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Jingyun Lee PhD

TitleAssistant Professor
InstitutionWake Forest School of Medicine
DepartmentInternal Medicine, Molecular Medicine
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    Collapse Biography 
    Collapse education and training
    Atrium Health, Charlotte, NC, United StatesSr. Postdoctoral10/2015Proteomics and Analytical Science
    Seoul National University, Seoul, South KoreaPostdoctoral10/2011Pharmaceutical Analysis
    Seoul National University, Seoul, South KoreaPh.D.08/2009Pharmaceutical Analysis

    Collapse Overview 
    Collapse overview
    My research interests lie primarily in analytical biochemistry that integrates instrumental analysis technique into biomedical studies. My early career started in pharmaceutical analysis where chromatography was mainly utilized in combination with spectrophotometric detection to assess pharmaceutical drugs and naturally derived compounds in a variety of sample types. Biological research experience during my Ph.D. led me to the field of biological mass spectrometry at the time when large-scale proteome identification techniques were introduced by leading groups. Since then, my research activity has focused on biomarker discovery utilizing mass spectrometry-based omics platforms. In my current position as Assistant Director for the Proteomics and Metabolomics Shared Resource, I provide support with advanced mass spectrometry analysis to help researchers decipher biological events, advance biomedical science, and improve clinical care. My research interest currently dives into more challenging proteomics analyses in both bottom-up and top/mid-down strategies, particularly single-cell proteomics, and antibody drug characterization.

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Huynh MV, Parsonage D, Forshaw TE, Chirasani VR, Hobbs GA, Wu H, Lee J, Furdui CM, Poole LB, Campbell SL. Oncogenic KRAS G12C: Kinetic and redox characterization of covalent inhibition. J Biol Chem. 2022 Aug; 298(8):102186. PMID: 35753348.
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    2. Rather HA, Mishra S, Su Y, Kumar A, Singh S, Misra BB, Lee J, Furdui CM, Hamilton LR, Gould RW, Nader SH, Nader MA, Deep G. Mass Spectrometry-Based Proteome Profiling of Extracellular Vesicles Derived from the Cerebrospinal Fluid of Adult Rhesus Monkeys Exposed to Cocaine throughout Gestation. Biomolecules. 2022 Mar 28; 12(4). PMID: 35454099.
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    3. Wolff DW, Deng Z, Bianchi-Smiraglia A, Foley CE, Han Z, Wang X, Shen S, Rosenberg MM, Moparthy S, Yun DH, Chen J, Baker BK, Roll MV, Magiera AJ, Li J, Hurley E, Feltri ML, Cox AO, Lee J, Furdui CM, Liu L, Bshara W, LaConte LEW, Kandel ES, Pasquale EB, Qu J, Hedstrom L, Nikiforov MA. Phosphorylation of guanosine monophosphate reductase triggers a GTP-dependent switch from pro- to anti-oncogenic function of EPHA4. Cell Chem Biol. 2022 Jun 16; 29(6):970-984.e6. PMID: 35148834.
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    4. Kasica NP, Zhou X, Yang Q, Wang X, Yang W, Zimmermann HR, Holland CE, Koscielniak E, Wu H, Cox AO, Lee J, Ryazanov AG, Furdui CM, Ma T. Antagonists targeting eEF2 kinase rescue multiple aspects of pathophysiology in Alzheimer's disease model mice. J Neurochem. 2022 Mar; 160(5):524-539. PMID: 34932218.
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    5. Wang X, Zhou X, Uberseder B, Lee J, Latimer CS, Furdui CM, Keene CD, Montine TJ, Register TC, Craft S, Shively CA, Ma T. Isoform-specific dysregulation of AMP-activated protein kinase signaling in a non-human primate model of Alzheimer's disease. Neurobiol Dis. 2021 Oct; 158:105463. PMID: 34363967.
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    6. Kwok AT, Mohamed NS, Plate JF, Yammani RR, Rosas S, Bateman TA, Livingston E, Moore JE, Kerr BA, Lee J, Furdui CM, Tan L, Bouxsein ML, Ferguson VL, Stodieck LS, Zawieja DC, Delp MD, Mao XW, Willey JS. Spaceflight and hind limb unloading induces an arthritic phenotype in knee articular cartilage and menisci of rodents. Sci Rep. 2021 May 18; 11(1):10469. PMID: 34006989.
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    7. Lipchick BC, Utley A, Han Z, Moparthy S, Yun DH, Bianchi-Smiraglia A, Wolff DW, Fink E, Liu L, Furdui CM, Lee J, Lee KP, Nikiforov MA. The fatty acid elongase ELOVL6 regulates bortezomib resistance in multiple myeloma. Blood Adv. 2021 04 13; 5(7):1933-1946. PMID: 33821992.
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    8. Su J, Song Q, Qasem S, O'Neill S, Lee J, Furdui CM, Pasche B, Metheny-Barlow L, Masters AH, Lo HW, Xing F, Watabe K, Miller LD, Tatter SB, Laxton AW, Whitlow CT, Chan MD, Soike MH, Ruiz J. Multi-Omics Analysis of Brain Metastasis Outcomes Following Craniotomy. Front Oncol. 2020; 10:615472. PMID: 33889540.
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    9. Holmila R, Wu H, Lee J, Tsang AW, Singh R, Furdui CM. Integrated Redox Proteomic Analysis Highlights New Mechanisms of Sensitivity to Silver Nanoparticles. Mol Cell Proteomics. 2021 Mar 20; 20:100073. PMID: 33757833.
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    10. Yang W, Zhou X, Wang X, Lee J, Wu D, Sun P, Furdui CM, Ma T. Protein expression alteration in hippocampus upon genetic repression of AMPKa isoforms. Hippocampus. 2021 Apr; 31(4):353-361. PMID: 33492732.
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    11. Kumar A, Kim S, Su Y, Sharma M, Kumar P, Singh S, Lee J, Furdui CM, Singh R, Hsu FC, Kim J, Whitlow CT, Nader MA, Deep G. Brain cell-derived exosomes in plasma serve as neurodegeneration biomarkers in male cynomolgus monkeys self-administrating oxycodone. EBioMedicine. 2021 Jan; 63:103192. PMID: 33418508.
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    12. Quillen EE, Beavers DP, O'Brien Cox A, Furdui CM, Lee J, Miller RM, Wu H, Beavers KM. Use of Metabolomic Profiling to Understand Variability in Adiposity Changes Following an Intentional Weight Loss Intervention in Older Adults. Nutrients. 2020 Oct 19; 12(10). PMID: 33086512.
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    13. Zimmermann HR, Yang W, Kasica NP, Zhou X, Wang X, Beckelman BC, Lee J, Furdui CM, Keene CD, Ma T. Brain-specific repression of AMPKa1 alleviates pathophysiology in Alzheimer's model mice. J Clin Invest. 2020 07 01; 130(7):3511-3527. PMID: 32213711.
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    14. Bayne RS, Puckett S, Rodrigues LU, Cramer SD, Lee J, Furdui CM, Chou JW, Miller LD, Ornelles DA, Lyles DS. MAP3K7 and CHD1 Are Novel Mediators of Resistance to Oncolytic Vesicular Stomatitis Virus in Prostate Cancer Cells. Mol Ther Oncolytics. 2020 Jun 26; 17:496-507. PMID: 32529027.
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    15. Poole LB, Parsonage D, Sergeant S, Miller LR, Lee J, Furdui CM, Chilton FH. Acyl-lipid desaturases and Vipp1 cooperate in cyanobacteria to produce novel omega-3 PUFA-containing glycolipids. Biotechnol Biofuels. 2020; 13:83. PMID: 32399061.
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    16. Tesfay L, Paul BT, Konstorum A, Deng Z, Cox AO, Lee J, Furdui CM, Hegde P, Torti FM, Torti SV. Stearoyl-CoA Desaturase 1 Protects Ovarian Cancer Cells from Ferroptotic Cell Death. Cancer Res. 2019 10 15; 79(20):5355-5366. PMID: 31270077.
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    17. Kwok AT, Moore JE, Rosas S, Kerr BA, Andrews RN, Nguyen CM, Lee J, Furdui CM, Collins BE, Munley MT, Willey JS. Knee and Hip Joint Cartilage Damage from Combined Spaceflight Hazards of Low-Dose Radiation Less than 1 Gy and Prolonged Hindlimb Unloading. Radiat Res. 2019 06; 191(6):497-506. PMID: 30925135.
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    18. Chen X, Lee J, Wu H, Tsang AW, Furdui CM. Mass Spectrometry in Advancement of Redox Precision Medicine. Adv Exp Med Biol. 2019; 1140:327-358. PMID: 31347057.
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    19. Bolduc JA, Nelson KJ, Haynes AC, Lee J, Reisz JA, Graff AH, Clodfelter JE, Parsonage D, Poole LB, Furdui CM, Lowther WT. Novel hyperoxidation resistance motifs in 2-Cys peroxiredoxins. J Biol Chem. 2018 07 27; 293(30):11901-11912. PMID: 29884768.
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    20. Baek SH, Lee JG, Park SY, Bae ON, Kim DH, Park JH. Correction to "Pectic Polysaccharides from Panax ginseng as the Antirotavirus Principals in Ginseng". Biomacromolecules. 2018 Jul 09; 19(7):3149. PMID: 29799192.
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    21. Lee J, McKinney KQ, Pavlopoulos AJ, Niu M, Kang JW, Oh JW, Kim KP, Hwang S. Altered Proteome of Extracellular Vesicles Derived from Bladder Cancer Patients Urine. Mol Cells. 2018 Mar 31; 41(3):179-187. PMID: 29562735.
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    22. Dean TC, Yang M, Liu M, Grayson JM, DeMartino AW, Day CS, Lee J, Furdui CM, Bierbach U. Human Serum Albumin-Delivered [Au(PEt3)]+ Is a Potent Inhibitor of T Cell Proliferation. ACS Med Chem Lett. 2017 May 11; 8(5):572-576. PMID: 28523113.
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    23. Xu Z, Feng X, Dong J, Wang ZM, Lee J, Furdui C, Files DC, Beavers KM, Kritchevsky S, Milligan C, Jin JP, Delbono O, Zhang T. Cardiac troponin T and fast skeletal muscle denervation in ageing. J Cachexia Sarcopenia Muscle. 2017 Oct; 8(5):808-823. PMID: 28419739.
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    24. Lee J, McKinney KQ, Pavlopoulos AJ, Han MH, Kim SH, Kim HJ, Hwang S. Exosomal proteome analysis of cerebrospinal fluid detects biosignatures of neuromyelitis optica and multiple sclerosis. Clin Chim Acta. 2016 Nov 01; 462:118-126. PMID: 27609124.
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    25. Bossi K, Lee J, Schmeltzer P, Holburton E, Groseclose G, Besur S, Hwang S, Bonkovsky HL. Homeostasis of iron and hepcidin in erythropoietic protoporphyria. Eur J Clin Invest. 2015 Oct; 45(10):1032-41. PMID: 26199063.
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    26. Lee JG, McKinney KQ, Lee YY, Chung HN, Pavlopoulos AJ, Jung KY, Kim WK, Kuroda MJ, Han DK, Hwang S. A draft map of rhesus monkey tissue proteome for biomedical research. PLoS One. 2015; 10(5):e0126243. PMID: 25974132.
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    27. Lee JG, McKinney KQ, Pavlopoulos AJ, Park JH, Hwang S. Data supporting the identification of anti-metastatic drug and natural compound targets in isogenic colorectal cancer cells. Data Brief. 2014 Dec; 1:73-5. PMID: 26217691.
      Citations:    
    28. Lee JG, McKinney KQ, Pavlopoulos AJ, Park JH, Hwang S. Identification of anti-metastatic drug and natural compound targets in isogenic colorectal cancer cells. J Proteomics. 2015 Jan 15; 113:326-36. PMID: 25451013.
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    29. Lee JG, McKinney KQ, Mougeot JL, Bonkovsky HL, Hwang SI. Proteomic strategy for probing complementary lethality of kinase inhibitors against pancreatic cancer. Proteomics. 2013 Dec; 13(23-24):3554-62. PMID: 24167056.
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    30. Larion S, Caballes FR, Hwang SI, Lee JG, Rossman WE, Parsons J, Steuerwald N, Li T, Maddukuri V, Groseclose G, Finkielstein CV, Bonkovsky HL. Circadian rhythms in acute intermittent porphyria--a pilot study. Eur J Clin Invest. 2013 Jul; 43(7):727-39. PMID: 23650938.
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    31. Kang YP, Yu J, Huh Y, Oh JH, Kwon CH, Lee SJ, Ee JW, Kim GT, Lee JG, Lee J, Park JH, Kim YS, Kwon SW. Development of high performance liquid chromatography-ultraviolet detection method for screening mebendazole, clorsulon, diaveridine, and tolfenamic acid in animal-based food samples. Drug Test Anal. 2014 Mar; 6(3):246-56. PMID: 23576386.
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    32. Ju HK, Lee JG, Park MK, Park SJ, Lee CH, Park JH, Kwon SW. Metabolomic investigation of the anti-platelet aggregation activity of ginsenoside Rk1 reveals attenuated 12-HETE production. J Proteome Res. 2012 Oct 05; 11(10):4939-46. PMID: 22873173.
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    33. McKinney KQ, Lee JG, Sindram D, Russo MW, Han DK, Bonkovsky HL, Hwang SI. Identification of differentially expressed proteins from primary versus metastatic pancreatic cancer cells using subcellular proteomics. Cancer Genomics Proteomics. 2012 Sep-Oct; 9(5):257-63. PMID: 22990105.
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    34. Park SR, Lee JG, Roh SH, Kim G, Kwon CH, Park HR, Kwon KS, Kim D, Kwon SW. Determination of PDE-5 inhibitors and appetite suppressants in adulterated dietary supplements using LC/PDA and LC/MS. Food Addit Contam Part B Surveill. 2012; 5(1):29-32. PMID: 24779692.
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    35. Shin JS, Hong SW, Lee JG, Lee YM, Kim DW, Kim JE, Jung DJ, An SK, Hong NJ, Kim D, Jin DH, Lee SY. An ethanol extract of Iris nertschinskia induces p53-dependent apoptosis in the MCF7 human breast cancer cell line. Int J Mol Med. 2011 Mar; 27(3):401-5. PMID: 21240456.
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    36. Lee JG, Baek SH, Lee YY, Park SY, Park JH. Anti-complementary ginsenosides isolated from processed ginseng. Biol Pharm Bull. 2011; 34(6):898-900. PMID: 21628891.
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    37. Baek SH, Lee JG, Park SY, Bae ON, Kim DH, Park JH. Pectic polysaccharides from Panax ginseng as the antirotavirus principals in ginseng. Biomacromolecules. 2010 Aug 09; 11(8):2044-52. PMID: 20597500.
      Citations:    
    38. Lee JG, Lee YY, Wu B, Kim SY, Lee YJ, Yun-Choi HS, Park JH. Inhibitory activity of ginsenosides isolated from processed ginseng on platelet aggregation. Pharmazie. 2010 Jul; 65(7):520-2. PMID: 20662322.
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    39. Lee JG, Lee YY, Kim SY, Pyo JS, Yun-Choi HS, Park JH. Platelet antiaggregating activity of ginsenosides isolated from processed ginseng. Pharmazie. 2009 Sep; 64(9):602-4. PMID: 19827304.
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    40. Pyo JS, Roh SH, Kim DK, Lee JG, Lee YY, Hong SS, Kwon SW, Park JH. Anti-cancer effect of Betulin on a human lung cancer cell line: a pharmacoproteomic approach using 2 D SDS PAGE coupled with nano-HPLC tandem Mass Spectrometry. Planta Med. 2009 Feb; 75(2):127-31. PMID: 19085751.
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    41. Lee YJ, Kim HY, Kang KS, Lee JG, Yokozawa T, Park JH. The chemical and hydroxyl radical scavenging activity changes of ginsenoside-Rb1 by heat processing. Bioorg Med Chem Lett. 2008 Aug 15; 18(16):4515-20. PMID: 18676142.
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