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Kenneth L.Koch MD

TitleProfessor
InstitutionWake Forest School of Medicine
DepartmentInternal Medicine, Gastroenterology
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    Other Positions
    TitleProfessor
    InstitutionWake Forest School of Medicine
    DepartmentWake Forest Institute for Regenerative Medicine


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    U01DK073974     (KOCH, KENNETH L)Apr 15, 2006 - Aug 31, 2021
    NIH
    Subtypes of Gastroparesis
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Wellington J, Stuart P, Westcott C, Koch KL. Obstructive Gastroparesis: Patient Selection and Effect of Laparoscopic Pyloroplasty. J Gastrointest Surg. 2020 08; 24(8):1778-1784. PMID: 31270719.
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    2. Parkman HP, Wilson LA, Hasler WL, McCallum RW, Sarosiek I, Koch KL, Abell TL, Schey R, Kuo B, Snape WJ, Nguyen L, Farrugia G, Grover M, Clarke J, Miriel L, Tonascia J, Hamilton F, Pasricha PJ. Abdominal Pain in Patients with Gastroparesis: Associations with Gastroparesis Symptoms, Etiology of Gastroparesis, Gastric Emptying, Somatization, and Quality of Life. Dig Dis Sci. 2019 08; 64(8):2242-2255. PMID: 30852767.
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    3. Parkman HP, Yamada G, Van Natta ML, Yates K, Hasler WL, Sarosiek I, Grover M, Schey R, Abell TL, Koch KL, Kuo B, Clarke J, Farrugia G, Nguyen L, Snape WJ, Miriel L, Tonascia J, Hamilton F, Pasricha PJ, McCallum RW. Ethnic, Racial, and Sex Differences in Etiology, Symptoms, Treatment, and Symptom Outcomes of Patients With Gastroparesis. Clin Gastroenterol Hepatol. 2019 07; 17(8):1489-1499.e8. PMID: 30404035.
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    4. Hasler WL, Wilson LA, Nguyen LA, Snape WJ, Abell TL, Koch KL, McCallum RW, Pasricha PJ, Sarosiek I, Farrugia G, Grover M, Lee LA, Miriel L, Tonascia J, Hamilton FA, Parkman HP. Opioid Use and Potency Are Associated With Clinical Features, Quality of Life, and Use of Resources in Patients With Gastroparesis. Clin Gastroenterol Hepatol. 2019 06; 17(7):1285-1294.e1. PMID: 30326297.
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    5. Grover M, Gibbons SJ, Nair AA, Bernard CE, Zubair AS, Eisenman ST, Wilson LA, Miriel L, Pasricha PJ, Parkman HP, Sarosiek I, McCallum RW, Koch KL, Abell TL, Snape WJ, Kuo B, Shulman RJ, McKenzie TJ, Kellogg TA, Kendrick ML, Tonascia J, Hamilton FA, Farrugia G. Transcriptomic signatures reveal immune dysregulation in human diabetic and idiopathic gastroparesis. BMC Med Genomics. 2018 Aug 07; 11(1):62. PMID: 30086735.
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    6. Sendi H, Mead I, Wan M, Mehrab-Mohseni M, Koch K, Atala A, Bonkovsky HL, Bishop CE. miR-122 inhibition in a human liver organoid model leads to liver inflammation, necrosis, steatofibrosis and dysregulated insulin signaling. PLoS One. 2018; 13(7):e0200847. PMID: 30024933.
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    7. Calles-Escandón J, Koch KL, Hasler WL, Van Natta ML, Pasricha PJ, Tonascia J, Parkman HP, Hamilton F, Herman WH, Basina M, Buckingham B, Earle K, Kirkeby K, Hairston K, Bright T, Rothberg AE, Kraftson AT, Siraj ES, Subauste A, Lee LA, Abell TL, McCallum RW, Sarosiek I, Nguyen L, Fass R, Snape WJ, Vaughn IA, Miriel LA, Farrugia G. Glucose sensor-augmented continuous subcutaneous insulin infusion in patients with diabetic gastroparesis: An open-label pilot prospective study. PLoS One. 2018; 13(4):e0194759. PMID: 29652893.
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    8. Siraj ES, Homko C, Wilson LA, May P, Rao AD, Calles J, Farrugia G, Hasler WL, Koch KL, Nguyen L, Snape WJ, Abell TL, Sarosiek I, McCallum RW, Pasricha PJ, Clarke J, Tonascia J, Hamilton F, Parkman HP. Islet Cell Associated Autoantibodies and C-Peptide Levels in Patients with Diabetes and Symptoms of Gastroparesis. Front Endocrinol (Lausanne). 2018; 9:32. PMID: 29487566.
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    9. Gibbons SJ, Grover M, Choi KM, Wadhwa A, Zubair A, Wilson LA, Wu Y, Abell TL, Hasler WL, Koch KL, McCallum RW, Nguyen LAB, Parkman HP, Sarosiek I, Snape WJ, Tonascia J, Hamilton FA, Pasricha PJ, Farrugia G. Repeat polymorphisms in the Homo sapiens heme oxygenase-1 gene in diabetic and idiopathic gastroparesis. PLoS One. 2017; 12(11):e0187772. PMID: 29161307.
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    10. Pasricha PJ, Yates KP, Sarosiek I, McCallum RW, Abell TL, Koch KL, Nguyen LAB, Snape WJ, Hasler WL, Clarke JO, Dhalla S, Stein EM, Lee LA, Miriel LA, Van Natta ML, Grover M, Farrugia G, Tonascia J, Hamilton FA, Parkman HP. Aprepitant Has Mixed Effects on Nausea and Reduces Other Symptoms in Patients With Gastroparesis and Related Disorders. Gastroenterology. 2018 01; 154(1):65-76.e11. PMID: 29111115.
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    11. Orthey P, Yu D, Van Natta ML, Ramsey FV, Diaz JR, Bennett PA, Iagaru AH, Fragomeni RS, McCallum RW, Sarosiek I, Hasler WL, Farrugia G, Grover M, Koch KL, Nguyen L, Snape WJ, Abell TL, Pasricha PJ, Tonascia J, Hamilton F, Parkman HP, Maurer AH. Intragastric Meal Distribution During Gastric Emptying Scintigraphy for Assessment of Fundic Accommodation: Correlation with Symptoms of Gastroparesis. J Nucl Med. 2018 04; 59(4):691-697. PMID: 28970332.
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    12. Zakhem E, Tamburrini R, Orlando G, Koch KL, Bitar KN. Transplantation of a Human Tissue-Engineered Bowel in an Athymic Rat Model. Tissue Eng Part C Methods. 2017 11; 23(11):652-660. PMID: 28653858.
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    13. Cengia BT, Stuart PS, Koch KL. Pancreatic Adenocarcinoma Invading the Duodenum and Presenting as Idiopathic Gastroparesis with Nausea and Vomiting. ACG Case Rep J. 2016 Aug; 3(4):e109. PMID: 27807571.
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    14. Hasler WL, Li BU, Koch KL, Parkman HP, Kovacic K, McCallum RW. Methodologic considerations for studies of chronic nausea and vomiting in adults and children. Auton Neurosci. 2017 01; 202:28-39. PMID: 27539628.
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    15. Wellington J, Scott B, Kundu S, Stuart P, Koch KL. Effect of endoscopic pyloric therapies for patients with nausea and vomiting and functional obstructive gastroparesis. Auton Neurosci. 2017 01; 202:56-61. PMID: 27460691.
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    16. Pasricha PJ, Yates KP, Nguyen L, Clarke J, Abell TL, Farrugia G, Hasler WL, Koch KL, Snape WJ, McCallum RW, Sarosiek I, Tonascia J, Miriel LA, Lee L, Hamilton F, Parkman HP. Outcomes and Factors Associated With Reduced Symptoms in Patients With Gastroparesis. Gastroenterology. 2015 Dec; 149(7):1762-1774.e4. PMID: 26299414.
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    17. Tung-Thompson G, Libera DA, Koch KL, de Los Reyes FL, Jaykus LA. Aerosolization of a Human Norovirus Surrogate, Bacteriophage MS2, during Simulated Vomiting. PLoS One. 2015; 10(8):e0134277. PMID: 26287612.
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    18. Levine ME, Koch SY, Koch KL. Lipase Supplementation before a High-Fat Meal Reduces Perceptions of Fullness in Healthy Subjects. Gut Liver. 2015 Jul; 9(4):464-9. PMID: 25287168.
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    19. Hasler WL, Koch KL. Amitriptyline for Functional Dyspepsia: Importance of Symptom Profile and Making a Case for Gastric Emptying Testing. Gastroenterology. 2015 Aug; 149(2):270-2. PMID: 26116797.
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    20. Koch KL, Calles-Escandón J. Diabetic gastroparesis. Gastroenterol Clin North Am. 2015 Mar; 44(1):39-57. PMID: 25667022.
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    21. Koch KL. Gastric dysrhythmias: a potential objective measure of nausea. Exp Brain Res. 2014 Aug; 232(8):2553-61. PMID: 24916149.
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    22. Levine ME, Stern RM, Koch KL. Enhanced perceptions of control and predictability reduce motion-induced nausea and gastric dysrhythmia. Exp Brain Res. 2014 Aug; 232(8):2675-84. PMID: 24748483.
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    23. Parkman HP, Van Natta ML, Abell TL, McCallum RW, Sarosiek I, Nguyen L, Snape WJ, Koch KL, Hasler WL, Farrugia G, Lee L, Unalp-Arida A, Tonascia J, Hamilton F, Pasricha PJ. Effect of nortriptyline on symptoms of idiopathic gastroparesis: the NORIG randomized clinical trial. JAMA. 2013 Dec 25; 310(24):2640-9. PMID: 24368464.
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    24. Cox AJ, Ng MC, Xu J, Langefeld CD, Koch KL, Dawson PA, Carr JJ, Freedman BI, Hsu FC, Bowden DW. Association of SNPs in the UGT1A gene cluster with total bilirubin and mortality in the Diabetes Heart Study. Atherosclerosis. 2013 Jul; 229(1):155-60. PMID: 23642732.
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    25. Parkman HP, Yates K, Hasler WL, Nguyen L, Pasricha PJ, Snape WJ, Farrugia G, Koch KL, Calles J, Abell TL, Sarosiek I, McCallum RW, Lee L, Unalp-Arida A, Tonascia J, Hamilton F. Cholecystectomy and clinical presentations of gastroparesis. Dig Dis Sci. 2013 Apr; 58(4):1062-73. PMID: 23456496.
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    26. Koch KL, Bitar KN, Fortunato JE. Tissue engineering for neuromuscular disorders of the gastrointestinal tract. World J Gastroenterol. 2012 Dec 21; 18(47):6918-25. PMID: 23322989.
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    27. Faussone-Pellegrini MS, Grover M, Pasricha PJ, Bernard CE, Lurken MS, Smyrk TC, Parkman HP, Abell TL, Snape WJ, Hasler WL, Unalp-Arida A, Nguyen L, Koch KL, Calles J, Lee L, Tonascia J, Hamilton FA, Farrugia G. Ultrastructural differences between diabetic and idiopathic gastroparesis. J Cell Mol Med. 2012 Jul; 16(7):1573-81. PMID: 21914127.
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    28. Orlando G, Wood KJ, De Coppi P, Baptista PM, Binder KW, Bitar KN, Breuer C, Burnett L, Christ G, Farney A, Figliuzzi M, Holmes JH, Koch K, Macchiarini P, Mirmalek Sani SH, Opara E, Remuzzi A, Rogers J, Saul JM, Seliktar D, Shapira-Schweitzer K, Smith T, Solomon D, Van Dyke M, Yoo JJ, Zhang Y, Atala A, Stratta RJ, Soker S. Regenerative medicine as applied to general surgery. Ann Surg. 2012 May; 255(5):867-80. PMID: 22330032.
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    29. Orlando G, Domínguez-Bendala J, Shupe T, Bergman C, Bitar KN, Booth C, Carbone M, Koch KL, Lerut JP, Neuberger JM, Petersen B, Ricordi C, Atala A, Stratta RJ, Soker S. Cell and organ bioengineering technology as applied to gastrointestinal diseases. Gut. 2013 May; 62(5):774-86. PMID: 22267591.
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    30. Parkman HP, Yates K, Hasler WL, Nguyen L, Pasricha PJ, Snape WJ, Farrugia G, Koch KL, Calles J, Abell TL, McCallum RW, Lee L, Unalp-Arida A, Tonascia J, Hamilton F. Similarities and differences between diabetic and idiopathic gastroparesis. Clin Gastroenterol Hepatol. 2011 Dec; 9(12):1056-64; quiz e133-4. PMID: 21871247.
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    31. Fortunato JE, Shaltout HA, Larkin MM, Rowe PC, Diz DI, Koch KL. Fludrocortisone improves nausea in children with orthostatic intolerance (OI). Clin Auton Res. 2011 Dec; 21(6):419-23. PMID: 21796356.
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    32. Parkman HP, Yates KP, Hasler WL, Nguyan L, Pasricha PJ, Snape WJ, Farrugia G, Calles J, Koch KL, Abell TL, McCallum RW, Petito D, Parrish CR, Duffy F, Lee L, Unalp-Arida A, Tonascia J, Hamilton F. Dietary intake and nutritional deficiencies in patients with diabetic or idiopathic gastroparesis. Gastroenterology. 2011 Aug; 141(2):486-98, 498.e1-7. PMID: 21684286.
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    33. Peyrot des Gachons C, Beauchamp GK, Stern RM, Koch KL, Breslin PA. Bitter taste induces nausea. Curr Biol. 2011 Apr 12; 21(7):R247-8. PMID: 21481757.
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    34. Hasler WL, Wilson LA, Parkman HP, Nguyen L, Abell TL, Koch KL, Pasricha PJ, Snape WJ, Farrugia G, Lee L, Tonascia J, Unalp-Arida A, Hamilton F. Bloating in gastroparesis: severity, impact, and associated factors. Am J Gastroenterol. 2011 Aug; 106(8):1492-502. PMID: 21483459.
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    35. Pasricha PJ, Colvin R, Yates K, Hasler WL, Abell TL, Unalp-Arida A, Nguyen L, Farrugia G, Koch KL, Parkman HP, Snape WJ, Lee L, Tonascia J, Hamilton F. Characteristics of patients with chronic unexplained nausea and vomiting and normal gastric emptying. Clin Gastroenterol Hepatol. 2011 Jul; 9(7):567-76.e1-4. PMID: 21397732.
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    36. Grover M, Farrugia G, Lurken MS, Bernard CE, Faussone-Pellegrini MS, Smyrk TC, Parkman HP, Abell TL, Snape WJ, Hasler WL, Ünalp-Arida A, Nguyen L, Koch KL, Calles J, Lee L, Tonascia J, Hamilton FA, Pasricha PJ. Cellular changes in diabetic and idiopathic gastroparesis. Gastroenterology. 2011 May; 140(5):1575-85.e8. PMID: 21300066.
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    37. Parkman HP, Yates K, Hasler WL, Nguyen L, Pasricha PJ, Snape WJ, Farrugia G, Koch KL, Abell TL, McCallum RW, Lee L, Unalp-Arida A, Tonascia J, Hamilton F. Clinical features of idiopathic gastroparesis vary with sex, body mass, symptom onset, delay in gastric emptying, and gastroparesis severity. Gastroenterology. 2011 Jan; 140(1):101-15. PMID: 20965184.
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    38. Selim MM, Wendelschafer-Crabb G, Redmon JB, Khoruts A, Hodges JS, Koch K, Walk D, Kennedy WR. Gastric mucosal nerve density: a biomarker for diabetic autonomic neuropathy? Neurology. 2010 Sep 14; 75(11):973-81. PMID: 20837965.
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    39. Koch KL. Gastric electrical stimulation and the "eye of the beholder". Clin Gastroenterol Hepatol. 2010 Nov; 8(11):908-9. PMID: 20692370.
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    40. Hasler WL, Parkman HP, Wilson LA, Pasricha PJ, Koch KL, Abell TL, Snape WJ, Farrugia G, Lee L, Tonascia J, Unalp-Arida A, Hamilton F. Psychological dysfunction is associated with symptom severity but not disease etiology or degree of gastric retention in patients with gastroparesis. Am J Gastroenterol. 2010 Nov; 105(11):2357-67. PMID: 20588262.
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    41. Kloetzer L, Chey WD, McCallum RW, Koch KL, Wo JM, Sitrin M, Katz LA, Lackner JM, Parkman HP, Wilding GE, Semler JR, Hasler WL, Kuo B. Motility of the antroduodenum in healthy and gastroparetics characterized by wireless motility capsule. Neurogastroenterol Motil. 2010 May; 22(5):527-33, e117. PMID: 20122128.
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    42. Saad RJ, Rao SS, Koch KL, Kuo B, Parkman HP, McCallum RW, Sitrin MD, Wilding GE, Semler JR, Chey WD. Do stool form and frequency correlate with whole-gut and colonic transit? Results from a multicenter study in constipated individuals and healthy controls. Am J Gastroenterol. 2010 Feb; 105(2):403-11. PMID: 19888202.
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    43. Hasler WL, Saad RJ, Rao SS, Wilding GE, Parkman HP, Koch KL, McCallum RW, Kuo B, Sarosiek I, Sitrin MD, Semler JR, Chey WD. Heightened colon motor activity measured by a wireless capsule in patients with constipation: relation to colon transit and IBS. Am J Physiol Gastrointest Liver Physiol. 2009 Dec; 297(6):G1107-14. PMID: 19808653.
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    44. Rao SS, Kuo B, McCallum RW, Chey WD, DiBaise JK, Hasler WL, Koch KL, Lackner JM, Miller C, Saad R, Semler JR, Sitrin MD, Wilding GE, Parkman HP. Investigation of colonic and whole-gut transit with wireless motility capsule and radiopaque markers in constipation. Clin Gastroenterol Hepatol. 2009 May; 7(5):537-44. PMID: 19418602.
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    45. Butler SG, Stuart A, Castell D, Russell GB, Koch K, Kemp S. Effects of age, gender, bolus condition, viscosity, and volume on pharyngeal and upper esophageal sphincter pressure and temporal measurements during swallowing. J Speech Lang Hear Res. 2009 Feb; 52(1):240-53. PMID: 19064903.
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    46. Levine ME, Gillis MG, Koch SY, Voss AC, Stern RM, Koch KL. Protein and ginger for the treatment of chemotherapy-induced delayed nausea. J Altern Complement Med. 2008 Jun; 14(5):545-51. PMID: 18537470.
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    47. Hasler WL, Coleski R, Chey WD, Koch KL, McCallum RW, Wo JM, Kuo B, Sitrin MD, Katz LA, Hwang J, Semler JR, Parkman HP. Differences in intragastric pH in diabetic vs. idiopathic gastroparesis: relation to degree of gastric retention. Am J Physiol Gastrointest Liver Physiol. 2008 Jun; 294(6):G1384-91. PMID: 18403619.
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    48. Kuo B, McCallum RW, Koch KL, Sitrin MD, Wo JM, Chey WD, Hasler WL, Lackner JM, Katz LA, Semler JR, Wilding GE, Parkman HP. Comparison of gastric emptying of a nondigestible capsule to a radio-labelled meal in healthy and gastroparetic subjects. Aliment Pharmacol Ther. 2008 Jan 15; 27(2):186-96. PMID: 17973643.
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    49. Intagliata N, Koch KL. Gastroparesis in type 2 diabetes mellitus: prevalence, etiology, diagnosis, and treatment. Curr Gastroenterol Rep. 2007 Aug; 9(4):270-9. PMID: 17883973.
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    50. Outlaw WM, Koch KL. Dyspepsia and its overlap with irritable bowel syndrome. Curr Gastroenterol Rep. 2006 Aug; 8(4):266-72. PMID: 16888867.
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    51. Levine ME, Stern RM, Koch KL. The effects of manipulating expectations through placebo and nocebo administration on gastric tachyarrhythmia and motion-induced nausea. Psychosom Med. 2006 May-Jun; 68(3):478-86. PMID: 16738082.
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    52. Frissora CL, Koch KL. The role of gender and biological sex in irritable bowel syndrome. Curr Gastroenterol Rep. 2005 Aug; 7(4):257-63. PMID: 16042908.
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    53. Frissora CL, Koch KL. Symptom overlap and comorbidity of irritable bowel syndrome with other conditions. Curr Gastroenterol Rep. 2005 Aug; 7(4):264-71. PMID: 16042909.
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    54. Riley TR, Koch K. Characteristics of upper abdominal pain in those with chronic liver disease. Dig Dis Sci. 2003 Oct; 48(10):1914-8. PMID: 14627332.
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    55. Koch KL. Diagnosis and treatment of neuromuscular disorders of the stomach. Curr Gastroenterol Rep. 2003 Aug; 5(4):323-30. PMID: 12864963.
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    56. Abell T, McCallum R, Hocking M, Koch K, Abrahamsson H, Leblanc I, Lindberg G, Konturek J, Nowak T, Quigley EM, Tougas G, Starkebaum W. Gastric electrical stimulation for medically refractory gastroparesis. Gastroenterology. 2003 Aug; 125(2):421-8. PMID: 12891544.
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    57. Raymer GS, Hartman DE, Rowe WA, Werkman RF, Koch KL. An open-label trial of L-glucose as a colon-cleansing agent before colonoscopy. Gastrointest Endosc. 2003 Jul; 58(1):30-5. PMID: 12838217.
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    58. Koch KL, Frissora CL. Nausea and vomiting during pregnancy. Gastroenterol Clin North Am. 2003 Mar; 32(1):201-34, vi. PMID: 12635417.
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    59. Stern RM, Koch KL. EGG data. Dig Dis Sci. 2003 Mar; 48(3):522. PMID: 12757164.
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    60. Koch KL. Gastrointestinal factors in nausea and vomiting of pregnancy. Am J Obstet Gynecol. 2002 May; 186(5 Suppl Understanding):S198-203. PMID: 12011886.
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