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Guangxu Jin PhD

TitleAssistant Professor
InstitutionWake Forest School of Medicine
DepartmentCancer Biology
Address
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    Chinese Academy of Sciences, BeijingPh.D.09/2008Bioinformatics

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    I am an Assistant Professor of Bioinformatics in the Department of Cancer Biology, Wake Forest School of Medicine, and currently a Full Member of Bioinformatics Shared Resources at the Wake Forest Baptist Comprehensive Cancer Center. I have been studying clinical genetics in cancer treatments and single-cell genomics in cancer immunotherapy. My team has pioneered work in single-cell modeling of response to checkpoint immunotherapy and developed an innovative projection-free single-cell modeling algorithm for this field. My current research focuses are the roles of CAR T cells in inducing neurotoxicity associated with CAR-T cell therapies, genetic biomarkers for surgical outcomes in appendiceal cancer, and genetics-level understanding of the SARS-CoV-2 variants. Our lab published over 40 papers in this field (i10-index=29, h-index=20). Our papers published in high-impact journals, including Cancer Cell, Lancet Oncology, JAMA Oncology, Nature Communications, Nature Biomedical Engineering, Briefings of Bioinformatics, etc. Our collaborating projects have been well funded by NIH/NCI, DoD, and other federal funding agencies. Our lab has a long-term interest in developing novel computational methods for sequencing analysis and their application to translational and clinical research.

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Zheng N, Fang J, Xue G, Wang Z, Li X, Zhou M, Jin G, Rahman MM, McFadden G, Lu Y. Induction of tumor cell autosis by myxoma virus-infected CAR-T and TCR-T cells to overcome primary and acquired resistance. Cancer Cell. 2022 Aug 15. PMID: 36027915.
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    2. Zhao H, Han K, Gao C, Madhira V, Topaloglu U, Lu Y, Jin G. VOC-alarm: Mutation-based prediction of SARS-CoV-2 variants of concern. Bioinformatics. 2022 May 31. PMID: 35640977.
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    3. Sirkisoon SR, Wong GL, Aguayo NR, Doheny DL, Zhu D, Regua AT, Arrigo A, Manore SG, Wagner C, Thomas A, Singh R, Xing F, Jin G, Watabe K, Lo HW. Breast cancer extracellular vesicles-derived miR-1290 activates astrocytes in the brain metastatic microenvironment via the FOXA2?CNTF axis to promote progression of brain metastases. Cancer Lett. 2022 May 16; 540:215726. PMID: 35589002.
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    4. Rimkus TK, Arrigo AB, Zhu D, Carpenter RL, Sirkisoon S, Doheny D, Regua AT, Wong GL, Manore S, Wagner C, Lin HK, Jin G, Ruiz J, Chan M, Debinski W, Lo HW. NEDD4 degrades TUSC2 to promote glioblastoma progression. Cancer Lett. 2022 04 10; 531:124-135. PMID: 35167936.
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    5. Lu Y, Xue G, Zheng N, Han K, Yang W, Wang RS, Wu L, Miller LD, Pardee T, Triozzi PL, Lo HW, Watabe K, Wong STC, Pasche BC, Zhang W, Jin G. hDirect-MAP: projection-free single-cell modeling of response to checkpoint immunotherapy. Brief Bioinform. 2022 Jan 17. PMID: 35037026.
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    6. Pullikuth AK, Routh ED, Zimmerman KD, Chifman J, Chou JW, Soike MH, Jin G, Su J, Song Q, Black MA, Print C, Bedognetti D, Howard-McNatt M, O'Neill SS, Thomas A, Langefeld CD, Sigalov AB, Lu Y, Miller LD. Bulk and Single-Cell Profiling of Breast Tumors Identifies TREM-1 as a Dominant Immune Suppressive Marker Associated With Poor Outcomes. Front Oncol. 2021; 11:734959. PMID: 34956864.
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    7. Xue G, Wang Z, Zheng N, Fang J, Mao C, Li X, Jin G, Ming X, Lu Y. Elimination of acquired resistance to PD-1 blockade via the concurrent depletion of tumour cells and immunosuppressive cells. Nat Biomed Eng. 2021 Nov; 5(11):1306-1319. PMID: 34725506.
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    8. Xue G, Zheng N, Fang J, Jin G, Li X, Dotti G, Yi Q, Lu Y. Adoptive cell therapy with tumor-specific Th9 cells induces viral mimicry to eliminate antigen-loss-variant tumor cells. Cancer Cell. 2021 Oct 05. PMID: 34678150.
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    9. Gao C, Jin G, Forbes E, Mangala LS, Wang Y, Rodriguez-Aguayo C, Amero P, Bayraktar E, Yan Y, Lopez-Berestein G, Broaddus RR, Sood AK, Xue F, Zhang W. Inactivating Mutations of the IK Gene Weaken Ku80/Ku70-Mediated DNA Repair and Sensitize Endometrial Cancer to Chemotherapy. Cancers (Basel). 2021 May 20; 13(10). PMID: 34065218.
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    10. Regua AT, Aguayo NR, Jalboush SA, Doheny DL, Manore SG, Zhu D, Wong GL, Arrigo A, Wagner CJ, Yu Y, Thomas A, Chan MD, Ruiz J, Jin G, Strowd R, Sun P, Lin J, Lo HW. TrkA Interacts with and Phosphorylates STAT3 to Enhance Gene Transcription and Promote Breast Cancer Stem Cells in Triple-Negative and HER2-Enriched Breast Cancers. Cancers (Basel). 2021 May 12; 13(10). PMID: 34066153.
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    11. Yang W, Jin G. Origin-independent analysis links SARS-CoV-2 local genomes with COVID-19 incidence and mortality. Brief Bioinform. 2021 03 22; 22(2):905-913. PMID: 32924062.
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    12. Moaven O, Su J, Jin G, Votanopoulos KI, Shen P, Mangieri C, O'Neill SS, Perry KC, Levine EA, Miller LD. Clinical Implications of Genetic Signatures in Appendiceal Cancer Patients with Incomplete Cytoreduction/HIPEC. Ann Surg Oncol. 2020 Dec; 27(13):5016-5023. PMID: 32705511.
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    13. Routh ED, Pullikuth AK, Jin G, Chifman J, Chou JW, D'Agostino RB, Seino KI, Wada H, Print CG, Zhang W, Lu Y, Miller LD. Transcriptomic Features of T Cell-Barren Tumors Are Conserved Across Diverse Tumor Types. Front Immunol. 2020; 11:57. PMID: 32117236.
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    14. Su J, Jin G, Votanopoulos KI, Craddock L, Shen P, Chou JW, Qasem S, O'Neill SS, Perry KC, Miller LD, Levine EA. Prognostic Molecular Classification of Appendiceal Mucinous Neoplasms Treated with Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy. Ann Surg Oncol. 2020 May; 27(5):1439-1447. PMID: 31980985.
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    15. Jimenez H, Wang M, Zimmerman JW, Pennison MJ, Sharma S, Surratt T, Xu ZX, Brezovich I, Absher D, Myers RM, DeYoung B, Caudell DL, Chen D, Lo HW, Lin HK, Godwin DW, Olivier M, Ghanekar A, Chen K, Miller LD, Gong Y, Capstick M, D'Agostino RB, Munden R, Merle P, Barbault A, Blackstock AW, Bonkovsky HL, Yang GY, Jin G, Liu L, Zhang W, Watabe K, Blackman CF, Pasche BC. Tumour-specific amplitude-modulated radiofrequency electromagnetic fields induce differentiation of hepatocellular carcinoma via targeting Cav3.2?T-type voltage-gated calcium channels and Ca2+ influx. EBioMedicine. 2019 Jun; 44:209-224. PMID: 31160272.
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    16. Cao C, Mak L, Jin G, Gordon P, Ye K, Long Q. PRESM: personalized reference editor for somatic mutation discovery in cancer genomics. Bioinformatics. 2019 05 01; 35(9):1445-1452. PMID: 30247633.
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    17. Song Q, Hawkins GA, Wudel L, Chou PC, Forbes E, Pullikuth AK, Liu L, Jin G, Craddock L, Topaloglu U, Kucera G, O'Neill S, Levine EA, Sun P, Watabe K, Lu Y, Alexander-Miller MA, Pasche B, Miller LD, Zhang W. Dissecting intratumoral myeloid cell plasticity by single cell RNA-seq. Cancer Med. 2019 06; 8(6):3072-3085. PMID: 31033233.
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    18. Xue G, Jin G, Fang J, Lu Y. IL-4 together with IL-1ß induces antitumor Th9 cell differentiation in the absence of TGF-ß signaling. Nat Commun. 2019 03 26; 10(1):1376. PMID: 30914642.
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    19. Naczki C, John B, Patel C, Lafferty A, Ghoneum A, Afify H, White M, Davis A, Jin G, Kridel S, Said N. SPARC Inhibits Metabolic Plasticity in Ovarian Cancer. Cancers (Basel). 2018 Oct 16; 10(10). PMID: 30332737.
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    20. Thomas A, Routh ED, Pullikuth A, Jin G, Su J, Chou JW, Hoadley KA, Print C, Knowlton N, Black MA, Demaria S, Wang E, Bedognetti D, Jones WD, Mehta GA, Gatza ML, Perou CM, Page DB, Triozzi P, Miller LD. Tumor mutational burden is a determinant of immune-mediated survival in breast cancer. Oncoimmunology. 2018; 7(10):e1490854. PMID: 30386679.
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    21. Xing F, Liu Y, Wu SY, Wu K, Sharma S, Mo YY, Feng J, Sanders S, Jin G, Singh R, Vidi PA, Tyagi A, Chan MD, Ruiz J, Debinski W, Pasche BC, Lo HW, Metheny-Barlow LJ, D'Agostino RB, Watabe K. Loss of XIST in Breast Cancer Activates MSN-c-Met and Reprograms Microglia via Exosomal miRNA to Promote Brain Metastasis. Cancer Res. 2018 08 01; 78(15):4316-4330. PMID: 30026327.
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    22. Sirkisoon SR, Carpenter RL, Rimkus T, Anderson A, Harrison A, Lange AM, Jin G, Watabe K, Lo HW. Interaction between STAT3 and GLI1/tGLI1 oncogenic transcription factors promotes the aggressiveness of triple-negative breast cancers and HER2-enriched breast cancer. Oncogene. 2018 05; 37(19):2502-2514. PMID: 29449694.
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    23. Pardee TS, Anderson RG, Pladna KM, Isom S, Ghiraldeli LP, Miller LD, Chou JW, Jin G, Zhang W, Ellis LR, Berenzon D, Howard DS, Hurd DD, Manuel M, Dralle S, Lyerly S, Powell BL. A Phase I Study of CPI-613 in Combination with High-Dose Cytarabine and Mitoxantrone for Relapsed or Refractory Acute Myeloid Leukemia. Clin Cancer Res. 2018 05 01; 24(9):2060-2073. PMID: 29437791.
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    24. Fu C, Deng S, Jin G, Wang X, Yu ZG. Bayesian network model for identification of pathways by integrating protein interaction with genetic interaction data. BMC Syst Biol. 2017 Sep 21; 11(Suppl 4):81. PMID: 28950903.
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    25. Alistar A, Morris BB, Desnoyer R, Klepin HD, Hosseinzadeh K, Clark C, Cameron A, Leyendecker J, D'Agostino R, Topaloglu U, Boteju LW, Boteju AR, Shorr R, Zachar Z, Bingham PM, Ahmed T, Crane S, Shah R, Migliano JJ, Pardee TS, Miller L, Hawkins G, Jin G, Zhang W, Pasche B. Safety and tolerability of the first-in-class agent CPI-613 in combination with modified FOLFIRINOX in patients with metastatic pancreatic cancer: a single-centre, open-label, dose-escalation, phase 1 trial. Lancet Oncol. 2017 06; 18(6):770-778. PMID: 28495639.
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    26. Peng H, Tan H, Zhao W, Jin G, Sharma S, Xing F, Watabe K, Zhou X. Computational systems biology in cancer brain metastasis. Front Biosci (Schol Ed). 2016 Jan 01; 8:169-86. PMID: 26709906.
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    27. Liu L, Jin G, Zhou X. Modeling the relationship of epigenetic modifications to transcription factor binding. Nucleic Acids Res. 2015 Apr 30; 43(8):3873-85. PMID: 25820421.
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    28. Choi DS, Blanco E, Kim YS, Rodriguez AA, Zhao H, Huang TH, Chen CL, Jin G, Landis MD, Burey LA, Qian W, Granados SM, Dave B, Wong HH, Ferrari M, Wong ST, Chang JC. Chloroquine eliminates cancer stem cells through deregulation of Jak2 and DNMT1. Stem Cells. 2014 Sep; 32(9):2309-23. PMID: 24809620.
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    29. Liu T, Ren D, Zhu X, Yin Z, Jin G, Zhao Z, Robinson D, Li X, Wong K, Cui K, Zhao H, Wong ST. Transcriptional signaling pathways inversely regulated in Alzheimer's disease and glioblastoma multiform. Sci Rep. 2013 Dec 10; 3:3467. PMID: 24322672.
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    30. Jin G, Wong ST. Toward better drug repositioning: prioritizing and integrating existing methods into efficient pipelines. Drug Discov Today. 2014 May; 19(5):637-44. PMID: 24239728.
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    31. Zhao H, Jin G, Cui K, Ren D, Liu T, Chen P, Wong S, Li F, Fan Y, Rodriguez A, Chang J, Wong ST. Novel modeling of cancer cell signaling pathways enables systematic drug repositioning for distinct breast cancer metastases. Cancer Res. 2013 Oct 15; 73(20):6149-63. PMID: 24097821.
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    32. Fu C, Jin G, Gao J, Zhu R, Ballesteros-Villagrana E, Wong ST. DrugMap Central: an on-line query and visualization tool to facilitate drug repositioning studies. Bioinformatics. 2013 Jul 15; 29(14):1834-6. PMID: 23681121.
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    33. Li F, Yin Z, Jin G, Zhao H, Wong ST. Chapter 17: bioimage informatics for systems pharmacology. PLoS Comput Biol. 2013 Apr; 9(4):e1003043. PMID: 23633943.
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    34. Jin G, Fu C, Zhao H, Cui K, Chang J, Wong ST. A novel method of transcriptional response analysis to facilitate drug repositioning for cancer therapy. Cancer Res. 2012 Jan 01; 72(1):33-44. PMID: 22108825.
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    35. Zhao H, Cui K, Nie F, Wang L, Brandl MB, Jin G, Li F, Mao Y, Xue Z, Rodriguez A, Chang J, Wong ST. The effect of mTOR inhibition alone or combined with MEK inhibitors on brain metastasis: an in vivo analysis in triple-negative breast cancer models. Breast Cancer Res Treat. 2012 Jan; 131(2):425-36. PMID: 21394501.
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    36. Jin G, Zhou X, Wang H, Zhao H, Cui K, Zhang XS, Chen L, Hazen SL, Li K, Wong ST. The knowledge-integrated network biomarkers discovery for major adverse cardiac events. J Proteome Res. 2008 Sep; 7(9):4013-21. PMID: 18665624.
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