feliz-Mosquea, Elizabeth Stirling, Katherine L. Cook, Adam Wilson, Manish Bharadwaj, Anthony J. Molina, Liliya Yamaleyeva, Pierre L. Triozzi, and David R. Soto-Pantoja. Anti-CD47 immunotherapy regulates T cell metabolism and hypoxia in the tumor microenvironment. AACR; Cancer Res. 2018; 78(13 Suppl):Abstract nr 3528..
    11. Abunimer AN, Mohammed H, Cook KL, Soto-Pantoja DR, Campos MM, Abu-Asab MS. Mitochondrial autophagosomes as a mechanism of drug resistance in breast carcinoma. Ultrastruct Pathol. 2018 Mar-Apr; 42(2):170-180. PMID: 29419344.
      View in: PubMed
    12. Cook KL, Soto-Pantoja DR. "UPRegulation" of CD47 by the endoplasmic reticulum stress pathway controls anti-tumor immune responses. Biomark Res. 2017; 5:26. PMID: 28815041.
      View in: PubMed
    13. Soto-Pantoja DR, Wilson AS, Clear KY, Westwood B, Triozzi PL, Cook KL. Unfolded protein response signaling impacts macrophage polarity to modulate breast cancer cell clearance and melanoma immune checkpoint therapy responsiveness. Oncotarget. 2017 Oct 06; 8(46):80545-80559. PMID: 29113324.
      View in: PubMed
    14. Yismeilin R. Feliz Mosquea, David R. Soto Pantoja, Adam Wilson, Pierre L. Triozzi, and Katherine L. Cook. UPR signaling promotes T-cell dysfunction to prevent immune-mediated cancer cell killing and immune checkpoint therapy resistance. AACR; Cancer Res. 2017; 77(13 Suppl):Abstract nr 1704.
    15. KL Cook, A Wilson, B Westwood, and DR Soto-Pantoja. Targeting of the unfolded protein response signaling arms differentially regulates macrophage proliferation, plasticity, and breast cancer cell clearance. AACR; Cancer Res. 2017; 77(4 Suppl):Abstract nr P2-04-06.
    16. Zhang X, Cook KL, Warri A, Cruz IM, Rosim M, Riskin J, Helferich W, Doerge D, Clarke R, Hilakivi-Clarke L. Lifetime Genistein Intake Increases the Response of Mammary Tumors to Tamoxifen in Rats. Clin Cancer Res. 2017 Feb 01; 23(3):814-824. PMID: 28148690.
      View in: PubMed
    17. Meinersmann RJ, Ladely SR, Plumblee JR, Cook KL, Thacker E. Prevalence of mcr-1 in the Cecal Contents of Food Animals in the United States. Antimicrob Agents Chemother. 2017 02; 61(2). PMID: 27855065.
      View in: PubMed
    18. Jessica L. Swanner, Iliana Tenvooren, Brian W. Bernish, Cale D. Fahrenholtz, Pierre A. Vidi, Katherine L. Cook, and Ravi N. Singh. Silver nanoparticles exhibit subtype specific cytotoxic and therapeutic effects in claudin low breast cancer in vitro and in vivo. AACR; Cancer Res. 2017; 77(2 Suppl):Abstract nr B47.
    19. Cook KL, Soto-Pantoja DR, Clarke PA, Cruz MI, Zwart A, Wärri A, Hilakivi-Clarke L, Roberts DD, Clarke R. Endoplasmic Reticulum Stress Protein GRP78 Modulates Lipid Metabolism to Control Drug Sensitivity and Antitumor Immunity in Breast Cancer. Cancer Res. 2016 10 01; 76(19):5657-5670. PMID: 27698188.
      View in: PubMed
    20. Hilakivi-Clarke L, Wärri A, Bouker KB, Zhang X, Cook KL, Jin L, Zwart A, Nguyen N, Hu R, Cruz MI, de Assis S, Wang X, Xuan J, Wang Y, Wehrenberg B, Clarke R. Effects of In Utero Exposure to Ethinyl Estradiol on Tamoxifen Resistance and Breast Cancer Recurrence in a Preclinical Model. J Natl Cancer Inst. 2017 01; 109(1). PMID: 27609189.
      View in: PubMed
    21. Sumis A, Cook KL, Andrade FO, Hu R, Kidney E, Zhang X, Kim D, Carney E, Nguyen N, Yu W, Bouker KB, Cruz I, Clarke R, Hilakivi-Clarke L. Social isolation induces autophagy in the mouse mammary gland: link to increased mammary cancer risk. Endocr Relat Cancer. 2016 10; 23(10):839-56. PMID: 27550962.
      View in: PubMed
    22. Leena A. Hilakivi-Clarke, Fabia O. Andrade, Allison Sumis, Kerrie B. Bouker, Rong Hu, Robert Clarke, and Katherine L. Cook. Autophagy as a mediator of increased mammary cancer risk in socially isolated mice. AACR; Cancer Res. 2016; 76(14 Suppl):Abstract nr 1027.
    23. Robert Clarke, Pamela A.G. Clarke, Anni Wärri, and Katherine L. Cook. Heterozygous ATG7 inhibition enhances endocrine therapy responsiveness through regulation of damage associated molecular patterns and priming the immune system in ER+ breast tumors. AACR; Cancer Res. 2016; 76(14 Suppl):Abstract nr 904.
    24. Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV, Aguirre-Ghiso J, Airoldi EM, Ait-Si-Ali S, Akematsu T, Akporiaye ET, Al-Rubeai M, Albaiceta GM, Albanese C, Albani D, Albert ML, Aldudo J, Algül H, Alirezaei M, Alloza I, Almasan A, Almonte-Beceril M, Alnemri ES, Alonso C, Altan-Bonnet N, Altieri DC, Alvarez S, Alvarez-Erviti L, Alves S, Amadoro G, Amano A, Amantini C, Ambrosio S, Amelio I, Amer AO, Amessou M, Amon A, An Z, Anania FA, Andersen SU, Andley UP, Andreadi CK, Andrieu-Abadie N, Anel A, Ann DK, Anoopkumar-Dukie S, Antonioli M, Aoki H, Apostolova N, Aquila S, Aquilano K, Araki K, Arama E, Aranda A, Araya J, Arcaro A, Arias E, Arimoto H, Ariosa AR, Armstrong JL, Arnould T, Arsov I, Asanuma K, Askanas V, Asselin E, Atarashi R, Atherton SS, Atkin JD, Attardi LD, Auberger P, Auburger G, Aurelian L, Autelli R, Avagliano L, Avantaggiati ML, Avrahami L, Awale S, Azad N, Bachetti T, Backer JM, Bae DH, Bae JS, Bae ON, Bae SH, Baehrecke EH, Baek SH, Baghdiguian S, Bagniewska-Zadworna A, Bai H, Bai J, Bai XY, Bailly Y, Balaji KN, Balduini W, Ballabio A, Balzan R, Banerjee R, Bánhegyi G, Bao H, Barbeau B, Barrachina MD, Barreiro E, Bartel B, Bartolomé A, Bassham DC, Bassi MT, Bast RC, Basu A, Batista MT, Batoko H, Battino M, Bauckman K, Baumgarner BL, Bayer KU, Beale R, Beaulieu JF, Beck GR, Becker C, Beckham JD, Bédard PA, Bednarski PJ, Begley TJ, Behl C, Behrends C, Behrens GM, Behrns KE, Bejarano E, Belaid A, Belleudi F, Bénard G, Berchem G, Bergamaschi D, Bergami M, Berkhout B, Berliocchi L, Bernard A, Bernard M, Bernassola F, Bertolotti A, Bess AS, Besteiro S, Bettuzzi S, Bhalla S, Bhattacharyya S, Bhutia SK, Biagosch C, Bianchi MW, Biard-Piechaczyk M, Billes V, Bincoletto C, Bingol B, Bird SW, Bitoun M, Bjedov I, Blackstone C, Blanc L, Blanco GA, Blomhoff HK, Boada-Romero E, Böckler S, Boes M, Boesze-Battaglia K, Boise LH, Bolino A, Boman A, Bonaldo P, Bordi M, Bosch J, Botana LM, Botti J, Bou G, Bouché M, Bouchecareilh M, Boucher MJ, Boulton ME, Bouret SG, Boya P, Boyer-Guittaut M, Bozhkov PV, Brady N, Braga VM, Brancolini C, Braus GH, Bravo-San Pedro JM, Brennan LA, Bresnick EH, Brest P, Bridges D, Bringer MA, Brini M, Brito GC, Brodin B, Brookes PS, Brown EJ, Brown K, Broxmeyer HE, Bruhat A, Brum PC, Brumell JH, Brunetti-Pierri N, Bryson-Richardson RJ, Buch S, Buchan AM, Budak H, Bulavin DV, Bultman SJ, Bultynck G, Bumbasirevic V, Burelle Y, Burke RE, Burmeister M, Bütikofer P, Caberlotto L, Cadwell K, Cahova M, Cai D, Cai J, Cai Q, Calatayud S, Camougrand N, Campanella M, Campbell GR, Campbell M, Campello S, Candau R, Caniggia I, Cantoni L, Cao L, Caplan AB, Caraglia M, Cardinali C, Cardoso SM, Carew JS, Carleton LA, Carlin CR, Carloni S, Carlsson SR, Carmona-Gutierrez D, Carneiro LA, Carnevali O, Carra S, Carrier A, Carroll B, Casas C, Casas J, Cassinelli G, Castets P, Castro-Obregon S, Cavallini G, Ceccherini I, Cecconi F, Cederbaum AI, Ceña V, Cenci S, Cerella C, Cervia D, Cetrullo S, Chaachouay H, Chae HJ, Chagin AS, Chai CY, Chakrabarti G, Chamilos G, Chan EY, Chan MT, Chandra D, Chandra P, Chang CP, Chang RC, Chang TY, Chatham JC, Chatterjee S, Chauhan S, Che Y, Cheetham ME, Cheluvappa R, Chen CJ, Chen G, Chen GC, Chen G, Chen H, Chen JW, Chen JK, Chen M, Chen M, Chen P, Chen Q, Chen Q, Chen SD, Chen S, Chen SS, Chen W, Chen WJ, Chen WQ, Chen W, Chen X, Chen YH, Chen YG, Chen Y, Chen Y, Chen Y, Chen YJ, Chen YQ, Chen Y, Chen Z, Chen Z, Cheng A, Cheng CH, Cheng H, Cheong H, Cherry S, Chesney J, Cheung CH, Chevet E, Chi HC, Chi SG, Chiacchiera F, Chiang HL, Chiarelli R, Chiariello M, Chieppa M, Chin LS, Chiong M, Chiu GN, Cho DH, Cho SG, Cho WC, Cho YY, Cho YS, Choi AM, Choi EJ, Choi EK, Choi J, Choi ME, Choi SI, Chou TF, Chouaib S, Choubey D, Choubey V, Chow KC, Chowdhury K, Chu CT, Chuang TH, Chun T, Chung H, Chung T, Chung YL, Chwae YJ, Cianfanelli V, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016; 12(1):1-222. PMID: 26799652.
      View in: PubMed
    25. Cook KL, Clarke R. Role of GRP78 in promoting therapeutic-resistant breast cancer. Future Med Chem. 2015 Aug; 7(12):1529-34. PMID: 26302335.
      View in: PubMed
    26. Katherine L. Cook and Robert Clarke. In vivo inhibition of GRP78 potentiates antiestrogen therapy effectiveness in ER+ breast tumors. AACR; Cancer Res. 2015; 75(15 Suppl):Abstract nr 1257.
    27. Cook KL, Clarke R. Overcoming cancer resistance. Future Med Chem. 2015 Aug; 7(12):1471. PMID: 26334204.
      View in: PubMed
    28. Clarke R, Cook KL. Unfolding the Role of Stress Response Signaling in Endocrine Resistant Breast Cancers. Front Oncol. 2015; 5:140. PMID: 26157705.
      View in: PubMed
    29. Cook KL, Schwartz-Roberts JL, Baumann WT, Clarke R. Linking autophagy with inflammation through IRF1 signaling in ER+ breast cancer. Mol Cell Oncol. 2016 Jan; 3(1):e1023928. PMID: 27308537.
      View in: PubMed
    30. Schwartz-Roberts JL, Cook KL, Chen C, Shajahan-Haq AN, Axelrod M, Wärri A, Riggins RB, Jin L, Haddad BR, Kallakury BV, Baumann WT, Clarke R. Interferon regulatory factor-1 signaling regulates the switch between autophagy and apoptosis to determine breast cancer cell fate. Cancer Res. 2015 Mar 15; 75(6):1046-55. PMID: 25576084.
      View in: PubMed
    31. Cook KL, Soto-Pantoja DR, Jin L, Abu-Asab M, Clarke R. When is a vesicle not just a vesicle: mitochondrial spheroids and mitochondrial autophagosomes. Cell Biosci. 2014; 4:66. PMID: 25699171.
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    32. Shajahan-Haq AN, Cook KL, Schwartz-Roberts JL, Eltayeb AE, Demas DM, Warri AM, Facey CO, Hilakivi-Clarke LA, Clarke R. MYC regulates the unfolded protein response and glucose and glutamine uptake in endocrine resistant breast cancer. Mol Cancer. 2014 Oct 23; 13:239. PMID: 25339305.
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    33. Katherine L. Cook, Pamela A.G. Clarke, Margaret Axelrod, Anni Wärri, and Robert Clarke. Novel role of glucose-regulated protein 78 mediating lipid metabolism through controlling stearoyl-CoA desaturase 1. AACR; Cancer Res. 2014; 74(19 Suppl):Abstract nr 2443.
    34. Ayesha N. Shajahan-Haq, Katherine L. Cook, Jessica L. Schwartz-Roberts, Ahreej E. Eltayeb, Diane M. Demas, Anni M. Warri, Leena A. Hilakivi-Clarke, and Robert Clarke. Glutamine metabolism in MYC-driven antiestrogen resistant breast cancer cells confers metabolic flexibility through the unfolded protein response. AACR; Cancer Res. 2014; 74(19 Suppl):Abstract nr 679.
    35. Cook KL, Wärri A, Soto-Pantoja DR, Clarke PA, Cruz MI, Zwart A, Clarke R. Hydroxychloroquine inhibits autophagy to potentiate antiestrogen responsiveness in ER+ breast cancer. Clin Cancer Res. 2014 Jun 15; 20(12):3222-32. PMID: 24928945.
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    36. Cook KL, Clarke PA, Parmar J, Hu R, Schwartz-Roberts JL, Abu-Asab M, Wärri A, Baumann WT, Clarke R. Knockdown of estrogen receptor-a induces autophagy and inhibits antiestrogen-mediated unfolded protein response activation, promoting ROS-induced breast cancer cell death. FASEB J. 2014 Sep; 28(9):3891-905. PMID: 24858277.
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    37. Soto-Pantoja DR, Shih HB, Maxhimer JB, Cook KL, Ghosh A, Isenberg JS, Roberts DD. Thrombospondin-1 and CD47 signaling regulate healing of thermal injury in mice. Matrix Biol. 2014 Jul; 37:25-34. PMID: 24840925.
      View in: PubMed
    38. Cook KL, Soto-Pantoja DR, Abu-Asab M, Clarke PA, Roberts DD, Clarke R. Mitochondria directly donate their membrane to form autophagosomes during a novel mechanism of parkin-associated mitophagy. Cell Biosci. 2014 Mar 27; 4(1):16. PMID: 24669863.
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    39. Figg WD, Cook K, Clarke R. Aromatase inhibitor plus ovarian suppression as adjuvant therapy in premenopausal women with breast cancer. Cancer Biol Ther. 2014; 15(12):1586-7. PMID: 25535893.
      View in: PubMed
    40. Cook KL, Clarke R. Estrogen receptor-a signaling and localization regulates autophagy and unfolded protein response activation in ER+ breast cancer. Receptors Clin Investig. 2014; 1(6). PMID: 26005699.
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    41. Parmar JH, Cook KL, Shajahan-Haq AN, Clarke PA, Tavassoly I, Clarke R, Tyson JJ, Baumann WT. Modelling the effect of GRP78 on anti-oestrogen sensitivity and resistance in breast cancer. Interface Focus. 2013 Aug 06; 3(4):20130012. PMID: 24511377.
      View in: PubMed
    42. Cook KL, Clarke PA, Clarke R. Targeting GRP78 and antiestrogen resistance in breast cancer. Future Med Chem. 2013 Jun; 5(9):1047-57. PMID: 23734687.
      View in: PubMed
    43. Ayesha N. Shajahan, Katherine L. Cook, Jessica L. Schwartz-Roberts, Ahreej E. Eltayeb, Diane M. Demas, Anni Warri, Leena Hilakivi-Clarke, Steven Metallo, and Robert Clarke. MYC-driven glutamine metabolism promotes antiestrogen resistance in breast cancer. AACR; Cancer Res. 2013; 73(8 Suppl):Abstract nr 5397.
    44. Katherine L. Cook, Anni Warri, Rong Hu, Lu Jin, Alan Zwart, David R. Soto Pantoja, Jie Liu, Toren Finkel, and Robert Clarke. Autophagy and unfolded protein response (UPR) signaling regulates progression of apoptosis in mammary gland involution. AACR; Cancer Res. 2013; 73(8 Suppl):Abstract nr 1667.
    45. Jessica L. Schwartz-Roberts, Katherine L. Cook, Ayesha N. Shajahan, Margaret Axelrod, Anni Warri, and Robert Clarke. Inhibition of autophagy proteins ATG7 and BECN1 correlates with increased interferon regulatory factor-1 (IRF1) protein expression through STAT1 phosphorylation. AACR; Cancer Res. 2013; 73(8 Suppl):Abstract nr 1677.
    46. Schwartz-Roberts JL, Shajahan AN, Cook KL, Wärri A, Abu-Asab M, Clarke R. GX15-070 (obatoclax) induces apoptosis and inhibits cathepsin D- and L-mediated autophagosomal lysis in antiestrogen-resistant breast cancer cells. Mol Cancer Ther. 2013 Apr; 12(4):448-59. PMID: 23395885.
      View in: PubMed
    47. Cook KL, Clarke R. Heat shock 70 kDa protein 5/glucose-regulated protein 78 "AMP"ing up autophagy. Autophagy. 2012 Dec; 8(12):1827-9. PMID: 22931685.
      View in: PubMed
    48. Cook KL, Shajahan AN, Wärri A, Jin L, Hilakivi-Clarke LA, Clarke R. Glucose-regulated protein 78 controls cross-talk between apoptosis and autophagy to determine antiestrogen responsiveness. Cancer Res. 2012 Jul 01; 72(13):3337-49. PMID: 22752300.
      View in: PubMed
    49. Katherine L. Cook, Ayesha N. Shajahan, Lu Jin, Anni Warri, Leena A. Hilakivi-Clarke, and Robert Clarke. Glucose-regulated protein 78 regulates crosstalk between apoptosis and autophagy to determine antiestrogen responsiveness. AACR; Cancer Res. 2012; 72(8 Suppl):Abstract nr 4995.
    50. Aiyer HS, Bouker KB, Cook KL, Facey CO, Hu R, Schwartz JL, Shajahan AN, Hilakivi-Clarke L, Clarke R. Interaction of dietary polyphenols with molecular signaling pathways of antiestrogen resistance: possible role in breast cancer recurrence. Horm Mol Biol Clin Investig. 2012 Apr; 9(2):127-41. PMID: 25436704.
      View in: PubMed
    51. Clarke R, Cook KL, Hu R, Facey CO, Tavassoly I, Schwartz JL, Baumann WT, Tyson JJ, Xuan J, Wang Y, Wärri A, Shajahan AN. Endoplasmic reticulum stress, the unfolded protein response, autophagy, and the integrated regulation of breast cancer cell fate. Cancer Res. 2012 Mar 15; 72(6):1321-31. PMID: 22422988.
      View in: PubMed
    52. R Clarke, AN Shajahan, KL Cook, FE Hickman, and CO Facey. The Unfolded Protein Response (UPR) and Pro-Survival Autophagy Contributes to Antiestrogen Resistance in Breast Cancer. Cancer Res. 2011; 71(24 Suppl):Abstract nr P4-01-12.
    53. Cook KL, Shajahan AN, Clarke R. Autophagy and endocrine resistance in breast cancer. Expert Rev Anticancer Ther. 2011 Aug; 11(8):1283-94. PMID: 21916582.
      View in: PubMed
    54. Gallagher PE, Cook K, Soto-Pantoja D, Menon J, Tallant EA. Angiotensin peptides and lung cancer. Curr Cancer Drug Targets. 2011 May; 11(4):394-404. PMID: 21395552.
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    55. Alison L. Arter, Katherine L. Cook, David L. Soto-Pantoja, Patricia E. Gallagher, and E. Ann Tallant. Molecular mechanisms for the angiotensin-(1-7)-mediated reduction in triple negative breast cancer. AACR; Cancer Res. 2011; 71(8 Suppl):Abstract nr 3274.
    56. Clarke R, Shajahan AN, Wang Y, Tyson JJ, Riggins RB, Weiner LM, Bauman WT, Xuan J, Zhang B, Facey C, Aiyer H, Cook K, Hickman FE, Tavassoly I, Verdugo A, Chen C, Zwart A, Wärri A, Hilakivi-Clarke LA. Endoplasmic reticulum stress, the unfolded protein response, and gene network modeling in antiestrogen resistant breast cancer. Horm Mol Biol Clin Investig. 2011 Mar; 5(1):35-44. PMID: 23930139.
      View in: PubMed
    57. Cook KL, Metheny-Barlow LJ, Tallant EA, Gallagher PE. Angiotensin-(1-7) reduces fibrosis in orthotopic breast tumors. Cancer Res. 2010 Nov 01; 70(21):8319-28. PMID: 20837666.
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    58. Katherine L. Cook, E. Ann Tallant, and Patricia E. Gallagher. Angiotensin-(1-7) reduces angiogenesis and fibrosis in orthotopic breast cancer. AACR; Cancer Res. 2010; 70(8 Suppl):Abstract nr 2273.
    59. KL Cook, D Soto Pantoja, P Gallagher, and E Tallant. Angiotensin-(1-7) inhibition of human breast tumors with distinct hormone receptor expression results in a differential regulation of Akt. Cancer Res 2009. 2009; 69 (2 Suppl):Abstract nr 3127.
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