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William G.Hundley MD

TitleProfessor
InstitutionWake Forest School of Medicine
DepartmentInternal Medicine, Cardiovascular Medicine
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    Other Positions
    TitleProfessor
    InstitutionWake Forest School of Medicine
    DepartmentBiomedical Engineering


    Collapse Research 
    Collapse research activities and funding
    R21CA109224     (HUNDLEY, WILLIAM GREGORY)Apr 5, 2006 - Jan 31, 2009
    NIH
    MRI Detection of Doxorubicin Induced Cardiotoxicity
    Role: Principal Investigator

    R21CA121296     (HUNDLEY, WILLIAM GREGORY)Aug 21, 2006 - Aug 20, 2007
    NIH
    Optimized CMR imaging of chemotherapy cardiotoxicity
    Role: Principal Investigator

    R33CA121296     (HUNDLEY, WILLIAM GREGORY)Aug 21, 2006 - Apr 30, 2013
    NIH
    Optimized CMR imaging of chemotherapy cardiotoxicity
    Role: Principal Investigator

    R01HL076438     (HUNDLEY, WILLIAM GREGORY)Feb 1, 2007 - Dec 31, 2013
    NIH
    Vascular Stiffness and Pulmonary Congestion
    Role: Principal Investigator

    R41AG030248     (HUNDLEY, WILLIAM GREGORY)May 15, 2008 - Apr 30, 2010
    NIH
    Comprehensive MR Imaging of Elderly Vascular Function
    Role: Principal Investigator

    R42AG030248     (HUNDLEY, WILLIAM GREGORY)May 15, 2008 - Jul 31, 2013
    NIH
    Comprehensive MR Imaging of Elderly Vascular Function: Phase II
    Role: Principal Investigator

    T32HL091824     (HUNDLEY, WILLIAM GREGORY)Sep 1, 2009 - Aug 31, 2015
    NIH
    Multidisciplinary Training in Cardiovascular Imaging
    Role: Principal Investigator

    R01CA167821     (HUNDLEY, WILLIAM GREGORY)Jun 1, 2012 - Apr 30, 2019
    NIH
    Early Imaging Detection of CV Injury after Cancer
    Role: Principal Investigator

    R43CA174261     (GOODWIN, HOLLY)Jul 23, 2013 - Oct 31, 2015
    NIH
    Advanced Non-Contrast Imaging for Cardiotoxicity Detection after Cancer
    Role: Co-Principal Investigator

    R01HL118740     (HUNDLEY, WILLIAM GREGORY)Aug 14, 2013 - Dec 31, 2020
    NIH
    Preventing Anthracycline Cardiovascular Toxicity with Statins
    Role: Principal Investigator

    R01CA199167     (HUNDLEY, WILLIAM GREGORY)Sep 1, 2015 - May 31, 2022
    NIH
    Understanding and Predicting Fatigue, CV Decline & Events After Breast CA Treatment
    Role: Principal Investigator

    R34HL138110     (HUIZAR, JOSE FRANCISCO)Aug 1, 2017 - Jul 31, 2021
    NIH
    Prospective Assessment of Premature Ventricular Contractions Suppression in Cardiomyopathy(PAPS): A Pilot Study
    Role: Co-Principal Investigator

    R21CA226960     (HUNDLEY, WILLIAM GREGORY)Dec 1, 2018 - May 31, 2021
    NIH
    Improving Exercise Capacity with a Tailored Physical Activity Intervention in Lymphoma Patients Undergoing Treatment
    Role: Principal Investigator

    T32HL149645     (HUNDLEY, WILLIAM GREGORY)Mar 1, 2020 - Feb 28, 2025
    NIH
    Multi-Disciplinary Training Program in Translational Cardiovascular Research
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Upadhya B, Rocco MV, Pajewski NM, Morgan T, Blackshear J, Hundley WG, Oparil S, Soliman EZ, Cohen DL, Hamilton CA, Cho ME, Kostis WJ, Papademetriou V, Rodriguez CJ, Raj DS, Townsend R, Vasu S, Zamanian S, Kitzman DW. Effect of Intensive Blood Pressure Reduction on Left Ventricular Mass, Structure, Function, and Fibrosis in the SPRINT-HEART. Hypertension. 2019 Jul 01; HYPERTENSIONAHA11913073. PMID: 31256724.
      Citations:    
    2. Thomas A, Rhoads A, Pinkerton E, Schroeder MC, Conway KM, Hundley WG, McNally LR, Oleson J, Lynch CF, Romitti PA. Incidence and Survival Among Young Women With Stage I-III Breast Cancer: SEER 2000-2015. JNCI Cancer Spectr. 2019 Sep; 3(3):pkz040. PMID: 31392297.
      Citations:    
    3. Duprez DA, Gross MD, Kizer JR, Ix JH, Hundley WG, Jacobs DR. Predictive Value of Collagen Biomarkers for Heart Failure With and Without Preserved Ejection Fraction: MESA (Multi-Ethnic Study of Atherosclerosis). J Am Heart Assoc. 2018 02 23; 7(5). PMID: 29475876.
      Citations:    
    4. Chen-Scarabelli C, Hundley WG, Scarabelli TM. Cardio-oncology: an evolving hybrid subspecialty. Future Cardiol. 2018 05; 14(3):197-201. PMID: 29355045.
      Citations:    
    5. Upadhya B, Hundley WG, Brubaker PH, Morgan TM, Stewart KP, Kitzman DW. Effect of Spironolactone on Exercise Tolerance and Arterial Function in Older Adults with Heart Failure with Preserved Ejection Fraction. J Am Geriatr Soc. 2017 Nov; 65(11):2374-2382. PMID: 28542926.
      Citations:    
    6. de Lemos JA, Ayers CR, Levine BD, deFilippi CR, Wang TJ, Hundley WG, Berry JD, Seliger SL, McGuire DK, Ouyang P, Drazner MH, Budoff M, Greenland P, Ballantyne CM, Khera A. Multimodality Strategy for Cardiovascular Risk Assessment: Performance in 2 Population-Based Cohorts. Circulation. 2017 05 30; 135(22):2119-2132. PMID: 28360032.
      Citations:    
    7. Meléndez GC, Sukpraphrute B, D'Agostino RB, Jordan JH, Klepin HD, Ellis L, Lamar Z, Vasu S, Lesser G, Burke GL, Weaver KE, Ntim WO, Hundley WG. Frequency of Left Ventricular End-Diastolic Volume-Mediated Declines in Ejection Fraction in Patients Receiving Potentially Cardiotoxic Cancer Treatment. Am J Cardiol. 2017 05 15; 119(10):1637-1642. PMID: 28341361.
      Citations:    
    8. Brinkley TE, Leng X, Nicklas BJ, Kritchevsky SB, Ding J, Kitzman DW, Hundley WG. Racial differences in circulating levels of the soluble receptor for advanced glycation endproducts in middle-aged and older adults. Metabolism. 2017 05; 70:98-106. PMID: 28403949.
      Citations:    
    9. Meléndez GC, Hundley WG. Is Myocardial Fibrosis a New Frontier for Discovery in Cardiotoxicity Related to the Administration of Anthracyclines? Circ Cardiovasc Imaging. 2016 12; 9(12). PMID: 27923797.
      Citations:    
    10. Meléndez GC, Jordan JH, D'Agostino RB, Vasu S, Hamilton CA, Hundley WG. Progressive 3-Month Increase in LV Myocardial ECV After Anthracycline-Based Chemotherapy. JACC Cardiovasc Imaging. 2017 06; 10(6):708-709. PMID: 27544895.
      Citations:    
    11. Oseni AO, Qureshi WT, Almahmoud MF, Bertoni AG, Bluemke DA, Hundley WG, Lima JA, Herrington DM, Soliman EZ. Left ventricular hypertrophy by ECG versus cardiac MRI as a predictor for heart failure. Heart. 2017 01 01; 103(1):49-54. PMID: 27486144.
      Citations:    
    12. Jordan JH, Vasu S, Morgan TM, D'Agostino RB, Meléndez GC, Hamilton CA, Arai AE, Liu S, Liu CY, Lima JA, Bluemke DA, Burke GL, Hundley WG. Anthracycline-Associated T1 Mapping Characteristics Are Elevated Independent of the Presence of Cardiovascular Comorbidities in Cancer Survivors. Circ Cardiovasc Imaging. 2016 08; 9(8). PMID: 27502058.
      Citations:    
    13. Hall ME, Rocco MV, Morgan TM, Hamilton CA, Jordan JH, Edwards MS, Hall JE, Hundley WG. Beta-Blocker Use Is Associated with Higher Renal Tissue Oxygenation in Hypertensive Patients Suspected of Renal Artery Stenosis. Cardiorenal Med. 2016 Aug; 6(4):261-8. PMID: 27648007.
      Citations:    
    14. Whitlock MC, Yeboah J, Burke GL, Chen H, Klepin HD, Hundley WG. Cancer and Its Association With the Development of Coronary Artery Calcification: An Assessment From the Multi-Ethnic Study of Atherosclerosis. J Am Heart Assoc. 2015 Nov 09; 4(11). PMID: 26553214.
      Citations:    
    15. Zhang X, Ambale-Venkatesh B, Bluemke DA, Cowan BR, Finn JP, Kadish AH, Lee DC, Lima JA, Hundley WG, Suinesiaputra A, Young AA, Medrano-Gracia P. Information maximizing component analysis of left ventricular remodeling due to myocardial infarction. J Transl Med. 2015 Nov 03; 13:343. PMID: 26531126.
      Citations:    
    16. Vera T, D'Agostino RB, Jordan JH, Whitlock MC, Meléndez GC, Lamar ZS, Porosnicu M, Bonkovsky HL, Poole LB, Hundley WG. Relation of Pre-anthracycline Serum Bilirubin Levels to Left Ventricular Ejection Fraction After Chemotherapy. Am J Cardiol. 2015 Dec 01; 116(11):1752-5. PMID: 26433273.
      Citations:    
    17. Vasu S, Little WC, Morgan TM, Stacey RB, Ntim WO, Hamilton C, Thohan V, Chiles C, Hundley WG. Mechanism of decreased sensitivity of dobutamine associated left ventricular wall motion analyses for appreciating inducible ischemia in older adults. J Cardiovasc Magn Reson. 2015 Apr 08; 17:26. PMID: 25885436.
      Citations:    
    18. McEvoy JW, Nasir K, DeFilippis AP, Lima JA, Bluemke DA, Hundley WG, Barr RG, Budoff MJ, Szklo M, Navas-Acien A, Polak JF, Blumenthal RS, Post WS, Blaha MJ. Relationship of cigarette smoking with inflammation and subclinical vascular disease: the Multi-Ethnic Study of Atherosclerosis. Arterioscler Thromb Vasc Biol. 2015 Apr; 35(4):1002-10. PMID: 25745060.
      Citations:    
    19. Milks MW, Upadhya B, Hall ME, Vasu S, Hundley WG, Stacey RB. Right ventricular stress-induced perfusion defects and late gadolinium enhancement in coronary artery disease. J Comput Assist Tomogr. 2015 Mar-Apr; 39(2):185-8. PMID: 25423554.
      Citations:    
    20. Vasu S, Morgan TM, Kitzman DW, Bertoni A, Stacey RB, Hamilton C, Chiles C, Thohan V, Hundley WG. Abnormal stress-related measures of arterial stiffness in middle-aged and elderly men and women with impaired fasting glucose at risk for a first episode of symptomatic heart failure. J Am Heart Assoc. 2015 Jan 14; 4(1):e000991. PMID: 25589534.
      Citations:    
    21. McEvoy JW, Blaha MJ, DeFilippis AP, Lima JA, Bluemke DA, Hundley WG, Min JK, Shaw LJ, Lloyd-Jones DM, Barr RG, Budoff MJ, Blumenthal RS, Nasir K. Cigarette smoking and cardiovascular events: role of inflammation and subclinical atherosclerosis from the MultiEthnic Study of Atherosclerosis. Arterioscler Thromb Vasc Biol. 2015 Mar; 35(3):700-9. PMID: 25573855.
      Citations:    
    22. Chotenimitkhun R, D'Agostino R, Lawrence JA, Hamilton CA, Jordan JH, Vasu S, Lash TL, Yeboah J, Herrington DM, Hundley WG. Chronic statin administration may attenuate early anthracycline-associated declines in left ventricular ejection function. Can J Cardiol. 2015 Mar; 31(3):302-7. PMID: 25662284.
      Citations:    
    23. Zemrak F, Ahlman MA, Captur G, Mohiddin SA, Kawel-Boehm N, Prince MR, Moon JC, Hundley WG, Lima JA, Bluemke DA, Petersen SE. The relationship of left ventricular trabeculation to ventricular function and structure over a 9.5-year follow-up: the MESA study. J Am Coll Cardiol. 2014 Nov 11; 64(19):1971-80. PMID: 25440091.
      Citations:    
    24. Jordan JH, D'Agostino RB, Hamilton CA, Vasu S, Hall ME, Kitzman DW, Thohan V, Lawrence JA, Ellis LR, Lash TL, Hundley WG. Longitudinal assessment of concurrent changes in left ventricular ejection fraction and left ventricular myocardial tissue characteristics after administration of cardiotoxic chemotherapies using T1-weighted and T2-weighted cardiovascular magnetic resonance. Circ Cardiovasc Imaging. 2014 Nov; 7(6):872-9. PMID: 25273568.
      Citations:    
    25. Lin T, Milks MW, Upadhya B, Hundley WG, Stacey RB. Improvement in systolic function in left ventricular non-compaction cardiomyopathy: A case report. J Cardiol Cases. 2014 Dec; 10(6):231-234. PMID: 30534250.
      Citations:    
    26. Kongbundansuk S, Hundley WG. Noninvasive imaging of cardiovascular injury related to the treatment of cancer. JACC Cardiovasc Imaging. 2014 Aug; 7(8):824-38. PMID: 25124015.
      Citations:    
    27. Andersen MM, Kritchevsky SB, Morgan TM, Hire DG, Vasu S, Brinkley TE, Kitzman DW, Hamilton CA, Soots S, Hundley WG. Increased cardiovascular stiffness and impaired age-related functional status. J Gerontol A Biol Sci Med Sci. 2015 May; 70(5):545-53. PMID: 24963155.
      Citations:    
    28. Jordan JH, Haag JC, Morgan TM, Vasu S, Stacey B, Hamilton C, Robinson K, Kitzman D, Thohan V, Hundley WG. Small, short-duration, dobutamine-induced perfusion defects are not associated with adverse prognosis in intermediate-risk individuals receiving cardiovascular magnetic resonance stress imaging. J Comput Assist Tomogr. 2014 May-Jun; 38(3):427-33. PMID: 24651743.
      Citations:    
    29. Stacey RB, Andersen M, Haag J, Hall ME, McLeod G, Upadhya B, Hundley WG, Thohan V. Right ventricular morphology and systolic function in left ventricular noncompaction cardiomyopathy. Am J Cardiol. 2014 Mar 15; 113(6):1018-23. PMID: 24462071.
      Citations:    
    30. Vasu S, Hundley WG. Understanding cardiovascular injury after treatment for cancer: an overview of current uses and future directions of cardiovascular magnetic resonance. J Cardiovasc Magn Reson. 2013 Jul 31; 15:66. PMID: 23902649.
      Citations:    
    31. Liu CY, Liu YC, Wu C, Armstrong A, Volpe GJ, van der Geest RJ, Liu Y, Hundley WG, Gomes AS, Liu S, Nacif M, Bluemke DA, Lima JAC. Evaluation of age-related interstitial myocardial fibrosis with cardiac magnetic resonance contrast-enhanced T1 mapping: MESA (Multi-Ethnic Study of Atherosclerosis). J Am Coll Cardiol. 2013 Oct 01; 62(14):1280-1287. PMID: 23871886.
      Citations:    
    32. Drafts BC, Twomley KM, D'Agostino R, Lawrence J, Avis N, Ellis LR, Thohan V, Jordan J, Melin SA, Torti FM, Little WC, Hamilton CA, Hundley WG. Low to moderate dose anthracycline-based chemotherapy is associated with early noninvasive imaging evidence of subclinical cardiovascular disease. JACC Cardiovasc Imaging. 2013 Aug; 6(8):877-85. PMID: 23643285.
      Citations:    
    33. Eckman DM, Stacey RB, Rowe R, D'Agostino R, Kock ND, Sane DC, Torti FM, Yeboah J, Workman S, Lane KS, Hundley WG. Weekly doxorubicin increases coronary arteriolar wall and adventitial thickness. PLoS One. 2013; 8(2):e57554. PMID: 23437398.
      Citations:    
    34. Mandapaka S, Hamilton CA, Morgan TM, Hundley WG. Simultaneous measurement of left and right ventricular volumes and ejection fraction during dobutamine stress cardiovascular magnetic resonance. J Comput Assist Tomogr. 2011 Sep-Oct; 35(5):614-7. PMID: 21926858.
      Citations:    
    35. Chahal H, McClelland RL, Tandri H, Jain A, Turkbey EB, Hundley WG, Barr RG, Kizer J, Lima JAC, Bluemke DA, Kawut SM. Obesity and right ventricular structure and function: the MESA-Right Ventricle Study. Chest. 2012 Feb; 141(2):388-395. PMID: 21868467.
      Citations:    
    36. Banchs J, Jefferies JL, Plana JC, Hundley WG. Imaging for cardiotoxicity in cancer patients. Tex Heart Inst J. 2011; 38(3):268-9. PMID: 21720469.
      Citations:    
    37. Al-Mallah MH, Nasir K, Katz R, Takasu J, Lima JA, Bluemke DA, Hundley G, Blumenthal RS, Budoff MJ. Thoracic aortic distensibility and thoracic aortic calcium (from the Multi-Ethnic Study of Atherosclerosis [MESA]). Am J Cardiol. 2010 Aug 15; 106(4):575-80. PMID: 20691319.
      Citations:    
    38. Fernandes VR, Polak JF, Cheng S, Rosen BD, Carvalho B, Nasir K, McClelland R, Hundley G, Pearson G, O'Leary DH, Bluemke DA, Lima JA. Arterial stiffness is associated with regional ventricular systolic and diastolic dysfunction: the Multi-Ethnic Study of Atherosclerosis. Arterioscler Thromb Vasc Biol. 2008 Jan; 28(1):194-201. PMID: 17962621.
      Citations:    
    39. Mandapaka S, Hundley WG. Dobutamine cardiovascular magnetic resonance: a review. J Magn Reson Imaging. 2006 Sep; 24(3):499-512. PMID: 16892202.
      Citations:    
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