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Last Name

Dwayne W. Godwin, Ph.D.

TitleProfessor
InstitutionWake Forest School of Medicine
DepartmentNeurobiology and Anatomy
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    Other Positions
    TitleProfessor
    InstitutionWake Forest School of Medicine
    DepartmentInstitute for Regenerative Medicine

    TitleDean of Graduate School
    InstitutionWake Forest School of Medicine
    DepartmentMS Graduate Program


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    R01AA016852     (GODWIN, DWAYNE W)Apr 1, 2007 - Sep 14, 2020
    NIH
    Mechanisms of Alcohol Withdrawal
    Role Description: The goal of this study is to understand the molecular and cellular mechanisms leading to hyperexcitability in neural systems, with particular emphasis on the state of withdrawal from chronic alcohol use.
    Role: Principal Investigator

    R21NS116519     (GODWIN, DWAYNE W)Jul 15, 2020 - Jun 30, 2022
    NIH
    Evaluating Gene Therapy Strategies to Treat Epilepsy Using a Novel Optogenetic Measure of Network Excitability and Seizure Susceptibility
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Klorig DC, Alberto GE, Smith T, Godwin DW. Optogenetically-Induced Population Discharge Threshold as a Sensitive Measure of Network Excitability. eNeuro. 2019 Nov/Dec; 6(6). PMID: 31619450.
      View in: PubMed
    2. Jimenez H, Wang M, Zimmerman JW, Pennison MJ, Sharma S, Surratt T, Xu ZX, Brezovich I, Absher D, Myers RM, DeYoung B, Caudell DL, Chen D, Lo HW, Lin HK, Godwin DW, Olivier M, Ghanekar A, Chen K, Miller LD, Gong Y, Capstick M, D'Agostino RB, Munden R, Merle P, Barbault A, Blackstock AW, Bonkovsky HL, Yang GY, Jin G, Liu L, Zhang W, Watabe K, Blackman CF, Pasche BC. Tumour-specific amplitude-modulated radiofrequency electromagnetic fields induce differentiation of hepatocellular carcinoma via targeting Cav3.2?T-type voltage-gated calcium channels and Ca2+ influx. EBioMedicine. 2019 Jun; 44:209-224. PMID: 31160272.
      View in: PubMed
    3. Joshi RB, Duckrow RB, Goncharova II, Gerrard JL, Spencer DD, Hirsch LJ, Godwin DW, Zaveri HP. Seizure susceptibility and infraslow modulatory activity in the intracranial electroencephalogram. Epilepsia. 2018 11; 59(11):2075-2085. PMID: 30187919.
      View in: PubMed
    4. Masicampo ML, Shan HQ, Xu V, Speagle M, Godwin DW. Selective Blockade of T-Type Ca2+ Channels is Protective Against Alcohol-Withdrawal Induced Seizure and Mortality. Alcohol Alcohol. 2018 Sep 01; 53(5):526-531. PMID: 29912275.
      View in: PubMed
    5. Stapleton-Kotloski JR, Kotloski RJ, Popli G, Godwin DW. Magnetoencephalography: Clinical and Research Practices. Brain Sci. 2018 Aug 17; 8(8). PMID: 30126121.
      View in: PubMed
    6. Rowland JA, Stapleton-Kotloski JR, Dobbins DL, Rogers E, Godwin DW, Taber KH. Increased Small-World Network Topology Following Deployment-Acquired Traumatic Brain Injury Associated with the Development of Post-Traumatic Stress Disorder. Brain Connect. 2018 05; 8(4):205-211. PMID: 29634322.
      View in: PubMed
    7. Jimenez H, Blackman C, Lesser G, Debinski W, Chan M, Sharma S, Watabe K, Lo HW, Thomas A, Godwin D, Blackstock W, Mudry A, Posey J, O'Connor R, Brezovich I, Bonin K, Kim-Shapiro D, Barbault A, Pasche B. Use of non-ionizing electromagnetic fields for the treatment of cancer. Front Biosci (Landmark Ed). 2018 Jan 01; 23:284-297. PMID: 28930547.
      View in: PubMed
    8. Dobbins DL, Klorig DC, Smith T, Godwin DW. Expression of channelrhodopsin-2 localized within the deep CA1 hippocampal sublayer in the Thy1 line 18 mouse. Brain Res. 2018 01 15; 1679:179-184. PMID: 29191773.
      View in: PubMed
    9. Rowland JA, Stapleton-Kotloski JR, Alberto GE, Davenport AT, Kotloski RJ, Friedman DP, Godwin DW, Daunais JB. Changes in nonhuman primate brain function following chronic alcohol consumption in previously naïve animals. Drug Alcohol Depend. 2017 08 01; 177:244-248. PMID: 28622627.
      View in: PubMed
    10. Rowland JA, Stapleton-Kotloski JR, Alberto GE, Rawley JA, Kotloski RJ, Taber KH, Godwin DW. Contrasting Effects of Posttraumatic Stress Disorder and Mild Traumatic Brain Injury on the Whole-Brain Resting-State Network: A Magnetoencephalography Study. Brain Connect. 2017 02; 7(1):45-57. PMID: 28006976.
      View in: PubMed
    11. Riegle MA, Masicampo ML, Shan HQ, Xu V, Godwin DW. Ethosuximide Reduces Mortality and Seizure Severity in Response to Pentylenetetrazole Treatment During Ethanol Withdrawal. Alcohol Alcohol. 2015 Sep; 50(5):501-8. PMID: 25870316.
      View in: PubMed
    12. Stapleton-Kotloski JR, Kotloski RJ, Boggs JA, Popli G, O'Donovan CA, Couture DE, Cornell C, Godwin DW. Localization of interictal epileptiform activity using magnetoencephalography with synthetic aperture magnetometry in patients with a vagus nerve stimulator. Front Neurol. 2014; 5:244. PMID: 25505894.
      View in: PubMed
    13. Riegle MA, Masicampo ML, Caulder EH, Godwin DW. Ethosuximide reduces electrographical and behavioral correlates of alcohol withdrawal seizure in DBA/2J mice. Alcohol. 2014 Aug; 48(5):445-53. PMID: 24933286.
      View in: PubMed
    14. Santos L, Opris I, Hampson R, Godwin DW, Gerhardt G, Deadwyler S. Functional dynamics of primate cortico-striatal networks during volitional movements. Front Syst Neurosci. 2014; 8:27. PMID: 24653682.
      View in: PubMed
    15. Klorig DC, Godwin DW. A magnetic rotary optical fiber connector for optogenetic experiments in freely moving animals. J Neurosci Methods. 2014 Apr 30; 227:132-9. PMID: 24613796.
      View in: PubMed
    16. Caulder EH, Riegle MA, Godwin DW. Activation of group 2 metabotropic glutamate receptors reduces behavioral and electrographic correlates of pilocarpine induced status epilepticus. Epilepsy Res. 2014 Feb; 108(2):171-81. PMID: 24305700.
      View in: PubMed
    17. Shan HQ, Hammarback JA, Godwin DW. Ethanol inhibition of a T-type Ca²+ channel through activity of protein kinase C. Alcohol Clin Exp Res. 2013 Aug; 37(8):1333-42. PMID: 23488970.
      View in: PubMed
    18. Wiggins WF, Graef JD, Huitt TW, Godwin DW. Ethosuximide reduces ethanol withdrawal-mediated disruptions in sleep-related EEG patterns. Alcohol Clin Exp Res. 2013 Mar; 37(3):372-82. PMID: 23078554.
      View in: PubMed
    19. Alexander GM, Graef JD, Hammarback JA, Nordskog BK, Burnett EJ, Daunais JB, Bennett AJ, Friedman DP, Suomi SJ, Godwin DW. Disruptions in serotonergic regulation of cortical glutamate release in primate insular cortex in response to chronic ethanol and nursery rearing. Neuroscience. 2012 Apr 05; 207:167-81. PMID: 22305886.
      View in: PubMed
    20. Graef JD, Huitt TW, Nordskog BK, Hammarback JH, Godwin DW. Disrupted thalamic T-type Ca2+ channel expression and function during ethanol exposure and withdrawal. J Neurophysiol. 2011 Feb; 105(2):528-40. PMID: 21148095.
      View in: PubMed
    21. Graef JD, Godwin DW. Intrinsic plasticity in acquired epilepsy: too much of a good thing? Neuroscientist. 2010 Oct; 16(5):487-95. PMID: 20407126.
      View in: PubMed
    22. Dong C, Godwin DW, Brennan PA, Hegde AN. Protein kinase Calpha mediates a novel form of plasticity in the accessory olfactory bulb. Neuroscience. 2009 Oct 20; 163(3):811-24. PMID: 19580852.
      View in: PubMed
    23. McCauley AK, Frank ST, Godwin DW. Brainstem nitrergic innervation of the mouse visual thalamus. Brain Res. 2009 Jun 30; 1278:34-49. PMID: 19362078.
      View in: PubMed
    24. Graef JD, Nordskog BK, Wiggins WF, Godwin DW. An acquired channelopathy involving thalamic T-type Ca2+ channels after status epilepticus. J Neurosci. 2009 Apr 08; 29(14):4430-41. PMID: 19357270.
      View in: PubMed
    25. Wilson TW, Godwin DW, Czoty PW, Nader MA, Kraft RA, Buchheimer NC, Daunais JB. A MEG investigation of somatosensory processing in the rhesus monkey. Neuroimage. 2009 Jul 15; 46(4):998-1003. PMID: 19306931.
      View in: PubMed
    26. Alexander GM, Kurukulasuriya NC, Mu J, Godwin DW. Cortical feedback to the thalamus is selectively enhanced by nitric oxide. Neuroscience. 2006 Sep 29; 142(1):223-34. PMID: 16876956.
      View in: PubMed
    27. Alexander GM, Godwin DW. Metabotropic glutamate receptors as a strategic target for the treatment of epilepsy. Epilepsy Res. 2006 Sep; 71(1):1-22. PMID: 16787741.
      View in: PubMed
    28. Nordskog BK, Hammarback JA, Godwin DW. Diurnal gene expression patterns of T-type calcium channels and their modulation by ethanol. Neuroscience. 2006 Sep 01; 141(3):1365-73. PMID: 16750304.
      View in: PubMed
    29. Alexander GM, Carden WB, Mu J, Kurukulasuriya NC, McCool BA, Nordskog BK, Friedman DP, Daunais JB, Grant KA, Godwin DW. The native T-type calcium current in relay neurons of the primate thalamus. Neuroscience. 2006 Aug 11; 141(1):453-61. PMID: 16690211.
      View in: PubMed
    30. Alexander GM, Godwin DW. Unique presynaptic and postsynaptic roles of Group II metabotropic glutamate receptors in the modulation of thalamic network activity. Neuroscience. 2006 Aug 11; 141(1):501-13. PMID: 16690217.
      View in: PubMed
    31. Carden WB, Alexander GM, Friedman DP, Daunais JB, Grant KA, Mu J, Godwin DW. Chronic ethanol drinking reduces native T-type calcium current in the thalamus of nonhuman primates. Brain Res. 2006 May 17; 1089(1):92-100. PMID: 16631142.
      View in: PubMed
    32. Alexander GM, Fisher TL, Godwin DW. Differential response dynamics of corticothalamic glutamatergic synapses in the lateral geniculate nucleus and thalamic reticular nucleus. Neuroscience. 2006; 137(2):367-72. PMID: 16360282.
      View in: PubMed
    33. Alexander GM, Godwin DW. Presynaptic inhibition of corticothalamic feedback by metabotropic glutamate receptors. J Neurophysiol. 2005 Jul; 94(1):163-75. PMID: 15772234.
      View in: PubMed
    34. Carden WB, Guido W, Godwin DW, Bickford ME. Thalamocortical cells in the cat pulvinar nucleus transiently express nitric oxide synthase during development. Neurosci Lett. 2003 Nov 13; 351(2):87-90. PMID: 14583388.
      View in: PubMed
    35. Mu J, Carden WB, Kurukulasuriya NC, Alexander GM, Godwin DW. Ethanol influences on native T-type calcium current in thalamic sleep circuitry. J Pharmacol Exp Ther. 2003 Oct; 307(1):197-204. PMID: 12893844.
      View in: PubMed
    36. McCauley AK, Carden WB, Godwin DW. Brain nitric oxide synthase expression in the developing ferret lateral geniculate nucleus: analysis of time course, localization, and synaptic contacts. J Comp Neurol. 2003 Jun 09; 462(3):342-54. PMID: 12794737.
      View in: PubMed
    37. McCauley AK, Meyer GA, Godwin DW. Developmental regulation of brain nitric oxide synthase expression in the ferret thalamic reticular nucleus. Neurosci Lett. 2002 Mar 08; 320(3):151-5. PMID: 11852184.
      View in: PubMed
    38. Wang S, Bickford ME, Van Horn SC, Erisir A, Godwin DW, Sherman SM. Synaptic targets of thalamic reticular nucleus terminals in the visual thalamus of the cat. J Comp Neurol. 2001 Nov 26; 440(4):321-41. PMID: 11745627.
      View in: PubMed
    39. Moore RJ, Vinsant S, McCauley AK, Kurukulasuriya NC, Godwin DW. Transneuronal retrograde transport of attenuated pseudorabies viruses within central visual pathways. Vis Neurosci. 2001 Jul-Aug; 18(4):633-40. PMID: 11829309.
      View in: PubMed
    40. Carden WB, Guido W, Ziburkus J, Datskovskaia A, Godwin DW, Bickford ME. A novel means of Y cell identification in the developing lateral geniculate nucleus of the cat. Neurosci Lett. 2000 Dec 01; 295(1-2):5-8. PMID: 11078923.
      View in: PubMed
    41. Bickford ME, Ramcharan E, Godwin DW, Erisir A, Gnadt J, Sherman SM. Neurotransmitters contained in the subcortical extraretinal inputs to the monkey lateral geniculate nucleus. J Comp Neurol. 2000 Sep 04; 424(4):701-17. PMID: 10931491.
      View in: PubMed
    42. Carden WB, Datskovskaia A, Guido W, Godwin DW, Bickford ME. Development of the cholinergic, nitrergic, and GABAergic innervation of the cat dorsal lateral geniculate nucleus. J Comp Neurol. 2000 Feb 28; 418(1):65-80. PMID: 10701756.
      View in: PubMed
    43. Zhelyaskov VR, Godwin DW. A nitric oxide concentration clamp. Nitric Oxide. 1999 Oct; 3(5):419-25. PMID: 10534446.
      View in: PubMed
    44. Bickford ME, Guido W, Godwin DW. Neurofilament proteins in Y-cells of the cat lateral geniculate nucleus: normal expression and alteration with visual deprivation. J Neurosci. 1998 Aug 15; 18(16):6549-57. PMID: 9698342.
      View in: PubMed
    45. Zhelyaskov VR, Gee KR, Godwin DW. Control of NO concentration in solutions of nitrosothiol compounds by light. Photochem Photobiol. 1998 Mar; 67(3):282-8. PMID: 9523529.
      View in: PubMed
    46. Zhelyaskov VR, Godwin DW. Photolytic generation of nitric oxide through a porous glass partitioning membrane. Nitric Oxide. 1998; 2(6):454-9. PMID: 10342488.
      View in: PubMed
    47. Zhou Q, Godwin DW, O'Malley DM, Adams PR. Visualization of calcium influx through channels that shape the burst and tonic firing modes of thalamic relay cells. J Neurophysiol. 1997 May; 77(5):2816-25. PMID: 9163395.
      View in: PubMed
    48. Godwin DW, Che D, O'Malley DM, Zhou Q. Photostimulation with caged neurotransmitters using fiber optic lightguides. J Neurosci Methods. 1997 Apr 25; 73(1):91-106. PMID: 9130682.
      View in: PubMed
    49. Godwin DW, Van Horn SC, Eriir A, Sesma M, Romano C, Sherman SM. Ultrastructural localization suggests that retinal and cortical inputs access different metabotropic glutamate receptors in the lateral geniculate nucleus. J Neurosci. 1996 Dec 15; 16(24):8181-92. PMID: 8987843.
      View in: PubMed
    50. Godwin DW, Vaughan JW, Sherman SM. Metabotropic glutamate receptors switch visual response mode of lateral geniculate nucleus cells from burst to tonic. J Neurophysiol. 1996 Sep; 76(3):1800-16. PMID: 8890293.
      View in: PubMed
    51. Guido W, Lu SM, Vaughan JW, Godwin DW, Sherman SM. Receiver operating characteristic (ROC) analysis of neurons in the cat's lateral geniculate nucleus during tonic and burst response mode. Vis Neurosci. 1995 Jul-Aug; 12(4):723-41. PMID: 8527372.
      View in: PubMed
    52. Godwin DW. A tungsten-in-glass iontophoresis assembly for studying input-output relationships in central neurons. J Neurosci Methods. 1993 Sep; 49(3):211-23. PMID: 8271840.
      View in: PubMed
    53. Norton TT, Godwin DW. Inhibitory GABAergic control of visual signals at the lateral geniculate nucleus. Prog Brain Res. 1992; 90:193-217. PMID: 1631300.
      View in: PubMed
    54. Norton TT, Holdefer RN, Godwin DW. Effects of bicuculline on receptive field center sensitivity of relay cells in the lateral geniculate nucleus. Brain Res. 1989 May 29; 488(1-2):348-52. PMID: 2743130.
      View in: PubMed
    55. Holdefer RN, Norton TT, Godwin DW. Effects of bicuculline on signal detectability in lateral geniculate nucleus relay cells. Brain Res. 1989 May 29; 488(1-2):341-7. PMID: 2743129.
      View in: PubMed
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