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Christina E. Hugenschmidt PhD

TitleProfessor
InstitutionWake Forest School of Medicine
DepartmentEmergency Medicine
Address
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    Other Positions
    TitleAssociate Professor
    InstitutionWake Forest School of Medicine
    DepartmentTranslational Neuroscience

    TitleDirector
    InstitutionWake Forest School of Medicine
    DepartmentInternal Medicine, Gerontology & Geriatric Medicine


    Collapse Research 
    Collapse research activities and funding
    F32DK083214     (HUGENSCHMIDT, CHRISTINA E)Jan 14, 2009 - Jan 13, 2012
    NIH
    Genetic and imaging analysis of cerebrovascular disease and cognition in diabetes
    Role: Principal Investigator
    K01AG043547     (HUGENSCHMIDT, CHRISTINA E)Sep 1, 2013 - May 31, 2019
    NIH
    Cognitive/Brain Effects of Adding Weight Loss to Exercise in Obese Older Adults
    Role: Principal Investigator
    R01AT009444     (HUGENSCHMIDT, CHRISTINA E)May 1, 2017 - Apr 30, 2021
    NIH
    A randomized trial of dance on mood, balance and brain in Alzheimer's Disease
    Role: Principal Investigator
    R21AG054955     (HUGENSCHMIDT, CHRISTINA E)Jul 15, 2017 - Apr 30, 2021
    NIH
    The interaction between diabetes and estradiol on human brain metabolism in postmenopausal women
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Espeland MA, Yassine H, Hayden KD, Hugenschmidt C, Bennett WL, Chao A, Neiberg R, Kahn SE, Luchsinger JA. Sex-related differences in cognitive trajectories in older individuals with type 2 diabetes and overweight or obesity. Alzheimers Dement (N Y). 2021; 7(1):e12160. PMID: 33860069.
      Citations:    
    2. Ip EH, Pierce J, Chen SH, Lovato J, Hughes TM, Hayden KM, Hugenschmidt CE, Craft S, Kitzman D, Rapp S. Conversion between the Modified Mini-Mental State Examination (3MSE) and the Mini-Mental State Examination (MMSE). Alzheimers Dement (Amst). 2021; 13(1):e12161. PMID: 33816754.
      Citations:    
    3. Simpson FR, Carmichael O, Hayden KM, Hugenschmidt CE, McCaffery JM, Yasar S, Pajewski NM, Espeland MA. Does the impact of intensive lifestyle intervention on cognitive function vary depending baseline level of frailty? An ancillary study to the Action for Health in Diabetes (Look AHEAD) Trial. J Diabetes Complications. 2021 May; 35(5):107909. PMID: 33745805.
      Citations:    
    4. Neyland BR, Hugenschmidt CE, Lyday RG, Burdette JH, Baker LD, Rejeski WJ, Miller ME, Kritchevsky SB, Laurienti PJ. Effects of a Motor Imagery Task on Functional Brain Network Community Structure in Older Adults: Data from the Brain Networks and Mobility Function (B-NET) Study. Brain Sci. 2021 Jan 17; 11(1). PMID: 33477358.
      Citations:    
    5. Sullivan KJ, Ranadive R, Su D, Neyland BR, Hughes TM, Hugenschmidt CE, Lockhart SN, Wong DF, Jack CR, Gottesman RF, Mosley TH, Griswold ME, Windham BG. Imaging-based indices of Neuropathology and gait speed decline in older adults: the atherosclerosis risk in communities study. Brain Imaging Behav. 2021 Jan 13. PMID: 33439369.
      Citations:    
    6. Pastva AM, Hugenschmidt CE, Kitzman DW, Nelson MB, Brenes GA, Reeves GR, Mentz RJ, Whellan DJ, Chen H, Duncan PW. Cognition, Physical Function, and Quality of Life in Older Patients With Acute Decompensated Heart Failure. J Card Fail. 2021 Mar; 27(3):286-294. PMID: 32956816.
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    7. Yassine HN, Anderson A, Brinton R, Carmichael O, Espeland MA, Hoscheidt S, Hugenschmidt CE, Keller JN, Peters A, Pi-Sunyer X. Do menopausal status and APOE4 genotype alter the long-term effects of intensive lifestyle intervention on cognitive function in women with type 2 diabetes mellitus? Neurobiol Aging. 2020 08; 92:61-72. PMID: 32388179.
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    8. Nicklas BJ, Brinkley TE, Houston DK, Lyles MF, Hugenschmidt CE, Beavers KM, Leng X. Effects of Caloric Restriction on Cardiorespiratory Fitness, Fatigue, and Disability Responses to Aerobic Exercise in Older Adults With Obesity: A Randomized Controlled Trial. J Gerontol A Biol Sci Med Sci. 2019 06 18; 74(7):1084-1090. PMID: 29982294.
      Citations:    
    9. Hugenschmidt CE, Leng X, Lyles M, Michael L, Dougherty A, Babcock P, Baker LD, Brinkley TE, Nicklas BJ. Cognitive Effects of Adding Caloric Restriction to Aerobic Exercise Training in Older Adults with Obesity. Obesity (Silver Spring). 2019 08; 27(8):1266-1274. PMID: 31199592.
      Citations:    
    10. Espeland MA, Carmichael O, Yasar S, Hugenschmidt C, Hazzard W, Hayden KM, Rapp SR, Neiberg R, Johnson KC, Hoscheidt S, Mielke MM. Sex-related differences in the prevalence of cognitive impairment among overweight and obese adults with type 2 diabetes. Alzheimers Dement. 2018 09; 14(9):1184-1192. PMID: 30201101.
      Citations:    
    11. Hughes TM, Sink KM, Williamson JD, Hugenschmidt CE, Wagner BC, Whitlow CT, Xu J, Smith SC, Launer LJ, Barzilay JI, Ismail-Beigi F, Bryan RN, Hsu FC, Bowden DW, Maldjian JA, Divers J, Freedman BI. Relationships between cerebral structure and cognitive function in African Americans with type 2 diabetes. J Diabetes Complications. 2018 Oct; 32(10):916-921. PMID: 30042057.
      Citations:    
    12. Hsu FC, Sink KM, Hugenschmidt CE, Williamson JD, Hughes TM, Palmer ND, Xu J, Smith SC, Wagner BC, Whitlow CT, Bowden DW, Maldjian JA, Divers J, Freedman BI. Cerebral Structure and Cognitive Performance in African Americans and European Americans With Type 2 Diabetes. J Gerontol A Biol Sci Med Sci. 2018 03 02; 73(3):407-414. PMID: 29309525.
      Citations:    
    13. Freedman BI, Sink KM, Hugenschmidt CE, Hughes TM, Williamson JD, Whitlow CT, Palmer ND, Miller ME, Lovato LC, Xu J, Smith SC, Launer LJ, Barzilay JI, Cohen RM, Sullivan MD, Bryan RN, Wagner BC, Bowden DW, Maldjian JA, Divers J. Associations of Early Kidney Disease With Brain Magnetic Resonance Imaging and Cognitive Function in African Americans With Type 2 Diabetes Mellitus. Am J Kidney Dis. 2017 Nov; 70(5):627-637. PMID: 28648301.
      Citations:    
    14. Palmer Allred ND, Raffield LM, Hardy JC, Hsu FC, Divers J, Xu J, Smith SC, Hugenschmidt CE, Wagner BC, Whitlow CT, Sink KM, Maldjian JA, Williamson JD, Bowden DW, Freedman BI. APOE Genotypes Associate With Cognitive Performance but Not Cerebral Structure: Diabetes Heart Study MIND. Diabetes Care. 2016 Dec; 39(12):2225-2231. PMID: 27703028.
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    15. Martelle SE, Raffield LM, Palmer ND, Cox AJ, Freedman BI, Hugenschmidt CE, Williamson JD, Bowden DW. Dopamine pathway gene variants may modulate cognitive performance in the DHS - Mind Study. Brain Behav. 2016 04; 6(4):e00446. PMID: 27066308.
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    16. Batson G, Hugenschmidt CE, Soriano CT. Verbal Auditory Cueing of Improvisational Dance: A Proposed Method for Training Agency in Parkinson's Disease. Front Neurol. 2016; 7:15. PMID: 26925029.
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    17. Adams JN, Martelle SE, Raffield LM, Freedman BI, Langefeld CD, Hsu FC, Maldjian JA, Williamson JD, Hugenschmidt CE, Carr JJ, Cox AJ, Bowden DW. Analysis of advanced glycation end products in the DHS Mind Study. J Diabetes Complications. 2016 Mar; 30(2):262-8. PMID: 26739237.
      Citations:    
    18. Raffield LM, Cox AJ, Freedman BI, Hugenschmidt CE, Hsu FC, Wagner BC, Xu J, Maldjian JA, Bowden DW. Analysis of the relationships between type 2 diabetes status, glycemic control, and neuroimaging measures in the Diabetes Heart Study Mind. Acta Diabetol. 2016 Jun; 53(3):439-47. PMID: 26525870.
      Citations:    
    19. Espeland MA, Brinton RD, Hugenschmidt C, Manson JE, Craft S, Yaffe K, Weitlauf J, Vaughan L, Johnson KC, Padula CB, Jackson RD, Resnick SM. Impact of Type 2 Diabetes and Postmenopausal Hormone Therapy on Incidence of Cognitive Impairment in Older Women. Diabetes Care. 2015 Dec; 38(12):2316-24. PMID: 26486190.
      Citations:    
    20. Raffield LM, Brenes GA, Cox AJ, Freedman BI, Hugenschmidt CE, Hsu FC, Xu J, Wagner BC, Williamson JD, Maldjian JA, Bowden DW. Associations between anxiety and depression symptoms and cognitive testing and neuroimaging in type 2 diabetes. J Diabetes Complications. 2016 Jan-Feb; 30(1):143-9. PMID: 26476474.
      Citations:    
    21. Hugenschmidt CE, Sink KM. No pain, functional gain: the importance of pain management in older adults with cognitive impairment. Pain. 2015 Aug; 156(8):1377-1378. PMID: 25993550.
      Citations:    
    22. Hsu FC, Raffield LM, Hugenschmidt CE, Cox A, Xu J, Carr JJ, Freedman BI, Maldjian JA, Williamson JD, Bowden DW. Relationships between Cognitive Performance, Neuroimaging and Vascular Disease: The DHS-MIND Study. Neuroepidemiology. 2015; 45(1):1-11. PMID: 26185004.
      Citations:    
    23. Espeland MA, Brinton RD, Manson JE, Yaffe K, Hugenschmidt C, Vaughan L, Craft S, Edwards BJ, Casanova R, Masaki K, Resnick SM. Postmenopausal hormone therapy, type 2 diabetes mellitus, and brain volumes. Neurology. 2015 Sep 29; 85(13):1131-8. PMID: 26163429.
      Citations:    
    24. Murea M, Hsu FC, Cox AJ, Hugenschmidt CE, Xu J, Adams JN, Raffield LM, Whitlow CT, Maldjian JA, Bowden DW, Freedman BI. Structural and functional assessment of the brain in European Americans with mild-to-moderate kidney disease: Diabetes Heart Study-MIND. Nephrol Dial Transplant. 2015 Aug; 30(8):1322-9. PMID: 25722384.
      Citations:    
    25. Raffield LM, Cox AJ, Hugenschmidt CE, Freedman BI, Langefeld CD, Williamson JD, Hsu FC, Maldjian JA, Bowden DW. Heritability and genetic association analysis of neuroimaging measures in the Diabetes Heart Study. Neurobiol Aging. 2015 Mar; 36(3):1602.e7-15. PMID: 25523635.
      Citations:    
    26. Palmer ND, Sink KM, Smith SC, Xu J, Bowden DW, Hugenschmidt CE, Whitlow CT, Williamson JD, Maldjian JA, Divers J, Freedman BI. Kidney disease and cognitive function: African American-diabetes heart study MIND. Am J Nephrol. 2014; 40(3):200-7. PMID: 25323981.
      Citations:    
    27. Sink KM, Divers J, Whitlow CT, Palmer ND, Smith SC, Xu J, Hugenschmidt CE, Wagner BC, Williamson JD, Bowden DW, Maldjian JA, Freedman BI. Cerebral structural changes in diabetic kidney disease: African American-Diabetes Heart Study MIND. Diabetes Care. 2015 Feb; 38(2):206-12. PMID: 25205141.
      Citations:    
    28. Hugenschmidt CE, Lovato JF, Ambrosius WT, Bryan RN, Gerstein HC, Horowitz KR, Launer LJ, Lazar RM, Murray AM, Chew EY, Danis RP, Williamson JD, Miller ME, Ding J. The cross-sectional and longitudinal associations of diabetic retinopathy with cognitive function and brain MRI findings: the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial. Diabetes Care. 2014 Dec; 37(12):3244-52. PMID: 25193529.
      Citations:    
    29. Hugenschmidt CE, Burdette JH, Morgan AR, Williamson JD, Kritchevsky SB, Laurienti PJ. Graph theory analysis of functional brain networks and mobility disability in older adults. J Gerontol A Biol Sci Med Sci. 2014 Nov; 69(11):1399-406. PMID: 24717331.
      Citations:    
    30. Cox AJ, Hugenschmidt CE, Raffield LM, Langefeld CD, Freedman BI, Williamson JD, Hsu FC, Bowden DW. Heritability and genetic association analysis of cognition in the Diabetes Heart Study. Neurobiol Aging. 2014 Aug; 35(8):1958.e3-1958.e12. PMID: 24684796.
      Citations:    
    31. Hugenschmidt CE. A link between type 2 diabetes and brain function. JAAPA. 2013 Dec; 26(12):10-1. PMID: 24213220.
      Citations:    
    32. Hugenschmidt C, Williamson JD. Solving the mystery of the diabetes-dementia connection: new clues--but far from "case closed". J Diabetes Complications. 2014 Jan-Feb; 28(1):8-9. PMID: 24268940.
      Citations:    
    33. Hugenschmidt CE, Hsu FC, Hayasaka S, Carr JJ, Freedman BI, Nyenhuis DL, Williamson JD, Bowden DW. The influence of subclinical cardiovascular disease and related risk factors on cognition in type 2 diabetes mellitus: The DHS-Mind study. J Diabetes Complications. 2013 Sep-Oct; 27(5):422-8. PMID: 23659774.
      Citations:    
    34. Cox AJ, Hugenschmidt CE, Wang PT, Hsu FC, Kenchaiah S, Daniel K, Langefeld CD, Freedman BI, Herrington DM, Carr JJ, Stacey B, Bowden DW. Usefulness of biventricular volume as a predictor of mortality in patients with diabetes mellitus (from the Diabetes Heart Study). Am J Cardiol. 2013 Apr 15; 111(8):1152-8. PMID: 23351459.
      Citations:    
    35. Divers J, Hugenschmidt C, Sink KM, Williamson JD, Ge Y, Smith SC, Bowden DW, Whitlow CT, Lyders E, Maldjian JA, Freedman BI. Cerebral white matter hyperintensity in African Americans and European Americans with type 2 diabetes. J Stroke Cerebrovasc Dis. 2013 Oct; 22(7):e46-52. PMID: 22608346.
      Citations:    
    36. Moussa MN, Vechlekar CD, Burdette JH, Steen MR, Hugenschmidt CE, Laurienti PJ. Changes in cognitive state alter human functional brain networks. Front Hum Neurosci. 2011; 5:83. PMID: 21991252.
      Citations:    
    37. Sergeant S, Hugenschmidt CE, Rudock ME, Ziegler JT, Ivester P, Ainsworth HC, Vaidya D, Case LD, Langefeld CD, Freedman BI, Bowden DW, Mathias RA, Chilton FH. Differences in arachidonic acid levels and fatty acid desaturase (FADS) gene variants in African Americans and European Americans with diabetes or the metabolic syndrome. Br J Nutr. 2012 Feb; 107(4):547-55. PMID: 21733300.
      Citations:    
    38. Hayasaka S, Hugenschmidt CE, Laurienti PJ. A network of genes, genetic disorders, and brain areas. PLoS One. 2011; 6(6):e20907. PMID: 21695164.
      Citations:    
    39. Mathias RA, Sergeant S, Ruczinski I, Torgerson DG, Hugenschmidt CE, Kubala M, Vaidya D, Suktitipat B, Ziegler JT, Ivester P, Case D, Yanek LR, Freedman BI, Rudock ME, Barnes KC, Langefeld CD, Becker LC, Bowden DW, Becker DM, Chilton FH. The impact of FADS genetic variants on ?6 polyunsaturated fatty acid metabolism in African Americans. BMC Genet. 2011 May 20; 12:50. PMID: 21599946.
      Citations:    
    40. Peiffer AM, Hugenschmidt CE, Laurienti PJ. Ethics in 15 min per week. Sci Eng Ethics. 2011 Jun; 17(2):289-97. PMID: 20213534.
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    41. Hugenschmidt CE, Hayasaka S, Peiffer AM, Laurienti PJ. Applying capacity analyses to psychophysical evaluation of multisensory interactions. Inf Fusion. 2010 Jan 01; 11(1):12-20. PMID: 20161039.
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    42. Hugenschmidt CE, Mozolic JL, Tan H, Kraft RA, Laurienti PJ. Age-related increase in cross-sensory noise in resting and steady-state cerebral perfusion. Brain Topogr. 2009 May; 21(3-4):241-51. PMID: 19415481.
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    43. Hugenschmidt CE, Peiffer AM, McCoy TP, Hayasaka S, Laurienti PJ. Preservation of crossmodal selective attention in healthy aging. Exp Brain Res. 2009 Sep; 198(2-3):273-85. PMID: 19404621.
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    44. Hugenschmidt CE, Mozolic JL, Laurienti PJ. Suppression of multisensory integration by modality-specific attention in aging. Neuroreport. 2009 Mar 04; 20(4):349-53. PMID: 19218871.
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    45. Peiffer AM, Hugenschmidt CE, Maldjian JA, Casanova R, Srikanth R, Hayasaka S, Burdette JH, Kraft RA, Laurienti PJ. Aging and the interaction of sensory cortical function and structure. Hum Brain Mapp. 2009 Jan; 30(1):228-40. PMID: 18072271.
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    46. Peiffer AM, Laurienti PJ, Hugenschmidt CE. Fostering a culture of responsible lab conduct. Science. 2008 Nov 21; 322(5905):1186. PMID: 19023060.
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    47. Mozolic JL, Joyner D, Hugenschmidt CE, Peiffer AM, Kraft RA, Maldjian JA, Laurienti PJ. Cross-modal deactivations during modality-specific selective attention. BMC Neurol. 2008 Sep 25; 8:35. PMID: 18817554.
      Citations:    
    48. Mozolic JL, Hugenschmidt CE, Peiffer AM, Laurienti PJ. Modality-specific selective attention attenuates multisensory integration. Exp Brain Res. 2008 Jan; 184(1):39-52. PMID: 17684735.
      Citations:    
    49. Peiffer AM, Mozolic JL, Hugenschmidt CE, Laurienti PJ. Age-related multisensory enhancement in a simple audiovisual detection task. Neuroreport. 2007 Jul 02; 18(10):1077-81. PMID: 17558300.
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    50. Hayasaka S, Peiffer AM, Hugenschmidt CE, Laurienti PJ. Power and sample size calculation for neuroimaging studies by non-central random field theory. Neuroimage. 2007 Sep 01; 37(3):721-30. PMID: 17658273.
      Citations:    
    51. Hugenschmidt CE, Peiffer AM, Kraft RA, Casanova R, Deibler AR, Burdette JH, Maldjian JA, Laurienti PJ. Relating imaging indices of white matter integrity and volume in healthy older adults. Cereb Cortex. 2008 Feb; 18(2):433-42. PMID: 17575289.
      Citations:    
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