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Hu Huang

TitleAssociate Professor
InstitutionWake Forest School of Medicine
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Huang H, Saddala MS, Mukwaya A, Mohan RR, Lennikov A. Association of Placental Growth Factor and Angiopoietin in Human Retinal Endothelial Cell-Pericyte co-Cultures and iPSC-Derived Vascular Organoids. Curr Eye Res. 2023 Mar; 48(3):297-311. PMID: 36458540.
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    2. Yang X, Diaz V, Huang H. The Role of Interferon Regulatory Factor 1 in Regulating Microglial Activation and Retinal Inflammation. Int J Mol Sci. 2022 Nov 24; 23(23). PMID: 36498991.
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    3. Balne PK, Gupta S, Landon KM, Sinha NR, Hofmann AC, Hauser N, Sinha PR, Huang H, Kempuraj D, Mohan RR. Characterization of C-X-C chemokine receptor type 5 in the cornea and role in the inflammatory response after corneal injury. Exp Eye Res. 2023 Jan; 226:109312. PMID: 36400287.
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    4. Saddala MS, Lennikov A, Mukwaya A, Yang X, Tang S, Huang H. Data mining and network analysis reveals C-X-C chemokine receptor type 5 is involved in the pathophysiology of age-related macular degeneration. J Biomol Struct Dyn. 2022; 40(21):10783-10792. PMID: 34243690.
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    5. Saddala MS, Yang X, Tang S, Huang H. Transcriptome-wide analysis reveals core sets of transcriptional regulators of sensome and inflammation genes in retinal microglia. Genomics. 2021 Sep; 113(5):3058-3071. PMID: 34242709.
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    6. Hikage F, Lennikov A, Mukwaya A, Lachota M, Ida Y, Utheim TP, Chen DF, Huang H, Ohguro H. NF-?B activation in retinal microglia is involved in the inflammatory and neovascularization signaling in laser-induced choroidal neovascularization in mice. Exp Cell Res. 2021 Jun 01; 403(1):112581. PMID: 33811906.
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    7. Lennikov A, Mukwaya A, Fan L, Saddala MS, De Falco S, Huang H. Synergistic interactions of PlGF and VEGF contribute to blood-retinal barrier breakdown through canonical NF?B activation. Exp Cell Res. 2020 Dec 15; 397(2):112347. PMID: 33130176.
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    8. Huang H. Pericyte-Endothelial Interactions in the Retinal Microvasculature. Int J Mol Sci. 2020 Oct 08; 21(19). PMID: 33049983.
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    9. Lennikov A, Mukwaya A, Saddala MS, Huang H. Deficiency of C-X-C chemokine receptor type 5 (CXCR5) gene causes dysfunction of retinal pigment epithelium cells. Lab Invest. 2021 Feb; 101(2):228-244. PMID: 32994482.
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    10. Huang H, Saddala MS, Lennikov A, Mukwaya A, Fan L. RNA-Seq reveals placental growth factor regulates the human retinal endothelial cell barrier integrity by transforming growth factor (TGF-ß) signaling. Mol Cell Biochem. 2020 Dec; 475(1-2):93-106. PMID: 32813141.
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    11. Saddala MS, Lennikov A, Huang H. RNA-seq data from C-X-C chemokine receptor type 5 (CXCR5) gene knockout aged mice with retinal degeneration phenotype. Data Brief. 2020 Aug; 31:105915. PMID: 32642521.
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    12. Saddala MS, Lennikov A, Mukwaya A, Huang H. Transcriptome-Wide Analysis of CXCR5 Deficient Retinal Pigment Epithelial (RPE) Cells Reveals Molecular Signatures of RPE Homeostasis. Biomedicines. 2020 Jun 01; 8(6). PMID: 32492870.
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    13. Huang H, Lennikov A. CXCR5/NRF2 double knockout mice develop retinal degeneration phenotype at early adult age. Exp Eye Res. 2020 Jul; 196:108061. PMID: 32387618.
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    14. Saddala MS, Lennikov A, Mukwaya A, Yang Y, Hill MA, Lagali N, Huang H. Discovery of novel L-type voltage-gated calcium channel blockers and application for the prevention of inflammation and angiogenesis. J Neuroinflammation. 2020 Apr 25; 17(1):132. PMID: 32334630.
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    15. Saddala MS, Lennikov A, Huang H. Discovery of Small-Molecule Activators for Glucose-6-Phosphate Dehydrogenase (G6PD) Using Machine Learning Approaches. Int J Mol Sci. 2020 Feb 23; 21(4). PMID: 32102234.
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    16. Saddala MS, Lennikov A, Huang H. Placental growth factor regulates the pentose phosphate pathway and antioxidant defense systems in human retinal endothelial cells. J Proteomics. 2020 Apr 15; 217:103682. PMID: 32058040.
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    17. Saddala MS, Lennikov A, Bouras A, Huang H. RNA-Seq reveals differential expression profiles and functional annotation of genes involved in retinal degeneration in Pde6c mutant Danio rerio. BMC Genomics. 2020 Feb 07; 21(1):132. PMID: 32033529.
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    18. Huang H, Lennikov A, Saddala MS, Gozal D, Grab DJ, Khalyfa A, Fan L. Placental growth factor negatively regulates retinal endothelial cell barrier function through suppression of glucose-6-phosphate dehydrogenase and antioxidant defense systems. FASEB J. 2019 Dec; 33(12):13695-13709. PMID: 31585507.
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    19. Lennikov A, Saddala MS, Mukwaya A, Tang S, Huang H. Autoimmune-Mediated Retinopathy in CXCR5-Deficient Mice as the Result of Age-Related Macular Degeneration Associated Proteins Accumulation. Front Immunol. 2019; 10:1903. PMID: 31474986.
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    20. Cao X, Li W, Liu Y, Huang H, Ye CH. The Anti-Inflammatory Effects of CXCR5 in the Mice Retina following Ischemia-Reperfusion Injury. Biomed Res Int. 2019; 2019:3487607. PMID: 31355256.
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    21. Saddala MS, Huang H. Identification of novel inhibitors for TNFa, TNFR1 and TNFa-TNFR1 complex using pharmacophore-based approaches. J Transl Med. 2019 Jul 02; 17(1):215. PMID: 31266509.
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    22. Saddala MS, Lennikov A, Mukwaya A, Fan L, Hu Z, Huang H. Transcriptome-wide analysis of differentially expressed chemokine receptors, SNPs, and SSRs in the age-related macular degeneration. Hum Genomics. 2019 Mar 20; 13(1):15. PMID: 30894217.
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    23. Saddala MS, Lennikov A, Grab DJ, Liu GS, Tang S, Huang H. Proteomics reveals ablation of PlGF increases antioxidant and neuroprotective proteins in the diabetic mouse retina. Sci Rep. 2018 Nov 13; 8(1):16728. PMID: 30425286.
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    24. Bee YS, Ma YL, Chen J, Tsai PJ, Sheu SJ, Lin HC, Huang H, Liu GS, Tai MH. Inhibition of Experimental Choroidal Neovascularization by a Novel Peptide Derived from Calreticulin Anti-Angiogenic Domain. Int J Mol Sci. 2018 Sep 30; 19(10). PMID: 30274378.
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    25. Tsai CH, Wang PY, Lin IC, Huang H, Liu GS, Tseng CL. Ocular Drug Delivery: Role of Degradable Polymeric Nanocarriers for Ophthalmic Application. Int J Mol Sci. 2018 Sep 19; 19(9). PMID: 30235809.
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    26. Huang H, Liu Y, Wang L, Li W. Age-related macular degeneration phenotypes are associated with increased tumor necrosis-alpha and subretinal immune cells in aged Cxcr5 knockout mice. PLoS One. 2017; 12(3):e0173716. PMID: 28282423.
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    27. Liu Y, Huang H, Sun G, Alwadani S, Semba RD, Lutty GA, Yiu S, Edward DP. Gene Expression Profile of Extracellular Matrix and Adhesion Molecules in the Human Normal Corneal Stroma. Curr Eye Res. 2017 Apr; 42(4):520-527. PMID: 27442190.
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    28. He J, Wang H, Liu Y, Li W, Kim D, Huang H. Blockade of vascular endothelial growth factor receptor 1 prevents inflammation and vascular leakage in diabetic retinopathy. J Ophthalmol. 2015; 2015:605946. PMID: 25821590.
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    29. Huang H, Wen L, He J, Barnabie P, Shealy D, Vinores SA. Blockade of Tumor Necrosis Factor Alpha Prevents Complications of Diabetic Retinopathy. Journal of Clinical and Experimental Ophthalmology. 2014; 5(6).
    30. Huang H, He J, Johnson D, Wei Y, Liu Y, Wang S, Lutty GA, Duh EJ, Semba RD. Deletion of placental growth factor prevents diabetic retinopathy and is associated with Akt activation and HIF1a-VEGF pathway inhibition. Diabetes. 2015 Jan; 64(1):200-12. PMID: 25187372.
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    31. Semba RD, Huang H, Lutty GA, Van Eyk JE, Hart GW. The role of O-GlcNAc signaling in the pathogenesis of diabetic retinopathy. Proteomics Clin Appl. 2014 Apr; 8(3-4):218-31. PMID: 24550151.
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    32. Xu Z, Wei Y, Gong J, Cho H, Park JK, Sung ER, Huang H, Wu L, Eberhart C, Handa JT, Du Y, Kern TS, Thimmulappa R, Barber AJ, Biswal S, Duh EJ. NRF2 plays a protective role in diabetic retinopathy in mice. Diabetologia. 2014 Jan; 57(1):204-13. PMID: 24186494.
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    33. Huang H, Parlier R, Shen JK, Lutty GA, Vinores SA. VEGF receptor blockade markedly reduces retinal microglia/macrophage infiltration into laser-induced CNV. PLoS One. 2013; 8(8):e71808. PMID: 23977149.
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    34. Huang H, Van de Veire S, Dalal M, Parlier R, Semba RD, Carmeliet P, Vinores SA. Reduced retinal neovascularization, vascular permeability, and apoptosis in ischemic retinopathy in the absence of prolyl hydroxylase-1 due to the prevention of hyperoxia-induced vascular obliteration. Invest Ophthalmol Vis Sci. 2011 Sep 29; 52(10):7565-73. PMID: 21873682.
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    35. Chronopoulos A, Trudeau K, Roy S, Huang H, Vinores SA, Roy S. High glucose-induced altered basement membrane composition and structure increases trans-endothelial permeability: implications for diabetic retinopathy. Curr Eye Res. 2011 Aug; 36(8):747-53. PMID: 21780924.
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    36. Huang H, Shen J, Vinores SA. Blockade of VEGFR1 and 2 suppresses pathological angiogenesis and vascular leakage in the eye. PLoS One. 2011; 6(6):e21411. PMID: 21731737.
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    37. Huang H, Gandhi JK, Zhong X, Wei Y, Gong J, Duh EJ, Vinores SA. TNFalpha is required for late BRB breakdown in diabetic retinopathy, and its inhibition prevents leukostasis and protects vessels and neurons from apoptosis. Invest Ophthalmol Vis Sci. 2011 Mar; 52(3):1336-44. PMID: 21212173.
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    38. Zhong X, Huang H, Shen J, Zacchigna S, Zentilin L, Giacca M, Vinores SA. Vascular endothelial growth factor-B gene transfer exacerbates retinal and choroidal neovascularization and vasopermeability without promoting inflammation. Mol Vis. 2011 Feb 17; 17:492-507. PMID: 21364963.
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    39. Huang H, Vasilakis P, Zhong X, Shen JK, Geronatsiou K, Papadaki H, Maragoudakis ME, Gartaganis SP, Vinores SA, Tsopanoglou NE. Parstatin suppresses ocular neovascularization and inflammation. Invest Ophthalmol Vis Sci. 2010 Nov; 51(11):5825-32. PMID: 20538980.
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    40. Canto-Soler MV, Huang H, Romero MS, Adler R. Transcription factors CTCF and Pax6 are segregated to different cell types during retinal cell differentiation. Dev Dyn. 2008 Mar; 237(3):758-67. PMID: 18224715.
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    41. Wahlin KJ, Moreira EF, Huang H, Yu N, Adler R. Molecular dynamics of photoreceptor synapse formation in the developing chick retina. J Comp Neurol. 2008 Feb 10; 506(5):822-37. PMID: 18076030.
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    42. Huang H, Wahlin KJ, McNally M, Irving ND, Adler R. Developmental regulation of muscleblind-like (MBNL) gene expression in the chicken embryo retina. Dev Dyn. 2008 Jan; 237(1):286-96. PMID: 18095352.
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    43. Yu X, Tang Y, Li F, Frank MB, Huang H, Dozmorov I, Zhu Y, Centola M, Cao W. Protection against hydrogen peroxide-induced cell death in cultured human retinal pigment epithelial cells by 17beta-estradiol: a differential gene expression profile. Mech Ageing Dev. 2005 Nov; 126(11):1135-45. PMID: 16029884.
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    44. Huang H, Frank MB, Dozmorov I, Cao W, Cadwell C, Knowlton N, Centola M, Anderson RE. Identification of mouse retinal genes differentially regulated by dim and bright cyclic light rearing. Exp Eye Res. 2005 May; 80(5):727-39. PMID: 15862179.
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    45. Huang H, Li F, Alvarez RA, Ash JD, Anderson RE. Downregulation of ATP synthase subunit-6, cytochrome c oxidase-III, and NADH dehydrogenase-3 by bright cyclic light in the rat retina. Invest Ophthalmol Vis Sci. 2004 Aug; 45(8):2489-96. PMID: 15277468.
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    46. Káldi I, Martin RE, Huang H, Brush RS, Morrison KA, Anderson RE. Bright cyclic rearing protects albino mouse retina against acute light-induced apoptosis. Mol Vis. 2003 Jul 30; 9:337-44. PMID: 12891098.
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    47. Liu RS, Huang H, Yang Q, Liu WY. Purification of alpha-sarcin and an antifungal protein from mold (Aspergillus giganteus) by chitin affinity chromatography. Protein Expr Purif. 2002 Jun; 25(1):50-8. PMID: 12071698.
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    48. Huang H, Xu J, Gong Z. Characteristics of a New Antifungal Protein from Ginkgo biloba L. Protein & Peptide Letters;. 2001; 8(3):209-216. View Publication.