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Last Name

Hooman Sadri, M.D., Ph.D.

TitleAssistant Professor
InstitutionWake Forest School of Medicine
DepartmentWF Institute for Regen Medicine
Address
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    Other Positions
    TitleAssistant Professor
    InstitutionWake Forest School of Medicine
    DepartmentSurgical Sciences-Urology


    Collapse Biography 
    Collapse education and training
    SBMU, Tehran, IranM.D.1999Medicine
    University of Amsterdam, Amsterdam, The NetherlandsPh.D.2011Reproductive biology & Genetics
    Wake Forest Institute for Regenerative Medicine (WFIRM), Winston-Salem,NCResearch Fellowship2016Regenerative Medicine & Tissue Engineering
    Department of Urology, School of Medicine, Wake Forest Baptist Health University, Winston-Salem,NCClinical Fellowship2016Male Reproductive Medicine
    Collapse awards and honors
    2009 - 2009AMC Young scientist publication award (first place) , University of Amsterdam
    2010 - 201011th Royan International Research Award, Stem Cells and Developmental Biology field, Royan Institute
    2010 - 2010Jan Swammerdam Fertility , Dutch fertility prize selection committe
    2012 - 2012The 17th Razi research Festival award on medical science , National Research Center for Medical Sciences of Iran (NRCMSI)
    2015 - 2015AUA early career investigators training award , American Urological Association (AUA)
    2015 - 2015Gold Award,Fellow Basic Science, Surgical Sciences, 23th Annual Residents’ and Fellows Research Day, Wake Forest School of Medicine

    Collapse Overview 
    Collapse overview
    Dr. Hooman Sadri-Ardekani is currently the director of male fertility research program at Wake Forest Institute for Regenerative Medicine (WFIRM) and Department of Urology. He has been a fellowship trained male reproductive medicine clinician since 2003. After couple of years of providing clinical services and serving as the director of a reproductive medicine center in Tehran (Avicenna Infertility Center), he sought to learn more about reproductive biology and joined the University of Amsterdam where he got his PhD in December 2011. He has since established the first in vitro propagation system for human Spermatogonial Stem Cells (SSCs) (JAMA 2009 and 2011) which has been recognized as a milestone in autotransplantation of human SSCs (Nature Reviews Urology February 2010). He has received several awards based on his innovations in the field of male reproductive biology; including the AMC Young scientist publication 2009, The 11th Royan International Research Award in Stem Cells and Developmental Biology in 2010, the Jan Swammerdam Fertility Prize 2010 and The 17th Razi research Festival award on medical science 2012). In January 2012 he moved to WFIRM to establish male fertility research program. Dr. Sadri-Ardekani is currently practicing as a clinician in Urology clinic and Wake Forest Center for Reproductive Medicine. He is running a national comprehensive referral program to preserve fertility in high risk infertility patients in different ages, from childhood to adolescence to adults; including but not limited to those with cancer, Klinefelter syndrome, spinal cord injury, diabetes and multiple sclerosis.

    SYNOPSIS OF AREA OF INTEREST:
    *Male reproductive medicine and biology
    *Stem cell therapies for male infertility
    *Tissue engineering 3D human testis organoid platform for in vitro spermatogenesis, androgen replacement, toxicology and drug screening

    DETAILED AREA OF INTEREST:
    Dr.Sadri-Ardekani current laboratory’s research focuses on the dynamics of male germ lineage development, which establishes the pool of Spermatogonial Stem Cells (SSCs) and the mechanisms that regulate SSC self-renewal and differentiation, ensuring continuous sperm production. His lab is actively investigating the feasibility and safety of translating In Vitro Spermatogenesis and SSC transplantation to the male fertility clinic.


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Zarandi NP, Galdon G, Kogan S, Atala A, Sadri-Ardekani H. Cryostorage of immature and mature human testis tissue to preserve spermatogonial stem cells (SSCs): a systematic review of current experiences toward clinical applications. Stem Cells Cloning. 2018; 11:23-38. PMID: 30013372.
      View in: PubMed
    2. Strange DP, Zarandi NP, Trivedi G, Atala A, Bishop CE, Sadri-Ardekani H, Verma S. Human testicular organoid system as a novel tool to study Zika virus pathogenesis. Emerg Microbes Infect. 2018 05 09; 7(1):82. PMID: 29739931.
      View in: PubMed
    3. Pendergraft SS, Sadri-Ardekani H, Atala A, Bishop CE. Three-dimensional testicular organoid: a novel tool for the study of human spermatogenesis and gonadotoxicity in vitro. Biol Reprod. 2017 03 01; 96(3):720-732. PMID: 28339648.
      View in: PubMed
    4. Galdon G, Atala A, Sadri-Ardekani H. In Vitro Spermatogenesis: How Far from Clinical Application? Curr Urol Rep. 2016 Jul; 17(7):49. PMID: 27107595.
      View in: PubMed
    5. Sadri-Ardekani H, McLean TW, Kogan S, Sirintrapun J, Crowell K, Yousif MQ, Hodges SJ, Petty J, Pranikoff T, Sieren L, Zeller K, Atala A. Experimental testicular tissue banking to generate spermatogenesis in the future: A multidisciplinary team approach. Methods. 2016 Apr 15; 99:120-7. PMID: 26917042.
      View in: PubMed
    6. Sadri-Ardekani H, Atala A. Regenerative medicine for the treatment of reproductive system disorders: current and potential options. Adv Drug Deliv Rev. 2015 Mar; 82-83:145-52. PMID: 25453265.
      View in: PubMed
    7. Sadri-Ardekani H, Atala A. Testicular tissue cryopreservation and spermatogonial stem cell transplantation to restore fertility: from bench to bedside. Stem Cell Res Ther. 2014 May 28; 5(3):68. PMID: 25157677.
      View in: PubMed
    8. Sadri-Ardekani H, Homburg CH, van Capel TM, van den Berg H, van der Veen F, van der Schoot CE, van Pelt AM, Repping S. Eliminating acute lymphoblastic leukemia cells from human testicular cell cultures: a pilot study. Fertil Steril. 2014 Apr; 101(4):1072-1078.e1. PMID: 24581582.
      View in: PubMed
    9. Sadri-Ardekani H, Akhondi MM, Vossough P, Maleki H, Sedighnejad S, Kamali K, Ghorbani B, van Wely M, van der Veen F, Repping S. Parental attitudes toward fertility preservation in boys with cancer: context of different risk levels of infertility and success rates of fertility restoration. Fertil Steril. 2013 Mar 01; 99(3):796-802. PMID: 23332678.
      View in: PubMed
    10. Sadri-Ardekani H, Akhondi MA, van der Veen F, Repping S, van Pelt AM. In vitro propagation of human prepubertal spermatogonial stem cells. JAMA. 2011 Jun 15; 305(23):2416-8. PMID: 21673293.
      View in: PubMed
    11. Sadri-Ardekani H, Mizrak SC, van Daalen SK, Korver CM, Roepers-Gajadien HL, Koruji M, Hovingh S, de Reijke TM, de la Rosette JJ, van der Veen F, de Rooij DG, Repping S, van Pelt AM. Propagation of human spermatogonial stem cells in vitro. JAMA. 2009 Nov 18; 302(19):2127-34. PMID: 19920237.
      View in: PubMed
    12. Mizrak SC, Chikhovskaya JV, Sadri-Ardekani H, van Daalen S, Korver CM, Hovingh SE, Roepers-Gajadien HL, Raya A, Fluiter K, de Reijke TM, de la Rosette JJ, Knegt AC, Belmonte JC, van der Veen F, de Rooij DG, Repping S, van Pelt AM. Embryonic stem cell-like cells derived from adult human testis. Hum Reprod. 2010 Jan; 25(1):158-67. PMID: 19815622.
      View in: PubMed
    13. Ahmed EA, Barten-van Rijbroek AD, Kal HB, Sadri-Ardekani H, Mizrak SC, van Pelt AM, de Rooij DG. Proliferative activity in vitro and DNA repair indicate that adult mouse and human Sertoli cells are not terminally differentiated, quiescent cells. Biol Reprod. 2009 Jun; 80(6):1084-91. PMID: 19164176.
      View in: PubMed
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