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Dwayne W. Godwin PhD

TitleProfessor
InstitutionWake Forest School of Medicine
DepartmentTranslational Neuroscience
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    Other Positions
    TitleProfessor
    InstitutionWake Forest School of Medicine
    DepartmentNeurology

    TitleProfessor
    InstitutionWake Forest School of Medicine
    DepartmentWake Forest Institute for Regenerative Medicine

    TitleDean, Wake Forest School of Medicine
    InstitutionWake Forest School of Medicine

    TitleAssociate Dean
    InstitutionWake Forest School of Medicine


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    R01AA016852     (GODWIN, DWAYNE W)Apr 1, 2007 - Jun 30, 2025
    NIH
    Mechanisms of Alcohol Withdrawal
    Role Description: The goal of this study is to understand the molecular and cellular mechanisms leading to hyperexcitability in neural systems, with particular emphasis on the state of withdrawal from chronic alcohol use.
    Role: Principal Investigator
    R21NS116519     (GODWIN, DWAYNE W)Jul 15, 2020 - Jun 30, 2022
    NIH
    Evaluating Gene Therapy Strategies to Treat Epilepsy Using a Novel Optogenetic Measure of Network Excitability and Seizure Susceptibility
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Rowland JA, Stapleton-Kotloski J, Godwin D, Hamilton CA, Martindale SL. The Functional Connectome and Long-Term Symptom Presentation Associated With Mild TBI and Blast Exposure in Combat Veterans. J Neurotrauma. 2024 Aug 16. PMID: 39150013.
      Citations:    
    2. Shan HQ, Smith T, Klorig DC, Godwin DW. Protein kinase C epsilon-mediated modulation of T-type calcium channels underlies alcohol withdrawal hyperexcitability in the midline thalamus. Alcohol Clin Exp Res (Hoboken). 2024 Jul; 48(7):1278-1288. PMID: 38740544.
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    3. Sarma AK, Popli G, Anzalone A, Contillo N, Cornell C, Nunn AM, Rowland JA, Godwin DW, Flashman LA, Couture D, Stapleton-Kotloski JR. Use of magnetic source imaging to assess recovery after severe traumatic brain injury-an MEG pilot study. Front Neurol. 2023; 14:1257886. PMID: 38020602.
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    4. Alberto GE, Klorig DC, Goldstein AT, Godwin DW. Alcohol withdrawal produces changes in excitability, population discharge probability, and seizure threshold. Alcohol Clin Exp Res (Hoboken). 2023 Feb; 47(2):211-218. PMID: 36543333.
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    5. Rowland JA, Stapleton-Kotloski JR, Rogers E, Taber KH, Godwin DW, Martindale SL. Contextual Effects of Traumatic Brain Injury on the Connectome: Differential Effects of Deployment- and Non-Deployment-Acquired Injuries. J Head Trauma Rehabil. 2022 Nov-Dec 01; 37(6):E449-E457. PMID: 35862901.
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    6. Rowland JA, Stapleton-Kotloski JR, Martindale SL, Rogers EE, Ord AS, Godwin DW, Taber KH. Alterations in the Topology of Functional Connectomes Are Associated with Post-Traumatic Stress Disorder and Blast-Related Mild Traumatic Brain Injury in Combat Veterans. J Neurotrauma. 2021 Nov 15; 38(22):3086-3096. PMID: 34435885.
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    7. Steel TL, Afshar M, Edwards S, Jolley SE, Timko C, Clark BJ, Douglas IS, Dzierba AL, Gershengorn HB, Gilpin NW, Godwin DW, Hough CL, Maldonado JR, Mehta AB, Nelson LS, Patel MB, Rastegar DA, Stollings JL, Tabakoff B, Tate JA, Wong A, Burnham EL. Research Needs for Inpatient Management of Severe Alcohol Withdrawal Syndrome: An Official American Thoracic Society Research Statement. Am J Respir Crit Care Med. 2021 10 01; 204(7):e61-e87. PMID: 34609257.
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    8. Alberto GE, Stapleton-Kotloski JR, Klorig DC, Rogers ER, Constantinidis C, Daunais JB, Godwin DW. MEG source imaging detects optogenetically-induced activity in cortical and subcortical networks. Nat Commun. 2021 09 06; 12(1):5259. PMID: 34489452.
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    9. Rowland JA, Stapleton-Kotloski JR, Alberto GE, Davenport AT, Epperly PM, Godwin DW, Daunais JB. Rich Club Characteristics of Alcohol-Naïve Functional Brain Networks Predict Future Drinking Phenotypes in Rhesus Macaques. Front Behav Neurosci. 2021; 15:673151. PMID: 34149371.
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    10. Klorig DC, Alberto GE, Smith T, Godwin DW. Optogenetically-Induced Population Discharge Threshold as a Sensitive Measure of Network Excitability. eNeuro. 2019 Nov/Dec; 6(6). PMID: 31619450.
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    11. Jimenez H, Wang M, Zimmerman JW, Pennison MJ, Sharma S, Surratt T, Xu ZX, Brezovich I, Absher D, Myers RM, DeYoung B, Caudell DL, Chen D, Lo HW, Lin HK, Godwin DW, Olivier M, Ghanekar A, Chen K, Miller LD, Gong Y, Capstick M, D'Agostino RB, Munden R, Merle P, Barbault A, Blackstock AW, Bonkovsky HL, Yang GY, Jin G, Liu L, Zhang W, Watabe K, Blackman CF, Pasche BC. Tumour-specific amplitude-modulated radiofrequency electromagnetic fields induce differentiation of hepatocellular carcinoma via targeting Cav3.2?T-type voltage-gated calcium channels and Ca2+ influx. EBioMedicine. 2019 Jun; 44:209-224. PMID: 31160272.
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    12. Joshi RB, Duckrow RB, Goncharova II, Gerrard JL, Spencer DD, Hirsch LJ, Godwin DW, Zaveri HP. Seizure susceptibility and infraslow modulatory activity in the intracranial electroencephalogram. Epilepsia. 2018 11; 59(11):2075-2085. PMID: 30187919.
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    13. Masicampo ML, Shan HQ, Xu V, Speagle M, Godwin DW. Selective Blockade of T-Type Ca2+ Channels is Protective Against Alcohol-Withdrawal Induced Seizure and Mortality. Alcohol Alcohol. 2018 Sep 01; 53(5):526-531. PMID: 29912275.
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    14. Stapleton-Kotloski JR, Kotloski RJ, Popli G, Godwin DW. Magnetoencephalography: Clinical and Research Practices. Brain Sci. 2018 Aug 17; 8(8). PMID: 30126121.
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    15. Rowland JA, Stapleton-Kotloski JR, Dobbins DL, Rogers E, Godwin DW, Taber KH. Increased Small-World Network Topology Following Deployment-Acquired Traumatic Brain Injury Associated with the Development of Post-Traumatic Stress Disorder. Brain Connect. 2018 05; 8(4):205-211. PMID: 29634322.
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    16. Jimenez H, Blackman C, Lesser G, Debinski W, Chan M, Sharma S, Watabe K, Lo HW, Thomas A, Godwin D, Blackstock W, Mudry A, Posey J, O'Connor R, Brezovich I, Bonin K, Kim-Shapiro D, Barbault A, Pasche B. Use of non-ionizing electromagnetic fields for the treatment of cancer. Front Biosci (Landmark Ed). 2018 Jan 01; 23:284-297. PMID: 28930547.
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    17. Dobbins DL, Klorig DC, Smith T, Godwin DW. Expression of channelrhodopsin-2 localized within the deep CA1 hippocampal sublayer in the Thy1 line 18 mouse. Brain Res. 2018 01 15; 1679:179-184. PMID: 29191773.
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    18. Rowland JA, Stapleton-Kotloski JR, Alberto GE, Davenport AT, Kotloski RJ, Friedman DP, Godwin DW, Daunais JB. Changes in nonhuman primate brain function following chronic alcohol consumption in previously naïve animals. Drug Alcohol Depend. 2017 08 01; 177:244-248. PMID: 28622627.
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    19. Rowland JA, Stapleton-Kotloski JR, Alberto GE, Rawley JA, Kotloski RJ, Taber KH, Godwin DW. Contrasting Effects of Posttraumatic Stress Disorder and Mild Traumatic Brain Injury on the Whole-Brain Resting-State Network: A Magnetoencephalography Study. Brain Connect. 2017 02; 7(1):45-57. PMID: 28006976.
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    20. Riegle MA, Masicampo ML, Shan HQ, Xu V, Godwin DW. Ethosuximide Reduces Mortality and Seizure Severity in Response to Pentylenetetrazole Treatment During Ethanol Withdrawal. Alcohol Alcohol. 2015 Sep; 50(5):501-8. PMID: 25870316.
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    21. Stapleton-Kotloski JR, Kotloski RJ, Boggs JA, Popli G, O'Donovan CA, Couture DE, Cornell C, Godwin DW. Localization of interictal epileptiform activity using magnetoencephalography with synthetic aperture magnetometry in patients with a vagus nerve stimulator. Front Neurol. 2014; 5:244. PMID: 25505894.
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    22. Riegle MA, Masicampo ML, Caulder EH, Godwin DW. Ethosuximide reduces electrographical and behavioral correlates of alcohol withdrawal seizure in DBA/2J mice. Alcohol. 2014 Aug; 48(5):445-53. PMID: 24933286.
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    23. Santos L, Opris I, Hampson R, Godwin DW, Gerhardt G, Deadwyler S. Functional dynamics of primate cortico-striatal networks during volitional movements. Front Syst Neurosci. 2014; 8:27. PMID: 24653682.
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    24. Klorig DC, Godwin DW. A magnetic rotary optical fiber connector for optogenetic experiments in freely moving animals. J Neurosci Methods. 2014 Apr 30; 227:132-9. PMID: 24613796.
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    25. Caulder EH, Riegle MA, Godwin DW. Activation of group 2 metabotropic glutamate receptors reduces behavioral and electrographic correlates of pilocarpine induced status epilepticus. Epilepsy Res. 2014 Feb; 108(2):171-81. PMID: 24305700.
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    26. Shan HQ, Hammarback JA, Godwin DW. Ethanol inhibition of a T-type Ca²+ channel through activity of protein kinase C. Alcohol Clin Exp Res. 2013 Aug; 37(8):1333-42. PMID: 23488970.
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    27. Wiggins WF, Graef JD, Huitt TW, Godwin DW. Ethosuximide reduces ethanol withdrawal-mediated disruptions in sleep-related EEG patterns. Alcohol Clin Exp Res. 2013 Mar; 37(3):372-82. PMID: 23078554.
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    28. Alexander GM, Graef JD, Hammarback JA, Nordskog BK, Burnett EJ, Daunais JB, Bennett AJ, Friedman DP, Suomi SJ, Godwin DW. Disruptions in serotonergic regulation of cortical glutamate release in primate insular cortex in response to chronic ethanol and nursery rearing. Neuroscience. 2012 Apr 05; 207:167-81. PMID: 22305886.
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    29. Graef JD, Huitt TW, Nordskog BK, Hammarback JH, Godwin DW. Disrupted thalamic T-type Ca2+ channel expression and function during ethanol exposure and withdrawal. J Neurophysiol. 2011 Feb; 105(2):528-40. PMID: 21148095.
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    30. Graef JD, Godwin DW. Intrinsic plasticity in acquired epilepsy: too much of a good thing? Neuroscientist. 2010 Oct; 16(5):487-95. PMID: 20407126.
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    31. Dong C, Godwin DW, Brennan PA, Hegde AN. Protein kinase Calpha mediates a novel form of plasticity in the accessory olfactory bulb. Neuroscience. 2009 Oct 20; 163(3):811-24. PMID: 19580852.
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    32. McCauley AK, Frank ST, Godwin DW. Brainstem nitrergic innervation of the mouse visual thalamus. Brain Res. 2009 Jun 30; 1278:34-49. PMID: 19362078.
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    33. Graef JD, Nordskog BK, Wiggins WF, Godwin DW. An acquired channelopathy involving thalamic T-type Ca2+ channels after status epilepticus. J Neurosci. 2009 Apr 08; 29(14):4430-41. PMID: 19357270.
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    34. Wilson TW, Godwin DW, Czoty PW, Nader MA, Kraft RA, Buchheimer NC, Daunais JB. A MEG investigation of somatosensory processing in the rhesus monkey. Neuroimage. 2009 Jul 15; 46(4):998-1003. PMID: 19306931.
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    35. Alexander GM, Kurukulasuriya NC, Mu J, Godwin DW. Cortical feedback to the thalamus is selectively enhanced by nitric oxide. Neuroscience. 2006 Sep 29; 142(1):223-34. PMID: 16876956.
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    36. Alexander GM, Godwin DW. Metabotropic glutamate receptors as a strategic target for the treatment of epilepsy. Epilepsy Res. 2006 Sep; 71(1):1-22. PMID: 16787741.
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    37. Nordskog BK, Hammarback JA, Godwin DW. Diurnal gene expression patterns of T-type calcium channels and their modulation by ethanol. Neuroscience. 2006 Sep 01; 141(3):1365-73. PMID: 16750304.
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    38. Alexander GM, Carden WB, Mu J, Kurukulasuriya NC, McCool BA, Nordskog BK, Friedman DP, Daunais JB, Grant KA, Godwin DW. The native T-type calcium current in relay neurons of the primate thalamus. Neuroscience. 2006 Aug 11; 141(1):453-61. PMID: 16690211.
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    39. Alexander GM, Godwin DW. Unique presynaptic and postsynaptic roles of Group II metabotropic glutamate receptors in the modulation of thalamic network activity. Neuroscience. 2006 Aug 11; 141(1):501-13. PMID: 16690217.
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    40. Carden WB, Alexander GM, Friedman DP, Daunais JB, Grant KA, Mu J, Godwin DW. Chronic ethanol drinking reduces native T-type calcium current in the thalamus of nonhuman primates. Brain Res. 2006 May 17; 1089(1):92-100. PMID: 16631142.
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    41. Alexander GM, Fisher TL, Godwin DW. Differential response dynamics of corticothalamic glutamatergic synapses in the lateral geniculate nucleus and thalamic reticular nucleus. Neuroscience. 2006; 137(2):367-72. PMID: 16360282.
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    42. Alexander GM, Godwin DW. Presynaptic inhibition of corticothalamic feedback by metabotropic glutamate receptors. J Neurophysiol. 2005 Jul; 94(1):163-75. PMID: 15772234.
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    43. Carden WB, Guido W, Godwin DW, Bickford ME. Thalamocortical cells in the cat pulvinar nucleus transiently express nitric oxide synthase during development. Neurosci Lett. 2003 Nov 13; 351(2):87-90. PMID: 14583388.
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    44. Mu J, Carden WB, Kurukulasuriya NC, Alexander GM, Godwin DW. Ethanol influences on native T-type calcium current in thalamic sleep circuitry. J Pharmacol Exp Ther. 2003 Oct; 307(1):197-204. PMID: 12893844.
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    45. McCauley AK, Carden WB, Godwin DW. Brain nitric oxide synthase expression in the developing ferret lateral geniculate nucleus: analysis of time course, localization, and synaptic contacts. J Comp Neurol. 2003 Jun 09; 462(3):342-54. PMID: 12794737.
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    46. McCauley AK, Meyer GA, Godwin DW. Developmental regulation of brain nitric oxide synthase expression in the ferret thalamic reticular nucleus. Neurosci Lett. 2002 Mar 08; 320(3):151-5. PMID: 11852184.
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    47. Wang S, Bickford ME, Van Horn SC, Erisir A, Godwin DW, Sherman SM. Synaptic targets of thalamic reticular nucleus terminals in the visual thalamus of the cat. J Comp Neurol. 2001 Nov 26; 440(4):321-41. PMID: 11745627.
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    48. Moore RJ, Vinsant S, McCauley AK, Kurukulasuriya NC, Godwin DW. Transneuronal retrograde transport of attenuated pseudorabies viruses within central visual pathways. Vis Neurosci. 2001 Jul-Aug; 18(4):633-40. PMID: 11829309.
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    49. Carden WB, Guido W, Ziburkus J, Datskovskaia A, Godwin DW, Bickford ME. A novel means of Y cell identification in the developing lateral geniculate nucleus of the cat. Neurosci Lett. 2000 Dec 01; 295(1-2):5-8. PMID: 11078923.
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    50. Bickford ME, Ramcharan E, Godwin DW, Erisir A, Gnadt J, Sherman SM. Neurotransmitters contained in the subcortical extraretinal inputs to the monkey lateral geniculate nucleus. J Comp Neurol. 2000 Sep 04; 424(4):701-17. PMID: 10931491.
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    51. Carden WB, Datskovskaia A, Guido W, Godwin DW, Bickford ME. Development of the cholinergic, nitrergic, and GABAergic innervation of the cat dorsal lateral geniculate nucleus. J Comp Neurol. 2000 Feb 28; 418(1):65-80. PMID: 10701756.
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    52. Zhelyaskov VR, Godwin DW. A nitric oxide concentration clamp. Nitric Oxide. 1999 Oct; 3(5):419-25. PMID: 10534446.
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    53. Reinagel P, Godwin D, Sherman SM, Koch C. Encoding of visual information by LGN bursts. J Neurophysiol. 1999 May; 81(5):2558-69. PMID: 10322089.
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    54. Bickford ME, Guido W, Godwin DW. Neurofilament proteins in Y-cells of the cat lateral geniculate nucleus: normal expression and alteration with visual deprivation. J Neurosci. 1998 Aug 15; 18(16):6549-57. PMID: 9698342.
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    55. Zhelyaskov VR, Gee KR, Godwin DW. Control of NO concentration in solutions of nitrosothiol compounds by light. Photochem Photobiol. 1998 Mar; 67(3):282-8. PMID: 9523529.
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    56. Zhelyaskov VR, Godwin DW. Photolytic generation of nitric oxide through a porous glass partitioning membrane. Nitric Oxide. 1998; 2(6):454-9. PMID: 10342488.
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    57. Zhou Q, Godwin DW, O'Malley DM, Adams PR. Visualization of calcium influx through channels that shape the burst and tonic firing modes of thalamic relay cells. J Neurophysiol. 1997 May; 77(5):2816-25. PMID: 9163395.
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    58. Godwin DW, Che D, O'Malley DM, Zhou Q. Photostimulation with caged neurotransmitters using fiber optic lightguides. J Neurosci Methods. 1997 Apr 25; 73(1):91-106. PMID: 9130682.
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    59. Godwin DW, Van Horn SC, Eriir A, Sesma M, Romano C, Sherman SM. Ultrastructural localization suggests that retinal and cortical inputs access different metabotropic glutamate receptors in the lateral geniculate nucleus. J Neurosci. 1996 Dec 15; 16(24):8181-92. PMID: 8987843.
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    60. Godwin DW, Vaughan JW, Sherman SM. Metabotropic glutamate receptors switch visual response mode of lateral geniculate nucleus cells from burst to tonic. J Neurophysiol. 1996 Sep; 76(3):1800-16. PMID: 8890293.
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    61. Guido W, Lu SM, Vaughan JW, Godwin DW, Sherman SM. Receiver operating characteristic (ROC) analysis of neurons in the cat's lateral geniculate nucleus during tonic and burst response mode. Vis Neurosci. 1995 Jul-Aug; 12(4):723-41. PMID: 8527372.
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    62. Godwin DW. A tungsten-in-glass iontophoresis assembly for studying input-output relationships in central neurons. J Neurosci Methods. 1993 Sep; 49(3):211-23. PMID: 8271840.
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    63. Norton TT, Godwin DW. Inhibitory GABAergic control of visual signals at the lateral geniculate nucleus. Prog Brain Res. 1992; 90:193-217. PMID: 1631300.
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    64. Norton TT, Holdefer RN, Godwin DW. Effects of bicuculline on receptive field center sensitivity of relay cells in the lateral geniculate nucleus. Brain Res. 1989 May 29; 488(1-2):348-52. PMID: 2743130.
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    65. Holdefer RN, Norton TT, Godwin DW. Effects of bicuculline on signal detectability in lateral geniculate nucleus relay cells. Brain Res. 1989 May 29; 488(1-2):341-7. PMID: 2743129.
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