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Che-Chia Hsu PhD

TitleAssistant Professor
InstitutionWake Forest School of Medicine
DepartmentCancer Biology
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    Collapse Biography 
    Collapse education and training
    National Cheng Kung University, Tainan, TaiwanPhD2014
    National Cheng Kung University, Tainan, TaiwanMS2009
    Kaohsiung Medical University, Kaohsiung, TaiwanBS2007
    Department of Cancer Biology, Wake Forest University School of MedicineVisiting scholar2018
    Department of Cancer Biology, Wake Forest University School of MedicinePostdoctoral fellow2022

    Collapse Overview 
    Collapse overview
    My research has focused on mitochondrial functions in cancer metabolism and understand the role of mitochondrial dynamics in cellular function and human diseases. Additionally, I also continuously characterize several metabolic pathways in mitochondrial metabolism and explore how different metabolic pathways regulate cancer progression. Now, I also use several in vitro and in vivo genetical approaches such as CRISPR/Cas9 knockout or genetically engineered mice to identify potential metabolic targeting for cancer initiation, progression and metastasis.

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Hsu CC, Xu ZG, Lei J, Chen ZZ, Li HY, Lin HK. Identification of myo-inositol-binding proteins by using the biotin pull-down strategy in cultured cells. STAR Protoc. 2022 Jun 17; 3(2):101385. PMID: 35600928.
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    2. Xu C, Jin G, Wu H, Cui W, Wang YH, Manne RK, Wang G, Zhang W, Zhang X, Han F, Cai Z, Pan BS, Hsu CC, Liu Y, Zhang A, Long J, Zou H, Wang S, Ma X, Duan J, Wang B, Liu W, Lan H, Xiong Q, Xue G, Chen Z, Xu Z, Furth ME, Haigh Molina S, Lu Y, Xie D, Bian XW, Lin HK. SIRP?-expressing cancer stem-like cells promote immune escape of lung cancer via Hippo signaling. J Clin Invest. 2022 03 01; 132(5). PMID: 35229723.
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    3. Hsu CC, Tsai YS, Lin HK. UHRF1: a novel metabolic guardian restricting AMPK activity. Cell Res. 2022 01; 32(1):3-4. PMID: 34907338.
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    4. Hsu CC, Zhang X, Wang G, Zhang W, Cai Z, Pan BS, Gu H, Xu C, Jin G, Xu X, Manne RK, Jin Y, Yan W, Shao J, Chen T, Lin E, Ketkar A, Eoff R, Xu ZG, Chen ZZ, Li HY, Lin HK. Inositol serves as a natural inhibitor of mitochondrial fission by directly targeting AMPK. Mol Cell. 2021 09 16; 81(18):3803-3819.e7. PMID: 34547240.
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    5. Wang G, Long J, Gao Y, Zhang W, Han F, Xu C, Sun L, Yang SC, Lan J, Hou Z, Cai Z, Jin G, Hsu CC, Wang YH, Hu J, Chen TY, Li H, Lee MG, Lin HK. Author Correction: SETDB1-mediated methylation of Akt promotes its K63-linked ubiquitination and activation leading to tumorigenesis. Nat Cell Biol. 2021 Jun; 23(6):676. PMID: 33927372.
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    6. Hsu CC, Peng D, Cai Z, Lin HK. AMPK signaling and its targeting in cancer progression and treatment. Semin Cancer Biol. 2021 Apr 17. PMID: 33862221.
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    7. Yang WB, Hsu CC, Hsu TI, Liou JP, Chang KY, Chen PY, Liu JJ, Yang ST, Wang JY, Yeh SH, Chen RM, Chang WC, Chuang JY. Increased activation of HDAC1/2/6 and Sp1 underlies therapeutic resistance and tumor growth in glioblastoma. Neuro Oncol. 2020 10 14; 22(10):1439-1451. PMID: 32328646.
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    8. Cai Z, Li CF, Han F, Liu C, Zhang A, Hsu CC, Peng D, Zhang X, Jin G, Rezaeian AH, Wang G, Zhang W, Pan BS, Wang CY, Wang YH, Wu SY, Yang SC, Hsu FC, D'Agostino RB, Furdui CM, Kucera GL, Parks JS, Chilton FH, Huang CY, Tsai FJ, Pasche B, Watabe K, Lin HK. Phosphorylation of PDHA by AMPK Drives TCA Cycle to Promote Cancer Metastasis. Mol Cell. 2020 10 15; 80(2):263-278.e7. PMID: 33022274.
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    9. Cai Z, Moten A, Peng D, Hsu CC, Pan BS, Manne R, Li HY, Lin HK. The Skp2 Pathway: A Critical Target for Cancer Therapy. Semin Cancer Biol. 2020 12; 67(Pt 2):16-33. PMID: 32014608.
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    10. Zhang W, Wang G, Xu ZG, Tu H, Hu F, Dai J, Chang Y, Chen Y, Lu Y, Zeng H, Cai Z, Han F, Xu C, Jin G, Sun L, Pan BS, Lai SW, Hsu CC, Xu J, Chen ZZ, Li HY, Seth P, Hu J, Zhang X, Li H, Lin HK. Lactate Is a Natural Suppressor of RLR Signaling by Targeting MAVS. Cell. 2019 06 27; 178(1):176-189.e15. PMID: 31155231.
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    11. Wang G, Long J, Gao Y, Zhang W, Han F, Xu C, Sun L, Yang SC, Lan J, Hou Z, Cai Z, Jin G, Hsu CC, Wang YH, Hu J, Chen TY, Li H, Lee MG, Lin HK. SETDB1-mediated methylation of Akt promotes its K63-linked ubiquitination and activation leading to tumorigenesis. Nat Cell Biol. 2019 02; 21(2):214-225. PMID: 30692626.
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    12. Chang KY, Huang CT, Hsu TI, Hsu CC, Liu JJ, Chuang CK, Hung JJ, Chang WC, Tsai KK, Chuang JY. Stress stimuli induce cancer-stemness gene expression via Sp1 activation leading to therapeutic resistance in glioblastoma. Biochem Biophys Res Commun. 2017 11 04; 493(1):14-19. PMID: 28939040.
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    13. Chang KY, Hsu TI, Hsu CC, Tsai SY, Liu JJ, Chou SW, Liu MS, Liou JP, Ko CY, Chen KY, Hung JJ, Chang WC, Chuang CK, Kao TJ, Chuang JY. Specificity protein 1-modulated superoxide dismutase 2 enhances temozolomide resistance in glioblastoma, which is independent of O6-methylguanine-DNA methyltransferase. Redox Biol. 2017 10; 13:655-664. PMID: 28822335.
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    14. Hsu CC, Chang WC, Hsu TI, Liu JJ, Yeh SH, Wang JY, Liou JP, Ko CY, Chang KY, Chuang JY. Suberoylanilide hydroxamic acid represses glioma stem-like cells. J Biomed Sci. 2016 Nov 18; 23(1):81. PMID: 27863490.
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    15. Yang CP, Kuo YL, Lee YC, Lee KH, Chiang CW, Wang JM, Hsu CC, Chang WC, Lin DY. RINT-1 interacts with MSP58 within nucleoli and plays a role in ribosomal gene transcription. Biochem Biophys Res Commun. 2016 09 16; 478(2):873-80. PMID: 27530925.
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    16. Hsu CC, Chen CH, Hsu TI, Hung JJ, Ko JL, Zhang B, Lee YC, Chen HK, Chang WC, Lin DY. The 58-kda microspherule protein (MSP58) represses human telomerase reverse transcriptase (hTERT) gene expression and cell proliferation by interacting with telomerase transcriptional element-interacting factor (TEIF). Biochim Biophys Acta. 2014 Mar; 1843(3):565-79. PMID: 24361335.
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    17. Hsu CC, Lee YC, Yeh SH, Chen CH, Wu CC, Wang TY, Chen YN, Hung LY, Liu YW, Chen HK, Hsiao YT, Wang WS, Tsou JH, Tsou YH, Wu MH, Chang WC, Lin DY. 58-kDa microspherule protein (MSP58) is novel Brahma-related gene 1 (BRG1)-associated protein that modulates p53/p21 senescence pathway. J Biol Chem. 2012 Jun 29; 287(27):22533-48. PMID: 22563078.
      Citations:    
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